Abstract
The effects of prophylactic anticonvulsant use of phenytoin (PHT) and carbamazepine (CBZ) on the cognitive and emotional status of a total of 80 brain trauma patients are compared and reported from the Division of Neurosurgery and Department of Neurology, St Louis University School of Medicine and School of Public Health.
Highlights
Valproate-induced chorea in these patients appeared to be dose related, occurring at peak serum concentrations
The effects of prophylactic anticonvulsant use of phenytoin (PHT) and carbamazepine (CBZ) on the cognitive and emotional status of a total of 80 brain trauma patients are compared and reported from the Division of Neurosurgery and Department of Neurology, St Louis University School of Medicine and School of Public Health
The use of divalproex sodium sprinkles avoided the excessive fluctuations of serum levels seen with valproic acid and movements were controlled
Summary
Valproate-induced chorea in these patients appeared to be dose related, occurring at peak serum concentrations. The use of divalproex sodium sprinkles avoided the excessive fluctuations of serum levels seen with valproic acid and movements were controlled. Choreoathetosis is a known side effect of the majority of antiepileptic drugs. This may be the first recorded case of valproate-induced chorea.
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