Sparse-view Computed Tomography Research Articles

MAIR-Net: a sparse-view CT reconstruction network based on a combination of mixed attention and iterative optimization learning

Sparse-view computed tomography (CT) is one of the main means to reduce radiation risk. When the projection data is highly undersampled, the reconstructed CT image may suffer from serious stripe artifacts and structural information loss. In this paper, we propose a sparse-view CT reconstruction network architecture combining mixed attention (MA) and an iterative reconstruction strategy, called MAIR-Net. Firstly, the approach expands the proximal gradient descent into the neural network and uses an initial value enhancement module between the gradient descent module and the proximal mapping module. The aim is to enhance the flow of detailed information between different layers, fully retain image details, and improve the network convergence speed. Secondly, the mixed attention module (MAM) is introduced into the reconstruction process as a regularization term. It adaptively fuses local and non-local features of the image, which are used to reduce the over-smoothing of the reconstructed image and fully retain the details of the reconstructed image, respectively. Experimental results showed that the proposed method can better retain the details of the reconstructed image and improve the quality of the reconstructed image while inhibiting the sparse angle artifacts of the CT reconstructed image.

DdeNet: A dual-domain end-to-end network combining Pale-Transformer and Laplacian convolution for sparse view CT reconstruction

Sparse view (SV) computed tomography (CT) is a clinical diagnostic technique aimed at reducing radiation dose to the human body from X-rays. However, SVCT reconstructed using conventional filtered back-projection (FBP) algorithms will produce severe streak artifacts. In recent years, convolutional neural networks (CNNs) have demonstrated considerable success in addressing the inverse problem of SVCT reconstruction. However, the local convolutional operations of CNNs ignores long-range dependencies of contextual feature information, thereby limiting their capability in feature extraction. To address this limitation, we propose a dual-domain end-to-end network (DdeNet) combining Pale-Transformer and Laplacian convolution for SVCT reconstruction. Initially, in the projection domain, a UNet is employed to restore the interpolated sinogram. Subsequently, in the image domain, we introduce Pale-Transformer and Laplacian convolution to design a dual-stream feature fusion network for finely restoring the CT images reconstructed by FBP. The dual-stream feature fusion network comprises an image restoration network (IRN) module and an edge enhancement network (EEN) module. The depthwise separable convolution based modified pale-shaped self-attention mechanism in Pale-Transformer captures global feature information of the CT image in the IRN, while the Laplacian convolution and multi-scale convolution block with a squeeze and excitation mechanism in the EEN further extract and restore edge feature information of the CT image. Finally, the feature information output from IRN and EEN is fused along the channel dimension and then convolved to obtain the final reconstructed CT image. Experimental results demonstrate that DdeNet exhibits superior generalization and reconstruction performance compared to the previous CNN or Transformer-based reconstruction methods.

HEAL: High-Frequency Enhanced and Attention-Guided Learning Network for Sparse-View CT Reconstruction.

X-ray computed tomography (CT) imaging technology has become an indispensable diagnostic tool in clinical examination. However, it poses a risk of ionizing radiation, making the reduction of radiation dose one of the current research hotspots in CT imaging. Sparse-view imaging, as one of the main methods for reducing radiation dose, has made significant progress in recent years. In particular, sparse-view reconstruction methods based on deep learning have shown promising results. Nevertheless, efficiently recovering image details under ultra-sparse conditions remains a challenge. To address this challenge, this paper proposes a high-frequency enhanced and attention-guided learning Network (HEAL). HEAL includes three optimization strategies to achieve detail enhancement: Firstly, we introduce a dual-domain progressive enhancement module, which leverages fidelity constraints within each domain and consistency constraints across domains to effectively narrow the solution space. Secondly, we incorporate both channel and spatial attention mechanisms to improve the network's feature-scaling process. Finally, we propose a high-frequency component enhancement regularization term that integrates residual learning with direction-weighted total variation, utilizing directional cues to effectively distinguish between noise and textures. The HEAL network is trained, validated and tested under different ultra-sparse configurations of 60 views and 30 views, demonstrating its advantages in reconstruction accuracy and detail enhancement.

