Scientific Justification Research Articles

Dejustifying Scientific Progress

Abstract Stegenga (forthcoming) formulates and defends a novel account of scientific progress, according to which science makes progress just in case there is a change in scientific justification. Here, we present several problems for Stegenga’s account, concerning, respectively, (i) obtaining misleading evidence, (ii) losses or destruction of evidence, (iii) oscillations in scientific justification, and (iv) the possibility of scientific regress. We conclude by sketching a substantially different justification-based account of scientific progress that avoids these problems.

Features of Forming the Legal Consciousness in the Modern Settings and Its Influence on the State of Lawfulness

Introduction. The Constitution of the Russian Federation defines the benchmarks ensuring an appropriate level of development for the important spheres of life, a high living standard, which requires a comprehensive approach to forming the human potential of the generations of the Russian citizens. The quintessence of the Russian statehood strategic development implies minimisation of the prerequisites inducing formation of the destructive legal consciousness in citizens, which obstructs achievement of the legal order in the country. In the National Security Strategy of the Russian Federation, among the list of national interests, a significant place is allocated to saving the people of Russia, to development of the human potential. The state strategic planning document had defined the following goals: upbringing a harmoniously developed and socially responsible citizen, forming in the society the attitude of intolerance to illegal activities. No doubt, in Russia, the trend of the power exercising mechanism to undergo modern institutional changes is caused by the social modernization and is targeted at the conceptual ideas of the constitutionalism. The economic and socio-political transformations inevitably affect not only formation of the legal environment, but also structuring the public consciousness, which concepts predetermine the development of the reasoned and practically oriented legal solutions. The state of the public perception of the legal phenomena should be constantly monitored due to the continuous impact imposed on it by the transformations in the state structure of the governmental and administrative authorities. The scientific understanding of these processes should not be underestimated, otherwise this can cause the psychological turbulence of a significant part of the population in choosing the behavioural patterns of lawful behaviour. In the context of transformation of the social determination process, which is attributed with a complicated range of the antisocially-motivated impacts, significantly limiting the preventive social and law enforcement potential, the present research is relevant due to the special importance assigned to precise, steady and uniform application of the legislative provisions, the degree of their functional social harmonisation in the social relation regulation mechanism. The deformations of the citizens’ legal consciousness are the factors hindering the achievement of the high efficiency in implementation of the fundamental principles of the supremacy of law. The research aims at investigating the functional role of the legal consciousness in the legal regulation mechanism of the modern social formations, at analysing the problems of exercising the state policy in the frame of forming the positive perception of the legal phenomena among the citizens and revealing the interrelations of the legal consciousness deformations and stimulation of the legitimate behavioural variation.Materials and Methods. The article analyses the results of the research of the native and foreign scientists on the regularities in the public perception of the state and legal phenomena and impact thereof on the legitimate behavioural variation. The general scientific and specific scientific methods were used in the research, such as the statistical method and the method of system analysis of data characteristic of the phenomena affecting the state of lawfulness in Russia.Results. The regularities in the functional role of the legal consciousness within the mechanism of legal regulation of the social relations have been acknowledged. The substance of the legal consciousness interrelations with the legal ideology and legal psychology has been revealed. The problems of efficiency of the state policy in forming the civil legal consciousness have been determined. It has been proposed to integrate into the scholarly discourse such a type of legal consciousness deformation as legal dementia, which predetermines the state of lawfulness in the modern Russian society.Discussion and Conclusion. The practical side of the legal consciousness reflects the behavioural attitudes of a person, his readiness to use in practice his theoretical knowledge and value assessments. The law-related feelings, emotions, ideas, principles, attitudes that have become a part of a person’s legal consciousness, subsequently determine his actions in the legal framework. To ensure protection of the national mental values and to prevent emergence of the destructive attitudes in the society, changes in the educational, scientific, cultural and other spheres should be made taking into account the historical traditions and the experience accumulated by the Russian society. Unfortunately, nowadays, among the main problems of the lawmaking and law enforcement processes in Russia are weak scientific and analytical justification of the draft laws, low quality of laws, acute legal collisions within the law system, violations of the intra-system relations that result in a tendency of citizens’ legal estrangement.

