Event Abstract Back to Event Feed forward inhibition: a possible player in the adaptive filtering mechanism of sensory information in the shark's electroreception Naama Rotem1, 2*, Emanuel Sestieri2, Yosef Yarom1, 2 and J Hounsgaard3 1 Hebrew University of Jerusalem, Dept. Neurobiology, Israel 2 Inter-University Inst, Otto Loewi Minerva Ctr, Israel 3 Panum Inst, INF, Denmark Sharks sense the peripheral electric field generated by their own activity and the activity of other animals in their vicinity. The self-generated electrical field is filtered at the first synapse in the CNS in the Dorsal Octavolateral Nucleus (DON). However, the filter mechanism is poorly understood. Previously, we demonstrated the high fidelity of transmission from the peripheral nerve to the principal neurons in the DON (Ascending Efferent Neurons; AENs). Here we describe a powerful feed-forward inhibitory mechanism activated by the efferent input and exclusively acting on afferent sensory input. Intracellular recordings were obtained from AENs in the isolated DON of Iago omanensis sharks. The response to afferent and central synaptic input was investigated by stimulating the afferent electrosensory nerve (AFF) and parallel fibers (PF). Paired-pulse stimulation of the AFF showed a robust decrease in the response to the second stimulus. This decrease reached a maximum (up to 80%) at an interval of 30 msec, was relatively insensitive to stimulus intensity and was reversibly blocked by the selective GABAA blocker gabazine (300 nmol l–1). Surprisingly the response of AENs to PF stimulation was unaffected by preceding AFF stimulation. Hence the feed-forward inhibition to AENs was limited to its AFF input. Furthermore, inhibitory postsynaptic potentials were rarely observed in response to AFF stimulation. These results indicate that the feed-forward inhibition of the principal neurons in the DON, activated by peripheral input and mediated by GABAA receptors, is pre-synaptic. We hypothesize that this powerful feed forward inhibition serves as a mechanism to remove predictable self-generated electrical fields and highlight unpredictable novel sensory signals. Keywords: Cerebellum Conference: The Cerebellum: from neurons to higher control and cognition, Pavia, Italy, 8 Jul - 9 Jul, 2010. Presentation Type: Short Communication Topic: The Cerebellum: from neurons to higher control and cognition Citation: Rotem N, Sestieri E, Yarom Y and Hounsgaard J (2010). Feed forward inhibition: a possible player in the adaptive filtering mechanism of sensory information in the shark's electroreception. Front. Neurosci. Conference Abstract: The Cerebellum: from neurons to higher control and cognition. doi: 10.3389/conf.fnins.2010.83.00015 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 13 Oct 2010; Published Online: 13 Oct 2010. * Correspondence: Ms. Naama Rotem, Hebrew University of Jerusalem, Dept. Neurobiology, Jerusalem, Israel, naama.rotem@mail.huji.ac.il Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Naama Rotem Emanuel Sestieri Yosef Yarom J Hounsgaard Google Naama Rotem Emanuel Sestieri Yosef Yarom J Hounsgaard Google Scholar Naama Rotem Emanuel Sestieri Yosef Yarom J Hounsgaard PubMed Naama Rotem Emanuel Sestieri Yosef Yarom J Hounsgaard Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
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