Solutions to nonlinear optimal control problems (OCPs) exhibit dispersions under model uncertainties and it is desirable to generate optimal solutions that exhibit less sensitivity to model uncertainties. We propose a novel solution desensitization method dubbed “Reduced Desensitization Formulation (RDF)” by leveraging non-uniqueness of the solution of the costate differential equations when a hybrid indirect-direct optimization method is used. A key property of the RDF method is a significant reduction in the number of differential equations needed for generating desensitized solutions. This feature facilitates the generation of open-loop desensitized trajectories and makes the methodology applicable to OCPs with a larger number of uncertain parameters. To demonstrate the utility of the RDF method, three important classes of trajectory optimization problems are considered with uncertainty in the thrust magnitude of the propulsion system: (1) minimum-fuel low-thrust interplanetary rendezvous maneuvers, (2) low-thrust orbit-raising maneuvers, and (3) minimum-fuel high-thrust rocket-landing problems. For the considered problems with bang-bang control profiles, an analysis is presented on the change in the number of control switches between sensitive and desensitized optimal solutions. Numerical results demonstrate desensitization of the considered performance indices with respect to the thrust magnitude of the propulsion system.