In vitro evaluation of Morinda lucida root extracts against multi-drug resistant bacterial pathogens isolated from diabetic foot ulcers

Background: The continuous rise in microbial resistance to orthodox antimicrobial drugs has led to the search for alternative sources with proven efficacy to solve the challenges of antimicrobial resistance (AMR). The preferred alternatives are plant sources, and this has led to the evaluation of constituents and potency of medicinal plants to provide scientific justification for their use. Methodology: The root of Morinda lucida plant was dug up from the ground, washed clean, and cut into smaller pieces and dried. The root was then ground into fine powder and extracted with water (aqueous), methanol, ethyl acetate and n-hexane. Multi-drug resistant (MDR) Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas aeruginosa were isolated from wound swab samples collected from patients with diabetic foot ulcers using conventional cultures, biochemical identification, and antimicrobial susceptibility tests. The phytochemical and proximate contents of the extracts were assessed by standard technique. The in vitro antimicrobial activities of the extracts were determined at a concentration of 200mg/ml of the extract using the agar well diffusion technique. The minimum inhibitory and bactericidal concentrations were determined by serial doubling dilution. The methanol extract time-kill assay was performed to determine the time of kill of the bactericidal concentration. Results: The phytochemical analysis showed that M. lucida root contains essential secondary metabolites such as flavonoids, alkaloids, tannin, saponin, glucosides, anthraquinone and quinine. The methanol and aqueous extracts showed higher in vitro antibacterial activity, producing the highest zone of inhibition of 27mm against S. aureus but a lower activity of 18mm with n-hexane extract against all isolates except S. aureus. The MIC ranges from 3.125mg/ ml and 25mg/ml. The time-kill assay of methanol extract at 2x and 3x MIC showed that bactericidal activity occurred within 0-8 hours of incubation, indicating high activity. Conclusion: The antibacterial potency of M. lucida root extract and the phytochemical components from this study shows that it can serve as a source of alternative antimicrobial agent that may be effective in the treatment MDR bacterial infections.

Straddling the Line Between In Vitro and Ex Vivo Investigations.

Tissue engineering research fundamentally relies on experiments to advance knowledge, utilizing various models for research on both humans and animals. With scientific progress, experimental models have become increasingly complex over time. This complexity sometimes blurs the distinction between categories, making terminology less consistent. In biomedical research, three overarching terms are commonly used to characterize experimental environments: in vitro, ex vivo, and invivo. While in vitro translates from Latin as "in glass," referring historically to experimental conditions in a test tube or petri dish, invivo experiments occur within a living organism's natural environment. Conversely, ex vivo originates from living tissue outside its host environment while striving to maintain conditions as close to the host surroundings as possible. In the tissue engineering and regenerative medicine (TE&RM) community, there needs to be more clarity between in vitro and ex vivo terminology, with historical definitions sometimes disregarded and new terms often introduced without rigorous scientific justification. At this juncture, the question arises of when to refer to experiments as in vitro or ex vivo or whether the terms may be used synonymously in some instances. Moreover, what criteria must ex vivo experiments meet to be legitimately defined as such? This perspective is intended to address questions that would assist the TE&RM community in better understanding the differences between in vitro and ex vivo models. Impact Statement In the tissue engineering & regenerative medicine literature, the terms "in vitro" and "ex vivo" are often used interchangeably to describe experiments. This interchangeable usage can lead to a compromised interpretation of research results and, consequently, misleading scientific conclusions and teachings. This perspective aims to provide clarity on the various definitions of experimental designs. It also highlights the issue of using terms with inconsistent meanings that have origins dating back to the distant past. It's important to note that scientific definitions constantly evolve, and there is a scientifically rooted responsibility to evaluate and rethink the current state of affairs critically.

