Skinfold Measurements Research Articles

Food and nutritional security analysis of farm women in Siwalik region of North Western Himalayan Region

The multifaceted challenges concerning women's health in hills of Uttarakhand is associated with increasing malnutrition in the State, which ultimately affect the nutritional dividend of the nation. Sub-Himalayan range of the northern Indian subcontinent include regions where an overwhelming number of rural women have always been a part of the active work force in agriculture and allied sector. Present study is an attempt to document the nutritional status of farm women emphasizing their food consumption pattern, dietary intakes and diversification, energy and nutrient balance in Uttarakhand State in the year 2019-20. Collected field level data were analyzed with the help of suitable statistical techniques. It was found that 48 % women in foot hills and 40% women in mid hills had low dietary diversity. The findings also suggest that the prevalence of Chronic Energy Deficiency was high among farm women and energy balances in the respondents (from 171.97 kcal to 415.32 kcal) are corresponding to different grades of BMI. Multivariate regression analysis were employed to drive relationships between high dietary diversity (≥5 food groups) and other independent variables as age, BMI, MUAC, CC, skinfold measurements, body density (D), % body fat, fat mass, fat free mass (kg) . It was found that MDD-W is positively correlated with independent variables (R2=0.702, Adjusted R2=0.721, Standard Error of Estimate=0.0312).

Soft-tissue vibration and damping response to footwear changes across a wide range of anthropometrics in running.

Different factors were shown to alter the vibration characteristics of soft-tissue compartments during running. Changing pre-heel strike muscle activation or changing footwear conditions represents two possibilities to influence the vibration response via frequency shift or altered damping. Associated with the study of muscle pre-tuning is the difficulty in quantifying clean experimental data for the acceleration of soft-tissue compartments and muscle activities in heterogeneous populations. The purpose of this study was to determine the vibration and pre-tuning response to footwear across a wide range of participants during running and establish and describe groups formed according to the damping coefficient. 32 subjects were used for further analysis. The subjects ran at a self-selected speed (5 min) on a treadmill in two different shoes (soft & hard), while soft-tissue accelerations and muscle activation at the gastrocnemius medialis were quantified. Damping coefficients, total muscle intensity and dominant vibration frequencies were determined. Anthropometrics and skinfold measurements of the lower limbs were obtained. According to the damping coefficient response to the footwear intervention, three groups were formed, with most runners (n = 20) showing less damping in the hard shoe. Total muscle intensity, anthropometrics, and dominant vibration frequency across footwear were not different for these three groups. Most runners (84.4%) used the strategy of adjusting the damping coefficients significantly when switching footwear. Despite damping being the preferred adjustment to changes in footwear, muscle pre-tuning might not be the only mechanism to influence damping as previously suggested. Future studies should focus on the subject-specific composition of soft-tissue compartments to elucidate their contribution to vibrations.

Associations of Percent Body Fat and Motor Skill Development in Preschool-Aged Children: National Youth Fitness Survey.

Background: Body composition and motor skill development are important for the engagement in physical activity and healthy development of children. This study examined the associations between body composition and motor skill development in 3- to 5-year-old children. Methods: Data from preschool-aged children (N = 342, 51% males) who participated in the 2012 National Youth Fitness Survey were analyzed. Skinfold measurements (subscapular, calf, and triceps) were taken and percent body fat (%BF) was calculated using sex-specific equations. Lean muscle mass and fat mass were also calculated. Motor skill development was determined by the Test of Gross Motor Development-2nd Edition. Regression analyses were performed to determine the associations among %BF and locomotor skills, object control skills, and overall gross motor quotient (GMQ), controlling for sex, race, and poverty index ratio. Results: Most children were classified as with underweight/healthy weight (69%) and 31% were either with overweight or obesity. Average %BF was 17.02% ± 0.27%. The standard scores for locomotor skills, object control skills, and GMQ were 9.99 ± 0.16, 8.52 ± 0.14, and 95.57 ± 0.68, respectively. These scores were considered average. Regression analyses indicated that neither the %BF nor sum of skinfolds was associated with locomotor skills (β = -0.07 ± 0.05, p = 0.63; β = -0.03 ± 0.03, p = 0.22), object control skills (β = 0.03 ± 0.04, p = 0.55; β = 0.00 ± 0.02, p = 0.87), or GMQ (β = -0.13 ± 0.28, p = 0.63; β = -0.09 ± 0.14, p = 0.52). Furthermore, neither lean muscle mass nor fat mass was related with any motor skill measure (p > 0.05). Conclusions: Using different measures of body composition may provide additional insight into associations between obesity and motor skill development in preschool-aged children. Given the inconsistent findings in the literature, additional research is needed to elucidate these associations.

