St Louis University Research Articles

RESPONSE TO SMALLPOX VACCINE IN PERSONS IMMUNIZED IN THE DISTANT PAST

Frey SE, Newman FK, Yan L, Lottenbach KR, Belshe RB. JAMA. 2003;289:3295–3299There is renewed interest in the use of smallpox vaccine, because of the potential for a bioterrorist attack. One obvious question relates to the current status of people who have been vaccinated in the past. This study sought to evaluate the use of diluted vaccinia virus for vaccination of previously vaccinated (nonnaive) participants.Eighty nonnaive participants, 32 to 60 years of age, were randomized to receive either undiluted or diluted (1:3.2, 1:10, or 1:32) doses of smallpox vaccine, in a single-blinded study. A comparison group of 10 vaccinia-naive participants, 18 to 31 years of age, received undiluted vaccine.Participants were enrolled between April 1 and May 15, 2002, at the National Institute of Allergy and Infectious Diseases Vaccine and Treatment Evaluation Unit at St Louis University (St Louis, MO). Smallpox vaccine was administered through scarification, using 15 skin punctures in the deltoid region of the arm. Outcome measures included the presence of a major reaction, defined as a vesicular or pustular lesion or area of palpable induration surrounding a central lesion, after vaccination, measures of viral shedding, and antibody titers.Initial vaccination resulted in a major reaction for 64 of 80 nonnaive participants. Ninety-five percent of nonnaive participants had major reactions in the undiluted group, 90% in the 1:3.2 dilution group, 81% in the 1:10 dilution group, and 52.6% in the 1:32 dilution group. All of the vaccinia-naive participants (n = 10) experienced major reactions. Compared with vaccinia-naive participants, nonnaive participants had significantly smaller skin lesions (P = .04) and a significantly lower incidence of fever (P = .02). Preexisting antibody was present in 76 of 80 nonnaive participants. Antibody responses were significantly greater and occurred more rapidly among the nonnaive participants, compared with the vaccinia-naive participants (P = .002 for day 28 and P = .003 for 6 months). Vaccinia-naive participants shed virus from the vaccination site 2 to 6 days longer and had significantly higher mean peak viral titers, compared with the nonnaive participants (P = .002).Previously vaccinated persons could be successfully revaccinated with diluted (≤1:10) smallpox vaccine. Fewer adverse reactions were observed in this study among nonnaive participants, compared with vaccinia-naive participants, which might be attributable to immunologic memory.This is an excellent practical study addressing an important issue. Although we hope that widespread smallpox vaccination will not be necessary, these data should be useful for the design of whatever program might be necessary.

The Degaev Affair: Terror and Treason in Tsarist Russia by Richard s> Pipes (review)

