As an important part of renewable energy, the development and utilization of biomass hydrothermal liquefaction and oil production technology has become one of the important topics in the field of sustainable energy research in the new century. Based on China is rich in resources, low comprehensive utilization of seafood waste as raw materials, with low energy consumption, reaction conditions are relatively mild hydrothermal liquefaction process of the production of oil, to study the efficiency of oil in the process of hydrothermal liquefaction of biomass, and by comparing the experimental conditions (temperature, raw material and the water ratio, reaction time, catalyst and its concentration) the influence of the reaction. Through the analysis of the infrared spectrum, density and viscosity of the bio-oil, the bio-oil contains alcohols, phenols, acids, esters, ketones and amines. The product oil is heavy oil and can be used after certain processing.