Spinal Loading Research Articles

Estimation of Cervical Spinal Loading and Internal Motion at Adjacent Segments after C5–C6 Fusion Using a Musculoskeletal Multi-Body Dynamics Model during the Head Flexion–Extension Movement

Cervical spinal fusion is the standard of care for treating intractable spinal diseases. However, frequent adjacent segment disease (ASD) has recently drawn a great deal of attention among clinicians and researchers. At present, the etiology of ASD remains controversial. The investigation of cervical spine biomechanics after fusion may contribute to understanding the causes of ASD. In the present study, a cervical spinal musculoskeletal fusion model, with multi-body dynamics method, was established. Dynamic head flexion–extension movements were simulated for both a fusion subject and a normal subject. The cervical spinal loading pattern, load sharing ratios, and translations of instant centers of the rotation at adjacent segments were then predicted. The average intervertebral compressive forces, shear forces, and facet joint forces against the intervertebral angle were also obtained. By comparison, some obvious differences in cervical spinal loading patterns were found between the fusion subject and the normal subject. Fusion surgery would alter the postoperative biomechanical surrounding of the cervical spine, especially the adjacent segments. These changes might affect the intervertebral disc-bearing capacity, and even weaken the physiological structure. From a purely biomechanical perspective, the cervical spinal fusion model can contribute to comprehending the etiology of ASD after spinal fusion.

An artificial neural network for full-body posture prediction in dynamic lifting activities and effects of its prediction errors on model-estimated spinal loads

Musculoskeletal models have indispensable applications in occupational risk assessment/management and clinical treatment/rehabilitation programs. To estimate muscle forces and joint loads, these models require body posture during the activity under consideration. Posture is usually measured via video-camera motion tracking approaches that are time-consuming, costly, and/or limited to laboratories. Alternatively, posture-prediction tools based on artificial intelligence can be trained using measured postures of several subjects performing many activities. We aimed to use our previous posture-prediction artificial neural network (ANN), developed based on many measured static postures, to predict posture during dynamic lifting activities. Moreover, effects of the ANN posture-prediction errors on dynamic spinal loads were investigated using subject-specific musculoskeletal models. Seven individuals each performed twenty-five lifting tasks while their full-body three-dimensional posture was measured by a 10-camera Vicon system and also predicted by the ANN as functions of the hand-load positions during the lifting activities. The measured and predicted postures (i.e., coordinates of 39 skin markers) and their model-estimated L5-S1 loads were compared. The overall root-mean-squared-error (RMSE) and normalized (by the range of measured values) RMSE (nRMSE) between the predicted and measured postures for all markers/tasks/subjects was equal to 7.4 cm and 4.1 %, respectively (R2 = 0.98 and p < 0.05). The model-estimated L5-S1 loads based on the predicted and measured postures were generally in close agreements as also confirmed by the Bland-Altman analyses; the nRMSE for all subjects/tasks was < 10 % (R2 > 0.7 and p > 0.05). In conclusion, the easy-to-use ANN can accurately predict posture in dynamic lifting activities and its predicted posture can drive musculoskeletal models.

Effect of personalized spinal profile on its biomechanical response in an EMG-assisted optimization musculoskeletal model of the trunk

Recent developments in musculoskeletal (MS) modeling have been geared towards model customization. Personalization of the spine profile could affect estimates of spinal loading and stability, particularly in the upright standing posture where large inter-subject variations in the lumbar lordosis have been reported. This study investigates the biomechanical consequences of changes in the spinal profile.In 31 participants (healthy and with back pain), (1) the spine external profile was measured, (2) submaximal contractions were recorded in a dynamometer to calibrate the EMG-driven MS model and finally (3) static lifting in the upright standing challenging spine stability while altering load position and magnitude were considered. EMG signals of 12 trunk muscles and angular kinematics of 17 segments were recorded. For each participant, the MS model was constructed using either a generic or a personalized spinal profile and 17 biomechanical outcomes were computed, including individual muscle forces, ratios of muscle group forces, spinal loading and stability parameters.According to the ANOVA results and corresponding effect sizes, personalizing the spine profile induced medium and large effects on about half MS model outcomes related to the trunk muscle forces and negligible to small effects on spinal loading and stability as more aggregate outcomes.These effects are explained by personalized spine profiles that were a little more in extension as well as more pronounced spine curvatures (lordosis and kyphosis). These findings suggest that spine profile personalization should be considered in MS spine modeling as it may impact muscle force prediction and spinal loading.

