Limited organic matter (OM) characterisation studies on Cretaceous mudstone successions in the Koum Basin have resulted in a significant knowledge gap in the source rock potential; a petroleum system prerequisite. Field mapping and lithofacies analysis of outcrop sections point to fluvial channel and marginal to profundal lake deposits. Representative mudstone samples were evaluated using multiproxy organo-petrographic and bulk geochemical analyses to assess the kerogen type, thermal maturity, hydrocarbon generation potential, and deduce the paleodepositional environment. Results reveal that ∼90% of the samples are organic-lean and ∼10% organic-rich with TOC content of 2.81–6.91 wt%. Rock-Eval pyrolysis S2 yields of 14.50–54.18 mg HC/g rock and hydrogen index (HI) 784–846 mgHC/gTOC, suggest excellent potential for oil generation. High S1 values of 1.18–1.45 mg HC/g rock and low production indices (PI) of 0.02–0.03 indicate in situ generated free hydrocarbons. PI and Tmax of 438°C–443 °C, consistent with measured vitrinite reflectance (Ro% = 0.28–0.53%), Spore Colour Index (SCI = yellow to golden brown) and Thermal Alteration Index (TAI = 1.5 to 2.6) on the Chevron scale, portraying an immature to marginally mature OM. Oil-prone kerogen Type I-II dominates and to a lesser extent gas-prone Type III, derived from algal-terrestrial organic facies, typified by the predominance of amorphous OM 51.2%, liptinites 24.6%, vitrinite 16.4% and inertinite 7.8%. Based on lithofacies, and palynological evidence, a fluvio-lacustrine depositional setting with limited marine influence, under fluctuating warm humid to hot semi-arid paleoclimates, is inferred. A comparison with surrounding petroleum-producing basins further enhances the understanding of the Koum Basin's hydrocarbon potential within the West Central African rift system context.