Optic Cup Segmentation Research Articles

Lightweight Optic Disc and Optic Cup Segmentation Based on MobileNetv3 Convolutional Neural Network.

Glaucoma represents a significant global contributor to blindness. Accurately segmenting the optic disc (OD) and optic cup (OC) to obtain precise CDR is essential for effective screening. However, existing convolutional neural network (CNN)-based segmentation techniques are often limited by high computational demands and long inference times. This paper proposes an efficient end-to-end method for OD and OC segmentation, utilizing the lightweight MobileNetv3 network as the core feature-extraction module. Our approach combines boundary branches with adversarial learning, to achieve multi-label segmentation of the OD and OC. We validated our proposed approach across three public available datasets: Drishti-GS, RIM-ONE-r3, and REFUGE. The outcomes reveal that the Dice coefficients for the segmentation of OD and OC within these datasets are 0.974/0.900, 0.966/0.875, and 0.962/0.880, respectively. Additionally, our method substantially lowers computational complexity and inference time, thereby enabling efficient and precise segmentation of the optic disc and optic cup.

TriLA: Triple-Level Alignment Based Unsupervised Domain Adaptation for Joint Segmentation of Optic Disc and Optic Cup.

Cross-domain joint segmentation of optic disc and optic cup on fundus images is essential, yet challenging, for effective glaucoma screening. Although many unsupervised domain adaptation (UDA) methods have been proposed, these methods can hardly achieve complete domain alignment, leading to suboptimal performance. In this paper, we propose a triple-level alignment (TriLA) model to address this issue by aligning the source and target domains at the input level, feature level, and output level simultaneously. At the input level, a learnable Fourier domain adaptation (LFDA) module is developed to learn the cut-off frequency adaptively for frequency-domain translation. At the feature level, we disentangle the style and content features and align them in the corresponding feature spaces using consistency constraints. At the output level, we design a segmentation consistency constraint to emphasize the segmentation consistency across domains. The proposed model is trained on the RIGA+ dataset and widely evaluated on six different UDA scenarios. Our comprehensive results not only demonstrate that the proposed TriLA substantially outperforms other state-of-the-art UDA methods in joint segmentation of optic disc and optic cup, but also suggest the effectiveness of the triple-level alignment strategy.

A multi-scale convolutional neural network with adaptive weight fusion strategy for assisting glaucoma screening

The diagnosis of glaucoma primarily relies on the accurate segmentation of the optic disc (OD) and optic cup (OC). However, OC segmentation remains challenging due to significant individual differences. This study proposes a threshold-based OD extraction method and multi-scale residual U-Net with context attention mechanism and adaptive weight fusion strategy (MRCAAU-Net) to segment OC and OD jointly. Firstly, based on the intensity difference between the OD and the background, an improved thresholding criterion combined with template matching technique is used to effectively detect the OD region, providing accurate input images for network training. Secondly, considering the semantic gap issue during the encoder-decoder feature fusion in the segmentation network, this paper develops an adaptive weight fusion module to guide the effective connections of encoder-decoder features. Additionally, the 1D convolution-based attention mechanism has stronger local perceptiveness. This paper integrate it into various modules, combining multi-scale methods to enhance the segmentation performance of OC by incorporating both global and local features. Finally, the network is guided to learn image segmentation through a hybrid loss function that ignores the background. We conducted extensive experiments on three public datasets, and obtained more accurate segmentation outputs compared to other state-of-the-art methods, particularly in the OC segmentation, where the segmentation accuracy is very close to that of the OD. The proposed joint segmentation network effectively improves and balances the segmentation performance of two objectives, which can greatly assist in large-scale screening for glaucoma.

Multi-dimensional dense attention network for pixel-wise segmentation of optic disc in colour fundus images.

