Small Domestic Animals Research Articles

Systemic effect of the oncological process on the dog’s body

The article presents the results of an analysis of a non-randomized study of the prevalence of paraneoplastic syndromes in primary spontaneous malignant neoplasms in dogs. The study was conducted in 2022–2024 on the basis of the Department of Diseases of Small Domestic, Laboratory and Exotic Animals and the Research Laboratory of Oncology, Ophthalmology and Animal Biochemistry of the Russian Biotechnological University “ROSBIOTECH”. The object of the study were 948 dogs with primary spontaneous malignant neoplasms confirmed by morphological methods.The aim of the work was to study the frequency of paraneoplastic syndromes in dogs with neoplasia.The diagnosis of paraneoplastic syndrome was made by excluding other possible etiological factors for the development of clinical and laboratory abnormalities identified during a comprehensive examination of dogs. As a result of the study, the incidence of paraneoplasia was 54.54% of cases. Hematological (44.41%) and gastrointestinal (37.13%) paraneoplastic syndromes were most often recorded, less often endocrine (3.27%) and ophthalmological (3.38%), extremely rarely renal (1.27%), osteoarticular (0.42%) and dermatological (0.42%). The main hematological manifestations of the systemic effect of the oncological process were: anemia (12.87%), neutrophilic leukocytosis (12.76%) and thrombocytopenia (8.86%). Gastrointestinal paraneoplastic syndrome in most cases was manifested by a decrease in body weight (33.65%) and hyporexia (18.04%), inflammatory and erosive ulcerative lesions of the gastrointestinal tract (7.59%). During the study, a case of a nonspecific systemic reaction to a malignant tumor in the form of fever in the absence of infectious and inflammatory processes (0.11%) was registered.

Perceptions of Evidence in the Veterinary Medicine of Pets

Veterinary medicine for small domestic animals (SDA) in Russia began its development in the 1990s and is currently undergoing professional formation, engaging in a dialogue with traditional agricultural veterinary medicine. Over the last decade, the evidence-based approach has been actively developing as a foundation for making informed decisions in various aspects of professional practice. SDA veterinary medicine, as a relatively young and emerging professional field within the conservative profession of veterinary medicine, is facing a legitimacy crisis. This crisis is related to the lack of specialized education in the pathology of dogs and cats, as well as the absence of treatment protocols for SDA approved by the professional community and the state. The evidence-based approach is the foundation of modern medicine and serves as a method of legitimizing SDA veterinary practice. It addresses the needs of the primary stakeholders: colleagues, government regulators in case of disputes, and animal owners as service consumers.

Keratinolytic testing for diagnosing dermatophytosis in small domestic animals

Keratinolytic testing for diagnosing dermatophytosis in small domestic animals

Comparative efficacy of new combined drugs against complicated otodectic mange in small domestic animals

The purpose of the research is to evaluate the comparative efficacy of two veterinary drugs («Inspector ear drops» and «Rolf Club 3D ear drops») to treat dogs and cats for otodectic mange complicated by otitis media of bacterial etiology.Materials and methods. A total of 36 animals participated in the studies. The studies were carried out at the VNIIP – FSC VIEV. The diagnosis was confirmed comprehensively from epidemiological data, clinical signs and laboratory tests. Microscopy of scrapings taken from the inner surface of the ears was performed to detect Otodectes cynotis. Bacteriological and mycological examination of ear canal discharge was conducted according to established procedures. Ear canal otoscopic examination was performed using a veterinary otoscope. For therapeutic purposes, the experimental animals were treated with «Inspector ear drops» and «Rolf Club 3D ear drops» as per instructions for use.Results and discussion. The initial comprehensive clinical examination diagnosed otodectic mange in all animals as complicated by acute otitis media of bacterial etiology. On treatment day 8, the animals showed a positive effect of the studied drugs; clinical signs of the disease reduced significantly. In a repeated clinical examination on day 11, most animals showed clinical recovery that was confirmed by negative bacteriological and mycological studies. Acarological studies showed no mites on days 8 and 14-15. However, the course of treatment was extended to 14 days for two dogs, after which their complete clinical recovery was observed. After the end of the study, the animals from the control group were treated with «Rolf Club 3D ear drops». Thus, an assessment of the results revealed that the drugs for veterinary use, «Inspector ear drops» and «Rolf Club 3D ear drops» showed an identical therapeutic effect in dogs and cats against otodectic mange complicated by acute bacterial otitis media.

