Abstract
Neurological Soft Signs (NSS) are sensory-motor abnormalities linked with cerebellar and microstructural subcortical white matter alterations, which are not systematically evaluated during standard neurological examination. Although historically observed in psychiatric conditions, NSS have been recently associated with migraine, mild cognitive impairment and Alzheimer's disease (AD), and correlated with age and apoE polymorphisms. However, no study to date has evaluated the burden of NSS in other types of dementia. Our research aims to confirm the increase of NSS in AD patients, and extend their assessment to fronto-temporal dementia (FTD), cortico-basal syndrome (CBS) and Lewy-body dementia (LBD), correlating them with the severity of cognitive impairment.
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