366 SEER, 82, 2, 2004 LocalGovernment, I900-I9I4 (New Brunswick,NJ, I98I). To omit one source is a misfortune, to omit all of these looks like carelessness.In contrast to the above, however, Zuckermandoes include a considerablenumberofreferences to his previous book TheTsaristSecret Policein RussianSociety,I880-I9I7 (Basingstoke,I996) with over twenty, often unnecessary,citations. St CrossCollege IAIN LAUCHLAN University ofOxford Pipes, Richard. 7he DegaevAffair. Terror and Treason in TsaristRussia.Yale University Press, New Haven, CT, and London, 2003. xi+ I53 pp. Illustrations.Notes. Appendix. Index. $22.95: [i6.95. ON I6 December I883, Lt Colonel Georgii Sudeikin, the head of the St PetersburgSecurity Section the Okhrana was assassinated.For senior officials in the Russian government, the threat of murder was ever-present and, only twoyearspreviously,EmperorAlexanderII had himselfbeen blown to pieces by a terroristbomb. Sudeikin'smurderwas unusual, however, since the assassin, Sergei Degaev, was one of his own secret agents. Sixteen years later, the University of South Dakota appointed one Alexander Pell as its first professor of mathematics, unaware that Pell, with his strong Russian accent, was the Degaev who had assassinatedthe head of the St Petersburgsecret police. Richard Pipes's book is both a biography of Degaev-Pell and a wider reflection on aspects of terrorism.As Pipes notes, a full biographical study of this intriguing man is made difficult by the lack of source materials. In particular, while the basic facts and contours of his life can be established, evidence to explain Degaev's psychology and the motivation for his actions is largely lacking. Degaev's duplicitywas multifaceted:he became a member of the revolutionary People's Will organization in 88o and was arrestedtwice for seditious activity. In I882, during his second period in custody, he was recruited by Sudeikin as a police agent. Degaev provided Sudeikin with the names of revolutionarieswho were then duly arrested. Degaev's betrayal of his own comrades evidently weighed heavily on his mind, for he revealed his actions to Lev Tikhomirov, a fellow member of the People'sWillwho ordered Degaev to murderSudeikinas an act of contritionand to demonstratehis real commitment to the revolutionary movement. After assassinating Sudeikin, Degaev left Russia for Paris,emigratingto North America in i886 and, after engaging in coursesof studyin St Louis and atJohns Hopkins University,was appointed to teach at South Dakota, living a life of the utmost respectability until his death in 192 I. The centralpiece ofevidence to explainDegaev's behaviouristhe statement published by the People's Will after Sudeikin'sassassination.Unsurprisingly, thisattributedDegaev's treacheryto hisown psychologicalflawsanddescribed him as being in a condition of 'spiritualgloom and moral collapse'. Pipes, however, seeks to explain the attraction of terrorismin more general terms. He takes the example of terrorism in Russia, and contrasts this with the existence of the phenomenon in both modern Germany and the United States to reject the idea that revolutionaryviolence is prompted either by political oppression or by poverty. Instead, Pipes suggests that 'for some dimly REVIEWS 367 understood reason', from time to time nihilisticimpulses affectyoung people in modern societies and that these also become transformed into selfdestructive urges. This does not advance the discussion and leaves us in the dark about both Degaev's motivation and the causes of terrorism in the developed modern world. Pipes'sbook is an interestinginsightinto a hitherto unilluminated corner of the Russian revolutionary movement, but the shortageof sourcesfor Degaev's life inhibitsany deeper analysis. Department ofHistoy PETER WALDRON University ofSunderland Peter, Laszl6; Rady, Martyn and Sherwood, Peter (eds). LajosKossuth Sent Word. . . Papers Delivered on theOccasion of theBicentenagy ofKossuth's Birth. SSEES Occasional Papers, 56. Hungarian Cultural Centre and School of Slavonic and East European Studies, London, 2003. viii + 263 pp. Notes. Index. ?20.00 (paperback). THE reader of these essays may be somewhat startled to discover that two eminent English historians, perhaps not knowing what the other was up to, decided not to write on Kossuth, but on his uncompromising foes. Robert Evans is fascinated by the Slovak L'udovit Stiur,while Alan Sked is equally intriguedby the Croat nationalism of the imperial generalJosip Jelacic. The motive for their selection may well be that each dreaded uncriticaleulogies of Kossuth by the other essayistsand took evasive action in this way. However...

Acute Marijuana Use and Cerebellar Infarction

Three adolescent cases of ischemic stroke involving the posterior fossa circulation and cerebellum occurred within days after the illicit use of marijuana and presented over a span of 5 years at St Louis University School of Medicine, MO.

Accuracy of initial biopsy of melanoma and effects on staging, treatment & prognosis

How accurate is initial biopsy for melanoma? How often is a consultative reading or surgical excision significantly different than initial biopsy? How does this difference in histologic information affect staging/treatment/prognosis? Are there any established guidelines for dealing with differing histologic information for staging? These are some of the questions we attempt to answer through a retrospective review of the St. Louis University (SLU) Melanoma Database from June 2001 thru May 2003. A total of 59 cases of primary cutaneous melanoma were reviewed retrospectively. Breslow’s depth (BD) on initial biopsy report was compared with BD on consult report and WLE path report if residual tumor was seen for determination of accuracy. All cases in SLU Melanoma Database (n = 72) were reviewed. Patients with in-situ melanoma (n = 13) were excluded. Remaining patients with invasive melanoma (n = 59) were identified and their records reviewed for initial biopsy type, initial BD, consult BD, WLE residual BD, and other clinical information including presence of ulceration & clinical stage according to 2002 AJCC staging system. Accuracy was defined as Breslow’s depth in initial biopsy greater than or equal to that in 2nd biopsy or excision. Overall accuracy of initial biopsy was found to be 93% in this series. How accurate is initial biopsy for melanoma? How often is a consultative reading or surgical excision significantly different than initial biopsy? How does this difference in histologic information affect staging/treatment/prognosis? Are there any established guidelines for dealing with differing histologic information for staging? These are some of the questions we attempt to answer through a retrospective review of the St. Louis University (SLU) Melanoma Database from June 2001 thru May 2003. A total of 59 cases of primary cutaneous melanoma were reviewed retrospectively. Breslow’s depth (BD) on initial biopsy report was compared with BD on consult report and WLE path report if residual tumor was seen for determination of accuracy. All cases in SLU Melanoma Database (n = 72) were reviewed. Patients with in-situ melanoma (n = 13) were excluded. Remaining patients with invasive melanoma (n = 59) were identified and their records reviewed for initial biopsy type, initial BD, consult BD, WLE residual BD, and other clinical information including presence of ulceration & clinical stage according to 2002 AJCC staging system. Accuracy was defined as Breslow’s depth in initial biopsy greater than or equal to that in 2nd biopsy or excision. Overall accuracy of initial biopsy was found to be 93% in this series.