Segmentation of retinal fragments like blood vessels, Optic Disc (OD), and Optic Cup (OC) enables the early detection of different retinal pathologies like Diabetic Retinopathy (DR), Glaucoma, etc. Accurate segmentation of OD remains challenging due to blurred boundaries, vessel occlusion, and other distractions and limitations. These days, deep learning is rapidly progressing in the segmentation of image pixels, and a number of network models have been proposed for end-to-end image segmentation. However, there are still certain limitations, such as limited ability to represent context, inadequate feature processing, limited receptive field, etc., which lead to the loss of local details and blurred boundaries. A multi-dimensional dense attention network, or MDDA-Net, is proposed for pixel-wise segmentation of OD in retinal images in order to address the aforementioned issues and produce more thorough and accurate segmentation results. In order to acquire powerful contexts when faced with limited context representation capabilities, a dense attention block is recommended. A triple-attention (TA) block is introduced in order to better extract the relationship between pixels and obtain more comprehensive information, with the goal of addressing the insufficient feature processing. In the meantime, a multi-scale context fusion (MCF) is suggested for acquiring the multi-scale contexts through context improvement. Specifically, we provide a thorough assessment of the suggested approach on three difficult datasets. In the MESSIDOR and ORIGA data sets, the suggested MDDA-NET approach obtains accuracy levels of 99.28% and 98.95%, respectively. The experimental results show that the MDDA-Net can obtain better performance than state-of-the-art deep learning models under the same environmental conditions.

LC-MANet: Location-constrained joint optic disc and cup segmentation via multiplex aggregation network

Many early ophthalmology-related diseases can be detected through fundus images. The cup-to-disc ratio (CDR) is an important criterion for the early screening and diagnosis of glaucoma. However, accurately calculating it is a challenging task primarily due to blurred boundaries and the physiological structure of the fundus. To alleviate these issues, this paper designs a location-constrained joint optic disc (OD) and optic cup (OC) segmentation method using the multiplex aggregation network (LC-MANet). This method incorporates independent segmentation and joint segmentation within a coarse-to-fine framework. In the independent segmentation stage, this paper utilizes the initial OD and OC as prior location auto-context information to constrain the joint segmentation of OD and OC. The proposed multiplex aggregation network combines features from the corresponding layer and across layers to capture global and local information. This paper employs a multi-channel fusion strategy in image preprocessing to suppress vascular interference in OD independent segmentation. To emphasize the superiority of our method, it is important to highlight the significant number of test images used in the evaluation. Our experiments are conducted on three public datasets, namely RIM-ONE (60 images), Drishti-GS (51 images), and REFUGE (400 images). Experimental results demonstrate that our method outperforms most others in terms of Dice Coefficient and absolute error. The accuracy of glaucoma screening achieved by our proposed method for the Drishti-GS, REFUGE, and RIM-ONE-r3 datasets is 0.9216, 0.9600, and 0.9000, respectively. The proposed framework successfully designs a multiplex aggregation network for a coarse-to-fine joint segmentation model and achieves state-of-the-art performance in OD and OC segmentation. Furthermore, it can be applied to other medical image segmentation tasks.

GREnet: Gradually REcurrent Network With Curriculum Learning for 2-D Medical Image Segmentation.

Medical image segmentation is a vital stage in medical image analysis. Numerous deep-learning methods are booming to improve the performance of 2-D medical image segmentation, owing to the fast growth of the convolutional neural network. Generally, the manually defined ground truth is utilized directly to supervise models in the training phase. However, direct supervision of the ground truth often results in ambiguity and distractors as complex challenges appear simultaneously. To alleviate this issue, we propose a gradually recurrent network with curriculum learning, which is supervised by gradual information of the ground truth. The whole model is composed of two independent networks. One is the segmentation network denoted as GREnet, which formulates 2-D medical image segmentation as a temporal task supervised by pixel-level gradual curricula in the training phase. The other is a curriculum-mining network. To a certain degree, the curriculum-mining network provides curricula with an increasing difficulty in the ground truth of the training set by progressively uncovering hard-to-segmentation pixels via a data-driven manner. Given that segmentation is a pixel-level dense-prediction challenge, to the best of our knowledge, this is the first work to function 2-D medical image segmentation as a temporal task with pixel-level curriculum learning. In GREnet, the naive UNet is adopted as the backbone, while ConvLSTM is used to establish the temporal link between gradual curricula. In the curriculum-mining network, UNet++ supplemented by transformer is designed to deliver curricula through the outputs of the modified UNet++ at different layers. Experimental results have demonstrated the effectiveness of GREnet on seven datasets, i.e., three lesion segmentation datasets in dermoscopic images, an optic disc and cup segmentation dataset and a blood vessel segmentation dataset in retinal images, a breast lesion segmentation dataset in ultrasound images, and a lung segmentation dataset in computed tomography (CT).

