Effects Of Secondhand Smoke Research Articles

Relation between Women’s Knowledge and their Exposure to Second Hand Smoking

Background: Second Hand Smoking is a significant public health problem that may be associated with serious health problems. Exposure to Second hand smoking may increase the risk of developing lung cancer, heart disease, intrauterine growth retardation and childhood asthma. Aim of the study: investigate the relation between women’s knowledge and their exposure to second hand smoking in outpatient clinics at Woman Health Hospital. Subjects and methods: Descriptive Cross-sectional design was used. Quota sample of 700 women was participated. Tool: an interview questionnaire was used it included three parts: part one: socio- demographic characteristics, part two History of exposure to second hand smoking. Part three: Second hand smoking knowledge questionnaire. Results 73.3% of studied women were exposed to second hand smoking, 45.7% of them had poor knowledge about second hand smoking. Conclusion: The majority of participated women are exposed to second hand smoking at their homes also; more than one - third of them have poor knowledge regarding second hand smoking. Recommendations: Regular programs should be conducted to increase public awareness regarding effects of second-hand smoking through different mass media especially T.V.

"It's Worse to Breathe It Than to Smoke It": Secondhand Smoke Beliefs in a Group of Mexican and Central American Immigrants in the United States.

This analysis describes beliefs about secondhand smoke and its health effects held by Mexican and Central American immigrants in North Carolina. Data from 60 semistructured, in-depth interviews were subjected to saliency analysis. Participant discussions of secondhand smoke centered on four domains: (1) familiarity and definition of secondhand smoke, (2) potency of secondhand smoke, (3) general health effects of secondhand smoke, and (4) child health effects of secondhand smoke. Secondhand smoke was generally believed to be more harmful than primary smoke. Mechanisms for the potency and health effects of secondhand smoke involved the smell of secondhand smoke, secondhand smoke being an infection and affecting the immune system, and personal strength being protective of secondhand smoke. Understanding these health beliefs informs a framework for further health education and intervention to reduce smoking and secondhand smoke exposure in this vulnerable population.

A Calibrated Sensitivity Analysis for Matched Observational Studies with Application to the Effect of Second-Hand Smoke Exposure on Blood Lead Levels in Children

Summary We conducted a matched observational study to investigate the causal relationship between second-hand smoke and blood lead levels in children. Our first analysis that assumes no unmeasured confounding suggests evidence of a detrimental effect of second-hand smoke. However, unmeasured confounding is a concern in our study as in other observational studies of second-hand smoke's effects. A sensitivity analysis asks how sensitive the conclusion is to a hypothesized unmeasured confounder U. For example, in our study, one potential unmeasured confounder is whether the child attends a public or private school. A commonly used sensitivity analysis for matched observational studies adopts a worst-case perspective, which assumes that, in each matched set, the unmeasured confounder is allocated to make the bias worst: in a matched pair, the child with higher blood lead level always attends public school and the other private school. This worst-case allocation of U does not correspond to any realistic distribution of U in the population and is difficult to compare with observed covariates. We proposed a new sensitivity analysis method that addresses these concerns. We apply the new method to our study and find that, to explain away the association between second-hand smoke exposure and blood lead levels as non-causal, the unmeasured confounder would have to be a bigger confounder than any measured confounder.

Secondhand smoke effects on rhinoconjunctivitis and sleep quality in an adolescent asthma study

Secondhand smoke effects on rhinoconjunctivitis and sleep quality in an adolescent asthma study

Living with parents who smoke predicts levels of toxicant exposure in children

The detrimental effect of secondhand smoke (SHS) on health is well known; due to various factors, efforts to prevent SHS cannot completely eliminate the effect of smoking substances, and SHS has not been sufficiently investigated among children. This study aimed to assess children’s smoke exposure with respect to parents smoking patterns using biomarkers. This study used data from the 2016/2017 Korea National Health and Nutrition Examination Survey. Data pertaining to 486 subjects was extracted. Exposure to smoking among non-smoking children was assessed based on urine levels of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). The urine NNAL concentration was highest among children with smoking parents and SHS exposure at home (3.829 pg/mg, 95% confidence interval [CI: 1.499–8.330), followed by children with smoking parents and no SHS exposure at home (1.297, 95% CI: 1.080–1.536), and children with nonsmoking parents and no SHS exposure at home (0.996 pg/mg, 95% CI: 1.026–1.427). Living with a smoking parent was associated with exposure to carcinogens, and a critical predictor of tobacco-specific nitrosamine. Prohibition of smoking at home is effective at preventing SHS in children. However, it cannot completely prevent passive smoking, which might be attributable to thirdhand smoking and undetected secondhand smoke.