Sparse-View Spectral CT Reconstruction Based on Tensor Decomposition and Total Generalized Variation

Spectral computed tomography (CT)-reconstructed images often exhibit severe noise and artifacts, which compromise the practical application of spectral CT imaging technology. Methods that use tensor dictionary learning (TDL) have shown superior performance, but it is difficult to obtain a high-quality pre-trained global tensor dictionary in practice. In order to resolve this problem, this paper develops an algorithm called tensor decomposition with total generalized variation (TGV) for sparse-view spectral CT reconstruction. In the process of constructing tensor volumes, the proposed algorithm utilizes the non-local similarity feature of images to construct fourth-order tensor volumes and uses Canonical Polyadic (CP) tensor decomposition instead of pre-trained tensor dictionaries to further explore the inter-channel correlation of images. Simultaneously, introducing the TGV regularization term to characterize spatial sparsity features, the use of higher-order derivatives can better adapt to different image structures and noise levels. The proposed objective minimization model has been addressed using the split-Bregman algorithm. To assess the performance of the proposed algorithm, several numerical simulations and actual preclinical mice are studied. The final results demonstrate that the proposed algorithm has an enormous improvement in the quality of spectral CT images when compared to several existing competing algorithms.

Improving image quality of sparse-view lung tumor CT images with U-Net

BackgroundWe aimed to improve the image quality (IQ) of sparse-view computed tomography (CT) images using a U-Net for lung metastasis detection and determine the best tradeoff between number of views, IQ, and diagnostic confidence.MethodsCT images from 41 subjects aged 62.8 ± 10.6 years (mean ± standard deviation, 23 men), 34 with lung metastasis, 7 healthy, were retrospectively selected (2016–2018) and forward projected onto 2,048-view sinograms. Six corresponding sparse-view CT data subsets at varying levels of undersampling were reconstructed from sinograms using filtered backprojection with 16, 32, 64, 128, 256, and 512 views. A dual-frame U-Net was trained and evaluated for each subsampling level on 8,658 images from 22 diseased subjects. A representative image per scan was selected from 19 subjects (12 diseased, 7 healthy) for a single-blinded multireader study. These slices, for all levels of subsampling, with and without U-Net postprocessing, were presented to three readers. IQ and diagnostic confidence were ranked using predefined scales. Subjective nodule segmentation was evaluated using sensitivity and Dice similarity coefficient (DSC); clustered Wilcoxon signed-rank test was used.ResultsThe 64-projection sparse-view images resulted in 0.89 sensitivity and 0.81 DSC, while their counterparts, postprocessed with the U-Net, had improved metrics (0.94 sensitivity and 0.85 DSC) (p = 0.400). Fewer views led to insufficient IQ for diagnosis. For increased views, no substantial discrepancies were noted between sparse-view and postprocessed images.ConclusionsProjection views can be reduced from 2,048 to 64 while maintaining IQ and the confidence of the radiologists on a satisfactory level.Relevance statementOur reader study demonstrates the benefit of U-Net postprocessing for regular CT screenings of patients with lung metastasis to increase the IQ and diagnostic confidence while reducing the dose.Key points• Sparse-projection-view streak artifacts reduce the quality and usability of sparse-view CT images.• U-Net-based postprocessing removes sparse-view artifacts while maintaining diagnostically accurate IQ.• Postprocessed sparse-view CTs drastically increase radiologists’ confidence in diagnosing lung metastasis.Graphical

Image fast reconstruction for sparse view computed tomography with reduced sampling integration time