Surgical Pearl: Use of the Vacutainer as a closed, active, surgical drain

J Am Acad Dermatol 2003;48:933-4.

Associate Editor's Notes

It has been some time and many scholarly conferences and articles since late 70s, when we first began to look at general education more closely. We have become wiser (and more attentive), despite fact that in many institutions of higher education, general educa tion still is part of problem of the commons, which tells us that which is commonly owned is subject to a lack of close attention. This issue of Journal of General Education certainly indicates that general education, when considered as seriously as disciplinary teaching, can produce a wealth of information across every aspect of academic environment. Our contemporary understanding is that educators must have more than content awareness if we are to be effective; we must know about course structures, student abilities, pedagogy, and assessment, as well as have knowledge of institu tion's selection of students. This leaves us with a very full plate indeed; however, we are aided and encouraged in this complex work by faculty and administration scholars who have chosen to do schol arly work in all of these areas. The common curriculum is subject investigated in Five Features of Effective Core Courses by Julie Weissman and Kenneth J. Boning of St Louis University. They open with fact that in fall of 2000, St. Louis University began offering a set of general edu cation core requirements and included an evaluation of objectives with program. This evaluation provided large amounts of valu able information; what Weissman and Boning discuss specifically in their article are [f]ive features of teaching and learning envi ronment that emerged as new program was carried out. Their qualitative study covers creation of community and collaborative learning, students' ownership of learning, interdisciplinary and real world connections, evaluation, and course design to facilitate disci plinary learning. The article also briefly discusses way pro gram itself was developed and integrated into overall University curriculum. The program has received much attention, resulting in broad campus distribution of information through internal reports and meetings, as well as national notice through publication and par ticipation in conferences.

Surgical bypass for subclavian vein occlusion in hemodialysis patients.

The majority of patients with end-stage renal disease are dependent on hemodialysis. Significant stenosis or occlusion of the subclavian vein is known to occur in 20% to 50% of patients who have had central venous catheters inserted into the subclavian vein or the internal jugular vein. Surgical bypass of the obstructed venous segment proximal to a functioning dialysis access site is an established treatment to relieve symptoms and salvage the functional dialysis access. A retrospective review of all subclavian venous bypass procedures performed at St Louis University Hospital from May 1987 to May 2000 was undertaken. Twelve procedures were performed during this time. The mean age of the patient was 55.5 years (range 17 to 72 years). There were 11 men and 1 woman. Before surgical bypass, all patients underwent bilateral venograms to evaluate their central venous systems. An extraanatomic surgical bypass was performed in all patients. Patients were followed for a mean of 16 months (range 1 to 79 months). At 1 month, 100% of hemodialysis access sites remained functional. At 1 year, 80%; 2 years, 60%; and 3 years, 25% of the salvaged arteriovenous hemodialysis access sites provided for functional dialysis. One patient required thrombectomy of the bypass graft at 14 months. Surgical bypass of an occluded or stenotic subclavian vein segment is successful in providing both symptomatic relief and salvage of a functioning dialysis access in the hemodialysis patient population. Study of the central venous system is essential in selecting an appropriate bypass procedure in individual patients.