Evaluation of secondhand smoke effects on CFTR function in vivo

Evaluation of secondhand smoke effects on CFTR function in vivo

Effects of second-hand smoking on lung functions in athlete and non-athlete school-aged children - observational study.

Second-hand smoking or environmental tobacco smoke is a critical health risk. Children are the most vulnerable to second-hand smoking because of their small bronchial ducts, less developed immunity, and low-physical activity. The purpose of this study was to ascertain the effects of second-hand smoking on lung functions in athlete and non-athlete school-aged children. This observational study included forty-six school-aged children, their age was 8-15 years, assigned to three groups; 2 study groups and 1 control group (n=15). The study groups comprised of 16 football players, and of 15 cyclists. Lung functions were evaluated recording forced vital capacity, forced expiratory volume in 1 sec and peak expiratory flow using digital spirometer. All measures were recorded in definite values and the children were also classified into second-hand smoking (SH), or non-exposed to tobacco smoking (NE). The findings presented a significant increase (p<0.05) of the study groups in forced vital capacity, forced expiratory volume in 1 sec and peak expiratory flow solely for the non-exposed children. However, there were non-significant differences between the cyclists and football players or between the passive smoking children and non-exposed children in any of the two study groups (p>0.05). The outcomes of this study suggest beneficial influences of the sports activity on the lung functions, without different influences of the cyclists and football players on the lung functions.

A Review of Common Independent Variables Used in Tobacco Smoking Related Studies

Tobacco is the only legal drug, killing many of tobacco users when used exactly as intended by its manufacturers. According to the report of World Health Organization, tobacco use including smoking and smokeless is currently responsible for about six million deaths across the world each year [1]. This figure includes about 600,000 people who may die from the effects of secondhand smoke. Tobacco smoking has been proved associated with ill health, disability and death from non-communicable chronic diseases. However, it also leads to an increased risk of death from communicable diseases. Thus, tobacco use is still one of the biggest preventable causes of diseases and premature deaths until now. Although smoking rates fell in the higher income countries during the 1970s and 1980s, evidence shows that this trend is levelling out [2].

A Longitudinal Assessment of Corrective Advertising Mandated in United States v. Philip Morris USA, Inc.

Due to the ethical breaches of tobacco companies over a 50-year period, a U.S. Court ruled in United States v. Philip Morris USA, Inc. that major U.S. tobacco companies had misled consumers and the government about tobacco’s addictiveness, effects of environmental (secondhand) smoke, marketing targeted at adolescents, and deceptive practices related to harmfulness of smoking. We address the actions of the tobacco companies based on the consumer’s right to be informed and values for ethical corporate behavior, and we draw from psychological theories and the smoking literature to develop our conceptual framework and test the effectiveness of the ensuing corrective advertising campaign mandated in the Court decision. We use a quota sample of 470 smokers and non-smoker participants in a longitudinal study to test the impact of the corrective advertising campaign on key antismoking beliefs from the campaign. Results reveal that the corrective ad campaign has not been successful in affecting smokers’ or non-smokers’ antismoking beliefs. However, differences are found between smokers’ and non-smokers’ beliefs about the adverse health effects of smoking, effects of secondhand smoke, and tobacco company deceptiveness, with these beliefs being stronger for non-smokers. Smokers’ weaker beliefs about the effects of secondhand smoke are viewed as particularly problematic, given the established health risks. We address the implications of the ethical breaches and the corrective advertising attempt to address the deception identified by the Court.

Impact of gender, age and smoking habits on the effectiveness of health warning messages on cigarette packets: research on a highly educated Turkish sample

ABSTRACT This study investigated the perceived effectiveness of health warning labels (HWs) on smokers and non-smokers. Data were collected online and 342 valid responses were obtained. The impact of HWs in smoking abstinence was analyzed with canonical correlation technique and the results illustrated that the perceived effectiveness of HWs changed with gender, age and smoking levels. HWs depicting unhealthy infants due to second-hand smoking were found to be more effective for female participants. In contrast, depicting male figures who had had heart surgery, a sexual impotence problem and difficulty in breathing during a treadmill stress test were found more effective for males. Although the impact was not very strong, HW that read “smoking causes lethal lung cancer’ was considered effective mostly by the older participants. Finally, smoking frequency was not a significant predictor of the perceived effectiveness of all HWs, except for the two warnings which illustrated the adverse effect of second-hand smoking on infants. These two warnings were considered ineffective against the increase in smoking frequency. From a health promotion viewpoint, these findings highlight the importance of including social determinants in the process of HWs design since the effectiveness of HWs changed based on age, gender and the smoking status of participants. Thus, this study recommends that health policymakers tailor HWs based on gender, age, and smoking status rather than mass communicating the same message across different social groups.

