A physical model for acoustic resonance in the annular cavity structure is developed to represent the typical characteristic when acoustic resonance occurs. Firstly, the measurement of sound pressure in the casing and rotor blades vibration is operated in a multistage high pressure compressor. The sharp peak frequency and discrete multi-tone occur in the frequency spectrum of sound pressure in the compressor, and the vibration of the first stage of rotor blades synchronously presents the high amplitude. The frequencies associated with rotor blades vibration can be calculated with rotating sound source theory. It is also confirmed that acoustic resonance occurs in the multistage compressor. With acoustic similarity principle, an annular cavity model is established to simulate the typical characteristics of acoustic resonance in the compressor based on Large Eddy Simulation (LES) and Lighthill acoustic analogy. The coupling relationship between cavity acoustic mode and disc vibration mode shape is expounded when acoustic resonance occurs in the model. And acoustic resonance will be locked in the certain flow rate range. All these characteristics match well with those occur in the multistage high pressure compressor.