Role Of Honey Research Articles

SURVIVAL TIME AND HISTOLOGICAL OUTCOME OF MAJOR ORGANS FOLLOWING HONEY ADMINISTRATION TO ACUTE PARAQUAT-INTOXICATED RATS: A PRELIMINARY STUDY

<p><strong>Objective: </strong>The objective of this research was to investigate the possible protective effect of Tualang honey (TH) in acute paraquat (PQ) toxicity in rats.</p><p><strong>Methods: </strong>A total of 48 male Sprague-Dawley rats aged eight weeks old were used. Oral PQ and TH were administered at 225 mg/kg and 0.2 g/kg, respectively. The effects of single and multiple TH treatmentson PQ-intoxicated rats were then investigated. Single TH treatment groups received TH at 0.5 (PQ+TH0.5h), 2 (PQ+TH2h) or 6 (PQ+TH6h) hours following PQ administration. Multiple TH treatment groups received TH at 0.5, 2 and 6 h (PQ+THtrp) or further daily treatment for the following six days (PQ+TH7d) after PQ administration (n=6 per group). The survival time of the rat was recorded until day 28 before sacrifice, which was followed by a histological examination.</p><p><strong>Results: </strong>Treatment with TH did not improve the survival rate of PQ-intoxicated rats. However, the median survival time of rats that received multiple TH treatments was significantly longer compared to that of the PQ+TH6h group. TH treatment was found to improve the histological outcomes of PQ-intoxicated rats, particularly in the lungs.</p><p><strong>Conclusion: </strong>Our findings suggest the potential role of honey in delaying the toxic effects of PQ.</p>

Role of honey as adjuvant therapy in patients with sore throat

Background: Honey is a natural product which has been used since ages for curing of various ailments. Aims and Objectives: To evaluate the effect of honey for control of infection and inflammation in patients with sore throat. Materials and Methods: A total of 200 patients with sore throat were taken up for the study. 100 patients, in the study group, were given one tablespoon of honey twice a day along with anti-inflammatory drugs, antibiotics, and antiseptic gargles. Remaining 100 patients in control group were given other same medications without honey. Patients were evaluated after 5, 10 and 15 days for throat congestion, fever, pain, patient satisfaction, and other criteria. Results: There was faster relief of signs and symptoms of sore throat in the study group as compared to control group. There was greater patient satisfaction in the study group. Conclusion: Honey is effective in faster recovery of signs and symptoms of sore throat having antibacterial and anti-inflammatory properties without causing any side effects.

Role of honey in modern medicine.

Use of honey has a very long history. Honey has been used since ancient time due to its nutritional and therapeutic values. There had been varied ways of consumption honey including its use as a sweetener and flavoring agent. Honey is produced all over the world. The most important nutriment of honey is carbohydrates present in the form of monosaccharides, fructose and glucose. Honey plays an important role as an antioxidant, anti-inflammatory, anti-bacterial agent and augments the adherence of skin grafts and wound healing process. The role of honey has been acknowledged in the scientific literature and there is convincing evidence in support of its antioxidant and antibacterial nature, cough prevention, fertility and wound healing properties. However, its use has been controversially discussed and has not been well accepted in the modern medicine. The aim of this review was explore and highlight the role of honey in modern medicine.

Role of honey after tonsillectomy: a systematic review and meta-analysis of randomised controlled trials.