The Effect of Secondhand Smoking on Dental Caries among Schoolchildren in Riyadh, Saudi Arabia: A Cross-sectional Study.

Aim:The aim of this study was to explore the relationship between dental caries and exposure to secondhand smoking in mixed teeth among Saudi children.Materials and Methods:A cross-sectional study was designed to target schoolchildren aged between 6 and 13 years in their mixed dentition stage. A cluster random sample of schools teaching first to sixth grades from different regions in Riyadh city was used. Data were obtained by self-reported questionnaires and clinical dental examinations. Questionnaires comprised sections related to sociodemographic, behavioral, health characteristics, and questions related to mother and father smoking status, type, and duration of smoking, and whether parents smoked inside homes or not. The clinical dental examination was based on the basic methods of the World Health Organization criteria for decayed, missing, and filled teeth (DMFT) (1997). Statistical analyses included descriptive statistics, t test, and one-way analysis of variance.Results:Of the 302 participating schoolchildren, 56% were females, 72% were Saudi nationals, and 84% were of normal weight. Of the total 3246 teeth examined, DMFT was found in 1922 teeth (mean DMFT = 6.36). Only eight mothers (2.7%) were smokers, seven of them smoked inside their homes. Majority of fathers were smokers (110, 37%) and 82% smoked inside their houses. It had been found that 26% of schoolchildren were exposed to secondhand smoking. The mean DMF scores were higher among schoolchildren with smoking fathers and mothers, and the difference was statistically significant (P = 0.05).Conclusion:The DMFT among Saudi schoolchildren was 6.36. Children, who are exposed to secondhand smoking by their family members, are more likely to have dental caries in their mixed dentitions.

RAGE and AXL expression following secondhand smoke (SHS) exposure in mice

Aim and Purpose: Tobacco exposure is one of the top three global health risks leading to the development of chronic obstructive pulmonary disease (COPD). Although there is extensive research into the effects of cigarette smoke, the effect of secondhand smoke (SHS) in the lung remains limited. SHS induces receptors for advanced glycation end-products (RAGE) and an inflammatory response that leads to COPD characteristics. Semi-synthetic glycosaminoglycan ethers (SAGEs) are sulfated polysaccharides derived from hyaluronic acid that inhibit RAGE signaling. The growth arrest-specific 6 (Gas6) protein is known to induce dynamic cellular responses and is correlated with cell function. Gas6 binds to the AXL tyrosine kinase receptor and AXL-mediated signaling is implicated in proliferation and inflammation. This project’s purpose was to study the correlation between RAGE, AXL, and Gas6 during SHS exposure in the lung. Methods: C57Bl/6 mice were exposed to SHS alone or SHS + SAGEs for 4 weeks and compared to control animals exposed to room air (RA). Results: Compared to controls we observed: 1) increased RAGE mRNA and protein expression in SHS-exposed lungs which was decreased by SAGEs; 2) decreased expression of total AXL, but highly elevated pAXL expression following exposure; 3) highly elevated Gas6 expression when RAGE was targeted by SAGEs during SHS exposure; 4) SHS-mediated BALF cellularity and inflammatory molecule elaboration; and 5) the induction of both RAGE and AXL by Gas6 in cell culture models. Conclusions: Our results suggest that there is a possible correlation between RAGE and AXL during SHS exposure. Additional research is critically needed that dissects the molecular interplay between these two important signaling cascades. At this point, the current studies provide insight into tobacco-mediated effects in the lung and clarify possible avenues for alleviating complications that could arise during SHS exposure such as those observed during COPD exacerbations.

