Size Fit Research Articles

Gene flow stimulates recovery of reproductive fitness in a captive bred insect

Abstract Captive breeding can be a useful tool for the management of threatened species, but such programs often begin with a bottleneck which may lower reproductive fitness by increasing inbreeding and allowing deleterious alleles to increase in frequency by reducing effective population size. Dryococelus australis, the Lord Howe Island stick insect, is a critically endangered insect that has been bred at the Melbourne Zoo in Melbourne, Australia, since shortly after the species was rediscovered in 2001. We analysed a long‐term dataset of phenotypic measurements from this captive breeding program to determine whether reproductive fitness has declined in captivity. We found a clear signal of decline in direct (egg hatching success) and indirect (egg and nymph size) fitness indicators over time. We compared a captive line descended from the original program founders to a new hybrid line that has recent wild ancestry. The hybrid line showed an immediate improvement in egg hatch rate, suggesting the potential for genetic rescue. Egg and nymph size did not show as dramatic a change, although this line had only existed for just over a single generation at the time of data collection. These results argue strongly for the regular sourcing of new genetic material from the wild D. australis population to counteract fitness declines in captivity. Aside from benefiting the captive population, this would also improve the prospects of establishing new wild populations in the future, using individuals sourced from captivity.

Basal insulin analogues in type 1 diabetes – does one size fit all? Lessons from the HypoDeg trial based on single-patient outcomes

AimsIn the HypoDeg trial, a randomised crossover trial in people with type 1 diabetes prone to nocturnal severe hypoglycaemia, treatment with insulin degludec (IDeg) resulted in significantly reduced rates of nocturnal symptomatic hypoglycaemia and all-day severe hypoglycaemia compared to insulin glargine U100 (IGlar). We analysed HypoDeg data at a single-patient level to assess the proportion of participants to whom the overall result applied. MethodsPost hoc analysis using single-patient data (n=133) on nocturnal symptomatic hypoglycaemia, all-day severe hypoglycaemia and HbA1c. The outcome was classified as superior with IDeg, superior with IGlar, or similar between treatments for the three outcomes. We also assessed a composite endpoint based on these outcomes to evaluate the overall superior treatment for each participant. ResultsA higher percentage (38%) had IDeg as superior treatment compared to IGlar (15%) for nocturnal symptomatic hypoglycaemia (p < 0.001). There was no difference between the treatments for all-day severe hypoglycaemia or HbA1c. A higher percentage (44%) had a composite endpoint favouring IDeg compared to IGlar (16%) (p < 0.001). ConclusionsThe superiority of IDeg was confirmed in many of the participants. However, a minority had IGlar as superior treatment, underscoring the need for individualised basal insulin therapy in clinical practice.

Does one size fit all? Developing an evaluation strategy to assess large language models for patient safety event report analysis.

Collecting and analyzing patient safety event (PSE) reports is a key component to the improvement of patient safety yet report analysis has been challenging. Large language models (LLMs) may support analysis; however, PSE reports tend to be a hybrid of clinical and general language. We propose a data-driven evaluation strategy to assess LLM fit for report analysis. We identify target tokens and sentences from PSE reports and use perplexity to evaluate four LLMs comprehension of the target sentence. LLMs had statistically significantly different perplexity measures in six of seven event categories. Clinical models perform better with clinical narratives, often reported by nurses and physicians. General models perform better with colloquial language and communication themes. For LLMs to support PSE report analysis there must be a good fit between the language model and the nature of the text in reports. A single LLM approach may not be the most useful strategy.

Searching for the Scale-Able Weight Loss Intervention: Can One Size Fit All? Lessons to Be Learned from the EQUAL Trial.

Overweight and obesity affect 71.2% of adults in the United States, with cancer survivors not far behind at 70.3%. Subgroups such as those diagnosed with acute lymphoblastic leukemia (ALL) face even greater challenges. The Exercise and Quality Diet after Leukemia (EQUAL) trial sought to address weight management issues among ALL survivors by implementing a remotely delivered weight loss intervention, leveraging the previously proven Practice-based Opportunities for Weight Reduction (POWER) program. Despite a strong foundation and design, the EQUAL trial yielded null results. Key differences in study populations and intervention contexts between the EQUAL and POWER trials, such as the lack of primary care physician involvement in EQUAL, contributed to these outcomes. EQUAL's failure to meet its accrual target and poor adherence among participants highlighted challenges in engaging this unique population. Contrary to EQUAL's conclusions, evidence from other studies supports the efficacy of remote interventions for weight loss among cancer survivors. The lack of qualitative assessment among ALL survivors and key integration to inform intervention adaptations undermined EQUAL's impact. However, EQUAL's impressive retention rate offers valuable insights. Lessons from EQUAL underscore the need for well-fitted, remotely delivered interventions and the importance of thoughtfully adapted and tailored approaches to specific survivor populations. See related article by Fiedmann et al., p. 1158.