Charles Ernst Schmidt, MD

died September 18, 2000, at his home in Aiken, SC. He was born on November 24, 1931, in Mayfield, Ky. In 1964, he received his MD degree from St Louis University School of Medicine, Mo. He completed his residency training in radiology at Brook Army Medical Center in San Antonio, Tex, in 1972. Dr Blalock served in the U.S. Army in Vietnam as a medical officer at the Company Commander Headquarters and Support Company, 1st Cavalry Division from June 1967 until May 1968. He also served at various army medical facilities until his retirement from the army in 1976 as a colonel. From 1976 to 1990, he served as chief of radiology at Aiken Regional Medical Center, SC, and thereafter continued as staff radiologist at the same location until his retirement in 2000. Dr Blalock was an avid golfer, pursuing this sport with great passion throughout his life. He was a loving, generous, and tolerant husband and father, a caring and compassionate physician, and a great friend. Although he was not in a bedside specialty, he had a superb bedside manner, always able to speak to any patient as an equal and valued human being, regardless of life circumstances. He is survived by his wife, Joanne; two sons, James, Jr, and Jeffery; a daughter, Stephanie; one brother; one sister; and nine grandchildren.

Sensitization to cockroach allergens in individuals with perennial rhinitis in belarus

18 years, who achieved adequate symptoms after priming with ragweed pollen were randomized to one dose of DL 5 mg (n=81), DPH 50 mg (n=84), or placebo (n=83). A battery of repeatable, automated neuropsychological tests was administered to symptomatic subjects prior to treatment (baseline) and 90 minutes after dosing with study medication. The test battery measured vigilance as well as a broad array of cognitive functions. RESULTS: Both DL and DPH alleviated the symptoms of SAR compared to PLA (p<0.05). Treatment with DPH caused clinically meaningful decrements on all vigilance parameters (p<0.05 for DL/DPH contrasts; moderate effect sizes, ranging from .58 to .67 standard deviations). Subjects treated with DPH also performed significantly worse across all of the other cognitive domains assessed. The majority of the effect sizes for the mean DL/DPH differences were between .4 to .8 (moderate to high). The distribution of Stanford Sleepiness Scale scores also indicated significantly more sedation with DPH vs. DL or PLA (p<0.001). There was no difference in performance between subjects treated with DL and PLA on any cognitive parameter. CONCLUSION: Treatment with DL significantly improved SAR symptoms without adversely affecting cognitive performance. In contrast, DPH improved SAR symptoms but caused significant impairment of cognitive performance and significantly more sedation. Therefore, the efficacy of treatment with DPH must be balanced against the associated effects on cognitive functioning. 2 ' ~ Tecastemizole 30 mg Effectively Reduces the Symptoms of / ~ l l Allergic Rhinitis Jonathan Corren*, Paul Chervinsky§, Phillip Korenblat~, Rudolf A Baumgartner~ *Allergy Research Foundation Incorporated, Los Angeles, CA §New England Clinical Study, North Dartmouth, MA ¥St Louis University, St Louis, MO ~Sepracor incorporated, Marlborough, MA Tecastemizole (TEC) is a potent, non-sedating, once-daily antihistamine with a high affinity for the H I receptor that provides rapid and sustained relief from symptoms of allergic rhinitis. This randomized, double-blind, multicenter study evaluated the efficacy of TEC in subjects with seasonal allergic rhinitis. Subjects received placebo (PBO) or TEC 30 mg for 2 Weeks, and completed daily diary cards at 12,and 24 hours following each dose. Twelve hours after the first dose, TEC provided significant reductions in Total Symptoms Score (TSS: the sum of runny nose/postnasal drip, sneezing, itchy nose, itchy/gritty eyes, tearing/watery eyes, red/burning eyes, and ear/palate itching scores) compared with PBO (TEC LSMean1.24 over PBO, p=0.001; ie, approximately 729% over PBO). Trough TSS, measured 24 hours following the previoUs dose, was significantly decreased from baseline during the entire double-blind period (TEC LSMean -0.89 over PBO, p=0.009; ie, approximately 113% over PBO). TEC was also significantly more effective than PBO in reducing TSS, Nasal TSS, Trough Nasal TSS, Non-Nasal TSS, and Trough Non-Nasal TSS (p<0.049 for each parameter). TEC produced no significant adverse events, no change in the number or intensity of adverse events, and did not affect laboratory parameters, vital signs, or ECG results including QT intervals. Fewer TEC-treated subjects experienced sedation than PBO-treated subjects (0.5% vs 4.3%, respectively). These combined data illustrate that TEC is safe and well tolerated and provides significant allergic rhinitis symptom reduction 24 hours after dosing.