Early Risk Factors for Obesity in the First 1000 Days-Relationship with Body Fat and BMI at 2 Years.

(1) Background: Obesity is defined as an excessive accumulation of body fat. Several early developmental factors have been identified which are associated with an increased risk of childhood obesity and increased adiposity in childhood. The primary objective of the present study is to analyse the effect of various early risk factors on Body Mass Index (BMI) and body fat percentage at 2 years of age. (2) Methods: A prospective cohort study design was used, with the sample consisting of 109 mother-child pairs from whom data were collected between early pregnancy and 2 years old. Adiposity was determined based on skinfold measurements using the Brooks and Siri formulae. Mean comparison tests (Student’s t-test and ANOVAs) and multiple linear regression models were used to analyse the relationship between early programming factors and dependent variables. (3) Results: Maternal excess weight during early pregnancy (β = 0.203, p = 0.026), gestational smoking (β = 0.192, p = 0.036), and accelerated weight gain in the first 2 years (β = − 0.269, p = 0.004) were significantly associated with high body fat percentage. Pre-pregnancy BMI and accelerated weight gain in the first 2 years were associated with high BMI z-score (β = 0.174, p = 0.047 and β = 0.417, p = 0.000 respectively). The cumulative effect of these variables resulted in high values compared to the baseline zero-factor group, with significant differences in BMI z-score (F = 8.640, p = 0.000) and body fat percentage (F = 5.402, p = 0.002) when three factors were present. (4) Conclusions: The presence of several early risk factors related to obesity in infancy was significantly associated with higher BMI z-score and body fat percentage at 2 years of age. The presence of more than one of these variables was also associated with higher adiposity at 2 years of age. Early prevention strategies should address as many of these factors as possible.

Relationships Between Body Composition, Abdominal Muscle Strength, And Well Defined Abdominal Muscles

BACKGROUND Physically fit individuals may desire to have well defined abdominal muscles (also known as “6 Pack Abs”). They seek to obtain 6 Pack Abs through numerous exercises that strengthen and tone the abdominal muscles. It has also been purported that to have 6 Pack Abs an individual must have low amounts of total body fat. However, there has been little to no research to determine the amount of body fatness or abdominal muscle strength necessary to have 6 Pack Abs. PURPOSE: The aim of this study was to evaluate the relationship between total and regional body fatness, abdominal muscle strength, and the aesthetic quality of an individual's abs. METHODS: 56 male and 31 female subjects between the ages of 19 and 35 years old were recruited for measurement of body composition via dual-energy x-ray absorptiometry, abdominal skinfold measurement, abdominal muscle strength assessment through a 60 second sit up test, and a photograph of the subject’s bare abdomens. The photographs were then scored on a 10 point scale for overall quality of 6 Pack Abs based on visual appearance for symmetry, muscle mass, and definition (total possible score of 30 points). Regression analysis was used to determine what factors predict 6 Pack Ab score. RESULTS: The strongest predictor of 6 pack ab score for women was having a low percent of android body fat (r2 = 0.52), followed by total percent body fat (r2 = 0.46), abdominal skinfold thickness (r2 = 0.45), and percent of gynoid body fat (r2 = 0.33). The strongest predictor of 6 pack ab score for males was having a low percent of android body fat (r2 = 0.43), followed by total percent body fat (r2 = 0.38) and then abdominal skinfold thickness (r2 = 0.33). 1 minute sit up performance did not significantly predict 6 pack ab score. CONCLUSION: The present data suggest that the strongest predictor of 6 pack ab score is having a low percent of android body fat followed by total percent body fat. Since total body fatness can be influenced by diet and exercise, but body fat distribution is determined by genetics, 6 pack abs may be an unattainable goal for some individuals. Furthermore, the present data indicate that performance on the 1 minute sit up test is not a significant predictor of 6 pack ab score, suggesting that abdominal muscle strength is not a significant influence on 6 pack abs in physically active individuals.

A nutritional profile of patients with tuberculosis at Standerton Tuberculosis Specialised Hospital, Mpumalanga, South Africa.