Research on segmentation model of optic disc and optic cup in fundus

BackgroundGlaucoma is a worldwide eye disease that can cause irreversible vision loss. Early detection of glaucoma is important to reduce vision loss, and retinal fundus image examination is one of the most commonly used solutions for glaucoma diagnosis due to its low cost. Clinically, the cup-disc ratio of fundus images is an important indicator for glaucoma diagnosis. In recent years, there have been an increasing number of algorithms for segmentation and recognition of the optic disc (OD) and optic cup (OC), but these algorithms generally have poor universality, segmentation performance, and segmentation accuracy.MethodsBy improving the YOLOv8 algorithm for segmentation of OD and OC. Firstly, a set of algorithms was designed to adapt the REFUGE dataset’s result images to the input format of the YOLOv8 algorithm. Secondly, in order to improve segmentation performance, the network structure of YOLOv8 was improved, including adding a ROI (Region of Interest) module, modifying the bounding box regression loss function from CIOU to Focal-EIoU. Finally, by training and testing the REFUGE dataset, the improved YOLOv8 algorithm was evaluated.ResultsThe experimental results show that the improved YOLOv8 algorithm achieves good segmentation performance on the REFUGE dataset. In the OD and OC segmentation tests, the F1 score is 0.999.ConclusionsWe improved the YOLOv8 algorithm and applied the improved model to the segmentation task of OD and OC in fundus images. The results show that our improved model is far superior to the mainstream U-Net model in terms of training speed, segmentation performance, and segmentation accuracy.

MA‐ResUNet: Multi‐attention optic cup and optic disc segmentation based on improved U‐Net

AbstractGlaucoma poses a significant threat to vision, capable of causing irreversible damage and, in severe instances, leading to permanent blindness. Accurate optic cup (OC) and optic disc (OD) segmentation are essential in glaucoma screening. In this study, a novel OC and OD segmentation approach is proposed. Based on U‐Net, it is optimized by introducing cardinality dimensions. Moreover, attention gates are implemented to reinforce salient features while suppressing irrelevant information. Additionally, a convolutional block attention module (CBAM) is integrated into the decoder segment. This fusion hones in on effective information in both channel and spatial dimensions. Meanwhile, an image processing procedure is proposed for image normalization and enhancement. All of these increase the accuracy of the model. This model is evaluated on the ORIGA and REFUGE datasets, demonstrating the model's superiority in OC and OD segmentation compared to the state‐of‐the‐art methods. Additionally, after the proposed image processing, cup‐to‐disc ratio (CDR) prediction on a batch of 155 in‐house fundus images yields an absolute CDR error of 0.099, which is reduced by 0.04 compared to the case where only conventional processing was performed.

Entropy and distance-guided super self-ensembling for optic disc and cup segmentation.

Segmenting the optic disc (OD) and optic cup (OC) is crucial to accurately detect changes in glaucoma progression in the elderly. Recently, various convolutional neural networks have emerged to deal with OD and OC segmentation. Due to the domain shift problem, achieving high-accuracy segmentation of OD and OC from different domain datasets remains highly challenging. Unsupervised domain adaptation has taken extensive focus as a way to address this problem. In this work, we propose a novel unsupervised domain adaptation method, called entropy and distance-guided super self-ensembling (EDSS), to enhance the segmentation performance of OD and OC. EDSS is comprised of two self-ensembling models, and the Gaussian noise is added to the weights of the whole network. Firstly, we design a super self-ensembling (SSE) framework, which can combine two self-ensembling to learn more discriminative information about images. Secondly, we propose a novel exponential moving average with Gaussian noise (G-EMA) to enhance the robustness of the self-ensembling framework. Thirdly, we propose an effective multi-information fusion strategy (MFS) to guide and improve the domain adaptation process. We evaluate the proposed EDSS on two public fundus image datasets RIGA+ and REFUGE. Large amounts of experimental results demonstrate that the proposed EDSS outperforms state-of-the-art segmentation methods with unsupervised domain adaptation, e.g., the Dicemean score on three test sub-datasets of RIGA+ are 0.8442, 0.8772 and 0.9006, respectively, and the Dicemean score on the REFUGE dataset is 0.9154.