Therapeutic efficacy of a three-component anthelmintic drug against cestodosis and nematodosis of small domestic animals

The purpose of the study therapeutic efficacy of combined anthelmintic drug on dogs and cats of different age groups naturally infected with cestodes and nematodes.Materials and methods. The study drug in the suspension form contains oxantel pamoate, pyrantel pamoate, praziquantel, and additives as active ingredients. The therapeutic efficacy of the drug was evaluated on 228 animals naturally infected with nematodes or cestodes in the Podolsk Experimental Production Base of the VNIIP – FSC VIEV. The animals were divided into experimental and control groups of 6 animals each. The experimental dogs and cats were administered the study drug while the control animals were not given the drug. Clinical examinations and laboratory tests of fecal samples were performed on days 10, 20 and 30 after the start of the experiment. The method of helminthoscopy was used to detect segments and helminthoovoscopy as per Fülleborn to detect helminth eggs/cocoons in animal fecal samples with their subsequent differentiation. The results were statistically processed by the Student method using Microsoft Excel 2016.Results and discussion. It was found that anthelmintic drug based on oxantel pamoate, pyrantel pamoate and praziquantel had high therapeutic efficacy against parasitism in dogs and cats of nematodes Toxocara spp., Toxascaris leonina, Trichuris vulpis, Uncinaria stenocephala, Ancylostoma spp. and cestodes Echinococcus spp. (except for cats), Mesocestoides spp., Taenia spp., Dipylidium caninum, and Diphyllobothrium latum. When the drug was used in the animals of different age groups, no side effects or complications were recorded.

Retrospective analysis of data on the prevalence of malignant neoplasms in dogs and cats

The article presents the results of a study on the primary incidence of malignant tumors in dogs and cats in Moscow over the period from January 1, 2023, to July 1, 2024. The study was conducted on the basis of the Department of Diseases of Small Domestic, Laboratory and Exotic Animals and the Research Laboratory of Oncology, Ophthalmology and Animal Biochemistry of the Russian Biotechnological University “ROSBIOTECH”. The study included 208 cats and 325 dogs with primary, spontaneous malignant tumors of various origins. To confirm the diagnosis, a comprehensive approach was used, including clinical examination, hematological tests, and special diagnostic techniques such as ultrasonography, radiography, computed tomography (CT), and magnetic resonance imaging (MRI). Verification of the tumor process was based on cytological and histological methods.The purpose of this work is to analyze the structure of the incidence of small domestic animals with malignant tumors. As a result, we identified the most common types of tumors in cats and dogs. In cats, breast carcinoma was the most common type (44.23%), followed by lymphoma (18.27%), sarcomas (13.46%) and carcinomas (13.94%), as well as squamous cell carcinoma (6.25%). In dogs, breast carcinoma also accounted for the majority of cases (37.23%), along with sarcomas (23.38%), mastocytomas (16.31%), and carcinomas (14.15%).

Sonographic signs of abdominal neoplasms in feline uveitis

Feline uveitis is a common inflammatory disease of the vascular membrane of the eye. Damage to the uveal tract can be caused by a variety of causes, including systemic diseases, autoimmune processes, viral and bacterial infections, parasitic diseases, and oncological pathologies. Differential diagnosis of etiological factors is difficult and requires a comprehensive examination of the animal: careful collection of anamneses in order to exclude a traumatic factor, laboratory tests, serological tests to detect viral infections and parasitic infestations, visual diagnostic examination to diagnose systemic diseases and search for the oncological process. The research was conducted in 2023-2024 on the basis of the Department of Diseases of small domestic, laboratory and exotic animals, as well as the laboratory of "Oncology, Ophthalmology and Biochemistry of Animals" of the Federal State Budgetary Educational Institution "ROSBIOTECH". The aim of the study was to substantiate the use of sonographic and morphological research methods in the differential diagnosis of the etiology of feline uveitis. During the study, in 20.8% of cases (15 cats), sonographic examination of the abdominal cavity allowed to determine the cause of uveitis. We found: thickening of the muscular layer of the intestinal wall with partial or complete loss of layer differentiation, a local increase in the echogenicity of the surrounding adipose tissue, signs of mechanical obstruction of the proximally affected area, diffuse changes in mesenteric lymph nodes, diffuse focal changes in the liver and spleen, a volumetric neoplasm in the abdominal cavity located caudal to the right kidney, moderate nephromegaly and diffuse changes with violation of the differentiation of the cortical and cerebral layers. According to the results of morphological examination of the biopsy material, the diagnosis of large cell lymphoma was established in all cases. Uveitis in this group of cats is attributed to ophthalmopathy associated with paraneoplastic syndrome.