BackgroundTuberculosis (TB) is strongly influenced by nutritional status, with nutrition interventions being likely to have an impact on the prevalence of disease, response to drugs and quality of life.AimThe aim of this research study was to determine the nutritional profile of patients with TB and TB and human immunodeficiency virus (HIV) co-infection.SettingThe study was conducted at Standerton TB Specialised Hospital, Mpumalanga.MethodsA cross-sectional study was undertaken. A structured interview was conducted by the researcher with each patient. The Malnutrition Universal Screening Tool (MUST) was used to determine the risk of malnutrition. Weight, height, mid-upper arm circumference (MUAC) and triceps skinfold were measured using standard techniques. Biochemical parameters that were part of the routine hospital procedure were noted.ResultsMore than two-thirds of the participants (68%) were found to be HIV positive. Food-related side effects included loss of appetite (59%) and dry mouth (48%). According to the MUST, 70% had a high risk of malnutrition. The median body mass index (BMI) was in the underweight category at 18.3 kg/m². About half of the participants had low MUAC measurements (51%) and triceps skinfold measurements below the 15th percentile (49.9%), indicating malnutrition. Most participants had low albumin and haemoglobin levels (79% and 92%, respectively).ConclusionsPatients with both TB and TB and HIV co-infection had a compromised nutritional status and an increased risk for developing malnutrition. Interventions aimed at addressing malnutrition could make a meaningful contribution to improving the quality of life in these patients.ContributionThis research provides evidence on the nutritional profile of patients with tuberculosis at Standerton TB Specialised Hospital, it gives opportunity to extend this research project to confirm these findings in other TB burdened areas.

Sleep duration and eating behaviours are associated with body composition in 5-year-old children: findings from the ROLO longitudinal birth cohort study.

Inadequate sleep and poor eating behaviours are associated with higher risk of childhood overweight and obesity. Less is known about the influence sleep has on eating behaviours and consequently body composition. Furthermore, whether associations differ in boys and girls has not been investigated extensively. We investigate associations between sleep, eating behaviours and body composition in cross-sectional analysis of 5-year-old children. Weight, height, BMI, mid upper arm circumference (MUAC), abdominal circumference (AC) and skinfold measurements were obtained. Maternal reported information on child's eating behaviour and sleep habits were collected using validated questionnaires. Multiple linear regression examined associations between sleep, eating behaviours and body composition. Sleep duration was negatively associated with BMI, with 1-h greater sleep duration associated with 0·24 kg/m2 (B = 0·24, CI -0·42, -0·03, P = 0·026) lower BMI and 0·21 cm lower (B = -0·21, CI -0·41, -0·02, P = 0·035) MUAC. When stratified by sex, girls showed stronger inverse associations between sleep duration (h) and BMI (kg/m2) (B = -0·32; CI -0·60, -0·04, P = 0·024), MUAC (cm) (B = -0·29; CI -0·58, 0·000, P = 0·05) and AC (cm) (B = -1·10; CI -1·85, -0·21, P = 0·014) than boys. Positive associations for 'Enjoys Food' and 'Food Responsiveness' with BMI, MUAC and AC were observed in girls only. Inverse associations between sleep duration and 'Emotional Undereating' and 'Food Fussiness' were observed in both sexes, although stronger in boys. Sleep duration did not mediate the relationship between eating behaviours and BMI. Further exploration is required to understand how sleep impacts eating behaviours and consequently body composition and how sex influences this relationship.

Which Body Density Equations Calculate Body Fat Percentage Better in Olympic Wrestlers?—Comparison Study with Air Displacement Plethysmography

Although skinfold-derived equations seem to be practical for field application in estimating body fat percentage (BF%) and minimum body mass in Olympic wrestlers, prediction equations applied first need to be cross-validated in Olympic wrestlers to define the best prediction equation. This study aimed to evaluate the most accurate field method to predict BF% in Olympic wrestlers compared to BF% estimated by air displacement plethysmography (ADP). Sixty-one male (body mass 72.4 ± 13.5 kg; height 170.3 ± 7.0 cm; body mass index (BMI) 24.9 ± 3.5 kg.m−2; BF% 8.5 ± 4.9%) and twenty-five female wrestlers (body mass 60.3 ± 9.9 kg; height 161.3 ± 7.1 cm; BMI 23.1 ± 2.5 kg.m−2; BF% 18.7 ± 4.7%) undertook body composition assessments including ADP and nine-site skinfold measurements. Correlations, bias, limits of agreement, and standardized differences between alterations in BF% measured by ADP and other prediction equations were evaluated to validate measures, and multiple regression analyses to develop an Olympic wrestlers-specific prediction formula. The Stewart and Hannan equation for male wrestlers and the Durnin and Womersley equation for female wrestlers provided the most accurate BF% compared to the measured BF% by ADP, with the lowest bias and presented no significant differences between the measured and predicted BF%. A new prediction equation was developed using only abdominal skinfold and sex as variables, predicting 83.2% of the variance. The findings suggest the use of the new wrestler-specific prediction equation proposed in the study as a valid and accurate alternative to ADP to quantify BF% among Olympic wrestlers.