Creation of a Smoke-free Environment for Children: An Assessment of Compliance to COTPA 2003 Legislation in an Urban Area

To ascertain the compliance to Cigarette and Other Tobacco Products Act (COTPA) 2003 which ensures the protection of children from the adverse health effects of second hand smoke. This cross-sectional study assessed the compliance of 32 educational institutions and 157 points of sale of Shimla city. About 88% of the educational institutions and mere 7.6% points of sale were found having good compliance to the key indicators. No point of sale was found within the premises of educational institutions; however, 26% were found selling tobacco products within 100 metres radius of an educational institution. 7.6% points of sale were found selling a tobacco product to children. Despite having the status of a smoke-free city, lapses were observed in compliance to the Act. Strict adherence to the provisions of the Act would ultimately lead to a smoke-free environment for our children.

The association between exposure to secondhand smoke and psychological symptoms among Chinese children

BackgroundThe effect of secondhand smoke (SHS) exposure on child psychological problems remained inconclusive in previous studies. The aim of this study is to explore the association between SHS exposure and psychological symptoms in children.MethodsThis population-based cross-sectional survey used cluster random probability sampling and recruited children aged 6–13 years in 26 primary schools in Shanghai, China, in 2014. Duration of SHS exposure in children were categorized as none, < 1 h/day, 1–2 h/day, ≥3 h/day. Psychological symptoms were assessed by the parental version of the Strengths and Difficulties Questionnaire (SDQ). We used logistic regression to estimate the adjusted associations of SHS exposure with total SDQ and its specific domains. Multiple imputation was used for handling missing data.ResultsA total of 17,571 children completed this survey, with a response rate of 99.7%. SDQ scores were available for 15,344 participants, of whom 20.9% were not exposed to SHS, 63.0% exposed for < 1 h/day, 10.4% for 1–2 h/day, and 5.7% for ≥3 h/day. Compared to children not exposed to SHS, SHS exposure was positively associated with total SDQ score: OR 1.42, 95% confidence interval (CI) 1.22 to 1.66 for SHS exposure < 1 h/day, OR 2.14, 95% CI 1.76 to 2.62 for 1–2 h/day and OR 2.53, 95% CI 2.01 to 3.18 for ≥3 h/day after adjusting for sex, age, mode of birth, family socio-economic status and place of birth. These associations did not vary by sex.ConclusionSHS exposure is an independent risk factor for psychological problems among children. Nonetheless, our study is unable to distinguish between fetal and child exposure to SHS.

A review of the effects of tobacco smoking on cancer treatment: smoking cessation intervention should be integrated into the cancer care continuum

AbstractBackground:The adverse health effects associated with smoking tobacco have been well investigated, and its detrimental effects on cancer treatment outcomes, efficacy and quality of life (QOL) for cancer patients have also been well documented. Tobacco smoke contains many thousands of chemicals, including a plethora of carcinogens, and the exposure of human cells to these carcinogens, and their metabolic activation, is the main mechanism by which smoking-related cancer is initiated.Materials and Methods:This paper reports on a narrative review of recent studies in the field of effects of tobacco smoking on cancer treatment, including the effects of carcinogens in smoke on carcinogenesis, cell mutations and the immune system. The health effects of smokeless tobacco, effects of tobacco smoking on cancer treatment, and its impact on surgery, radiation therapy and chemotherapy are reported. The potential risks of second primary cancers or recurrence from tobacco use, the effects of second-hand smoking and cancer treatment, the impact of smoking on the QOL after cancer treatment and the need to integrate smoking cessation programs into the cancer care continuum are also reported.Conclusions:Tobacco use has a direct impact on cellular function by inhibiting apoptosis, stimulating proliferation and decreasing the efficacy of cancer treatment; therefore, quitting its use has the potential to improve treatment response rates and survival, as well as reduces the risk of developing second cancers and potentially improves the QOL after treatment. Smoking cessation is one of the most important interventions to prevent cancer and is also essential after the diagnosis of cancer to improve clinical outcomes. Due to the numerous benefits of smoking cessation, it should become a critical component of the cancer care continuum in all oncology programs – from prevention of cancer through diagnosis, treatment, survivorship and palliative care. Evidence-based smoking cessation intervention should be sustainably integrated into any comprehensive cancer program, and the information should be targeted to the specific benefits of cessation in cancer patients.

Effects of Second-Hand Smoke on Pancreatitis in Children.