Cardiovascular news.

Cardiovascular news.

Response to Pasick

We appreciate Dr Pasick’s and others’ (Rimer, definition of ‘targeting’ speaks more to identifying or establishing the target group, our use of the 2000) thoughtful responses to our Editorial (Kreuter and Skinner, 2000), and shared interest term is more closely associated with the process of aiming at or for something. Importantly, both in arriving at common definitions for tailoring and targeting. Before addressing Dr Pasick’s concerns are consistent with the dictionary definition. For example, health educators may target a group by specifically, we would like to call attention to the considerable common ground in our perspectives, selecting it to receive some program or intervention, but also subsequently target specific messages as well as that shared with Dr Rimer. First, implicit in our Editorial and in the responses from Pasick to address the unique characteristics of that group. Dr Pasick also offers a dictionary definition of and Rimer is endorsement of the health education truism that any program or educational materials ‘tailoring’ as a process of alteration or adaptation for a particular purpose. We agree that by this will be more effective when audience characteristics are taken into account in the development definition a message can be ‘tailored’ to better fit a group or an individual. However, we see a clarity process. Second, we each recognize the important—and to date underutilized—role of culture as and parallelism in calling a message ‘targeted’ when it is aimed toward a ‘target group’ and one such audience characteristic. Third, we all agree that customization based on group-level ‘tailored’ as in the case of a tailor-made suit— when it is aimed toward an individual. Dr Pasick variables differs from customization based on individual-level variables. Finally, we concur that our suggests using the term ‘individual tailoring’ to distinguish between approaches aimed at indifield needs to move towards clear and consistent use of key terminology. viduals versus groups. We, too, have used this term and its derivatives (e.g. ‘individually tailored’), Our differences with Dr Pasick on definitions of tailoring and targeting are semantic, not conceptual. but have recently discontinued this usage due to another problem. Rather than being interpreted as Her inclusion of the American Heritage Dictionary’s definition of ‘targeting’ is helpful in illustrat‘for individuals’ as we and Pasick intended it to be, the term connotes to some a process of creating ing this point. The definition includes two components—establishing a target and aiming for intervention materials one at a time, rather than mass-producing them. Indeed, there are differences the target. Whereas Dr Pasick and colleagues’ in the ways tailored messages can be produced. Whereas some programmers ‘hand-finish’ each Health Communication Research Laboratory, School of individual piece—and we have done this ourPublic Health, St Louis University, St Louis, MO 63108 selves—others produce tailored messages en mass and 1Department of Surgery, Duke University Medical using fully automated computer programs. Titling Center and Prevention and Control Program, Duke the latter process as ‘individually tailored’ is probUniversity Comprehensive Cancer Center, Durham, NC 27710, USA lematic in that it may imply a manual process that

RSNA 2000: Review of Education Exhibits Presented on Videotape

HomeRadioGraphicsVol. 21, No. 2 PreviousNext EditorialRSNA 2000: Review of Education Exhibits Presented on VideotapeHarry J. Griffiths, David S. MartinHarry J. Griffiths, David S. MartinAuthor Affiliations1From the Department of Radiology, University of Missouri Hospital and Clinics, One Hospital Dr, Columbia, MO 65212 (H.J.G.) and Department of Radiology, St Louis University School of Medicine, Mo (D.S.M.). Received and accepted January 8, 2001. Address correspondence to H.J.G.Harry J. GriffithsDavid S. MartinPublished Online:Mar 1 2001https://doi.org/10.1148/radiographics.21.2.g01mr36371MoreSectionsFull textPDF ToolsImage ViewerAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinked In Article HistoryPublished in print: Mar 2001 FiguresReferencesRelatedDetailsRecommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 21, No. 2 Metrics Altmetric Score PDF download