Use of drug in the form of spray based on Flumethrin, Moxidectin and Pyriproxyfen against entomosis in small domestic animals

The purpose of the research is to study the efficacy of a Flumethrin-, Moxidectin and Pyriproxyfen-based spray against entomosis in dogs and cats.Materials and methods. The therapeutic efficacy of the multicomponent spray against entomosis of cats and dogs was evaluated in the Podolsk Experimental Production Base of the VNIIP – FSC VIEV on 100 animals naturally infected with fleas Ctenocephalides spp. (20 cats and 20 dogs), Linognathus setosus (20 dogs), chewing lice Felicola subrostratus (20 cats) and Trichodectes canis (20 dogs). The animals were divided into experimental and control groups of 10 animals each. The experimental dogs and cats were given the drug topically with a bottle pump directed to the skin and fur from 20–25 cm, treating the entire body of the animal at a dose of 3–6 pumps per 1 kg of animal weight, and the control animals were not given the drug. The animals were observed for 60 days after a single dose of the drug; clinical examination was performed before and at 24, 48 hours and 5, 30 and 60 days after the start of the experiment.Results and discussion. The examination of the skin and coat of some experimental animals infected with ectoparasites found single ectoparasite imago at 24 hours after treatment. At 48 hours and on day 5, 30 and 60 of the experiment, all animals treated once with the drug were free from ectoparasites, which was evidenced by clinical studies. The study results showed that the study drug had high therapeutic efficacy against ctenocephalidosis, linognathosis, and trichodectosis in dogs and cats.

Otitis externa in dogs (prevalence, etiology, clinical course, and treatment regimens)

Otitis externa is a reasonably common problem in dogs. The most difficult is the treatment of recurrent chronic otitis media. After all, otitis externa in dogs is a polyetiological disease; therefore, to prescribe effective treatment, the doctor needs to identify the primary cause and take it under control, as well as identify and eliminate secondary infections and develop a prevention plan following predisposing factors. That is why a detailed analysis of the scientific literature on the distribution, etiology, clinical course, and scheme of treatment of dogs with the development of otitis externa was made. To ensure the accuracy and speed of diagnosis of otitis externa, it is promising to develop a diagnostic algorithm that will help the general practitioner clearly understand the etiological factors and eliminate them or take them under control. Many researchers have confirmed that otitis is characterized by seasonality (18.6 % occurs in summer, 30.2 % in autumn, 15.6 % in winter, and 35.6 % in spring). Depending on otitis's etiology in small domestic animals, microorganisms, fungi, and mites are decisive. According to the reports of some authors, otitis externa can be secondary; that is, the etiology of such pathology is already an infection (Staphylococcus and Pseudomonas bacteria, Malassezia yeast). Clinically, otitis externa in dogs, as a rule, is manifested by characteristic symptoms, while the existing peculiarities of the course are, in most cases, determined by etiological factors. In most cases, otitis externa is treated locally with drugs applied directly to the ear. Most of these products contain different ingredients that are active against bacteria, yeast, and inflammation at the same time. There are several remedies for the treatment of otitis externa at the veterinarian's choice, which require different treatment regimens. Recently, the practice of veterinary medicine has increasingly included complex drugs that, on the one hand, are effective in the treatment of otitis and, on the other hand, are safe for the animal body. Such drugs, as a rule, should show, at the same time, anti-inflammatory, anti-parasitic, anti-allergic, analgesic, immunomodulating, and other types of action. Because of this, the search and development of new drugs in the system of comprehensive measures for the prevention and treatment of inflammation of the external ear is relevant and promising.