Pediatric pancreatitis incidence is increasing, but little is known about risk factors. Smoking increases the risk for adult pancreatitis and has been shown to affect CFTR function in vitro. Therefore, we evaluated passive smoke exposure effects on disease outcomes in children with various pancreatitis etiologies. We conducted a 5-year retrospective chart review of patients admitted for pancreatitis to Children's Healthcare of Atlanta. Demographic data, etiology of pancreatitis, and number of hospitalizations with length of stay (LOS) were compared with smoking exposure, obtained through telephone query. Of the 134 subjects admitted for pancreatitis, 90 reported no smoke exposure (none), 33 reported outdoor smoke exposure (outside), and 11 reported exposure to indoor smoking (inside). Average hospital admissions (P = 0.038) and LOS (P = 0.004) were significantly higher among subjects with inside smoke exposure compared with those with outdoor or no exposure. Average hospital admissions were significantly higher in subjects with CFTR mutations compared with those with nongenetic or other genetic etiologies (P ≤ 0.001). Second-hand smoke exposure may increase hospital admission rates and LOS for pediatric pancreatitis. Children with an identifiable CFTR mutation may have increased risk for hospital admissions compared with those who do not.

Effect of Second hand Smoke on Arterial Stiffness among Healthy Women

Introduction: Arterial stiffness is recognised as a significant cardiovascular risk factor and an independent predictor of all causes of cardiovascular death. Women are the largest population exposed to cigarette smoke either at work or from their partner. The objectives of this study are to compare the arterial stiffness (augmentation index and pulse wave velocity) between second hand smoke (SHS) and non second hand smoke (non-SHS).&#x0D; Designs and method: Comparative cross-sectional study was conducted among 118 healthy female subjects (64 SHS and 54 non- SHS). The women were in the SHS group if their spouse is a smoker and they had an exposure to cigarette smoke for at least three years, minimum of15 minutes two days a week. Pulse wave analysis and pulse wave velocity was used to study the arterial stiffness. Pulse wave analysis reported as percentage of augmentation index. Pulse wave velocity equal to carotid femoral distance (meter) divided by time (second)&#x0D; Results: The mean augmentation index (AIx) for SHS groups was 17.9 (SD7.06) and for non SHS groups was 20.7(SD6.11). The mean of Pulse wave velocity was 8.94 (SD1.36) in SHS groups and 9.02 (SD8.68) in non SHS groups. ANOVA and ANCOVA shown significance difference in crude mean (p = 0.047) and estimated marginal mean (p = 0.028) of augmentation index between SHS and non - SHS after controlling for age and BMI. However, there was no significant difference in crude mean (p = 0.795) and estimated marginal mean (p = 0.716) pulse wave velocity between SHS and non - SHS after controlling for age and BMI.&#x0D; Conclusion: An increase in augmentation index amongst non SHS in this study most probably due to exposure to environmental tobacco at work compared to exposure to spouse’s smoke&#x0D; Bangladesh Journal of Medical Science Vol.18(2) 2019 p.340-346

The effect of second hand smoke in patients with squamous cell carcinoma of the head and neck

BackgroundActive tobacco smoking is a well-known risk factor for head and neck malignancy, and strong evidence has associated tobacco as the main carcinogenic factor in squamous cell cancers of this region. Evidence supporting a carcinogenic effect of second-hand smoke (SHS) on head and neck organs in non-smokers was also demonstrated with results consistent with those for active smokers. There is little data on the effects of SHS in patients previously treated for squamous cell carcinomas of the head and neck.ObjectiveThe purpose of this study was to prospectively evaluate the role of SHS on recurrence and survival in treated head and neck cancer patients.MethodsWe conducted a prospective cohort study to examine the association between self-reported SHS exposure and the risk of recurrence and mortality in patients treated for squamous cell cancers of the head and neck in a longitudinal fashion. Patients filled out an exhaustive smoking questionnaire on presentation and abbreviated questionnaires at each follow-up visit, which occurred every 6 months. Primary outcome measures were recurrence, development of a second primary malignancy, and recurrence-free survival. Chi square analysis was used to assess the association between SHS and the primary outcomes. A multivariate binary logistic regression analysis was applied to determine the independent predictors of recurrence. Cox proportional hazards and Kaplan Meier modeling were employed to assess the possible relationships between SHS exposure and time to develop the primary outcomes.ResultsUntreated new patients with a histologically confirmed diagnosis of first primary SCC of the UADT (defined as cancer of the oral cavity, the oropharynx, the hypopharynx, and the larynx) were recruited. Patients seen at The University of Texas Medical Branch (UTMB) Head and Neck oncology clinic from 1988 to 1996 were considered as cases in this study. One hundred and thirty-five patients were enrolled in the study. The median follow-up time for the sample was 54 months (3.92 years). Complete records were achieved for 92% of patients, thus 124 patients were included in the final analysis. SHS significantly correlated with recurrence and recurrence-free survival. The rate of recurrence was 46% in the group exposed to SHS and 22% in the non-exposed group. Based on multivariate binary logistic regression analysis, SHS exposure was detected as a significant independent predictor for recurrence (HR = 3.00 [95% CI 1.18–7.63]). Kaplan-Meier analysis demonstrated that patients who were not exposed to SHS had a statistically significant longer recurrence-free survival (log-rank P = 0.029). The mean survival for non SHS-exposed patients was 76 [63–89] months versus 54 [45–63] months for those exposed to SHS.ConclusionsSHS exposure is an independent predictor of recurrence and survival after head and neck cancer treatment. These results support the importance and efforts of reducing smoking at home in in the work-place.