Modern approaches to psychoterapy of somatoform disorders

The scientific review focuses on the relevant for modern medicine problem of psychotherapy of somatoform disorders (SFD). It is based on the analysis of 106 publications on this topic (46 of them in Russian and 60 in English). The search for publications was carried out in the RSCI and Medline bibliographic databases. The purpose of the review was to form ideas about the current state of the psychotherapy of SFD with the highlighting and comparison of the main current approaches in this area. The review analyzes the overall effectiveness of psychotherapy of SFD and considers the following modern its directions: cognitive behavioral therapy, mindfulness-based psychotherapy, dynamic psychotherapy, group psychotherapy, other (rarely mentioned) psychotherapeutic methods, as well as polymodal and remote approaches to psychotherapy of SFD.The summary of the literary information presented in the review allows to conclude that psychotherapy today is considered by most authors as an important, possibly even leading component of the treatment of the considered mental pathology type. At the same time, data on its clinical effectiveness, especially in isolated use, remains ambiguous, in addition, among researchers there is still no unity of views on the main targets of psychotherapeutic impacts in SFD, as well as on the most suitable forms and methods of psychotherapy for the treatment of this pathology. Information on the clinical effectiveness of specific psychotherapeutic methods currently used for the treatment of SFD is either ambiguous or incomplete, and the polymodal approaches to psychotherapy of SFD proposed by some authors have insufficient scientific justification for the methodological combinations used in them. The future of psychotherapy of SFD is seen by the authors of this review in the development of integrative psychotherapeutic programs that combine elements of several multidirectional methods of psychotherapy, but that are based on knowledge of the general personal and psychological characteristics of patients suffering from SFD.

Assessment of the readiness of the medical and preventive facility for actions in an extraordinary situation of a military character with combined radiation injury to the population

Background. In emergency situations of a military nature, medical institutions at all levels, especially specialized (radiological) medical facilities, are tasked with providing qualified assistance to the affected population. The effectiveness of these measures depends not only on the promptness, equipment, and training of operational teams but also on adherence to radiation safety standards, which differ from peacetime norms in terms of the scale of combined radiation injuries, injury criteria, and the methods of implementing measures. At the same time, against the backdrop of the multi-criteria uncertainty of possible radiological scenarios, there is no scientific justification for the necessary connections between the features of radiation safety and specific organizational and technical tasks within the system of overall readiness of medical institutions. Purpose – scientifically justify the potential readiness of a medical institution to act during a special period to provide qualified assistance to the population with combined radiation injuries, based on a systematic analysis of the features of the radiation safety system during military emergencies. Materials and Methods. In this paper, an attempt is made to assess the readiness of a medical and preventive institution to take action in emergency situations of a military nature by applying the method of analysis of hierarchies by T. Saati, adapted for the relevant tasks. Results. The conducted analysis of generalized weight coefficients and priorities in percentages (%) for each element of the hierarchical structure (Fig. 3) shows that more than 50% of «actions» are related to the effective provision of personnel safety and the effective delivery of medical care («Dia-1» and «Dia-2»). These components should receive key attention in the practical training of healthcare facility personnel and involved individuals through special training for emergency actions during special periods. Conclusions. This work attempts to assess the readiness of a medical institution to act in military emergencies by applying the Analytic Hierarchy Process (AHP) method by T. Saaty, adapted for the relevant tasks.

