Large-scale landslides often cause severe damage due to their long run-out distances and having disaster chain effects. Scenario simulation has been adopted in the current work in order to analyze the Xiaomojiu landslide dynamic processes. The landslide characteristics and topography data are obtained via field investigations, whereas high-resolution topographic data (0.17 m) are obtained using an Unmanned Aerial Vehicle. The landslide sliding velocity, deposition characteristics, and flood outburst after a landslide dam failure were obtained using Particle Flow Code (PFC-3D) which introduced the changeable friction coefficient and the HEC-RAS software. The results showed that: 1. The landslide presents a scallop shape with a length of 1110 m, an average width of 950 m, and an area of 1.05 × 106 m2. The average thickness and volume of the sliding body are approximately 50 m and 5.45 × 107 m3. The InSAR (Interferometric Synthetic Aperture Radar) deformation analysis showed that the Xiaomojiu landslide has a maximum annual displacement rate of 60 mm/y and a maximum accumulation deformation of 180 mm since November 25, 2017. 2. The failure process of the Xiaomojiu landslide lasted for 65 s with a maximum velocity of 78.2 m/s. According to the landslide simulation results, the deposited area is approximately 2023 m long, 900 m wide, and has a maximum height of approximately 149 m. 3. A landslide-dammed lake with an elevation of 2940 m and a storage capacity of 4.13 × 109 m3 is formed after the landslide blocks the Jinsha River, and the maximum peak flow rate of the breach is 12051.7 m3/s, 43,451.4 m3/s, 148,635.6 m3/s, and 304,544.7 m3/s for the landslide-dammed failure degrees of 15%, 25%, 50%, and 75%, respectively. These results provide a reference for the risk analysis and mitigation of the landslide.