Tension-activated nanofiber patches delivering an anti-inflammatory drug improve repair in a goat intervertebral disc herniation model.

Conventional microdiscectomy treatment for intervertebral disc herniation alleviates pain but does not repair the annulus fibrosus, resulting in a high incidence of recurrent herniation and persistent dysfunction. The lack of repair and the acute inflammation that arise after injury can further compromise the disc and result in disc-wide degeneration in the long term. To address this clinical need, we developed tension-activated repair patches (TARPs) for annulus fibrosus repair and local delivery of the anti-inflammatory factor anakinra (a recombinant interleukin-1 receptor antagonist). TARPs transmit physiologic strain to mechanically activated microcapsules embedded within the patch, which release encapsulated bioactive molecules in direct response to spinal loading. Mechanically activated microcapsules carrying anakinra were loaded into TARPs, and the effects of TARP-mediated annular repair and anakinra delivery were evaluated in a goat model of annular injury in the cervical spine. TARPs integrated with native tissue and provided structural reinforcement at the injury site that prevented aberrant disc-wide remodeling resulting from detensioning of the annular fibrosus. The delivery of anakinra by TARP implantation increased matrix deposition and retention at the injury site and improved maintenance of disc extracellular matrix. Anakinra delivery additionally attenuated the inflammatory response associated with TARP implantation, decreasing osteolysis in adjacent vertebrae and preserving disc cellularity and matrix organization throughout the annulus fibrosus. These results demonstrate the therapeutic potential of TARPs for the treatment of intervertebral disc herniation.

Finite element analysis comparing a PEEK posterior fixation device versus pedicle screws for lumbar fusion

BackgroundPedicle screw loosening and breakage are common causes of revision surgery after lumbar fusion. Thus, there remains a continued need for supplemental fixation options that offer immediate stability without the associated failure modes. This finite element analysis compared the biomechanical properties of a novel cortico-pedicular posterior fixation (CPPF) device with those of a conventional pedicle screw system (PSS).MethodsThe CPPF device is a polyetheretherketone strap providing circumferential cortical fixation for lumbar fusion procedures via an arcuate tunnel. Using a validated finite element model, we compared the stability and load transfer characteristics of CPPF to intact conditions under a 415 N follower load and PSS conditions under a 222 N preload. Depending on the instrumented levels, two different interbody devices were used: a lateral lumbar interbody device at L4–5 or an anterior lumbar interbody device at L5-S1. Primary outcomes included range of motion of the functional spinal units and anterior load transfer, defined as the total load through the disk and interbody device after functional motion and follower load application.ResultsAcross all combinations of interbody devices and lumbar levels evaluated, CPPF consistently demonstrated significant reductions in flexion (ranging from 90 to 98%), extension (ranging from 88 to 94%), lateral bending (ranging from 75 to 80%), and torsion (ranging from 77 to 86%) compared to the intact spine. Stability provided by the CPPF device was comparable to PSS in all simulations (range of motion within 0.5 degrees for flexion–extension, 0.6 degrees for lateral bending, and 0.5 degrees for torsion). The total anterior load transfer was higher with CPPF versus PSS, with differences across all tested conditions ranging from 128 to 258 N during flexion, 89–323 N during extension, 135–377 N during lateral bending, 95–258 N during torsion, and 82–250 N during standing.ConclusionUnder the modeled conditions, cortico-pedicular fixation for supplementing anterior or lateral interbody devices between L4 and S1 resulted in comparable stability based on range of motion measures and less anterior column stress shielding based on total anterior load transfer measures compared to PSS. Clinical studies are needed to confirm these finite element analysis findings.