Antibacterial therapy for kidney pathology of small pets

The article considers etiological factors, clinical manifestations, laboratory and instrumental methods for diagnosing kidney pathology, which requires the use of antibacterial drugs – pyelonephritis. However, this pathology can be difficult to diagnose and not every antibacterial drug is suitable for its treatment. The main ways of kidney damage by bacterial infection in small domestic animals are ascending infection and hematogenous introduction, when pathogenic microorganisms enter the kidneys along with the bloodstream. The article provides predisposing factors leading to the development of pyelonephritis. Pyelonephritis has several types of course. The acute form of the disease is most easily diagnosed due to the vivid clinical signs and pronounced changes in blood, urine, and kidney sonography tests. Whereas the chronic form and latent course may be overlooked due to the nonspecific clinical picture. In the treatment of pyelonephritis, the occurrence of antibiotic resistance in bacteria can be fatal for the patient, because if it is impossible to eliminate infection in the kidneys, the development of renal failure is inevitable, leading to all manifestations of uremia, anemia and other changes that occur with impaired renal function. To prevent the development of antibiotic resistance, it is extremely important to make a final diagnosis through bacteriological urine culture, but pyelonephritis is a pathology that requires a comprehensive diagnostic approach and, if suspected, it is advisable to start etiological treatment immediately, correctly choosing an antibiotic. Not every antibacterial drug is suitable for the treatment of pyelonephritis. For example, one of the first-line drugs of choice in the treatment of urinary tract infection (UTI), amoxicillin with clavulanic acid does not penetrate the renal parenchyma. The group of choice for the treatment of bacterial inflammation of the kidneys are fluoroquinolones, but not every drug from this group is suitable for treatment in animals and there are certain restrictions in their use in the case of puppies, kittens, as well as in cats as a species, therefore, the selection of an antibiotic should be carried out individually in each clinical case, taking into account the pharmacokinetics and pharmacodynamics of the drug, the result of urine sampling and other studies, as well as the physiological characteristics of the patient.

The effects of gastrointestinal diet therapy for chronic pathologies of the digestive system in cats

Gastroeintestinal diseases are one of the most common groups of diseases among small domestic animals. The gastro-intestinal tract includes the oral cavity, pharynx, esophagus, stomach, pancreas, small intestine and large intestine. General signs of digestive system disorders in cats with diseases of the digestive tract are vomiting, regurgitation, capricious appetite, as well as various defecation disorders: diarrhea, coprostasis, various inclusions in feces (blood, mucus). Diseases of the gastrointestinal tract of a chronic nature often involve the manifestation of symptoms on an ongoing basis or are recur-rent in nature. Chronic gastritis, enteropathy, pancreatitis require specialized diets that normalize the functioning of the digestive tract and help improve digestive function. These therapeutic complete diets are presented in ready-made feeds in dry (pellets) and wet (pates, pouches) variations from many manufacturers of industrial feeds. Dietary therapy is required long-term or lifelong; during remission it is the basis in the treatment of chronic patients. The compositions of these diets take into account the physiological and specific needs of the animal, and are also developed on the basis of easily digestible ingredients and a reduced amount of fat, but completely replenishing the required amount of calories.

The relevance of the treatment of lung tumors in small domestic animals and the prospects for the use of targeted therapy for EGFR and ALK/ROS1 mutations on the example of clinical data from humane and veterinary medicine