Механізми забезпечення економічної стійкості та безпеки на засадах національної укоріненості економічного розвитку

The article shows that the countries that made an economic breakthrough and entered the world of states with high per capita incomes in any variant of using the strategies of catch-up or anticipatory development, export orientation or import substitution relied on the creation of industries in their own country, that is, on nationally rooted development. The author reveals the content of nationally rooted development as a basis for economic stability and security. The relationship between the concepts of "sustainability" and "resilience" has been clarified. "Resilience" is interpreted as a specific form of stability of an economic object, associated with its flexibility and ability to recover from destructive impacts. In a broader context, the sustainability of economic development is considered as the ability to develop the production of a network of various goods (material and ideal, public and individual, institutional and social) to meet the needs of society, its communities and citizens on the basis of technical and technological development and its corresponding socio-economic organization, which is based on the comprehensive use of national resources and international cooperation to create added value in the national space-time and has the property of maintaining dynamic balance in conditions of uncertainties and destabilizing influences of the hybrid "peace-war" system. The author reveals the mechanisms for ensuring the national rooting of economic development as the basis of its stability and security. It is shown that the components of the structure of these mechanisms are goal setting with scientific justification of the relevant policy, strategic planning and development of planning and market mechanisms for solving strategic tasks with logistical, organizational and monetary support for achieving the goal of nationally rooted development. It is concluded that national projects should become the key organizational link of the mechanism of national rooting of economic development. The article shows that in conditions of uncertainty and extreme complexity of social processes, it is possible to solve the task of national rooting of economic development only by relying on a meritocratic approach to management.

When and Why the Doctrine of a “Rules-Based International Order” Emerged

INTRODUCTION. It is no understatement to say that the “rules-based international order” doctrine, as opposed to the “international order based on law”, has emerged as one of the most debated concepts in global politics during in the late ХХ and early ХХI centuries. This concept presents a framework where general rules of conduct for states, though not norms of jus cogens under general international law, are considered legally binding for all states and other participants in international relations. Consequently, it challenges the traditionally recognized supremacy of international law in governing these relations, seeking to erode established practices of international law-making. This doctrine is actively utilized by leading Western powers to substantiate their political positions and accuse strategic competitors of failing to adhere to these “rules” deemed as legally binding. Understanding the essence and origin of this doctrine is crucial in unraveling its significance. MATERIALS AND METHODS. The set of used methodological approaches encompass a range of general scientific and specialized methods, including historical analysis, formal logic, synthesis, as well as systemic and comparative legal methods.RESEARCH RESULTS. The research indicates that the doctrine of a rules-based international order entered international diplomatic discourse in the early 1990s, arising as a consequence of the collapse of the Soviet Union and the emergence of a unipolar world.DISCUSSION AND CONCLUSIONS. The author reaches the conclusion that in the context of this emerging unipolarity, the United States deemed it appropriate to unilaterally (or at most in conjunction with its closest allies) dictate universally binding rules of conduct in international relations to the global community. The doctrine of a rules-based internation[1]al order provided the necessary scientific justification to validate such a policy. Initially, this doctrine garnered substantial support in international politics but subsequently faced a decline in its proponents, particularly with the shift towards a polycentric world order. While it continues to exist to some extent, the goals for which it was originally conceived have been largely nullified.