Impact of attentional dysfunction in dyscalculia

Developmental Medicine & Child NeurologyVolume 41, Issue 9 p. 639-642 Free Access Impact of attentional dysfunction in dyscalculia Ronald L Lindsay MD, Corresponding Author Nisonger Center UAP, The Ohio State University, Columbus, OH * Correspondence to first author at Nisonger Center UAP, 1581 Dodd Drive, Columbus, OH 43210–1296, USA. E-mail: lindsay.34@osu.eduSearch for more papers by this authorTerry Tomazic PhD, Department of Research Methodology, St Louis University, St Louis, MOSearch for more papers by this authorMelvin D Levine MD, Clinical Center for the Study of Development and Learning, University of North Carolina, Chapel Hill, NCSearch for more papers by this authorPasquale J Accardo MD, Westchester Institute for Human Development, New York Medical College, Valhalla, NY, USA.Search for more papers by this author Ronald L Lindsay MD, Corresponding Author Nisonger Center UAP, The Ohio State University, Columbus, OH * Correspondence to first author at Nisonger Center UAP, 1581 Dodd Drive, Columbus, OH 43210–1296, USA. E-mail: lindsay.34@osu.eduSearch for more papers by this authorTerry Tomazic PhD, Department of Research Methodology, St Louis University, St Louis, MOSearch for more papers by this authorMelvin D Levine MD, Clinical Center for the Study of Development and Learning, University of North Carolina, Chapel Hill, NCSearch for more papers by this authorPasquale J Accardo MD, Westchester Institute for Human Development, New York Medical College, Valhalla, NY, USA.Search for more papers by this author First published: 13 February 2007 https://doi.org/10.1111/j.1469-8749.1999.tb00669.xCitations: 3AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Citing Literature Volume41, Issue9September 1999Pages 639-642 ReferencesRelatedInformation

Molecular movies capture first steps of immune response

Researchers at Washington University School of Medicine, St Louis, and Stanford University School of Medicine have made an unusual video that captures the molecular rearrangements that are among the first steps in the immune system's response to a foreign substance. By attaching fluorescent labels to different peptides found on the surface of an antigen-presenting cell, graduate student Arash Grakoui, associate professor of pathology Michael L. Dustin, and their colleagues can watch these peptides move around to form a precise bull's eye pattern that enables these cells to bind to helper T lymphocytes (T cells), activating the immune system [ Science , 285 , 221 (1999)]. When bacteria or other foreign substances enter the body, they are quickly scavenged by dendritic cells or macrophages that circulate in the blood. These cells degrade the invader into peptide fragments (antigens), which, together with membrane proteins, form an antigen-presenting complex on the surface of the cell. T ...

Annemarie Weber: Ca 2+ and the regulation of muscle contraction

Annemarie Weber has an MD from the University of Tubingen, Germany. However, she never intended to practise medicine. After an introduction into muscle research by her famous father (H. H. Weber), she never looked back. Following postdoctoral training at University College London, she moved to the USA, where she was a member of the Institute for Muscle Disease and of Columbia University in New York. She was Professor of Biochemistry at St Louis University before finally moving to the University of Pennsylvania. She is currently engaged in kinetic studies of actin polymerization and on the effect of actin-binding and -capping proteins.

Autologous lymphocyte therapy (ALT) for chronic hepatitis B: A preliminary study in chimpanzees: [formula omitted] St Louis University, Cellcor Inc and Massachusetts General Hospital

Autologous lymphocyte therapy (ALT) for chronic hepatitis B: A preliminary study in chimpanzees: [formula omitted] St Louis University, Cellcor Inc and Massachusetts General Hospital

Theodore Cooper Memorial Lectureship

With this issue of the journal, we initiate a new periodic series of articles honoring a major leader in cardiovascular biomedical sciences and a strong supporter of research and education in hypertension. Through an educational grant-in-aid from the Upjohn Company, innovative investigators in the field of hypertension and related areas will honor the memory of Theodore Cooper, MD, PhD (Fig 1⇓), who was an outstanding fundamental and clinical investigator, a superb leader in medical education and in industry, and a visionary in biomedical and health administration. After his graduation and training as a cardiovascular surgeon at St Louis University, Ted worked at the National Institutes of Health (NIH) where he had a productive …

Cognitive Effects of PHT and CBZ After Brain Trauma

The effects of prophylactic anticonvulsant use of phenytoin (PHT) and carbamazepine (CBZ) on the cognitive and emotional status of a total of 80 brain trauma patients are compared and reported from the Division of Neurosurgery and Department of Neurology, St Louis University School of Medicine and School of Public Health.

Perioperative Stroke in Patients Undergoing Head and Neck Surgery

Departments of Otolaryngology-Head and Neck Surgery, and Neurology, St Louis University Medical Center, St. Louis, Missouri

Transplantation at St Louis University results, dials and lessons learned

Transplantation at St Louis University results, dials and lessons learned