This paper presented an analysis for the couette flow of a generalized Oldroyd-B fluid within an infinite cylinder subject to a time-dependent shear stress with the influence of the internal constantly decelerated pressure gradient. The exact solutions are established by means of the combine of the sequential fractional derivatives Laplace transform and finite Hankel transform and presented by integral and series form in terms of the Mittag-Leffler function. Moreover, the effects of various parameters are analyzed in detail by graphical illustrations.