In the period from 2020 to 2023 was conducted a retrospective study of animal disease histories with lung neoplasia. 43 animals (15 dogs and 28 cats) were included in the study. Neoplasms were identified by instrumental and histopathological methods. Malignant lung tumors have different histological structure, differ in clinical course and treatment results. Surgery is the method of choice for dogs and cats with primary lung tumors. In humans, the surgical method is one of the main methods of treating lung cancer (LC). Since in 70% of cases LC develops without clinical signs, most cases of the trachea, bronchi and lung tumors are detected at IV stage not only in animals, but also in humans, which makes radical surgery impossible. The development of molecular biology methods leads to the development of new treatment methods based on the use of more effective antitumor drugs. One of the innovative methods of cancer treatment is targeted therapy. Molecular-oriented drugs block the growth of cancer cells by interfering with the mechanism of action of specific target molecules necessary for carcinogenesis and tumor growth. In veterinary medicine, surgical and chemotherapeutic methods of treatment are mainly used, while the latter does not show sufficient effectiveness. At the same time, in humane medicine for the treatment of lung cancer widely use targeted therapy, the effect of which is more accurate and effective. There is not much information in the available literature on the use of targeted therapy in animals and there are practically no studies on the treatment of inoperable LC in cats, which makes it relevant to conduct clinical studies on the use of targeted drugs in companion animals.

Prevalence and diagnostic methods of surgical pathology in the digestive system of animals

The relevance of the study is driven by the rapid increase in the number of small domestic animals with surgical pathology of the digestive system, requiring effective diagnosis and surgical intervention. In this regard, the purpose of this study is to investigate the prevalence of various diseases of the digestive organs in small domestic animals and to determine the most informative methods of their diagnosis. The primary approach in the study is to compare the informativeness of results obtained from examining sick animals, including general (history collection, examination, palpation) and special (ultrasound diagnostics of abdominal organs, endoscopy of the digestive tract, radiography) diagnostic methods. The advantages and disadvantages of different special diagnostic methods were identified and analysed, providing a comprehensive assessment of indications and contraindications for their application in clinical veterinary practice. Out of 1863 animals that presented to the veterinary clinic, pathologies of the digestive tract of various origins were diagnosed in 957 animals. Conservative care was provided to 79.7% of the affected animals (763 individuals). Complicated pathologies requiring surgical treatment were diagnosed in 194 (20.3%) animals. Among these, 170 (17.7%) had foreign bodies in the stomach, 14 (1.5%) had gastric erosions, 4 (0.4%) had neoplasms, 3 (0.3%) had perforations, and 3 (0.3%) had inflammatory diseases. The use of ultrasound diagnostics allowed for the detection of linear foreign bodies in the stomach and the identification of associated complications such as stomach or intestinal perforations caused by foreign bodies. Radiographic examination proved effective when radiopaque structures (metals, stones, bones) were present as foreign bodies. The materials of the study provide practical value for both researchers and practising veterinarians, offering the opportunity to utilise new instrumental diagnostic methods to assess the feasibility of surgical manipulations on the stomach and intestines in dogs and cats

Assessment of Babesia spp. prevalence in various domestic animals across Southern Punjab, Pakistan.

Parasitic diseases, notably babesiosis, exert a substantial impact on the global cattle industry, posing challenges to commerce, economies, and human health. This study, conducted in Southern Punjab, Pakistan, aimed to assess the prevalence of Babesia spp. across various livestock species using microscopic and PCR methods. A total of 180 blood samples (60 from each district) were systematically collected from apparently healthy animals, with 36 samples obtained from each domestic animal species, including camel, cattle, buffalo, goat, and sheep, noting that 12 samples were collected from each district for each animal species. Overall prevalence was determined to be 32.8% (59/180), with varying rates among species: 25.0% in cattle, 41.66% in buffalo, 30.55% in goats, 33.3% in sheep, and 33.3% in camels. Microscopic examination revealed slightly varied infection rates among large and small domestic animals (22.2%), while PCR results indicated a 32.8% overall infection rate in both large and small domestic animals, with no statistical significance. District-wise analysis showed regional variations, with Muzaffargarh recording a prevalence rate of 23.33% through microscopic examination, while Lodhran and Bahawalpur recorded 21.67%. PCR results revealed higher rates (38.33%, 26.67%, and 33.33%, respectively), underlining the importance of employing PCR for accurate detection. Examining ruminant types, large ruminants exhibited a 32.4% infection rate, while small domestic animals showed 33.3%, with no significant difference (p=0.897). District-wise prevalence showcased significant variation, with Muzaffargarh demonstrating a 25% prevalence, Lodhran 22%, and Bahawalpur 22%, through microscopic examination. PCR results displayed 38.33%, 27%, and 33.3%, respectively, with no statistical significance. Detailed analysis of individual districts highlighted variations in infection rates among camels, cattle, buffalo, goats, and sheep. The binomial test indicated significant differences through microscopic analysis (P=0.011) but non-significant variations through PCR (P=0.065), emphasizing the precision of PCR. Regional variations in prevalence, notably with Punjab exhibiting the highest frequency (33.87%) and KPK the lowest (13.24%), suggest potential influences from varying veterinary practices and environmental factors. This study underscores the pivotal role of PCR alongside microscopy for accurate babesiosis diagnosis. These findings contribute to the broader understanding of babesiosis prevalence, emphasizing the necessity of advanced molecular techniques for informed control measures.