THE REPORT ON SUSTAINABLE DEVELOPMENT AND INVESTMENTS IN THE AGRICULTURAL SECTOR: THE ENVIRONMENTAL CAPITAL PERSPECTIVE

Introduction. Ukrainian agribusiness works in challenging conditions today, and the international community greatly supports it. The decision to grant Ukraine the status of a candidate for EU accession, adopted by the European Council in June 2022, and initiatives such as the provision of financial assistance under the Ukraine Facility program (June 2023) opened up new opportunities for the agricultural sector of Ukraine. The realization of these opportunities depends not only on Ukraine's ability to carry out reforms in the direction of European integration but also on the readiness of business entities to overcome the consequences of hostilities through recovery and reconstruction. Purpose. The article aims to provide scientific justification for the standardized forms of the Report on Sustainable Development and Investments (ESGI-report) in the agricultural sector of the economy for the preparation and publication of environmental capital indicators. Methods. The methods of induction and deduction, analysis, and synthesis formed the basis for developing environmental indicators for the ESGI report. The abstract-logical method became the basis for the study of the norms of European legislation and the leading systems for measuring sustainable development. The analogy method made it possible to propose indicative (reference) indicators for measuring sustainable development at the micro level. Results. The article systematizes the estimated and verifiable indicators of ecological capital. The first group includes risks and opportunities connected with climate change, the transition to sustainable technologies, and martial law. The second group comprises indicators that can be accurately measured with the help of calculators and technical means. They are related to the use of natural resources and the impact on the environment. To prepare the ESGI report, it is proposed that all materials posted on the Sustainable Reporting Platform (SR platform) be used: reporting forms, survey questionnaires, video recordings, as well as materials of webinars, presentations, and articles. The SR platform was developed within the framework of the MSCA4Ukraine program funded by the European Union. Conclusion. Attracting foreign investments for the post-war reconstruction of Ukraine's agribusiness is impossible without preparing and disclosing non-financial information about environmental capital at the micro level. One of the tools for disclosing such information is the ESGI report, which is posted on the SR platform. It is advisable to publish environmental indicators in standardized reporting forms to ensure their comparability with the data of other enterprises. At the same time, to assess the level of sustainable development, it is necessary to apply scientifically based reference values, which are based on best practices, statistical data and the company's own experience.

ІНСТРУМЕНТИ СТИМУЛЮВАННЯ МІСЦЕВОГО ЕКОНОМІЧНОГО РОЗВИТКУ УКРАЇНИ В УМОВАХ НЕСТАБІЛЬНОСТІ

The research emphasizes the objectively existing need, as well as the problems of ensuring local economic development in Ukraine, in particular under conditions of critically acute economic and social instability caused by a full-scale war and its consequences. The purpose of the study is to determine the scientific justification of the tools for stimulating and ensuring the local economic development of Ukraine under the instability. It is shown that in the conditions of a full-scale war, the regional socio-economic systems of Ukraine faced such challenges as large-scale external and internal migrations of the population, deepening of depopulation problems, reduction of employment and the number of jobs due to the cessation of activities or relocation of enterprises, the growth of precarization in the labor market and social and labor insecurity of vulnerable categories of the population, the development of sectoral and structural imbalances and the strengthening of personnel problems in the labor markets. Accordingly, the latest challenges have become the main causes of destabilization of the spatial development of Ukraine's economy. The results of the analysis made it possible to identify, firstly, the significant typicality of existing problems, secondly, the significant resource limitations of local self-government bodies, thirdly, the need to involve innovative solutions, fourthly, the relevance of developing practices of intermunicipal socio-economic cooperation and integration of efforts in this way, fifthly, the need for a systemic and strategic approach, when based on visions, strategies and development programs, investment passports of territorial communities, a single coordinated regional master plan of industry specialization and development will be formed. The basic principles of two regional policy strategies in terms of stimulating local economic development are substantiated: (1) stabilization, (2) proactive. The strategic goal of each of these approaches is indicated, as well as a set of tools is defined, the implementation of which allows to activate the processes of local economic development in Ukraine under current conditions of instability.

Choosing the optimal technology for obtaining Crocus alatavicus extract with a high content of flavonoids and carotenoids

In recent years, there has been a significant increase in demand for herbal medicines, due to the growing interest of consumers in natural and safe alternatives to synthetic medicines. In response to these trends, manufacturers are focusing on developing new formulas and extraction technologies to meet the increased demand for herbal medicines. Modern extraction methods make it possible to efficiently extract secondary metabolites from plant raw materials, maintaining an almost complete chemical composition and ensuring a high yield of extractives. The possibility of regulating the concentration of extracted biologically active substances during the process opens up new prospects for the use of plant raw materials as basic pharmaceutical substances. It was found that all the studied plant species of the genus Crocus L. demonstrate antioxidant, anti-inflammatory and cardioprotective activity. Crocus alatavicus, which is a representative of the flora of Kazakhstan, is of particular interest. The purpose of this study is to select the optimal extraction method for obtaining extracts with the maximum content of flavonoids and carotenoids from the aboveground part of Crocus alatavicus. The study of the technological parameters of obtaining an extract from this plant active substance is of practical importance for the further development of medicines and the formation of a scientific justification for their use.