The Audible Contrast Threshold (ACT) test: A clinical spectro-temporal modulation detection test

Over the last decade, multiple studies have shown that hearing-impaired listeners’ speech-in-noise reception ability, measured with audibility compensation, is closely associated with performance in spectro-temporal modulation (STM) detection tests. STM tests thus have the potential to provide highly relevant beyond-the-audiogram information in the clinic, but the available STM tests have not been optimized for clinical use in terms of test duration, required equipment, and procedural standardization. The present study introduces a quick-and-simple clinically viable STM test, named the Audible Contrast Threshold (ACT™) test. First, an experimenter-controlled STM measurement paradigm was developed, in which the patient is presented bilaterally with a continuous audibility-corrected noise via headphones and asked to press a pushbutton whenever they hear an STM target sound in the noise. The patient's threshold is established using a Hughson-Westlake tracking procedure with a three-out-of-five criterion and then refined by post-processing the collected data using a logistic function. Different stimulation paradigms were tested in 28 hearing-impaired participants and compared to data previously measured in the same participants with an established STM test paradigm. The best stimulation paradigm showed excellent test-retest reliability and good agreement with the established laboratory version. Second, the best stimulation paradigm with 1-second noise “waves” (windowed noise) was chosen, further optimized with respect to step size and logistic-function fitting, and tested in a population of 25 young normal-hearing participants using various types of transducers to obtain normative data. Based on these normative data, the “normalized Contrast Level” (in dB nCL) scale was defined, where 0 ± 4 dB nCL corresponds to normal performance and elevated dB nCL values indicate the degree of audible contrast loss. Overall, the results of the present study suggest that the ACT test may be considered a reliable, quick-and-simple (and thus clinically viable) test of STM sensitivity. The ACT can be measured directly after the audiogram using the same set up, adding only a few minutes to the process.

Does one (unconventional) size fit all? Effects of the ECB’s unconventional monetary policies on the euro area economies

This paper assesses the macroeconomic impact of ECB’s unconventional monetary policies (UMPs) in the euro area. We show that: (i) the relevance of the transmission channels has changed over time, with portfolio re-balancing becoming more important than the signalling effect after June 2014; (ii) there exists a substantial heterogeneity in the transmission to core and peripheral economies. By leveraging on these findings, we identify UMP shocks in a time-varying SVAR with “dynamic” restrictions and we quantify the macroeconomic impact of ECB’s measures via counterfactual analyses. We find that, absent those measures between 2014 and 2018, output growth would be on average 0.27 pp lower in peripheral countries, whereas inflation would drop on average by 0.2 pp in core economies.

Seizing the economic and social impact of universities’ knowledge exchange activities: Does one size fit all?

Seizing the economic and social impact of universities’ knowledge exchange activities: Does one size fit all?

Consumers' interaction with online fashion retailers' body measurement guidance

PurposeOnline fashion retailers offer body measurement guidance, alongside their target consumer body size charts and fit information, to help consumers select the right size garment as the garment cannot be tried on. Its use by retailers suggests it can act as a means of mitigating garment returns as there has been a noted increase in returns due to incorrect size selection even though body measurement instructions are provided online. The purpose of this research is to determine how consumers interact with body measurement guidance, how they interpret it and use it, thereby interrogating its efficacy.Design/methodology/approachAn exploratory investigation was undertaken. Thirty participants were recruited and given a choice of fashion retailers' body measurement guidance and a tape measure. They took their body measurements over their clothes. A technician repeated the task, thereby providing two sets of body measurements. A paired t-test determined if there was a significant difference in both values in terms of their mean. Technicians also documented their observations of how the participants interacted with the task. The content of the fashion retailer measurement guidance was then compared to that of published anthropometric guidance for surveys.FindingsParticipants were familiar with the guidance and tape-measure; they were able to self-measure. The fashion retailer measurement guidance, however, lacked detail/clarity in visuals and written content when compared to anthropometric guidance. Interpretation of the guidance differed between participant and technician. This resulted in a significant difference in circumference measurements for the bust/chest and hips, yet no significant difference in waist and inside-leg measurements. For measurements that were difficult to take unaided, participants devised novel practices which resulted in little divergence from the technician taken body measurements. The results question the guidance efficacy in its current form.Originality/valueThere has been no study which addresses how consumers interpret and interact with fashion retailers' online measurement guidance. This is important as this can mitigate garment returns. This research provides insight to influence fashion retailers' measurement guidance policy. It also adds to the existing body of knowledge surrounding anthropometric practice for clothing.Research limitations/implicationsThe findings indicated that fashion retailers need to revise their body measurement guidance content. The content needs to be more comprehensive but still use accessible language and visuals. The broader implications of this study highlight that traditional anthropometrics for self-taken body measurement needs developing as an emerging concept through clothing-related academic study.Practical implicationsFashion retailers' measurement guidance needs to be more comprehensive but still use accessible language and visuals. The broader implications of this study highlight that traditional anthropometrics for self-taken body measurement needs further investigation and documentation as an emerging concept through clothing-related academic study.