Effect of strengthening and weakening of abdominal and dorsal muscles on lumbar spine loads in parents of disabled children

Pain in the lower part of the back is one of the most common chronic illnesses globally. This work aimed to determine the impact of the reinforcement of particular groups of abdominal and dorsal muscles on the loads exerted on the lumbar section of the spine in 30 mothers of children with motor disabilities. An optical Ariel Performance Analysis System recorded and processed the kinematics data of everyday activities. Tests investigating the effects of the strengthening or weakening of abdominal and dorsal muscles on loading in the lumbar section of the spine utilized the AnyBody Modelling System. Input data for the simulations included mean values of body positions, while the effects of strengthening or weakening of muscles were simulated in the muscle forces model by introducing different values for muscle physiological cross-sectional area (PCSA). Simulations used decreasing or increasing PCSA values of abdominal muscles and the erector spinae. The analysis involved component and resultant force values on the lumbosacral joint (L5-S1) of the spine and intra-abdominal pressure values. The highest reduction of the resultant reaction value in L5-S1 was observed in the simulations that increased the PCSA of the transverse abdominal (TrA). Indeed, a double increase in the TrA cross-section caused a reduction of the resultant reaction in L5-S1 by 30% and the anterior-posterior and proximal–distal forces by approximately 20–30%. Increased PCSA of the erector spinae exerted higher loads on the spine. These results indicate that strengthening weakened abdominal muscles, particularly TrA, in parents of children with motor disabilities reduces lower spinal loads during daily activities.

Numerical investigation of intra-abdominal pressure and spinal load-sharing upon the application of an abdominal belt

Chronic low back pain patients may experience spinal instability. Abdominal belts (ABs) have been shown to improve spine stability, trunk stiffness, and resiliency to spinal perturbations. However, research on the contributing mechanisms is inconclusive. ABs may increase intra-abdominal pressure (IAP) and reduce paraspinal soft tissue contribution to spine stability without increasing spinal compressive loads. A finite element model (FEM) of the spine inclusive of the T1-S1 vertebrae, intervertebral discs (IVDs), ribcage, pelvis, soft tissues, and abdominal cavity, without active muscle forces was developed. An identical FEM with an AB was developed. Both FEMs underwent trunk flexion. Following validation, the models’ intervertebral rotation (IVR), IAP, IVD pressure, and tensile stress in the multifidus (MF), erector spinae (ES), and thoracolumbar fascia (TLF) were compared. The inclusion of an AB resulted in a 3.8 kPa IAP increase, but a decreased average soft tissue tensile stress of 0.28 kPa. The TLF withstood the majority of tension being transferred across the paraspinal soft tissues (>70 %). The average IVR in the AB model decreased by 10 %, with the lumbar spine experiencing the largest reduction. The lumbar IVDs of the AB model likewise showed a 31 % reduction in average IVD pressure. Using an AB improved trunk bending stiffness, primarily in the lumbar spine. Wearing an AB had minimal effect on reducing tensile stress in theES. The skewed stress distribution towards the TLF suggests its large contribution to spine stability and the potential advantage in unloading the structure when wearing an AB, measured herein at8 %.

Redesign and ergonomic assessment of a chest-support baby walker.

Parents often use baby walkers (BWs) as assistive devices to improve their infants' independent movement and motor skill acquisition. However, the literature suggests that conventional baby walkers (CBW) may cause delays in an infant's ability to walk independently and musculoskeletal burden on parents. In the current study, a baby walker (RBW) with chest support was redesigned and ergonomically assessed during an infant-walking task. The anthropometric dimensions of 90 infants aged 7-11 months were measured in the city of Urmia, northwestern Iran. Following redesigning based on the results from expert panel meetings and prototyping of the RBW, 18 mothers (age: 28.33±4.27 and height: 163.75±5.32 and weight: 59.45±5.99) with their infants (9 boys and 9 girls) performed a simulated infant walking task in two experimental sessions using the CBW and RBW over a repeated measurements design. The infants' feet track patterns, including the number of steps and step distances were assessed via the image analysis of the footprints. The mothers' body posture and lower back spinal load were evaluated using Rapid Upper Limb Assessment (RULA) technique and 3D Static Strength Prediction Program (3DSSPP), respectively. Wilcoxon signed-rank tests showed infants walked more steps with the RBW (p = 0.002). Similarly, the distance between the infants' left heel strike (p = 0.008) and their right and left toe-off (p = 0.03 and 0.02 respectively) was also significantly lower in the RBW use. Additionally, the body posture of mothers was improved (RULA final score from 7 for CBW to 5 for RBW). Moreover, lower back compression and shear forces were reduced significantly (p = 0.002) by the RBW use. According to the feet track pattern, infants took more balanced steps when the RBW was used. In addition, mothers were subjected to less pressure on the lumbar region when they placed and lifted their infant from the RBW. However, further work is necessary to investigate potential long-term effects of the RBWs use.

