Abstract This work compares three different approaches to automatically segment the femoral artery from 2D ultrasound images. Two of the architectures follow a sequential structure, where each ultrasound image is considered a slice of the whole vessel volume, and its previous segmentation result will be part of the input, thus leading to a spatial prior. The Dice score on test data show a better performance on the baseline U-Net (0.819) compared to the sequential U-Net approaches (0.633, 0.725) for the femoral artery segmentation. This could be attributed to the misalignment of the slices being used in those networks. A possible improvement could be assumed in the implementation of a spatially calibrated and tracked ultrasound probe. Overall, these results indicate promising approaches for an automatic segmentation of the femoral artery using 2D ultrasound data.