Physiological, morphological characteristics and blood profile of female elite Brazilian soccer players according to position

The main goal of this study was to identify the performance parameters and blood profile found among female soccer players. The second aim was to examine if there were any systematic differences between players assigned to different playing positions. Thirty-six players (age: 23.7 ± 3.5 y; weight: 61.9 ± 5.7 kg; height: 165.7± 6.2 cm) underwent a set of laboratory tests (cardiopulmonary exercise test, skinfold measurements, Wingate test, sit-and-reach test, and blood biochemical tests). The following results were verified: maximal oxygen uptake (53±3.9 mL.kg-1.min-1), second ventilatory threshold (11.5 ± 0.8 km.h-1), body fat (14.1 ± 2.9%), Wingate anaerobic test (peak power: 9.5 ± 0.8 w.kg-1; mean power: 7.3 ± 0.4 w.kg-1 and fatigue index: 55.5 ± 4.9%), flexibility test [sit-and-reach] (18.1 ± 2.9 cm) and biochemical parameters of blood (Hb:13.9 ± 0.3 g.dL-1; iron: 85.2 ± 12.6 µ.dL-1; calcium: 9.2±0.5 mg.dL-1; total cholesterol: 204.7 ± 34.7 mg.dL-1; HDL-c: 50.7± 3.6 mg.dL-1; LDL-c: 125.8± 23.3 mg.dL-1; triglycerides: 96.8±18.5 mg.dL-1). In conclusion, the current results indicate that present elite players' physiological characteristics are similar to those previously shown, despite the rapid changes of the female soccer game worldwide. However, data showed that different playing positions had different physiological and anthropometrics differences.

О качестве измерений кожно-жировых складок калиперами и скользящим циркулем

A comparative study of the calipers GPM (DKSH, Switzerland), Holtain (Holtain Ltd, Great Britain), the caliper designed by V.E. Deryabin, and the sliding caliper GPM (Martin type) was carried out by the four measurers. The study was conducted using a metal caliper checking gauge GPM, a ‘sandwiches’ of soft silicone rubber kSil™ GP250 (Silicon Engineering, UK), as well as by measurements of subscapular, triceps, suprailiac, and calf skinfolds utilized in the Heath-Carter somatotype assessment scheme, in 20 adult volunteers (10 women and 10 men). Results and discussion. When measuring the caliper checking gauge, the V.E. Deryabin’s and the sliding caliper were accurate, the caliper GPM slightly underestimated (by 0.2 mm), and the caliper Holtain overestimated the exact values (by 0.4-0.6 mm). When measuring ‘sandwiches’ of silicone rubber, the GPM and Holtain calipers showed small but statistically significant differences between measurers (up to 1.4 mm), and for the V.E. Deryabin’s caliper, these differences were more pronounced (up to 5 mm). With a sufficiently high reproducibility of skinfold data, the mean values of their total thickness for the GPM and Holtain calipers differed significantly, and for the V.E. Deryabin and GPM calipers, there were no significant differences. The measurement data using the sliding caliper were consistent with those for the Holtain caliper but showed the largest variation of data between measurers: the maximal difference of the total skinfold thickness averages was 5.2 mm and 7.1 mm in the female and male subgroups, respectively, or 10-14% of the total averages. Conclusion. The results obtained support the need for mutual comparison of skinfold calipers and control of technical measurement errors to ensure data comparability. Cross-calibration of skinfold calipers is a necessary procedure that should precede the anthropometric study. When measured by an experienced anthropologist, the technical error of measuring skinfolds with a sliding caliper can be reduced, but this instrument is not recommended for training and subsequent use for skinfold measurements due to the high risk of obtaining inconsistent data.