SAMCF: Adaptive global style alignment and multi-color spaces fusion for joint optic cup and disc segmentation

The optic cup (OC) and optic disc (OD) are two critical structures in retinal fundus images, and their relative positions and sizes are essential for effectively diagnosing eye diseases. With the success of deep learning in computer vision, deep learning-based segmentation models have been widely used for joint optic cup and disc segmentation. However, there are three prominent issues that impact the segmentation performance. First, significant differences among datasets collecting from various institutions, protocols, and devices lead to performance degradation of models. Second, we find that images with only RGB information struggle to counteract the interference caused by brightness variations, affecting color representation capability. Finally, existing methods typically ignored the edge perception, facing the challenges in obtaining clear and smooth edge segmentation results. To address these drawbacks, we propose a novel framework based on Style Alignment and Multi-Color Fusion (SAMCF) for joint OC and OD segmentation. Initially, we introduce a domain generalization method to generate uniformly styled images without damaged image content for mitigating domain shift issues. Next, based on multiple color spaces, we propose a feature extraction and fusion network aiming to handle brightness variation interference and improve color representation capability. Lastly, an edge aware loss is designed to generate fine edge segmentation results. Our experiments conducted on three public datasets, DGS, RIM, and REFUGE, demonstrate that our proposed SAMCF achieves superior performance to existing state-of-the-art methods. Moreover, SAMCF exhibits remarkable generalization ability across multiple retinal fundus image datasets, showcasing its outstanding generality.

A review of optic disc and optic cup segmentation based on fundus images

AbstractOptic disc (OD) and optic cup (OC) segmentation is an important task in ophthalmic medicine and is crucial for aiding glaucoma screening. With the development of smart healthcare and the increase of large datasets, there is an increasing number of research efforts targeting OD and OC segmentation, making it particularly important to provide a systematic review of the latest advances in the field. This paper presents a systematic review of commonly used datasets, evaluation metrics, and related research results in the field of OD and OC segmentation. The advantages and disadvantages of segmentation techniques based on traditional and deep learning methods are comparatively analysed. In addition, this study emphasizes the importance of OD and OC segmentation efforts in smart healthcare. Despite the technological advances, the lack of generalization capability is still a major obstacle limiting its clinical application. To address this issue, this study explores unsupervised domain adaptation methods to enhance the generalization performance of segmentation techniques and provide new strategies for clinical diagnosis. Finally, this paper discusses the challenges and future research directions faced by OD and OC segmentation when applied in the medical field to help readers comprehensively grasp the research dynamics in this area.

Multi-granularity learning of explicit geometric constraint and contrast for label-efficient medical image segmentation and differentiable clinical function assessment

Automated segmentation is a challenging task in medical image analysis that usually requires a large amount of manually labeled data. However, most current supervised learning based algorithms suffer from insufficient manual annotations, posing a significant difficulty for accurate and robust segmentation. In addition, most current semi-supervised methods lack explicit representations of geometric structure and semantic information, restricting segmentation accuracy. In this work, we propose a hybrid framework to learn polygon vertices, region masks, and their boundaries in a weakly/semi-supervised manner that significantly advances geometric and semantic representations. Firstly, we propose multi-granularity learning of explicit geometric structure constraints via polygon vertices (PolyV) and pixel-wise region (PixelR) segmentation masks in a semi-supervised manner. Secondly, we propose eliminating boundary ambiguity by using an explicit contrastive objective to learn a discriminative feature space of boundary contours at the pixel level with limited annotations. Thirdly, we exploit the task-specific clinical domain knowledge to differentiate the clinical function assessment end-to-end. The ground truth of clinical function assessment, on the other hand, can serve as auxiliary weak supervision for PolyV and PixelR learning. We evaluate the proposed framework on two tasks, including optic disc (OD) and cup (OC) segmentation along with vertical cup-to-disc ratio (vCDR) estimation in fundus images; left ventricle (LV) segmentation at end-diastolic and end-systolic frames along with ejection fraction (LVEF) estimation in two-dimensional echocardiography images. Experiments on nine large-scale datasets of the two tasks under different label settings demonstrate our model’s superior performance on segmentation and clinical function assessment.

UGLS: an uncertainty guided deep learning strategy for accurate image segmentation.