Validity of evaluating spinal kinetics without participant-specific kinematics

Musculoskeletal models are commonly used to estimate in vivo spinal loads under various loading conditions. Typically, participant-specific measured kinematics (PSMK) are coupled with participant-specific models, but obtaining PSMK data can be costly and infeasible in large studies or clinical practice. Thus, we evaluated two alternative methods to estimate spinal loads without PSMK: 1) ensemble average kinematics (EAK) based on kinematics from all participants; and 2) using separately measured individual kinematics (SMIK) from multiple other participants as inputs, then averaging the resulting loads. This study compares the dynamic spine loading patterns and peak loads in older adults performing five lifting tasks using PSMK, EAK and SMIK. Median root mean square errors of EAK and SMIK methods versus PSMK ranged from 18 to 72% body weight for compressive loads and from 2 to 25% body weight for shear loads, with median cross-correlations ranging from 0.931 to 0.991. The root mean square errors and cross-correlations between repeated PSMK trials fell within similar ranges. Compressive peak loads evaluated by EAK and SMIK were not different than PSMK in 12 of 15 cases, while by comparison repeated PSMK trials were not different in 13 of 15 cases. Overall, the resulting spine loading magnitudes and profiles using EAK or SMIK were not notably different than using a PSMK approach, and differences were not greater than between two PSMK trials. Thus, these findings indicate that these approaches may be used to make reasonable estimates of dynamic spinal loading without direct measurement of participant kinematics.

Effect of obesity on spinal loads during load-reaching activities: A subject- and kinematics-specific musculoskeletal modeling approach

Obesity has been associated to increase the risk of low back disorders. Previous musculoskeletal models simulating the effect of body weight on intervertebral joint loads have assumed identical body postures for obese and normal-weight individuals during a given physical activity. Our recent kinematic-measurement studies, however, indicate that obese individuals adapt different body postures (segmental orientations) than normal-weight ones when performing load-reaching activities. The present study, therefore, used a subject- and kinematics-specific musculoskeletal modeling approach to compare spinal loads of nine normal-weight and nine obese individuals each performing twelve static two-handed load-reaching activities at different hand heights, anterior distances, and asymmetry angles (total of 12 tasks × 18 subjects = 216 model simulations). Each model incorporated personalized muscle architectures, body mass distributions, and full-body kinematics for each subject and task. Results indicated that even when accounting for subject-specific body kinematics obese individuals experienced significantly larger (by ∼38% in average) L5-S1 compression (2305 ± 468 N versus 1674 ± 337 N) and shear (508 ± 111 N versus 705 ± 150 N) loads during all reaching activities (p < 0.05 for all hand positions). This average difference of ∼38% was similar to the results obtained from previous modeling investigations that neglected kinematics differences between the two weight groups. Moreover, there was no significant interaction effect between body weight and hand position on the spinal loads; indicating that the effect of body weight on L5-S1 loads was not dependent on the position of hands. Postural differences alone appear, hence, ineffective in compensating the greater spinal loads that obese people experience during reaching activities.

Sensitivity of subject-specific upper body musculoskeletal model predictions to mass scaling methods