Industrial computed tomography (CT) can detect the internal structure of objects nondestructively. Its scanning and image reconstruction are time-consuming, which limits its application in the fast detection field. In this work, we reduce the sampling integration time in sparse view CT to achieve ultra-fast scanning in only 5 s. However, this ultra-fast scanning method produces more noise and streak artifacts in the reconstructed CT images. The existing reconstruction methods cannot effectively reconstruct high quality CT images under this ultra-fast scanning. To solve this issue, a faster and higher quality CT image reconstruction method is proposed in this paper. We construct a novel objective function using multi-directional TV and adaptive non-local means (ANLM), and design a solution algorithm to solve the objective function. The multi-directional TV-norm takes into account the differences in horizontal, vertical, and 45° directional gradients to obtain more image detail information, while the ANLM-norm focuses on noise suppression. Simulation and practical experiments show that the proposed method can reconstruct higher quality CT images under faster CT scanning strategy, and the peak signal to noise ratio (PSNR) is 1.3 dB higher than the optimal baseline algorithm. On the other hand, our method converges faster and achieves a shorter CT image reconstruction time, which is 47 s shorter than the current popular iterative reconstruction methods. This reconstruction method provides a reliable scheme for faster CT scanning and image reconstruction.

Robust residual-guided iterative reconstruction for sparse-view CT in small animal imaging

Objective. We introduce a robust image reconstruction algorithm named residual-guided Golub–Kahan iterative reconstruction technique (RGIRT) designed for sparse-view computed tomography (CT), which aims at high-fidelity image reconstruction from a limited number of projection views. Approach. RGIRT utilizes an inner-outer dual iteration framework, with a flexible least square QR (FLSQR) algorithm implemented in the inner iteration and a restarted iterative scheme applied in the outer iteration. The inner FLSQR employs a flexible Golub–Kahan bidiagonalization method to reduce the size of the inverse problem, and a weighted generalized cross-validation method to adaptively estimate the regularization hyper-parameter. The inner iteration efficiently yields the intermediate reconstruction result, while the outer iteration minimizes the residual and refines the solution by using the result obtained from the inner iteration. Main results. The reconstruction performance of RGIRT is evaluated and compared to other reference methods (FBPConvNet, SART-TV, and FLSQR) using projection data from both numerical phantoms and real experimental Micro-CT data. The experimental findings, from testing various numbers of projection views and different noise levels, underscore the robustness of RGIRT. Meanwhile, theoretical analysis confirms the convergence of residual for our approach. Significance. We propose a robust iterative reconstruction algorithm for x-ray CT scans with sparse views, thereby shortening scanning time and mitigating excessive ionizing radiation exposure to small animals.

Hierarchical decomposed dual-domain deep learning for sparse-view CT reconstruction

Objective. X-ray computed tomography employing sparse projection views has emerged as a contemporary technique to mitigate radiation dose. However, due to the inadequate number of projection views, an analytic reconstruction method utilizing filtered backprojection results in severe streaking artifacts. Recently, deep learning (DL) strategies employing image-domain networks have demonstrated remarkable performance in eliminating the streaking artifact caused by analytic reconstruction methods with sparse projection views. Nevertheless, it is difficult to clarify the theoretical justification for applying DL to sparse view computed tomography (CT) reconstruction, and it has been understood as restoration by removing image artifacts, not reconstruction. Approach. By leveraging the theory of deep convolutional framelets (DCF) and the hierarchical decomposition of measurement, this research reveals the constraints of conventional image and projection-domain DL methodologies, subsequently, the research proposes a novel dual-domain DL framework utilizing hierarchical decomposed measurements. Specifically, the research elucidates how the performance of the projection-domain network can be enhanced through a low-rank property of DCF and a bowtie support of hierarchical decomposed measurement in the Fourier domain. Main results. This study demonstrated performance improvement of the proposed framework based on the low-rank property, resulting in superior reconstruction performance compared to conventional analytic and DL methods. Significance. By providing a theoretically justified DL approach for sparse-view CT reconstruction, this study not only offers a superior alternative to existing methods but also opens new avenues for research in medical imaging. It highlights the potential of dual-domain DL frameworks to achieve high-quality reconstructions with lower radiation doses, thereby advancing the field towards safer and more efficient diagnostic techniques. The code is available at https://github.com/hanyoseob/HDD-DL-for-SVCT.