Accurate image segmentation plays a crucial role in computer vision and medical image analysis. In this study, we developed a novel uncertainty guided deep learning strategy (UGLS) to enhance the performance of an existing neural network (i.e., U-Net) in segmenting multiple objects of interest from images with varying modalities. In the developed UGLS, a boundary uncertainty map was introduced for each object based on its coarse segmentation (obtained by the U-Net) and then combined with input images for the fine segmentation of the objects. We validated the developed method by segmenting optic cup (OC) regions from color fundus images and left and right lung regions from Xray images. Experiments on public fundus and Xray image datasets showed that the developed method achieved a average Dice Score (DS) of 0.8791 and a sensitivity (SEN) of 0.8858 for the OC segmentation, and 0.9605, 0.9607, 0.9621, and 0.9668 for the left and right lung segmentation, respectively. Our method significantly improved the segmentation performance of the U-Net, making it comparable or superior to five sophisticated networks (i.e., AU-Net, BiO-Net, AS-Net, Swin-Unet, and TransUNet).

Optic disc and cup segmentation for glaucoma detection using Attention U-Net incorporating residual mechanism.

Glaucoma is a common eye disease that can cause blindness. Accurate detection of the optic disc and cup disc is crucial for glaucoma diagnosis. Algorithm models based on artificial intelligence can assist doctors in improving detection performance. In this article, U-Net is used as the backbone network, and the attention and residual modules are integrated to construct an end-to-end convolutional neural network model for optic disc and cup disc segmentation. The U-Net backbone is used to infer the basic position information of optic disc and cup disc, the attention module enhances the model's ability to represent and extract features of optic disc and cup disc, and the residual module alleviates gradient disappearance or explosion that may occur during feature representation of the neural network. The proposed model is trained and tested on the DRISHTI-GS1 dataset. Results show that compared with the original U-Net method, our model can more effectively separate optic disc and cup disc in terms of overlap error, sensitivity, and specificity.

Local–global pseudo-label correction for source-free domain adaptive medical image segmentation

Domain shift is a commonly encountered issue in medical imaging solutions, primarily caused by variations in imaging devices and data sources. To mitigate this problem, unsupervised domain adaptation techniques have been employed. However, concerns regarding patient privacy and potential degradation of image quality have led to an increased focus on source-free domain adaptation. In this study, we address the issue of false labels in self-training based source-free domain adaptive medical image segmentation methods. To correct erroneous pseudo-labels, we propose a novel approach called the local–global pseudo-label correction (LGDA) method for source-free domain adaptive medical image segmentation. Our method consists of two components: An offline local context-based pseudo-label correction method that utilizes local context similarity in image space. And an online global pseudo-label correction method based on class prototypes, which corrects erroneously predicted pseudo-labels by considering the relative distance between pixel-wise feature vectors and prototype vectors. We evaluate the performance of our method on three benchmark fundus image datasets for optic disc and cup segmentation. Our method achieves superior performance compared to the state-of-the-art approaches, even without using any source data.

Self-supervised pre-training for joint optic disc and cup segmentation via attention-aware network

Image segmentation is a fundamental task in deep learning, which is able to analyse the essence of the images for further development. However, for the supervised learning segmentation method, collecting pixel-level labels is very time-consuming and labour-intensive. In the medical image processing area for optic disc and cup segmentation, we consider there are two challenging problems that remain unsolved. One is how to design an efficient network to capture the global field of the medical image and execute fast in real applications. The other is how to train the deep segmentation network using a few training data due to some medical privacy issues. In this paper, to conquer such issues, we first design a novel attention-aware segmentation model equipped with the multi-scale attention module in the pyramid structure-like encoder-decoder network, which can efficiently learn the global semantics and the long-range dependencies of the input images. Furthermore, we also inject the prior knowledge that the optic cup lies inside the optic disc by a novel loss function. Then, we propose a self-supervised contrastive learning method for optic disc and cup segmentation. The unsupervised feature representation is learned by matching an encoded query to a dictionary of encoded keys using a contrastive technique. Finetuning the pre-trained model using the proposed loss function can help achieve good performance for the task. To validate the effectiveness of the proposed method, extensive systemic evaluations on different public challenging optic disc and cup benchmarks, including DRISHTI-GS and REFUGE datasets demonstrate the superiority of the proposed method, which can achieve new state-of-the-art performance approaching 0.9801 and 0.9087 F1 score respectively while gaining 0.9657 DCdisc\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$DC_{disc}$$\\end{document} and 0.8976 DCcup\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$DC_{cup}$$\\end{document}. The code will be made publicly available.