Accurate predictions of spinal loads in subject-specific musculoskeletal models require precise body segment parameters, including segment mass and center of mass (CoM) locations. Existing upper body models often assume a constant percentage of total body mass to calculate segmental masses, disregarding inter-individual variability and limiting their predictive capacity. This study evaluated the sensitivity of subject-specific upper body musculoskeletal model predictions to body mass scaling methods. The upper body segmental masses and corresponding CoM of six male subjects with varying body mass indices were computed using two mass scaling methods: the constant-percentage-based (CPB) scaling method, commonly used in AnyBody software; and our recently developed body-shape-based (BSB) method. Subsequently, these values were used by a validated musculoskeletal model to predict the muscle and disc forces in upright and flexed postures. The discrepancies between the results of the two scaling methods were compared across subjects and postures. Maximum deviations in thorax masses reached up to 7.5% of total body weight (TBW) in overweight subjects, while maximum CoM location differences of up to 35 mm were observed in normal weight subjects. The root mean squared errors (RMSE) of the CPB results, calculated with the BSB results as baseline, showed that the muscle and shear forces of the two scaling methods were quite similar (<4.5% of TBW). Though, there were small to moderate differences in compressive forces (6.5–16.0% of TBW). Thus, the compressive forces predicted with CPB method should be used with caution, particularly for overweight and obese subjects.

Influence of smartphone game play on head flexion angle, muscle activity, and load at C7 among adolescents.

Smartphones cause physiological problems due to inappropriate postures and extensive usage. India, being the second leading country with the highest number of smartphone users (492 million in 2021), has witnessed a significant rise in smartphone-related musculoskeletal disorders (MSD). This study compared the effects of 60-min smartphone gameplay on head flexion angle, muscle activity, and loads at C7 on Indian adolescents. A subjective assessment was conducted on 1659 participants, of which, 40 young male adults aged between 20-28 years performed the experimental trial. Muscle (Sternocleidomastoid) activity, head flexion angle, and load acting at the neck (C7) were analyzed through postural assessment, pre-and post-subjective analysis. Participants maintained an average of 28.46°±4.04° head flexion angle for more than 43 min (71%) in an hour while performing the task. The muscle activity increased to 23% (p < 0.001) of MVC at the end of the task compared to the beginning. The results indicated a significant increase in muscle activity (1.61 times), spinal loads (4.6 times) and subjective discomfort (2.9 times) after prolonged smartphone usage. It is evident that various aspects (duration, posture, content) play a vital role in smartphone-related MSD and there is a potential risk of cervical spine problems. The increased loads reduce muscle stiffness and increase intervertebral disc pressure.

Biomechanical and physiological responses to allowable load handling limits in Iranian female workers

AbstractIn 2017, load limit values for manual material handling (MMH) tasks were confirmed to protect workers from low back disorders without prior validity investigation for Iranian workers. The present study investigated the applicability and feasibility of the Washington State Department of Labor and Industries (WISHA) lifting method as an occupational exposure limit (OEL) for the MMH tasks in a sample of young Iranian female workers using biomechanical and physiological criteria. A laboratory study was conducted with 10 female participants performing lifting tasks as described in the Iranian OEL for the MMH tasks based on the WISHA checklist. Each participant completed 21 lifting task combinations that varied in height and reach with the maximal allowable load. To test the applicability of the WISHA method, the maximum aerobic capacity and the equivalent heart rate (EHR) were estimated for 10 young Iranian female workers using an ergometer and Astrand protocol. Moreover, spinal loads for each lifting task were calculated using a static biomechanical model. From a physiological point of view, approximately 38% of the lifting tasks resulted in an increase in the physical workload. For 33% of the lifting trials, the estimated compression loads exceeded 3400 N. The findings revealed that the weight and lift height of the loads affected the lifting capacity of the participants. It seems that the allowable weight limits for manual lifting are not matched to the biomechanical and physiological capacities of the Iranian women. Therefore, the Iranian guideline for manual lifting is recommended to be revised based on the physiological and biomechanical capacities of the Iranian women.

Age and gender differences in lumbar intervertebral disk strain using mechanical loading magnetic resonance imaging.