Effects of Second Hand Smoking on the Health of School Children in Awendo, Kenya

Exposure to secondhand smoke (SHS) can cause diseases and deaths among children. Yet children continue to be exposed especially among the low income countries. Epidemiological evidence shows that children of smoking parents have increased risk of neuro-behavioral deficits, neurodevelopmental deficits and childhood cancer. The aim of this study was to find out if children living in low-income countries are still exposed to SHS and its additional burden on the health and school absenteeism among children in the rural setting. A cross-sectional survey was conducted in February-March 2016. A 2-stage cluster-sample design was used to obtain a representative sample (N=600) of private and public primary day school students year 7 and 8 (aged 12-15 years old) in Awendo. A higher proportion (55.5%) of the younger children lived with one or more than two smokers in the home. A modest proportion of children reported complete restriction of smoking at home. The risk of Asthmatic attack increased by more than three fold and more than ten fold among children living with one smoker and among those living with more than two smokers respectively. Smoking has been associated with poor dietary intake, in this case children living with smokers were found to be significantly malnourished. Successful smoking cessation among residents living with children could contribute to decreased asthmatic attacks, malnutrition and school absenteeism.

Semi‐Synthetic Glycosaminoglycan Ethers Decrease Receptors for Advanced Glycation End‐Products and Increase AXL Receptor in the Lung from Secondhand Smoke Treated Mice

Tobacco exposure is one of the top three global health risks leading to the development of chronic obstructive pulmonary disease (COPD). Although there is extensive research into the effects of cigarette smoke, the effect of secondhand smoke (SHS) in the lung remains limited. SHS induces Receptors for advanced glycation end‐products (RAGE) and an inflammatory response that leads to the development of COPD characteristics. Semi‐synthetic glycosaminoglycan ethers (SAGEs) are sulfated polysaccharides derived from hyaluronic acid (HA) that inhibit RAGE signaling. The growth arrest‐specific 6 (Gas6) protein is known to induce dynamic cellular responses and is correlated with cell function. Gas6 binds to the AXL tyrosine kinase receptor and AXL‐mediated signaling is implicated in proliferation and migratory mechanisms in several tissues. This project's purpose was to study the correlation between RAGE, AXL, and Gas6 during SHS exposure in the lung. C57/Bl6 mice were exposed to SHS alone or SHS + SAGEs for 4 weeks and compared to control animals exposed to room air (RA). At the time of necropsy lungs were extracted, frozen for mRNA studies or embedded for immunohistological analysis. Compared to controls we observed: 1) increased RAGE mRNA expression in SHS‐exposed lungs which was decreased by SAGEs; 2) no difference in Gas6 or AXL expression in SHS lungs and expression was significantly increased with SAGEs; 3) increased RAGE protein expression in SHS lungs that was decreased by SAGEs; and 4) decreased AXL protein in SHS animals and increased AXL protein in animals treated with SAGEs. Our results suggest that there is a direct correlation between RAGE and AXL during SHS exposure. These studies provide insight into tobacco‐mediated effects in the lung and clarify possible avenues for alleviating complications that could arise during SHS exposure such as those observed during COPD.Support or Funding InformationThis work was supported by a grant from the Flight Attendant's Medical Research Institute (FAMRI, PRR and JAA) and a BYU Mentoring Environment Grant (JAA and PRR).This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.