During on-site throttling spray operations, the ground high-pressure manifold is subjected to the erosive effects of high-speed liquid-solid two-phase flow, which poses a high risk of erosive damage and eventual failure. In response to the erosive conditions caused by high-speed sand-carrying liquid-solid two-phase flow on the high-pressure manifold, an experimental apparatus for erosive testing was designed, taking into account key factors such as internal pressure loads. Microscopic erosive morphologies were observed in the experiments. Subsequently, numerical simulation methods were employed to investigate the identification of erosive danger zones and the influence of different installation angles, sand content, pipe flow velocities, and viscosity on erosive areas of the manifold.The research findings indicate that the microscopic morphological changes in erosive experiments align with the micro-cutting theory, which was successfully applied in simulation. Erosive danger zones are mainly distributed on the outer arch side, the curved arc connecting section, and the initial part of the outlet straight pipe. The erosive areas do not vary with changes in installation angles, sand content, and flow velocities. As viscosity increases, the erosive area shifts. The erosive rate is positively correlated with sand content and pipe flow velocity, and with increasing viscosity, the erosive rate on the first outer arch side shows an initial decrease followed by stabilization, while the second outer arch side exhibits an initial increase followed by stabilization. As the installation angle increases, the erosion rate on the second outer arch side first shows a stable trend and then decreases rapidly. At 75°, the erosion rate reaches the lowest.