The effects of dietary and lifestyle interventions among pregnant women with overweight or obesity on early childhood outcomes: an individual participant data meta-analysis from randomised trials

BackgroundThe impact of maternal obesity extends beyond birth, being independently associated with an increased risk of child obesity. Current evidence demonstrates that women provided with a dietary intervention during pregnancy improve their dietary quality and have a modest reduction in gestational weight gain. However, the effect of this on longer-term childhood obesity-related outcomes is unknown.MethodsWe conducted an individual participant data meta-analysis from RCTs in which women with a singleton, live gestation between 10+0 and 20+0 weeks and body mass index (BMI) ≥ 25 kg/m2 in early pregnancy were randomised to a diet and/or lifestyle intervention or continued standard antenatal care and in which longer-term maternal and child follow-up at 3–5 years of age had been undertaken. The primary childhood outcome was BMI z-score above the 90th percentile. Secondary childhood outcomes included skinfold thickness measurements and body circumferences, fat-free mass, dietary and physical activity patterns, blood pressure, and neurodevelopment.ResultsSeven primary trials where follow-up of participants occurred were identified by a systematic literature search within the International Weight Management in Pregnancy (i-WIP) Collaborative Group collaboration, with six providing individual participant data. No additional studies were identified after a systematic literature search. A total of 2529 children and 2383 women contributed data. Approximately 30% of all child participants had a BMI z-score above the 90th percentile, with no significant difference between the intervention and control groups (aRR 0.97; 95% CI 0.87, 1.08; p=0.610). There were no statistically significant differences identified for any of the secondary outcome measures.ConclusionsIn overweight and obese pregnant women, we found no evidence that maternal dietary and/or lifestyle intervention during pregnancy modifies the risk of early childhood obesity. Future research may need to target the pre-conception period in women and early childhood interventions.Trial registrationPROSPERO, CRD42016047165

Impact of promoting healthy infant feeding practices on energy intake and anthropometric measures of children up to 6years of age: A randomised controlled trial.

The first 2years of life are the window of opportunity to promote healthy feeding practices. Thus, the present study aimed to assess the impact of a health workers training in infant dietary guidelines on energy intake and anthropometric measurement into childhood. Cluster randomised field trial (NCT00635453) was conducted in Porto Alegre, Brazil. Healthcare centres were randomised into intervention (n=9) and control (n=11) groups. In intervention sites, health workers were trained to promote healthy feeding practices based on the Brazilian guideline for children's nutrition. Pregnant women who were in the last trimester of pregnancy were registered as potential mothers who would receive dietary counselling from the health workers. Energy and macronutrient intake and anthropometric measurements were obtained from children at ages 6months, 12months, 3years and 6years from low-income families. At age 3years, intervention group had lower consumption of energy [-92.5kcal; 95% confidence interval (CI)=-153.5 to -31.5], carbohydrates (-11.9g; 95% CI=-19.9 to -2.3), and total fat (-3.9g; 95% CI=-6.2 to -1.2), compared to the control group. At 6years of age, children in the intervention group had lower waist circumference (-1.3cm; 95% CI=-2.7 to -0.0), triceps (-1.3mm; 95% CI=-2.5 to -0.0) and subscapular skinfolds (-1.3mm; 16 95% CI=-2.6 to -0.0) thickness measurements compared to those in the control group. The health workers training to promote infant healthy feeding practices resulted in lower energy, carbohydrates and fat intake at 3years and lower waist circumference, triceps and subscapular skinfolds measurements at 6years.

Feasibility and Tolerance of Fingertip Peripheral Arterial Tonometry Measurements in School-Aged Children.

Background: Assessment of the endothelial function of the microvasculature by peripheral arterial tonometry (PAT) has gained increasing popularity in pediatrics. Discomfort or experienced pain during fingertip PAT has only been studied in adolescents and adults.Methods: In 142 children (aged 4–11 years old), a fingertip PAT with a commercial device (EndoPAT 2000®) as well as a caliper and ultrasound examination of peripheral skinfolds were performed as part of a cross-sectional cohort study. In 110 children, Faces Pain Scale (FPS-R) data were collected after PAT and skinfold measurements by caliper and ultrasound.Results: In 111 out of the 142 PAT measurements (78.2%), a reactive hyperemia index (RHI) could be obtained. The most frequent error messages by the software was a “too noisy” and/or a “poor quality” signal. The success rate was higher in children aged older than 6 years (83.1 vs. 44.4%; p < 0.001). Median (range) FPS-R after PAT was 0 (range 0–6) but was significantly higher than the median pain experienced after caliper measurements of peripheral skinfolds (p < 0.001). No pain was experienced by 59 of the 110 children (54.1%).Conclusion: PAT testing is feasible in the great majority of school-aged children, and the procedure is well-tolerated.