Prevalence and antimicrobial resistance of Enterobacteriaceae in the north of Kazakhstan.

An increasing number of drugs are used each year in the treatment of small pets (cats and dogs), including medicines (cephalosporins and fluoroquinolones) used in human therapy. The purpose of this study was to isolate and explore the antibiotic resistance of opportunistic Enterobacteriaceae (Escherichia coli, Klebsiella, Proteus, Ci trobacter, Enterobacter) from cats and dogs, and to isolate resistance genes in the microorganisms. In 2021, 808 samples of biological material from small domestic animals were collected in veterinary clinics in Kostanay. From these, 210 microorganisms were isolated and identified. A large majority of the strains sampled belonged to E. coli-149 (70.9%), Enterobacter-11 (5.2%), Klebsiella-28 (13.3%), Proteus-12 (5.7%) and 10 Citrobacter isolates (4.8%). In all isolates identified, antibiotic resistance/sensitivity was determined by disc-diffusion method to ampicillin, cefoxitin, gentamicin, levomycetin, tetracycline, ciprofloxacin, norfloxacin, ofloxacin, cefoperazone, cefpodoxime, streptomycin, kanamycin, doxycycline, gemifloxacin, nalidixic acid, furazolidone, furadonine, amoxicillin, and enrofloxacin. The study has demonstrated that the greatest number of Enterobacteriaceae were sensitive to the action of meropenem, which belongs to the group of beta-lactam antibiotics; resistance was demonstrated against tetracycline, doxycycline, ampicillin, amoxicillin, ofloxacin, and cefpodoxime. The most common genes encoding antimicrobial resistance were as follows: BlaTEM and OXA in 41 and 28 isolates, respectively, encoding resistance to beta-lactams; StrA and StrB in 45 and 48 isolates encoding aminoglycosides; and tetA and tetB in 43 and 28 isolates encoding tetracyclines. Obtained data demonstrate that uncontrolled and frequent use of beta-lactam and tetracycline antibacterials, in cats and dogs, results in the spread of genotypic resistance among micro-organisms of the family Enterobacteriaceae.

The problem of antibiotic resistance in the treatment of small domestic animals according to laboratory research data in the Moscow metropolis for the first half of 2023

Relevance. Widespread irrational use of antibiotics has turned antimicrobial resistance into a global problem not only in veterinary medicine, but also in healthcare, which is exacerbated by the cessation of antibiotic development. This study will help practitioners to promptly make decisions on the choice of tactics of antibacterial treatment even before the results of laboratory diagnostics.The aim of the study is to conduct a cross–sectional study for 2023 on the territory of the Moscow metropolis, aimed at determining the most common opportunistic pathogens in companion animal populations detected in diseases of various organ groups, while simultaneously investigating the phenomenon of antibiotic resistance and compiling a list of antibacterial agents with ranking by their effectiveness.Methods. The determination of antibiotic sensitivity was carried out by the discodiffuse method (DDM) in accordance with MUC 4.2.1890-04 “Determination of the sensitivity of microorganisms to antibacterial drugs”.Results. As a result of the research work, a study of samples of microbiological crops taken from companion animals (parrots, cats and domestic dogs) on the territory of the Moscow metropolis was carried out and 258 pathogens were identified.The most common bacteria were identified: epidermidis and Escherichia. coli are most often isolated from the urinary system of animals;gram-negative pathogens with a predominance of coli strains are most often isolated from the gastrointestinal tract;in dermatological diseases of animals, gram-positive bacteria with the dominance of spp. are most often isolated.The antibiotic resistance of pathogens was investigated, as well as the ranking of antibacterial drugs by effectiveness to certain types of microorganisms was carried out.