Novel Methods for Diagnosing Glaucoma: Segmenting Optic Discs and Cups using Ensemble Learning Algorithms and CDR Ratio Analysis

Glaucoma, a multifactorial group of eye diseases characterized by progressive damage to the Glaucoma, a group of progressive optic neuropathies, is a leading cause of irreversible blindness globally, affecting millions of individuals. This research addresses the critical task of glaucoma identification through the segmentation of the optic disc and optic cup using ensemble learning algorithms, Unet and Gnet. The study leverages the capabilities of these algorithms to enhance the accuracy of the segmentation process, a crucial step in early glaucoma detection. A meticulously curated dataset of ophthalmic images is utilized, with a focus on preprocessing techniques includes resizing, normalization, filtering and contrast enhancement process to optimize the input quality. The proposed architectures of Unet and Gnet, highlighting their suitability for segmenting the optic disc and cup. The experimental setup involves rigorous training, with an emphasis on fine-tuning the models for segmentation tasks. Evaluation metrics, including Dice coefficient and sensitivity, are employed to assess the precision of the segmentation results. The outcomes demonstrate the efficacy of ensemble Unet and Gnet. Consistently achieving accuracy levels surpassing 98.90% across various datasets, the suggested model demonstrates exceptional performance in accurately categorizing severe cases. The study concludes with insights into the potential clinical impact of improved optic disc and cup segmentation on early glaucoma diagnosis, emphasizing the significance of ensemble learning in advancing ophthalmic image analysis for medical applications.

Deep convolutional neural network for glaucoma detection based on image classification

PURPOSE: Many researchers have found that the improvement in computerised medical imaging has pushed them to their limits in terms of developing automated algorithms for the identification of illness without the need for human participation. The diagnosis of glaucoma, among other eye illnesses, has continued to be one of the most difficult tasks in the area of medicine. Because there are not enough skilled specialists and there are a lot of patients seeking treatment from ophthalmologists, we have been encouraged to build efficient computer-based diagnostic methods that can assist medical professionals in early diagnosis and help reduce the amount of time and effort they spend working on healthy situations. The Optic Disc position is determined with the help of the LoG operator, and a Disc Image map is projected with the help of a U-net architecture by utilising the location and intensity profile of the optic disc. After this, a Generative adversarial network is suggested as a possible solution for segmenting the disc border. In order to verify the performance of the model, a well-defined investigation is carried out on many retinal datasets. The usage of a multi-encoder U-net framework for optic cup segmentation is the second key addition made by this proposed work. This framework greatly outperforms the state-of-the-art in this area. The suggested algorithms have been tested on public standard datasets such as Drishti-GS, Origa, and Refugee, as well as a private community camp-based difficult dataset obtained from the All-India Institute of Medical Sciences (AIIMS), Delhi. All of these datasets have been verified. In conclusion, we have shown some positive outcomes for the detection of diseases. The unique strategy for glaucoma treatment is called ensemble learning, and it combines clinically meaningful characteristics with a deep Convolutional Neural Network.

Unsupervised Domain Adaptation Fundus Image Segmentation via Multi-Scale Adaptive Adversarial Learning.

Segmentation of the Optic Disc (OD) and Optic Cup (OC) is crucial for the early detection and treatment of glaucoma. Despite the strides made in deep neural networks, incorporating trained segmentation models for clinical application remains challenging due to domain shifts arising from disparities in fundus images across different healthcare institutions. To tackle this challenge, this study introduces an innovative unsupervised domain adaptation technique called Multi-scale Adaptive Adversarial Learning (MAAL), which consists of three key components. The Multi-scale Wasserstein Patch Discriminator (MWPD) module is designed to extract domain-specific features at multiple scales, enhancing domain classification performance and offering valuable guidance for the segmentation network. To further enhance model generalizability and explore domain-invariant features, we introduce the Adaptive Weighted Domain Constraint (AWDC) module. During training, this module dynamically assigns varying weights to different scales, allowing the model to adaptively focus on informative features. Furthermore, the Pixel-level Feature Enhancement (PFE) module enhances low-level features extracted at shallow network layers by incorporating refined high-level features. This integration ensures the preservation of domain-invariant information, effectively addressing domain variation and mitigating the loss of global features. Two publicly accessible fundus image databases are employed to demonstrate the effectiveness of our MAAL method in mitigating model degradation and improving segmentation performance. The achieved results outperform current state-of-the-art (SOTA) methods in both OD and OC segmentation.

Glaucoma Identification Using Convolutional Neural Networks Ensemble for Optic Disc and Cup Segmentation

Glaucoma Identification Using Convolutional Neural Networks Ensemble for Optic Disc and Cup Segmentation