Does one size fit all in the Euro Area? Some counterfactual evidence

This paper examines whether Euro Area countries would have faced a more favorable inflation output variability tradeoff without the Euro. We provide evidence supporting this claim for the periods of the Great Recession and the Sovereign Debt Crisis. The deterioration of the tradeoff becomes insignificant only after Draghi’s ‘whatever it takes’ announcement. Results show that the detrimental effect of the Euro is more severe for peripheral countries. We base our results on a novel empirical strategy that, consistent with monetary theory, models the joint determination of the variability of inflation and output conditional on structural supply and demand shocks.

KENYAMANAN GAUN DENGAN MENGGUNAKAN POLA MEYNEKE UNTUK WANITA BERBADAN GEMUK DI SURABAYA

The comfort in wearing clothes can be seen from two criteria, they are size precision and fitting factor precision on the wearer’s body. The precision of fitting factor is a location or spot on clotes that determines the properness of certain pattern system, for the wearing body. Meyneke pattern generally used for cloting fit the body because it has kupnat at the waist that suitable for obese women. The problems of the research that is how the comfort level of woman’s dresses with patters Mayneke obese. The purpose is to know wheather the pattern Meyneke suitable for obese women.This research includes with quantitative approach and its object is the comfort level on points fit, while the subject Meyneke pattern on making a dress with a size XL. The method used is the method of observasion, quistionnare and experiment methods.Based on the results the percentage of questionnaire data, the level of comfort at acomfortable level of usage pattern Meyneke 2,3% in later neckline, 2,9% on alayout position of the shoulder, 3,1% at the position of the body circumference, 3% at the position of concave arm, 3% the layout position kupnat, 3% on the position of waist circumference, 3% on a long standing dress, 3% on the positions of the sides, 3,1% on the back of 2,8% long position for the fall dresses for woman are obese are advised to wear patterns Meyneke because the results are good.

6289667 Does one size fit all? A survey of anaesthetists’ approach to estimating blood volume in obstetric patients at Luton & Dunstable University Hospital

6289667 Does one size fit all? A survey of anaesthetists’ approach to estimating blood volume in obstetric patients at Luton & Dunstable University Hospital

Performance of Urinalysis Parameters in Predicting Urinary Tract Infection: Does One Size Fit All?

In a multihospital cohort study of 3392 patients, positive urinalysis parameters had poor positive predictive value for diagnosing urinary tract infection (UTI). Combined urinalysis parameters (pyuria or nitrite) performed better than pyuria alone for ruling out UTI. However, performance of all urinalysis parameters was poor in older women.

Mitigating reverse recovery power losses in MOSFET switching cell using extra Schottky diodes—Application to voltage source inverter

This article introduces a comparative study of the losses in Voltage Source Inverter (VSI) based on Metal-Oxide- Semiconductor Field-Effect Transistors (MOSFETs) depending on whether or not the latter are associated with antiparallel diodes. These diodes are optional because MOSFETs have an intrinsic diode capable of conducting reverse currents when their channel is in OFF state. However, it induces additional reverse recovery losses and damaging voltage overshoots. This undesired circumstance occurs during the mandatory switching cell dead-time and is accurately modelled and assessed in this study. Conversely, Schottky diodes feature almost zero reverse recovery losses. Hence, combining each MOSFET with an antiparallel Schottky diode may reduce the converter overall losses. To assess this strategy, an analytical model of the charge stored within the body diode is developed and then compared to experiments using the Double Pulse Test (DPT). It reveals accurate and well suited because it requires only two constant macro parameters which permits to forecast the reverse recovery losses over a wide range of operating conditions, namely switched current, current slope and dead time duration. The selected model is applied in the case where a Schottky diode is placed antiparallel to the MOSFET. It then appears clearly that the interest of such a combination depends on the static characteristics of both the MOSFET and the Schottky diode. This output is a noteworthy point for power electronics designers. Finally, the developed model is applied in the standard use case of the Voltage Source Inverter (VSI). The results reveal the advantage of the suggested model in this use case because the current evolves significantly over time. The outcome of this VSI analysis shows that a significant recovery losses decrease is achieved with good sizing fit between the MOSFET transistor and the additional Schottky diode.