Сравнительная эффективность препаратов БАРС® капли инсектоакарицидные и ФРОНТЛАЙН Спот Он против иксодовых клещей, нападающих на собак и кошек

The article describes a study on comparative efficacy and safety of BARS® insectoacaricidal drops developed by «AVZ» Ltd (Russia), which contains fipronil, cyfluthrin, piperonylbutoxide and diflubenzuron as active substances, as well as auxiliary substances and Frontline Spot On (Boehringer Ingelheim Animal Health France SCS, France), the active substance of which is fipronil ‒ 10 %, as well as auxiliary substances.
 
 Purpose of the study. To compare acaricidal efficacy of BARS® insectoacaricidal drops and Frontline Spot On against ixodid ticks attacking dogs and cats.
 
 Materials and methods. The studies were conducted in parallel groups of 10 animals each: group 1 ‒ experimental group (tested preparation BARS® insectoacaricidal drops), group 2 ‒ comparison preparation (Frontline Spot On). The preparations were applied in accordance with the instructions once by drop application to dry intact skin in places inaccessible for licking. Then the acute and residual acaricidal efficacy was evaluated – (the duration of acaricidal action, day).
 Results and conclusions. Acute acaricidal efficacy of BARS® insectoacaricidal drops and comparison preparation ‒ Frontline Spot On, in spontaneous ixodidosis of cats and dogs in 3 hours after treatment was 100 %.
 The preparation BARS® insectocaricidal drops 1 hour and 2 hours after treatment of animals is more effective on average by 8.2…8.3 % than Frontline Spot On.
 The duration of acaricidal action was almost equivalent in the studied drugs and lasted from 30 to 50 days when using the drug BARS® insecticidal drops, and from 25 to 50 days when using the drug Frontline Spot On.
 The conducted studies allow us to conclude about high efficiency and safety of BARS® insectoacaricidal drops developed by «AVZ» Ltd. The domestic preparation can fully meet the needs of veterinary specialists in conducting prophylactic acaricidal measures of small domestic animals along with foreign preparation.

Biological Features of <i>Tenebrio Molitor</i>, <i>Zophobas Morio</i> and <i>Hermetia Illucens</i> Larvae as the Source of Feed Protein for Animals

Introduction. Due to the world’s population growth, the need for food products increases. The only way to solve the problem is to develop the animal husbandry, poultry and fish farming, which are currently facing the acute deficit of protein feedstuff. Due to the chemical composition, the larvae of the yellow mealworm (Tenebrio molitor) beetle, zofobas (Zophobas morio) beetle and the black soldier fly (Hermetia illucens) could be efficiently used in the compound feed production. Therefore, our research aims at the comparative study of the biological features of the above insects and their larvae in the context of improving the technology of the new types of feed protein production.Materials and Methods. The research was conducted by comparing the biological features of the following insects: Tenebrio molitor, Zophobas morio and Hermetia illucens.Results. The specific temperature conditions in the native ranges of the studied insect species were revealed. That could benefit the larvae artificial rearing technology. The aspects of the natural fodder base influence on the formation of the larvae nutrient medium upon their rearing for feed protein production were determined. The larvae growth intensity of the studied insect species was compared.Discussion and Conclusion. The study of Tenebrio molitor, Zophobas morio and Hermetia illucens biological features brought us to the conclusion that using their larvae as feed protein in production of the compound feed is expedient. Based on the chemical composition features of the above larvae, both in their natural and protein feed flour form, they can be recommended for feeding the valuable fish species, poultry, pigs and small domestic animals.

