This study aims to analysis the dynamic characteristics and seismic response behavior of aluminum alloy reticulated shell structures especially pay attention to the internal force changes in the elastic and elastic-plastic stages. A scaled test model of aluminum alloy single-layer spherical reticulated shell was designed and manufactured, and a shaking table test was carried out to obtain its dynamic characteristics and seismic response. The modal parameters of the reticulated shell structure, including frequency, modal shape and damping ratio, are obtained by white noise scanning frequency and frequency domain decomposition (FDD) technology. The response of the reticulated shell structure in the elastic stage and the elastic-plastic stage is discussed, including the node acceleration, displacement and strain response under different peak ground acceleration (PGA). The finite element method (FEM) is used for numerical simulation analysis. An effective numerical simulation method for analyzing the seismic performance of aluminum alloy single-layer reticulated shells is proposed. The internal force development and structural displacement of structures under strong earthquakes are studied. The test results show that under the action of horizontal ground motion, the vertical stiffness of the small rise-span ratio aluminum alloy reticulated shell is small, and the radial and ring members mainly bear the out-of-plane bending moment and axial force. In addition, the horizontal deformation of the reticulated shell structure and the in-plane rotation of the joints are the main reasons for the members to enter the plasticity, resulting in bending and torsional deformation of the members in the weak area. Axial pressure and bending moment control the force mechanism of the members, which is the cause of bending and torsional instability of the members.