Influence of sensor mass and adipose tissue on the mechanomyography signal of elbow flexor muscles

Mechanomyography (MMG) is a non-invasive technique that records muscle contraction using sensors positioned on the skin's surface. Therefore, it can have its signal attenuated due to the adipose tissue, directly influencing the results. This study evaluates the influence of different mass added to a sensor's assembly and the adipose tissue on MMG signals of elbow flexor muscles. Test protocol consisted of skinfold thickness measurement of 22 volunteers, followed by applying 2–3 s electrical stimulation for muscle contraction during the acquisition of MMG signals. MMG signals were processed in the time domain, using the average of the absolute amplitude, and expressed in gravity values (G), termed here as MMG(G). Tests occurred four times with different sensor masses. MMG data were processed and analyzed statistically using Friedman and Kruskal-Wallis tests to determine the differences between the MMG signals measured with different sensor masses. The Mann-Whitney analysis indicated differences in the MMG signals between groups with different skinfold thickness. MMG(G) signals suffered attenuation with increasing sensor mass (0.4416 G to 0.94 g; 0.3902 G to 2.64 g; 0.3762 G to 5.44 g; 0.3762 G to 7.14 g) and adipose tissue.

Anthropometric and body composition characterisation of competition Portuguese crossfit athletes

Introduction Anthropometric characteristics and body composition are an important element in sports performance. Skinfold and circumference measurement had been recognised as an adequate and valid tool to assess body composition through specific equations from several authors which should be validated for each sport. The aim of this work was to characterise a Portuguese sample of competition athletes in Crossfit comparing several equations based in skinfold measurement. Materials and methods This was an observational study conducted in a Crossfit box where 11 athletes were recruited, 7 were male and 4 female. The anthropometric assessment included the height measurement through a stadiometer (SECA123), a weigh in a digital scale with 100 g precision (ELECTRONIA) and the measurement of 7-site skinfold (bicep, tricep, subscapular, suprailiac, abdominal, thigh and calf) with a Slim Guide adipometer. Skinfold measurements were conducted according to ISAK protocol. All the results were treated with SPSS statistics 17.0 software. Results The sample included 11 athletes where 4 were female (36%). Participants were 25–39 (31.6 ± 4.4) years old. The average body fat in male and female athletes was 13.7%±3.98 and 28.4%±5.6, respectively. These results were compared through a paired-samle t-test. In men, Durnnin & Womersley gave the highest body fat percentage while in female this and Jackson & Pollock where the highest, the lowest values were obtained through Evans formula in both genders. There were significant differences between all the formulas used for men (p < .05) but in women results only the formulas Durnnin & Womersley and Jackson & Pollock had shown significant differences (p < .05). Discussion and Conclusions The sample of Crossfit athletes had shown values of body fat within the normal range. In spite of these, there were found some differences between several formulas which reinforces the need to use more than one formula in body fat assessment in nutrition clinical setting. Because this study was done in a convenience sample, the size and the heterogenous distribution of gender can be considered as study limitations.

Food intake assessment and anthropometric characterisation of teenage gymnasts

Introduction Food and nutrition have a critical role in health, sports performance but also in a proper growth a development when we consider young athletes [1,2]. In addition to the increased energy needs, there is a special concern in ensuring adequate intakes of specific micronutrients such as calcium and iron [3]. The aim of the present study was to evaluate the food intake of a group of teenager gymnasts and to compare energy, macronutrient and micronutrient intake with recommendations for this age group. Methods In this observational study, the teenager gymnasts had answered two 24 h dietary recall applied three days apart. The sample included 66 participants 11–17 (14.74 ± 1.79) years old and 26 (39%) were male. Participants were weighted in a 100 g digital sacale (Beurer GS-10) and had their height measured in a stadiometer (SECA213). Body fat had been assessed through skinfold measurement using a INNOVACARE Cescorf through Durnin & Womersley formula which included 5-site measures (bicep, tricep, subscapula, suprailiac and abdominal). Results Results had shown that 15% were overweight and only 3% were obese, 39% of the sample had normal values of body fat. The average energy intake was 1660 ± 621 kcal while the calcium average intake was 652 ± 307 mg, significantly lower than the recommended value (p = .02). The average Iron intake in female athletes was 7.68 ± 2.81 mg, also significantly lower than the recommended (p = .03). In this sample 23 participants (35%) of the young athletes did not had any dairy portion and 47 (72%) did not had any portion of vegetables daily. Conclusions Data of this sample had shown a very low calcium intake in the participants and also a low iron intake in female individuals. Considering the age group, these results reinforce the importance of the nutritionist role in sports specially in young athletes in order to improve not only individual choices but also nutritional knowledge.