Synchrotron radiation sparse-view CT artifact correction through deep learning neural networks

ABSTRACT Synchrotron radiation X-ray Computed Tomography(CT) imaging is an effective means of non-destructively revealing the internal structure of samples. To obtain high-quality reconstructed slices, the number of projections should be at least π 2 N detector ( N detector is the number of detector pixels occupied by the sample diameter). Acquiring excessive projections leads to high radiation doses and long scanning time. Insufficient projections, falling below the Nyquist sampling criterion, result in significant streaking artifacts. This paper proposes a method that fuses the structural similarity index and the peak signal-to-noise ratio as a loss function of the Attention U-Net network to correct streaking artifacts. Moreover, a new deep learning framework based on the Transformer and convolutional neural network is also proposed to solve the artifact problem. At 200 and 400 views, the two proposed methods significantly improve the reconstructed slices’ quality, qualitatively and quantitatively outperforming the classical streaking artifact correction method. The optimal sparsity ratio for sparse-view CT imaging is investigated: the Trans-attunet method corrects streaking artifacts at a 1/12 sparsity ratio to visualize large sample features, whereas ratios of 1/3 or 1/2 more effectively recover fine structures. The optimal sparsity ratio is contingent upon the trade-off between desired image quality and imaging efficiency.

A dense and U-shaped transformer with dual-domain multi-loss function for sparse-view CT reconstruction.

CT image reconstruction from sparse-view projections is an important imaging configuration for low-dose CT, as it can reduce radiation dose. However, the CT images reconstructed from sparse-view projections by traditional analytic algorithms suffer from severe sparse artifacts. Therefore, it is of great value to develop advanced methods to suppress these artifacts. In this work, we aim to use a deep learning (DL)-based method to suppress sparse artifacts. Inspired by the good performance of DenseNet and Transformer architecture in computer vision tasks, we propose a Dense U-shaped Transformer (D-U-Transformer) to suppress sparse artifacts. This architecture exploits the advantages of densely connected convolutions in capturing local context and Transformer in modelling long-range dependencies, and applies channel attention to fusion features. Moreover, we design a dual-domain multi-loss function with learned weights for the optimization of the model to further improve image quality. Experimental results of our proposed D-U-Transformer yield performance improvements on the well-known Mayo Clinic LDCT dataset over several representative DL-based models in terms of artifact suppression and image feature preservation. Extensive internal ablation experiments demonstrate the effectiveness of the components in the proposed model for sparse-view computed tomography (SVCT) reconstruction. The proposed method can effectively suppress sparse artifacts and achieve high-precision SVCT reconstruction, thus promoting clinical CT scanning towards low-dose radiation and high-quality imaging. The findings of this work can be applied to denoising and artifact removal tasks in CT and other medical images.

CT image reconstruction via industrial CT fast scanning

In automated manufacturing and safety inspection, there is a high demand for fast computed tomography (CT) scanning and image reconstruction. Currently, faster scanning can be achieved by reducing the X-ray exposure time within sparse view CT. The faster scanning strategy introduces significant streak artefacts and noise during the sampling process. Consequently, streak artefacts and noise need to be simultaneously suppressed, which is poses a challenge for existing reconstruction methods. This paper presents a fast iterative reconstruction algorithm that can simultaneously suppress both streak artefacts and noise. This method can not only reconstruct high-fidelity images from rapidly acquired projection data, but also has a faster reconstruction speed than the existing iterative reconstruction algorithms. First, we present a high-order multi-directional total variation (HOM-TV) method that specifically focuses on preserving edge details of the image. Then, we present a fast iterative reconstruction model by incorporating HOM-TV and non-local means into the objective function. Finally, the effectiveness of the presented reconstruction model is validated by simulation and real experiments. The faster scanning method can complete the scan in only 5 seconds, and the structural similarity index (SSIM) of the CT image reconstructed by our method is 0.9755, which is higher than 0.0175 of the Fast Null Space Reconstruction (FNSR) algorithm. The peak signal-to-noise ratio (PSNR) index is 1.656, which is higher than that of the contrast algorithm. In terms of reconstruction time, our algorithm can achieve reconstruction in as little as 36 seconds, outperforming the baseline algorithms.

Wavelet-Improved Score-Based Generative Model for Medical Imaging.