DEVELOPMENT OF THE GLOBAL AIR TRANSPORTATION MARKET IN CONDITIONS OF TURBULENCE

The purpose of the article is to develop and substantiate the strategic priorities of international cooperation of air transport enterprises of Ukraine in war and post-war times based on the study of turbulence factors affecting the activity of the global air transport market, as well as the analysis of the strategic development of the world's largest airlines in crisis conditions. The methodological basis of the research is scientific theories of economic cycles and crises, theories of market equilibrium, theories of market structures, theories of cooperation and integration. Both general scientific and special methods of scientific knowledge were used – historical-logical, descriptive-analytical, analysis and synthesis, methods of quantitative and qualitative comparisons. The informational basis of the article is monographic studies and periodical publications of Ukrainian and foreign economists, analytical reports of international aviation organizations, international consulting companies and analytical centres. The article examines the essence, structure and modern trends in the development of the global air transport market. Turbulence factors affecting the dynamics of air transport are identified and justified, including geopolitical instability, economic downturns, rising fuel prices, pandemics, technological innovations etc. The impact of crises on international air transportation was assessed, and the peculiarities of the regulation of the world air market were considered. The role of global strategic alliances in the formation of the world market of air transportation is determined, it is established that international cooperation of air transport enterprises allows to increase the market share. The results of the research made it possible to justify the strategic priorities of international cooperation of air transport enterprises of Ukraine in war and post-war times. Research results can be used for scientific justification and further creation of proper conditions for the effective functioning of the global air transport market, as well as in the development of new strategies for air transport enterprises of Ukraine, which will allow them to remain stable and competitive in conditions of uncertainty and growing threats.

Potential of kaempferol and caffeic acid to mitigate salinity stress and improving potato growth

Salinity stress adversely affects plant growth by disrupting water uptake, inducing ion toxicity, initiating osmotic stress, impairing growth, leaf scorching, and reducing crop yield. To mitigate this issue, the application of kaempferol (KP), caffeic acid (CA), and plant growth-promoting rhizobacteria (PGPR) emerges as a promising technology. Kaempferol, a flavonoid, protects plants from oxidative stress, while caffeic acid, a plant-derived compound, promotes growth by regulating physiological processes. PGPR enhances plant health and productivity through growth promotion, nutrient uptake, and stress mitigation, providing a sustainable solution. However, combining these compounds against drought requires further scientific justification. That’s why the current study was conducted using 4 treatments, i.e., 0, 20 µM KP, 30 μM CA, and 20 µM KP + 30 μM CA without and with PGPR (Bacillus altitudinis). There were 4 replications following a completely randomized design. Results showed that 20 µM KP + 30 μM CA with PGPR caused significant enhancement in potato stem length (14.32%), shoot root, and leaf dry weight (16.52%, 11.04%, 67.23%), than the control. The enrichment in potato chlorophyll a, b, and total (31.86%, 46.05%, and 35.52%) was observed over the control, validating the potential of 20 µM KP + 30 μM CA + PGPR. Enhancement in shoot N, P, K, and Ca concentration validated the effective functioning of 20 µM KP + 30 μM CA with PGPR evaluated to control. In conclusion, 20 µM KP + 30 μM CA with PGPR is the recommended amendment to alleviate salinity stress in potatoes.