The objective of the current study was to investigate age- and gender-related differences in lumbar intervertebral disk (IVD) strain with the use of static mechanical loading and continuous three-dimensional (3D) golden-angle radial sparse parallel (GRASP) MRI. A continuous 3D-GRASP stack-of-stars trajectory of the lumbar spine was performed on a 3-T scanner with static mechanical loading. Compressed sensing reconstruction, motion deformation maps, and Lagrangian strain maps during loading and recovery in the X-, Y-, and Z-directions were calculated for segmented IVD segments from L1/L2 to L5/S1. Mean IVD height was measured at rest. Spearman coefficients were used to evaluate the associations between age and global IVD height and global IVD strain. Mann-Whitney tests were used to compare global IVD height and global IVD strain in males and females. The prospective study enrolled 20 healthy human volunteers (10 males, 10 females; age 34.6± 11.4 [mean ± SD], range 22-56 years). Significant increases in compressive strain were observed with age, as evidenced by negative correlations between age and global IVD strain during loading (ρ = -0.76, p = 0.0046) and recovery (ρ = -0.68, p = 0.0251) in the loading X-direction. There was no significant correlation between age and global IVD height, global IVD strain during loading and recovery in the Y-direction, and global IVD strain during loading and recovery in the Z-direction. There were no significant differences between males and females in global IVD height and global IVD strain during loading and recovery in the X-, Y-, and Z-directions. It was concluded that our study demonstrated the significant role aging plays in internal dynamic strains in the lumbar IVD during loading and recovery. Older healthy individuals have reduced IVD stiffness and greater IVD compression during static mechanical loading of the lumbar spine. The GRASP-MRI technique demonstrates the feasibility to identify changes in IVD mechanical properties with early IVD degeneration due to aging.

Field measurement of hand forces of palm oil harvesters and evaluating the risk of work-related musculoskeletal disorders (WMSDs) through biomechanical analysis

Hand force data is critical in evaluating work-related musculoskeletal disorders (WMSDs). Nevertheless, earlier studies on oil palm workers relied on estimated or laboratory measurements, which may not accurately reflect the actual hand forces. This study is the first report on the field measurement of hand forces for palm oil harvesters using a chisel and sickle to harvest low and tall palm trees, respectively. The dynamic hand forces and ground reaction forces were measured using instrumented harvesting tools and force plates, while wearable motion (IMU) and electromyography (EMG) sensors were incorporated for quantifying postural angles and muscle activations, respectively. Additionally, the spinal loadings, continuous Rapid Entire Body Assessment (REBA) scores, and subjective pain scores were determined to evaluate the risk of WMSDs. A total of 10 harvesters were recruited to perform the palm pruning tasks using a chisel and sickle. Resultantly, the sickle and chisel recorded a maximum cutting force of 1601.23 ± 424.26 N and 420.80 ± 96.00 N, respectively. All pruning tasks were found to be highly risky to harvesters, with a peak REBA score of 12. Likewise, all investigated muscles were activated for over 40% MVC, thus inducing moderate pain in the muscles. The peak L5-S1 compression forces for all tasks exceeded the safety threshold (>3400 N), but the values were not significantly different. The shear force of the L5-S1 was extreme in pruning with a sickle (1446.10 ± 411.00 N) compared to using a chisel. In conclusion, palm harvesters were at a high risk of developing WMSDs following poor postures, high physical exertion and muscle activity, and excessive spinal loads.

The mechanical loading of the spine in physical activities

PurposeTo summarize the mechanical loading of the spine in different activities of daily living and sports.MethodsSince the direct measurement is not feasible in sports activities, a mathematical model was applied to quantify spinal loading of more than 600 physical tasks in more than 200 athletes from several sports disciplines. The outcome is compression and torque (normalized to body weight/mass) at L4/L5.ResultsThe data demonstrate high compressive forces on the lumbar spine in sport-related activities, which are much higher than forces reported in normal daily activities and work tasks. Especially ballistic jumping and landing skills yield high estimated compression at L4/L5 of more than ten times body weight. Jumping, landing, heavy lifting and weight training in sports demonstrate compression forces significantly higher than guideline recommendations for working tasks.ConclusionThese results may help to identify acute and long-term risks of low back pain and, thus, may guide the development of preventive interventions for low back pain or injury in athletes.