Honey reduced post-tonsillectomy pain, but its effects on awakening at night, inflammation and healing of the tonsillar fossa were controversial. This systematic review and meta-analysis of randomised controlled trials (RCTs) evaluated the effect of oral honey on pain, consumption of painkillers, awakening at night, healing of tonsillar fossa and adverse effects in children after tonsillectomy. A search of MEDLINE, EMBASE, Scopus, CINAHL and Cochrane Collaboration Library databases was performed without any restriction of publication year. The end date of search was 30 June 2016. The search was supplemented by search from Google, hand search of cross-references of selected articles and reviews, and contacting the authors of different studies. The inclusion criteria were RCTs comparing the effect of honey with control on different outcomes, in children after tonsillectomy. Our search generated 64 studies, and eight RCTs met our inclusion criteria. The methodological quality of RCTs was poor. Compared to control, honey significantly decreased postoperative pain from day 1 to day 7 (P = 0.05 to <0.0001); consumption of painkillers from days 1 to 5 (P = 0.03 to 0.003) and on day 10 (P = 0.002); and number of awakening at night due to pain on days 2 and 4 after tonsillectomy (P = 0.0001, 0.004). The healing of tonsillar fossa was significantly greater with honey compared to control on days 3-4 (P = 0.02) and days ≥9 (P = 0.01) after tonsillectomy. The adverse effects were not significantly different between honey and control groups. The Grading of Recommendation, Assessment, Development and Evaluation (GRADE) of the evidence for different outcomes varied from 'low' to 'very low'. Honey improved pain, requirement of painkillers and awakening at night due to pain in children after tonsillectomy. There was little improvement in healing of tonsillar fossa. The GRADE of the evidence varied from 'low' to 'very low'. A good-quality, placebo-controlled RCT of different doses and durations of administration of honey is required to evaluate its clear efficacy and safety in children after tonsillectomy.

‘The bees are our sheep’: the role of honey and fat in the transition to livestock keeping during the last two thousand years in southernmost Africa

In this paper we suggest a model for how some foragers may have become stock-keepers in the past. Forager beekeepers stay in one place and cultivate a storable and exchangeable product, honey. This desired product has been used by the Okiek forager beekeepers of Kenya to obtain livestock from their pastoralist/agropastoralist neighbours. We believe that amongst foragers such as these the transition to livestock-keeping would not have been as difficult as is sometimes postulated (cf. Marshall 2000; Smith 2005, 2014). We describe parallels between sheep, bees, their products and their keeping, which are informative to the debate. The difficulty for archaeologists is that the archaeology of beekeeping is largely invisible. One exception relates to evidence of interactions between foragers and bees documented in rock-paintings in the uKhahlamba-Drakensberg Mountains, KwaZulu-Natal, South Africa. Here, too, are paintings of sheep that we suggest are old and may represent how foragers thought of sheep during their first encounters with them.

Honey in the Prevention and Treatment of Infection in the CKD Population: A Narrative Review.

Infection is a major cause of morbidity and mortality at all stages of chronic kidney disease (CKD). Multiresistant organisms are becoming increasingly common, particularly in the CKD population. Unfortunately, the rapid evolution of antibiotic resistance has not been mirrored by innovation in new antibiotic agents. Novel treatments are therefore urgently needed. Honey has garnered much interest due to its broad-spectrum antibacterial properties based on extensive experimental data. Unlike conventional antibiotics, honey has an added advantage as it appears to avoid inducing antimicrobial resistance in bacteria. This review discusses the potential mechanisms of action and role of honey in infection management in the general population, epidemiology and special challenges of infections in CKD populations, and the clinical trial evidence pertaining to the safety and efficacy of honey for the prevention and treatment of infections in CKD population.

Abstract 3369: Differential biotherapeutic advantages of honey in targeting the Warburg effect and survival of MRC-5 and A549 cell lines

Abstract Lung cancer is a one of the most prevalent and deadly cancers in United States. Experimental evidence support that cancer cells do exhibit higher glycolytic rates than normal cells (Warburg effect). To exploit this unique cancer-dependent ATP generation phenomenon, we hypothesize that exposure of cancer cells to organic inhibitors of glycolysis would negatively impact their survival and alter their growth and viability resulting from the vast decrease in their essential glycolytic ATP production; no negative consequences will be seen on normal lung cells. The human lung fibroblast cell line MRC-5 and the human alveolar epithelial cell line A549 were used as models for normal lung and lung cancer in vitro in this study. Using standard methods, both cell lines were maintained and exposed to honey and D-glucose reagents at concentration levels ranging from 31.3-2,000 µg/ml in 96 well plates in quadruplets and experiments repeated at least three times using MTT, and cell counting (T4 Cellometer) assays as well as phase-contrast photo-imaging. Our results indicate that exposure of both cell lines to these natural nutraceutic organics resulted in concentration dependent cell destruction/cell survival depending on the cell line exposed. Honey and D-glucose showed statistically significant (p&amp;lt;0.05) differential negative effects on the A549 line in comparison to its unexposed control as well as to their effects on the MRC-5 cell line. Results show a promising role of honey and D-glucose as metabolites of interest for selective management of cancerous cells. Citation Format: Ibrahim O. Farah, Veshell L. Lewis, Wellington K. Ayensu, Joseph A. Cameron. Differential biotherapeutic advantages of honey in targeting the Warburg effect and survival of MRC-5 and A549 cell lines. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3369. doi:10.1158/1538-7445.AM2014-3369