Experimental study of toxic effects of cadmium against background of physical exercise

Introduction. Nowadays, working conditions in industry are often associated with chemical exposure along with manual labour. Given the evidence of the combined effect of heavy metals and muscular work, an increase in cadmium toxicity can be expected. However, an experimental study and actual assessment of exposure to both factors are necessary to avoid underestimation or overestimation of real risks. The purpose of our study was to establish health effects of subchronic cadmium toxicity against background of physical exercise. Materials and methods. In a subchronic animal experiment, four groups of outbred male rats, 14 animals each, were exposed to cadmium chloride at a single dose of 0.77 mg/kg body weight, forced physical exercise (treadmill running), both factors combined, or acted as a control group. Hematological, biochemical, and morphometric indices in rodents were assessed at the end of the experiment. The statistical significance of differences between the groups was established using Student’s t-test (p<0.05). For mathematical modelling, we used the Response Surface Methodology (RSM) with the construction of Loewe isoboles. Results. We observed significant unfavorauble shifts in 27.5% of the assessed morphometric, hematological, biochemical, cytological, and histomorphometric indices in rats following the exposure to cadmium only and in combination with exercise. The mathematical analysis based on the response surface modelling showed the typology of the combined impact of chemical and physical factors to vary depending on the specific effect by which it is assessed, as well as on the dose and level of effect. Limitations. Laboratory animals of only one biological species and sex were used for the experiment, exposed to a single concentration of cadmium and physical exercise of only one intensity level. Conclusion. The principles of health effects of cadmium and physical stress as risk factors of the workplace environment specified in the in vivo experiment may serve as a basis for scientific justification of risk assessment criteria to avoid under- or overestimation of real risks in the occupational setting.

Hygienic problems of using terahertz electromagnetic radiation (literature review)

The purpose of the work is to review and analyze domestic and foreign scientific works, systematize the scope of application of terahertz electromagnetic radiation (EMR) to determine hygienic problems in the field of health risk prevention in the development and use of modern radioelectronic devices. The literature search was conducted on the databases: eLibrary, Web of Science, and fifty. During the study of scientific literature, from over fifty works were analyzed, there 36 sources were selected 36 sources corresponded to the purpose of the study. Today, the urgent tasks are to predict the parameters of a complex electromagnetic environment in open areas and inside buildings using mobile communication standards 4, 5 and 6G, scientific justification of hygienic standards for the combined effects of the electromagnetic factor, methodological approaches to monitoring EMR levels, including the development of domestic selective EMR meters in a wide range of frequencies (radio frequency and terahertz ranges)

THERMODYNAMICS OF CARBOTHERMAL REDUCTION PROCESS COPPER SLAG

The article analyses the thermodynamic laws of processing iron-based compounds contained in copper production slag using the method of carbothermic recovery. Evaluation of the probable direction of carbothermic reactions occurring between oxidized compounds and carbon in the slag was carried out by changing the thermodynamic values of the system. In the thermodynamic scientific justification of the physic-chemical processes occurring in the carbothermic recovery of metal oxides in slag, the change of Gibbs energy of the system with temperature increases and the estimation of equilibrium constants of chemical reactions based on Gibbs energy and the method of determining the slowest (limiting) chemical process among them were used. The Microsoft Excel program was used to determine the thermodynamic values of the chemical reactions occurring in the slag and reducing agent system and to compile their Ellingham graphs.

Scientific Justification of the Rule-Making Initiative of Federal Executive Authorities

Scientific Justification of the Rule-Making Initiative of Federal Executive Authorities

Scientific Justification of the Selection of the Optimum Composition of the Phytocomposition Included in Phytosomal Gel for the Treatment of Cuperosis

Purpose: The research work aims to carry out the acquisition of phytoextracts from green tea leaves, hop cones, and horse chestnut seeds with the participation of various extraction methods for the future preparation of phytosomal gel in the treatment of couperosis, to study their technological and physico-chemical properties. Methods: In the scientific research laboratory of the Department of Pharmaceutical Technology of the Azerbaijan Medical University, a phytocomposition was developed in 5 variants from green tea leaves, hop cones, and horse chestnut seeds in different proportions. Phytoextract was obtained from compositions prepared by maceration and high-speed extraction methods. 70% ethyl alcohol was used as an extractant in the research work. The extraction process was performed twice for each composition. Results: Researches were performed with a high-speed extraction method (High-Speed Dispersator- STEGLER DG-360, 26-28 °C, 50Hs, 2800-28000 cycles/min). The extraction time was 7 minutes in the 1st stage, 3 minutes in the 2nd stage, temperature 26 °C, frequency 50 Hz, power 360 W, 3300 cycles/min. Extracts were also obtained by the maceration method in a cone-shaped glass macerator for 3 days. Physico-chemical properties of extracts (organoleptic properties, dry residue, density, pH, amount of heavy metals) were studied. According to the results of the research, the amount of extractive substances obtained in the Stegler DG 360 model device - a high-speed homogenizer was higher. During the comparative studies conducted with phytocompositions, compositions No. 3 and 5 showed more different results according to the relevant criteria.