Effects of non-extensible lumbar belts on static and dynamic postural stability

BackgroundPrevious studies have found that increased intra-abdominal pressure helps to reduce spinal loading and improve spine stability. Non-extensible lumbar belts (NEBs) could elevate intra-abdominal pressure and augment spinal stability. NEBs have been used in the healthcare field to help reduce pain and improve spine function for people with low back pain. However, the effect of NEBs on static and dynamic postural stability is not clear.MethodsThis study aimed to investigate whether NEBs affect static and dynamic postural stability. Twenty-eight healthy male subjects were recruited to finish four static postural stability tasks and two dynamic postural stability tests. Center of pressure (COP) values during 30 s of quiet standing, dynamic postural stability index (DPSI) and Y balance test (YBT) score with and without NEBs were analyzed.ResultsNEBs had no significant effect in all COP variables in the static postural tasks. The results of a repeated measure two-way ANOVA indicated the NEBs significantly improved the dynamic postural stability in YBT score and DPSI (F (1,27) = 5.506, p = .027, {{eta }_{p}}^{2}=.169 and F (1,27) = 83.94, p = .000, {{eta }_{p}}^{2}=.757 respectively).ConclusionsThe study results indicate that non-extensible belts improve dynamic stability in healthy male participants, with potential implications for rehabilitation and performance enhancement programs.

Hybrid musculoskeletal model-based 3D asymmetric lifting prediction and comparison with symmetric lifting.

In this study, a 3D asymmetric lifting motion is predicted by using a hybrid predictive model to prevent potential musculoskeletal lower back injuries for asymmetric lifting tasks. The hybrid model has two modules: a skeletal module and an OpenSim musculoskeletal module. The skeletal module consists of a dynamic joint strength based 40 degrees of freedom spatial skeletal model. The skeletal module can predict the lifting motion, ground reaction forces (GRFs), and center of pressure (COP) trajectory using an inverse dynamics-based motion optimization method. The musculoskeletal module consists of a 324-muscle-actuated full-body lumbar spine model. Based on the predicted kinematics, GRFs and COP data from the skeletal module, the musculoskeletal module estimates muscle activations using static optimization and joint reaction forces through the joint reaction analysis tool in OpenSim. The predicted asymmetric motion and GRFs are validated with experimental data. Muscle activation results between the simulated and experimental EMG are also compared to validate the model. Finally, the shear and compression spine loads are compared to NIOSH recommended limits. The differences between asymmetric and symmetric liftings are also compared.

Extension of an In Vitro Spine Test Rig to Track Load‐dependent Biomechanics of the Lumbar Spine under Physiological Conditions

AbstractLow back pain is a major cause of chronic health problems and is often related to loading history. A test rig was developed at the Institute of General Mechanics, RWTH Aachen University to investigate the influence of duration and intensity of spinal loading using in vitro experiments on spinal cadavers. In this work, several extensions of this spine test rig are presented: (1) a hydraulic cylinder with a force measuring unit was added to apply axial compression; (2) a new follower load principle system was developed to achieve uniform compression of the naturally curved spine; (3) the specimen is immersed in phosphate‐buffered saline with protease inhibitors during the testing period to allow osmotic interactions on the one hand and the investigation of the influence of different loading and rest cycles on the other hand; (4) a fiber‐optic pressure measurement system was added to successfully measure the intradiscal pressure during the test series. The first results obtained using these test rig extensions and the new pressure measurement system show their functionality. The new test rig enables the investigation of a wide range of load scenarios and further measurement parameters.

Bioinspired Construction of Annulus Fibrosus Implants with a Negative Poisson's Ratio for Intervertebral Disc Repair and Restraining Disc Herniation.

Inspired by the negative Poisson's ratio (NPR) effects of the annulus fibrosus (AF) in intervertebral discs (IVDs), we designed a re-entrant honeycomb model and then 3D printed it into a poly(ε-caprolactone) (PCL) scaffold with NPR effects, which was followed by in situ polymerization of polypyrrole (PPy), thus constructing a PPy-coated NPR-structured PCL scaffold (-vPCL-PPy) to be used as the AF implant for the treatment of lumbar herniated discs. Mechanical testing and finite element (FE) simulation indicated that the NPR composite implant could sustain axial spine loading and resist nucleus pulposus (NP) swelling while displaying uniform stress diffusion under NP swelling and contraction. More interestingly, the NPR-structured composite scaffold could also apply a reacting force to restrain NP herniation owing to the NPR effect. In addition, the in vitro biological assessment and in vivo implantation demonstrated that the NPR composite scaffold exhibited good biocompatibility and exerted the ability to restore the physiological function of the disc segments.