The score-based generative model (SGM) has demonstrated remarkable performance in addressing challenging under-determined inverse problems in medical imaging. However, acquiring high-quality training datasets for these models remains a formidable task, especially in medical image reconstructions. Prevalent noise perturbations or artifacts in low-dose Computed Tomography (CT) or under-sampled Magnetic Resonance Imaging (MRI) hinder the accurate estimation of data distribution gradients, thereby compromising the overall performance of SGMs when trained with these data. To alleviate this issue, we propose a wavelet-improved denoising technique to cooperate with the SGMs, ensuring effective and stable training. Specifically, the proposed method integrates a wavelet sub-network and the standard SGM sub-network into a unified framework, effectively alleviating inaccurate distribution of the data distribution gradient and enhancing the overall stability. The mutual feedback mechanism between the wavelet sub-network and the SGM sub-network empowers the neural network to learn accurate scores even when handling noisy samples. This combination results in a framework that exhibits superior stability during the learning process, leading to the generation of more precise and reliable reconstructed images. During the reconstruction process, we further enhance the robustness and quality of the reconstructed images by incorporating regularization constraint. Our experiments, which encompass various scenarios of low-dose and sparse-view CT, as well as MRI with varying under-sampling rates and masks, demonstrate the effectiveness of the proposed method by significantly enhanced the quality of the reconstructed images. Especially, our method with noisy training samples achieves comparable results to those obtained using clean data. Our code at https://zenodo.org/record/8266123.

Reducing image artifacts in sparse projection CT using conditional generative adversarial networks

Reducing the amount of projection data in computed tomography (CT), specifically sparse-view CT, can reduce exposure dose; however, image artifacts can occur. We quantitatively evaluated the effects of conditional generative adversarial networks (CGAN) on image quality restoration for sparse-view CT using simulated sparse projection images and compared them with autoencoder (AE) and U-Net models. The AE, U-Net, and CGAN models were trained using pairs of artifacts and original images; 90% of patient cases were used for training and the remaining for evaluation. Restoration of CT values was evaluated using mean error (ME) and mean absolute error (MAE). The image quality was evaluated using structural image similarity (SSIM) and peak signal-to-noise ratio (PSNR). Image quality improved in all sparse projection data; however, slight deformation in tumor and spine regions was observed, with a dispersed projection of over 5°. Some hallucination regions were observed in the CGAN results. Image resolution decreased, and blurring occurred in AE and U-Net; therefore, large deviations in ME and MAE were observed in lung and air regions, and the SSIM and PSNR results were degraded. The CGAN model achieved accurate CT value restoration and improved SSIM and PSNR compared to AE and U-Net models.

RegFormer: A Local–Nonlocal Regularization-Based Model for Sparse-View CT Reconstruction

Sparse-view computed tomography (CT) is one of the primal means to reduce radiation risk. However, the reconstruction of sparse-view CT with classic analytical method is usually contaminated by severe artifacts. By designing the regularization terms carefully, iterative reconstruction (IR) algorithms can produce promising results. Aided by the powerful deep learning techniques, learned regularization terms with convolution neural network (CNN) have attracted much attention and can further improve performance. In this paper, to further enhance the performance of existing learnable regularization-based networks, we propose a learnable local-nonlocal regularization-based model called RegFormer for sparse-view CT reconstruction. Specifically, we unroll the iterative scheme into a neural network and replace the gradient of handcrafted regularization terms with learnable kernels. The convolution layers are used to learn gradient of local regularization, resulting in excellent denoising performance. In addition, the transformer-based encoders and decoders incorporate the learned nonlocal prior into the model, preserving the structures and details. To enhance the ability to extract deep features, we propose an iteration transmission (IT) module that further improve the efficiency of each iteration. The experimental results show that our proposed RegFormer outperforms several state-of-the-art methods in artifact reduction and detail preservation.