Association Between Maternal Caffeine Consumption and Metabolism and Neonatal Anthropometry

Higher caffeine consumption during pregnancy has been associated with lower birth weight. However, associations of caffeine consumption, based on both plasma concentrations of caffeine and its metabolites, and self-reported caffeinated beverage intake, with multiple measures of neonatal anthropometry, have yet to be examined. To evaluate the association between maternal caffeine intake and neonatal anthropometry, testing effect modification by fast or slow caffeine metabolism genotype. A longitudinal cohort study, the National Institute of Child Health and Human Development Fetal Growth Studies-Singletons, enrolled 2055 nonsmoking women at low risk for fetal growth abnormalities with complete information on caffeine consumption from 12 US clinical sites between 2009 and 2013. Secondary analysis was completed in 2020. Caffeine was evaluated by both plasma concentrations of caffeine and paraxanthine and self-reported caffeinated beverage consumption measured/reported at 10-13 weeks gestation. Caffeine metabolism defined as fast or slow using genotype information from the single nucleotide variant rs762551 (CYP1A2*1F). Neonatal anthropometric measures, including birth weight, length, and head, abdominal, arm, and thigh circumferences, skin fold and fat mass measures. The β coefficients represent the change in neonatal anthropometric measure per SD change in exposure. A total of 2055 participants had a mean (SD) age of 28.3 (5.5) years, mean (SD) body mass index of 23.6 (3.0), and 580 (28.2%) were Hispanic, 562 (27.4%) were White, 518 (25.2%) were Black, and 395 (19.2%) were Asian/Pacific Islander. Delivery occurred at a mean (SD) of 39.2 (1.7) gestational weeks. Compared with the first quartile of plasma caffeine level (≤28 ng/mL), neonates of women in the fourth quartile (>659 ng/mL) had lower birth weight (β = -84.3 g; 95% CI, -145.9 to -22.6 g; P = .04 for trend), length (β = -0.44 cm; 95% CI, -0.78 to -0.12 cm; P = .04 for trend), and head (β = -0.28 cm; 95% CI, -0.47 to -0.09 cm; P < .001 for trend), arm (β = -0.25 cm; 95% CI, -0.41 to -0.09 cm: P = .02 for trend), and thigh (β = -0.29 cm; 95% CI, -0.58 to -0.04 cm; P = .07 for trend) circumference. Similar reductions were observed for paraxanthine quartiles, and for continuous measures of caffeine and paraxanthine concentrations. Compared with women who reported drinking no caffeinated beverages, women who consumed approximately 50 mg per day (~ 1/2 cup of coffee) had neonates with lower birth weight (β = -66 g; 95% CI, -121 to -10 g), smaller arm (β = -0.17 cm; 95% CI, -0.31 to -0.02 cm) and thigh (β = -0.32 cm; 95% CI, -0.55 to -0.09 cm) circumference, and smaller anterior flank skin fold (β = -0.24 mm; 95% CI, -0.47 to -0.01 mm). Results did not differ by fast or slow caffeine metabolism genotype. In this cohort study, small reductions in neonatal anthropometric measurements with increasing caffeine consumption were observed. Findings suggest that caffeine consumption during pregnancy, even at levels much lower than the recommended 200 mg per day of caffeine, are associated with decreased fetal growth.

Long-term follow-up of children with in utero exposure tosulfonylurea medications.

BackgroundOffspring born to mothers with gestational diabetes mellitus (GDM) are more likely to have negative neurodevelopmental health outcomes, early obesity, type 2 diabetes, and metabolic syndrome in childhood, adolescence, and adulthood. Standard of care management for GDM and type 2 diabetes mellitus during pregnancy is insulin, but oral sulfonylurea use is increasing, and these medications cross the placenta. Literature on treatment with sulfonylureas for maternal GDM has focused on maternal glycemic control and neonatal outcomes. Studies that have evaluated the long‐term outcomes of children exposed to sulfonylureas in utero are limited.ObjectiveThis study evaluated anthropometric and neurodevelopmental outcomes of 55 children (ages 5–10) born to mothers with diabetes during pregnancy treated with sulfonylurea or insulin.Methods and ResultsA group of 25 sulfonylurea‐exposed and 30 insulin‐exposed participants were age‐ and sex‐matched between groups. No significant differences were identified in z‐scores for body mass index (BMI), waist circumference, skinfold measurements, and body fat or rates of overweight/obese BMI between groups. On performance‐based cognitive assessment, the sulfonylurea‐exposed group had significantly lower scores on inhibition (p = 0.043).ConclusionIn summary, children with in utero sulfonylurea exposure had similar physical measurements compared to children with insulin exposure and lower performance on a measure of executive function (inhibition), which is associated with adverse health outcomes.