Identifying the key body size and maturity characteristics associated with superior physical fitness performance tests: does one size fit all?

Identifying the key body size and maturity characteristics associated with superior physical fitness performance tests: does one size fit all?

Detection and metrology of micro-nano particles through the integration of image and laser modes

Micro-nano particles are an indispensable component in various industrial and scientific applications. Accurate granular information is critical for manufacturing products involving these particles. This study presents a novel detection method that merges image and laser modes to achieve precise size and shape determination of micro-nano particles. The proposed method integrates adaptive image analysis with laser particle size fitting to ensure accurate feature detection. Experimental results using ternary precursor samples demonstrate that the fusion mode outperforms both the laser and image modes in terms of size and shape accuracy. The errors of D10, D50, and D90 of the fusion mode are 4.89%, 1.88%, and 2.94%, respectively, which are significantly lower than those obtained using the laser or image mode alone. Additionally, the fusion mode retains the particle shape information from the image mode. The fusion model offers a promising approach for dual-mode detection of micro-nano particles, demonstrating enhanced robustness compared to single-mode methods. Furthermore, the study introduces an image processing method based on a BP neural network classification model that accurately classifies and detects agglomerated and non-agglomerated particles. The classification accuracy reaches 94.98%, and the particle size information remains within the acceptable range.

Key predictors of food security and nutrition in Africa: a spatio-temporal model-based study

There is voluminous literature on Food Security in Africa. This study explicitly considers the spatio-temporal factors in addition to the usual FAO-based metrics in modeling and understanding the dynamics of food security and nutrition across the African continent. To better understand the complex trajectory and burden of food insecurity and nutrition in Africa, it is crucial to consider space-time factors when modeling and interpreting food security. The spatio-temporal anova model was found to be superior(employing statistical criteria) to the other three models from the spatio-temporal interaction domain models. The results of the study suggest that dietary supply adequacy, food stability, and consumption status are positively associated with severe food security, while average food supply and environmental factors have negative effects on Food Security and Nutrition. The findings also indicate that severe food insecurity and malnutrition are spatially and temporally correlated across the African continent. Spatio-temporal modeling and spatial mapping are essential components of a comprehensive practice to reduce the burden of severe food insecurity. likewise, any planning and intervention to improve the average food supply and environment to promote sustainable development should be regional instead of one size fit all.

Relevance of diet diversification in the coexistence between Orius laevigatus and Amblyseius swirskii: prey switching and intraguild predation

AbstractOmnivores obtain resources from more than one trophic level, choosing food based on quantity and quality. They usually engage in intraguild predation (IGP) when prey is scarce. Orius laevigatus is an example of omnivore that becomes superior predator of the predatory mite Amblyseius swirskii when released in a combined system under low levels of the preferred prey, the thrips Frankliniella occidentalis. Here, we test two genetically enhanced O. laevigatus strains for bigger size and better fitness feeding on pollen (BIG30 and 2POL-11, respectively), hence with a wider dietary diversification, to elucidate the potential effects on prey preference and IGP on the predatory mite, in comparison with a commercial population of O. laevigatus. To do that, predation rates were registered on adult phytoseiids solely or in a choice situation at different availability ratios of adult thrips under laboratory conditions. The effect of pollen as supplemental food on IGP and prey preference was examined, too. We found that our two enhanced lines killed up to 9% less predatory mites and fed preferably on adult thrips, compared to the commercial population. While BIG30 showed a significantly higher total predation rate, killing up to 150% more adult thrips, 2POL-11 is defined as an efficient user of resources, switching between different prey and pollen showing low IGP. Pollen supplementation had a significant effect on reducing IGP, but only for 2POL-11 the influence on prey preference was significant. The theory of intraguild predation and the impact of prey switching on food webs and biological control strategies are also discussed.