Sparse-view image reconstruction with total-variation minimization applied to sparsely sampled projection data from SiPM-based photon-counting CT

We constructed a sparse-view computed tomography (CT) system that combines a compressed sensing (CS)-based image-reconstruction algorithm and SiPM-based photon-counting (PC) CT. CS-based image-reconstruction algorithms have been extensively studied for X-ray CT image reconstruction using fewer projections because they are expected to reduce CT imaging time and radiation exposure while maintaining CT image quality. In most previous studies, CS-based image-reconstruction algorithms have been applied to data obtained through numerical simulations or conventional dual-energy CT. However, studies on PC-CT have been scarce. Therefore, we applied a CS-based image-reconstruction algorithm to the projection data obtained using our previously established SiPM-based PC-CT system and evaluated its image quality. We prepared static phantoms equivalent to iodine-containing contrast agents and a mouse model injected with iodine-containing contrast agents as subjects. Thereafter, CT scanning was performed. The obtained projection data were downsampled to simulate a sparse-view situation, and a CS-based image-reconstruction algorithm with total-variation minimization was applied. Consequently, sparse-view CT images were successfully reconstructed, and the image quality was maintained even after downsampling the projection data (downsampling ratios of 1/10 and 1/2 for the rod phantom and mouse model, respectively). Thus, the imaging time and exposure dose could be remarkably reduced (by a factor of 10 or 2), indicating that the CS-based image-reconstruction algorithm is effective for PC-CT.

Mud-Net: multi-domain deep unrolling network for simultaneous sparse-view and metal artifact reduction in computed tomography

Sparse-view computed tomography (SVCT) is regarded as a promising technique to accelerate data acquisition and reduce radiation dose. However, in the presence of metallic implants, SVCT inevitably makes the reconstructed CT images suffer from severe metal artifacts and streaking artifacts due to the lack of sufficient projection data. Previous stand-alone SVCT and metal artifact reduction (MAR) methods to solve the problem of simultaneously sparse-view and metal artifact reduction (SVMAR) are plagued by insufficient correction accuracy. To overcome this limitation, we propose a multi-domain deep unrolling network, called Mud-Net, for SVMAR. Specifically, we establish a joint sinogram, image, artifact, and coding domains deep unrolling reconstruction model to recover high-quality CT images from the under-sampled sinograms corrupted by metallic implants. To train this multi-domain network effectively, we embed multi-domain knowledge into the network training process. Comprehensive experiments demonstrate that our method is superior to both existing MAR methods in the full-view MAR task and previous SVCT methods in the SVMAR task.

Deep convolutional dictionary learning network for sparse view CT reconstruction with a group sparse prior

Purpose Numerous techniques based on deep learning have been utilized in sparse view computed tomography (CT) imaging. Nevertheless, the majority of techniques are instinctively constructed utilizing state-of-the-art opaque convolutional neural networks (CNNs) and lack interpretability. Moreover, CNNs tend to focus on local receptive fields and neglect nonlocal self-similarity prior information. Obtaining diagnostically valuable images from sparsely sampled projections is a challenging and ill-posed task.Method To address this issue, we propose a unique and understandable model named DCDL-GS for sparse view CT imaging. This model relies on a network comprised of convolutional dictionary learning and a nonlocal group sparse prior. To enhance the quality of image reconstruction, we utilize a neural network in conjunction with a statistical iterative reconstruction framework and perform a set number of iterations. Inspired by group sparsity priors, we adopt a novel group thresholding operation to improve the feature representation and constraint ability and obtain a theoretical interpretation. Furthermore, our DCDL-GS model incorporates filtered backprojection (FBP) reconstruction, fast sliding window nonlocal self-similarity operations, and a lightweight and interpretable convolutional dictionary learning network to enhance the applicability of the model.Results The efficiency of our proposed DCDL-GS model in preserving edges and recovering features is demonstrated by the visual results obtained on the LDCT-P and UIH datasets. Compared to the results of the most advanced techniques, the quantitative results are enhanced, with increases of 0.6-0.8 dB for the peak signal-to-noise ratio (PSNR), 0.005-0.01 for the structural similarity index measure (SSIM), and 1-1.3 for the regulated Fréchet inception distance (rFID) on the test dataset. The quantitative results also show the effectiveness of our proposed deep convolution iterative reconstruction module and nonlocal group sparse prior.Conclusion In this paper, we create a consolidated and enhanced mathematical model by integrating projection data and prior knowledge of images into a deep iterative model. The model is more practical and interpretable than existing approaches. The results from the experiment show that the proposed model performs well in comparison to the others.

