Abstract
The suspension state of crystals in the crystallizer is one of the important indicators for evaluating the adaptability of the crystallizer. This study adopted the Euler-Eulerian two-fluid model to simulate and analyze the fluid motion of solid-liquid two-phase flow in the industrial-grade DTB crystallization kettle, as well as the phase suspension distribution of crystal particles. The main influencing factors investigated are: the heat transfer effect, the height of the bottom of the crystallizer, the number and position of the stirring paddle, crystal size and crystal volume fraction. Based on the research of Euler-Eulerian method to simulate fluids, the Euler-Lagrangian method was further used to simulate the motion state of particle phases with different particle sizes in the crystallizer. It was found that the designed DTB crystallizer has good recycle mixing effect. The particles can be mixed evenly during the operation, which can fully realize the solid-liquid mixing and suspension effect of the drug under study.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