Does one size fit all? The role of job characteristics in cultivating work passion across knowledge, blue‐collar, nonprofit, and managerial work

AbstractWe integrate the job characteristics and dual work passion models to explore the indirect (via work meaningfulness) effects of job characteristics (i.e., job autonomy, task identity, skill variety, task significance, feedback from the job and feedback from others) on two types of work passion, harmonious passion (HP) and obsessive passion (OP). We first advance occupation‐specific predictions for job characteristics‐to‐work passion relationships and then explore differences in those relationships between HP and OP across four occupational sectors: knowledge work (n = 201), blue‐collar work (n = 148), nonprofit work (n = 141), and managerial work (n = 133). Our findings demonstrate that job characteristics are important drivers of work passion. However, our key discovery is that the motivational impact of the job characteristics is not universally applicable but rather depends on the specific occupational context and whether passion is harmonious or obsessive. We therefore conclude that when it comes to translating job characteristics into work passion, the one‐size‐fits‐all approach is not appropriate.

Choosing a bigger opponent: the path to victory and greater gains for the small contestant

Animals often engage in contests over limited resources. The probability of winning a contest is primarily determined by the individual's fighting ability relative to its opponent and the perceived value of the disputed resource. Individuals of the hermit crab Calcinus californiensis frequently fight over gastropod shells. We conducted a free-choice experiment to assess the factors that determine individuals’ choice of opponent, contest initiation, and contest resolution. We placed hermit crabs occupying two shell species into a large container and monitored agonistic interactions between crabs. We assessed the asymmetries in fighting ability based on the differences in body mass between the opponents. The shell species and fit (i.e., shell size relative to crab body size) were used as measures of the objective and subjective resource value, respectively. Motivation influenced contest initiation; the crabs occupying too-tight shells were more likely to initiate a contest than the ones in looser-fitting shells. In most cases, the attackers fought for a shell with a looser fit, even if that meant losing a tighter-fitting shell of the preferred shell species. The fighting success for attackers was positively associated with the number of bouts of rapping and the shell size improvement. However, success was negatively correlated with body size asymmetry; attackers that chose opponents larger than themselves were more likely to evict their opponent than the attackers that chose opponents that were smaller. Experimental designs that allow animals to select their own opponents, rather than assigning specific opponents, can strongly contribute to knowledge of agonistic interactions.Significance statementFighting dynamics are commonly assessed by estimating the influence of the resource-holding potential and resource value in pair-matched opponents. Here, however, we examined the influence of asymmetries in resource-holding potential and the objective and subjective value of gastropod shells on the choice of a contender and contest resolution through a free-choice opponent experiment in hermit crabs. The contest initiation was driven by the motivation to obtain a better gastropod shell species or one with a better size fit—factors which are known to improve individual fitness. Furthermore, fighting success was associated with an individual's persistence in displaying aggressive behaviors and its motivation to obtain a better resource. However, contrary to the predictions of game theoretical models, fighting success was higher when attackers chose opponents larger than themselves. Our results highlight the relevance of assessing fighting under more natural conditions by allowing animals to select their opponents.

Does one size fit all? A survey of preceptor perceptions and experiences with remote rotations

Background: During the pandemic, experiential rotations transitioned from in-person to remote rotations. Methods: The authors surveyed preceptors about their experiences and perceptions of remote rotations. Preceptors completed an online questionnaire divided into six domains: 1) General demographics; 2) Preceptor/student relationship; 3) Preceptor support and continuing professional development opportunities; 4) Technology; 5) Preceptor perceptions; and 6) Motivators and challenges. Responses were coded and analysed for emerging themes. Results: A total of 47 out of 157 preceptors (30%) responded to the questionnaire, and most preceptors were willing to precept remotely again (85%). Student responsiveness (87%) and enjoyment of teaching (83%) were the greatest motivators. Major themes reflected the preceptor’s struggles in building rapport and facilitating in-the-moment learning opportunities. Preceptors identified guidance and on-going support as key factors to ensure preceptor and student readiness and to manage expectations. The formula for a successful rotation included careful consideration of appropriate pedagogy, technology, and a dose of motivation. Conclusion: Preceptors reflected a positive experience in leading remote rotations. Traditional precepting approaches employed during in-person rotations need to be adapted and individualised for the context of remote rotations, highlighting that there is no ‘one-size-fits-all’ approach. Transitioning to a remote environment generates new opportunities and drives innovation.