Pregnancy Outcomes and Maternal Insulin Sensitivity: Design and Rationale of a Multi-Center Longitudinal Study in Mother and Offspring (PROMIS).

The worldwide prevalence of overweight and obesity in women of reproductive age is rapidly increasing and a risk factor for the development of gestational diabetes (GDM). Excess adipose tissue reduces insulin sensitivity and may underlie adverse outcomes in both mother and child. The present paper describes the rationale and design of the PRegnancy Outcomes and Maternal Insulin Sensitivity (PROMIS) study, an exploratory cohort study to obtain detailed insights in insulin sensitivity and glucose metabolism during pregnancy and its relation to pregnancy outcomes including early infancy growth. We aim to recruit healthy pregnant women with a body mass index (BMI) ≥ 25 kg/m2 before 12 weeks of gestation in Northern Netherlands. A total of 130 woman will be checked on fasted (≤7.0 mmol/L) or random (≤11.0 mmol/L) blood glucose to exclude pregestational diabetes at inclusion. Subjects will be followed up to six months after giving birth, with a total of nine contact moments for data collection. Maternal data include postprandial measures following an oral meal tolerance test (MTT), conducted before 16 weeks and repeated around 24 weeks of gestation, followed by a standard oral glucose tolerance test before 28 weeks of gestation. The MTT is again performed around three months postpartum. Blood analysis is done for baseline and postprandial glucose and insulin, baseline lipid profile and several biomarkers of placental function. In addition, specific body circumferences, skinfold measures, and questionnaires about food intake, eating behavior, physical activity, meal test preference, mental health, and pregnancy complications will be obtained. Fetal data include assessment of growth, examined by sonography at week 28 and 32 of gestation. Neonatal and infant data consist of specific body circumferences, skinfolds, and body composition measurements, as well as questionnaires about eating behavior and complications up to 6 months after birth. The design of the PROMIS study will allow for detailed insights in the metabolic changes in the mother and their possible association with fetal and postnatal infant growth and body composition. We anticipate that the data from this cohort women with an elevated risk for the development of GDM may provide new insights to detect metabolic deviations already in early pregnancy. These data could inspire the development of new interventions that may improve the management of maternal, as well as offsrping complications from already early on in pregnancy with the aim to prevent adverse outcomes for mother and child.

53746 Body Composition and Metabolic Profiles in Infants of Diabetic Mothers (IDM) as Predictors of Hunger Signaling Gene Expression

ABSTRACT IMPACT: This study aims to advance the understanding of the biological mechanisms associated with feeding disturbances in infants born to diabetic mothers through non-invasive salivary gene expression analyses and body composition measurements at birth. OBJECTIVES/GOALS: To determine if non-invasive salivary gene expression analyses and body composition measurements at birth could elucidate biological mechanisms associated with aberrant feeding behaviors and disrupted metabolic profiles commonly seen in infants born to diabetic mothers. METHODS/STUDY POPULATION: This prospective cohort study enrolls subjects born at ≥35 weeks’ gestation without a history of intrauterine growth restriction or major congenital anomalies. The diabetic cohort is defined as infants born to mothers with gestational diabetes or type 2 diabetes. The primary outcome is salivary expression of the hunger signaling genes, AMPK and NPY2R. Secondary outcomes include infant body composition measurements, obtained by skinfold measurement and/or air displacement plethysmography, and salivary expression of the adipokines, leptin, ghrelin, and adiponectin. Multiple logistic regression will be used to determine which factors are associated with AMPK and NPY2R expression. RESULTS/ANTICIPATED RESULTS: We propose that poor oral intake seen in infants of diabetic mothers may be due to alterations in the expression of hunger signaling genes (decreased expression of AMPK; increased expression of NPY2R) resulting in a diminished feeding drive in these large for gestational age infants. In addition, infant adiposity and the expression of genes involved in the adipoinsular axis will be inversely proportional to feeding volume intake. Namely, increased neonatal fat mass will be associated with increased expression of leptin and decreased expression of ghrelin and adiponectin. DISCUSSION/SIGNIFICANCE OF FINDINGS: Infants of diabetic mothers are at higher risk of poor oral feeding in the newborn period. This study aims to elucidate the link between neonatal body composition, adipoinsular axis, and hunger signaling to explain this unique feeding phenotype.