Methods of surgical treatment of pelvic bone fractures in dogs and postoperative rehabilitation

Pelvic ring injury is one of the most severe forms of musculoskeletal injury in small domestic animals. They usually do not survive due to the development of traumatic shock and complications from the pelvic organs, which develop in the post-traumatic period. In this article on the topic: "Methods of surgical treatment of pelvic bone fractures in dogs and postoperative rehabilitation" performed by a number of authors from the Kazakh National Agrarian Research University, examples of surgical intervention for various pelvic fractures in dogs are given, using various methods of fixing them.Such as: internal methods of fixing fractures of the pelvic ring, using plates, screws, various types of wires designed for osteosynthesis of bones; external methods of fixing fractures of the pelvic ring, using the spokerod method. The studies were carried out on 18 dogs for a year and a half in the veterinary clinic "Center for Veterinary Medicine" and in the "Daria Pankova Rehabilitation Center" in Almaty. The studied animals were aged from 1 year to 3.5 years. Breedchar-acteristic sranged from small breeds such as Chihuahuasand Dachshundstolarge out breds and CaneCorso .As well as the use of early rehabilitation in the postoperative period to eliminate various complications, such as muscle atrophy, neurological deficits of varying degrees, loss of limb sensitivity, and so on.The recovery rate of bone and cartilage tissue in the application of food additives in the nutrition of operated animals was estimated, with the data obtained being recorded every 10 days. The analysis of the data obtained shows that the use of additional dietary supplements significantly accelerates the process of formation of a callus and rapid consolidation of bone fractures.

Nosological profile and classification of infectious diseases of farm animals in the territory of the Pepublic of Sakha (Yakutia)

The results of the classification of infectious diseases of farm animals spread on the territory of the Republic of Sakha (Yakutia) for the period 2001-2021 are presented. It was found that there were 42 nosological units of animal diseases involved in the epizootic process on the territory of Yakutia. Infections in cattle are caused by 18 types of pathogens, horses - 12, reindeer - 4, pigs - 10, birds - 11, small ruminants - 3, fur-bearing animals - 7, other types of animals - 9. According to the OIE classification, 10 nosoforms of diseases are common in Yakutia: rabies, brucellosis, viral hemorrhagic septicemia, equine infectious anemia, avian infectious bronchitis, infectious bovine rhinotracheitis, paratuberculosis, pasteurellosis and tuberculosis. Diseases not on the OIE list, including Marek’s disease, swine dysentery, colibacillosis, parvoviral enteritis, salmonellosis, diamond-skin disease, blackleg were registered. A number of nosoforms common in Yakutia belong to particularly dangerous diseases for which restrictive measures (quarantine) may be imposed. These include actinomycosis, rabies, brucellosis, infectious equine anemia, avian infectious bronchitis, infectious bovine rhinotracheitis, bovine leukosis, leptospirosis, paratuberculosis, diamond-skin disease, tuberculosis and canine distemper virus. A number of diseases (Marek’s disease, carnivorous infectious hepatitis, bovine leukosis, horse strangles, avian ornithosis, egg drop syndrome, diamond-skin disease, and blackleg) are peculiar to only one species of animals. Many infections are characterized by the persistence of the pathogen in different species of farm and small domestic animals, birds and wildlife, which determines the interspecies degree of epizootic danger of these infections. Infections of bacterial etiology (bacterioses) prevail in Yakutia with 21 nosoforms. Viral diseases (viroses) are represented by 15 nosoforms, mycoplasmosis and chlamydia - one each. The most numerous infections are those with the main alimentary, or fecal-oral, route (22 diseases). Ten infections, including infectious atrophic rhinitis, infectious bovine rhinotracheitis, distemper, are classified as airborne or respiratory (major) pathogen transmission. Transmissive carry-over (by vectors) is characterized by actinomycosis and infectious equine anemia; through the outer covers (without the participation of vectors) - 5 diseases, including balanoposthitis and rabies. The majority of the infections are characterized by one or more additional mechanisms of transmission (rabies, Marek’s disease, bovine leukemia, diamond-skin disease, etc.) in addition to the main mechanism of transmission of the pathogen. According to the source of the causative agent for all diseases (ktenonoses) they are domestic animals, but for such infections as rabies, Marek’s disease, viral hemorrhagic septicemia, leptospirosis and others, along with domestic animals, wild animals are an additional source (ktenotherionoses). In terms of susceptibility, most infections (30) belong to zoonoses peculiar only to animals; the remaining 12 belong to the more dangerous zooanthroponoses common to animals and humans.