Cholesterol to saturated fat index (CSI), metabolic parameters and inflammatory factors among obese individuals

BackgroundThe role of dietary fat quality in promotion of cardiovascular diseases is studies before. However, the results are inconsistent. Recently, cholesterol to saturated fatty acid index (CSI) is suggested as a novel indicator of the atherogenicity and thrombogenicity potential of a diet. However, due to limited number of studies, in the current cross-sectional study, we aimed to evaluate the role of CSI in metabolic and inflammatory response among obese individuals.MethodsIn the current cross-sectional study 488 obese individuals aged 18–50 years old were involved in volunteer based invitation from outpatient obesity clinics. Subjects underwent anthropometric assays including weight, height, waist circumference (WC) and body composition and their fasting blood sample were obtained for biochemical assessments including blood sugar, serum lipids, hs-CRP and IL-6 concentrations by commercial kits. Physical activity was also assessed by short form of international physical activity questionnaire (IPAQ).ResultsAccording to our results, being at the top tetile of CSI was associated with higher anthropometric indices including weight, height, WC, FFM, and basal metabolic rate (BMR) compared with those at the lowest tertile (P < 0.05). Similarly, those at the highest category of CSI had significantly higher levels of serum glucose and hs-CRP both in crude and adjusted models in ANCOVA and in multinomial logistic regression models (P < 0.05).ConclusionIn the current study, for the first time, we identified the possible triggering role of dietary cholesterol to saturated fat index in increasing serum glucose and hs-CRP levels. due to cross-sectional design of the current study, causal inference is impossible. Further studies will help for better scientific justification.

Online exhibition as a tool for the formation of professional competencies of speech therapy students

Introduction. The modern educational model has changed. The organization of educational practices required attention: the search for new tools in the field of teaching methods. The purpose of the study is the scientific justification, design and implementation of an innovative form of work – the creation of an online book exhibition – in the professional training of future correctional teachers. Methodology and research methods. The empirical study, conducted from 2021 to 2023, was attended by students of the specialty "Special defectological education" (profile "Speech Therapy") Tyumen State University (Russia), in the number of 285 people. Methods: analysis of theoretical sources in the field of pedagogy and organization of exhibition activities; design; pedagogical experiment, observation, statistical processing of the results of a survey conducted using Google Forms. Results. We have developed a system of methodological principles for modeling an online exhibition. Over three years, students have created 232 projects. Speech therapists are focused on obtaining professional knowledge: 62% of exhibitions are devoted to speech therapy; 11% – sign language teaching; 8% – typhlopedagogy; 6% – oligophrenopedagogy; 4% – autism spectrum disorder; 4% – neuropsychology; 2% – genetic disorders, other topics – 3%. Microsoft Word (70%), PowerPoint (20%) and other digital tools (10%) were chosen for design; 50% chose the model "proposed by the teacher", 40% compiled ideas, 10% independently developed the concept. Students plan to apply their experience in further education (almost 80%), work with children (63%), consultations with parents (50%) and to improve personal competencies (60%). Practical significance. The presented form of implementation of distance practice forms the universal and professional competencies of students. The presented results are of methodological importance, since they open up prospects for the application of project work in the disciplines of both humanities and natural sciences.