High-performance electrical discharge machining (EDM) is a key technology for manufacturing high-precision components in a broad range of industrially relevant applications. Formation of debris in the working gap leads to arcing and short-circuits on the surface as well as related inaccuracies and process instabilities. Despite decades of research in the field of EDM excessive tool wear and limited process performance are still challenging. In order to overcome highly complex state-of-the-art challenges, dedicated processes, machine tools, peripheral systems, software, tool electrodes and technologies for the application of alternative dielectric fluids have been developed. Within this work novel advances in the development of a sophisticated dry EDM machine tool, including generator and process control technology based on open architecture, open source software, and commonly available machine tool components, are presented. Solutions for challenges regarding remaining debris and gas bubbles as well as related arc discharge and short-circuit pulses in sinking EDM are presented by new flushing methods, technologies and devices. A new system for inverted pressure flushing of a dielectric fluid in ED-drilling enables a highly efficient removal of debris and gas bubbles through the interior channels of the tool electrode. A new multi-fluidic spindle system for EDM provides the ability to use performance- and material-related application of gaseous, near-dry and liquid dielectric fluids sequentially within a single machining process. Recent advances in tool electrode design, tool electrode material application, modification and production have led to essential process improvements. A helical tool electrode design significantly improved flushing conditions and related material removal rate in ED-drilling. Modification of ED-drilling tool electrode surfaces by thermal oxidation of copper reveals a promising approach to minimize ineffective discharges. Application of a specific mesophase-pitch carbon fiber with a diameter of df = 10 µm using a new process and handling technology enabled drilling holes with a diameter of dh = 25 µm. Next to the shown advances in EDM, efficient development of new process technologies could be enabled by using a specially adapted natural analogue algorithm software tool.