A non-local total generalized variation regularization reconstruction method for sparse-view x-ray CT

Sparse-view x-ray computed tomography (CT) reconstruction, employing total generalized variation (TGV), effectively mitigates the stepwise artifacts associated with total variation (TV) regularization while preserving structural features within transitional regions of the reconstructed image. Despite TGV surpassing TV in reconstruction quality, it neglects the non-local self-similarity prior, recognized for its efficacy in restoring details during CT reconstruction. This study introduces a non-local TGV (NLTGV) to address the limitation of TGV regularization method. Specifically, we propose an NLTGV-regularized method for sparse-view CT reconstruction, utilizing non-local high-order derivative information to maintain image features and non-local self-similarity for detail recovery. Owing to the non-differentiability of the NLTGV regularized, we employ an alternating direction method of multipliers optimization method, facilitating an efficient solution by decomposing the reconstruction model into sub-problems. The proposed method undergoes evaluation using both simulated and real-world projection data. Simulation and experimental results demonstrate the efficacy of the proposed approach in enhancing the quality of reconstructed images compared to other competitive variational reconstruction methods. In conclusion, the simultaneous incorporation of sparsity priors of high-order TV and non-local similarity proves advantageous for structural detail recovery in sparse-view CT reconstruction.

Sparse-view X-ray CT based on a box-constrained nonlinear weighted anisotropic TV regularization.

Sparse-view computed tomography (CT) is an important way to reduce the negative effect of radiation exposure in medical imaging by skipping some X-ray projections. However, due to violating the Nyquist/Shannon sampling criterion, there are severe streaking artifacts in the reconstructed CT images that could mislead diagnosis. Noting the ill-posedness nature of the corresponding inverse problem in a sparse-view CT, minimizing an energy functional composed by an image fidelity term together with properly chosen regularization terms is widely used to reconstruct a medical meaningful attenuation image. In this paper, we propose a regularization, called the box-constrained nonlinear weighted anisotropic total variation (box-constrained NWATV), and minimize the regularization term accompanying the least square fitting using an alternative direction method of multipliers (ADMM) type method. The proposed method is validated through the Shepp-Logan phantom model, alongisde the actual walnut X-ray projections provided by Finnish Inverse Problems Society and the human lung images. The experimental results show that the reconstruction speed of the proposed method is significantly accelerated compared to the existing $ L_1/L_2 $ regularization method. Precisely, the central processing unit (CPU) time is reduced more than 8 times.

Solving Zero-Shot Sparse-View CT Reconstruction With Variational Score Solver.

Computed tomography (CT) stands as a ubiquitous medical diagnostic tool. Nonetheless, the radiation-related concerns associated with CT scans have raised public apprehensions. Mitigating radiation dosage in CT imaging poses an inherent challenge as it inevitably compromises the fidelity of CT reconstructions, impacting diagnostic accuracy. While previous deep learning techniques have exhibited promise in enhancing CT reconstruction quality, they remain hindered by the reliance on paired data, which is arduous to procure. In this study, we present a novel approach named Variational Score Solver (VSS) for solving sparse-view reconstruction without paired data. Our approach entails the acquisition of a probability distribution from densely sampled CT reconstructions, employing a latent diffusion model. High-quality reconstruction outcomes are achieved through an iterative process, wherein the diffusion model serves as the prior term, subsequently integrated with the data consistency term. Notably, rather than directly employing the prior diffusion model, we distill prior knowledge by finding the fixed point of the diffusion model. This framework empowers us to exercise precise control over the process. Moreover, we depart from modeling the reconstruction outcomes as deterministic values, opting instead for a distribution-based approach. This enables us to achieve more accurate reconstructions utilizing a trainable model. Our approach introduces a fresh perspective to the realm of zero-shot CT reconstruction, circumventing the constraints of supervised learning. Our extensive qualitative and quantitative experiments unequivocally demonstrate that VSS surpasses other contemporary unsupervised and achieves comparable results compared with the most advance supervised methods in sparse-view reconstruction tasks. Codes are available in https://github.com/fpsandnoob/vss.