Effects of Honey and Its Mechanisms of Action on the Development and Progression of Cancer

Honey is a natural product known for its varied biological or pharmacological activities—ranging from anti-inflammatory, antioxidant, antibacterial, antihypertensive to hypoglycemic effects. This review article focuses on the role of honey in modulating the development and progression of tumors or cancers. It reviews available evidence (some of which is very recent) with regards to the antimetastatic, antiproliferative and anticancer effects of honey in various forms of cancer. These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. In contrast, limited but promising data are available for other forms of cancers including prostate, bladder, endometrial, kidney, skin, cervical, oral and bone cancer cells. The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. Honey is highly cytotoxic against tumor or cancer cells while it is non-cytotoxic to normal cells. The data indicate that honey can inhibit carcinogenesis by modulating the molecular processes of initiation, promotion, and progression stages. Thus, it may serve as a potential and promising anticancer agent which warrants further experimental and clinical studies.

PO-107: Role of Honey in Prevention of Radiation Induced Mucositis in Head and Neck Cancer

PO-107: Role of Honey in Prevention of Radiation Induced Mucositis in Head and Neck Cancer

The role of honey in healing of bedsores in cancer patients

Background:Honey was used to treat infected wounds as long as 2000 years before bacteria were discovered. It has been reported to have inhibitory action to around 50 species of bacteria and fungi (aspergillus, penicillium). Usually, Metronidazole powder is used in our palliative clinic for wound healing due to low cost & effectivity. Honey is cheap, easily available ingredient with high astringent activity.Objective:Objectives of the study were to find out the effectiveness of Honey in terms of rate of wound healing & pain control in bedsores of cancer patients.Materials and Methods:40 cancer patients with bedsore wounds were randomly assigned (1:1 ratio i.e. 20 in each arm) for Study Arm (Honey plus Metronidazole powder) and Control Arm (only Metronidazole powder), attending Palliative clinic of our department in between July 2010 to September 2011.Washing of the wound with normal saline done daily before application of above medicaments. Change of posture & soft bed were encouraged in both groups. A pre designed interview proforma, standardised Bates Jensen Wound Assessment Tool and Visual Analogue Pain assessment scale were used to collect and assess data.Results:There was significant difference in wound healing status (F value = 6.523; Critical Difference =14.03, P>0.05) from day 10 and pain reduction also (F value = 6.638 and Critical Difference = 1.667, P>0.05) from day 7 in study arm.Conclusion:Application of honey dressing provides a better wound healing, rapid pain relief in cancer patients with bedsores in palliative settings.

Honey-Based Mixtures Used in Home Medicine by Nonindigenous Population of Misiones, Argentina

Honey-based mixtures used in home medicine by nonindigenous population of Misiones, Argentina. Medicinal mixtures are an underinvestigated issue in ethnomedical literature concerning Misiones, one of the most bioculturally diverse province of Argentina. The new culturally sensitive politics of the Provincial Health System is a response to cultural practices based on the medicinal use of plant and animal products in the home medicine of the local population. Honey-based medicinal formulas were investigated through interviews with 39 farmers of mixed cultural (Criollos) and Polish origins in northern Misiones. Fifty plant species and 8 animal products are employed in honey-based medicines. Plants are the most dominant and variable elements of mixtures. Most of the mixtures are food medicines. The role of honey in more than 90% of formulas is perceived as therapeutic. The ecological distribution of taxa and the cultural aspects of mixtures are discussed, particularly the European and American influences that have shaped the character of multispecies medicinal recipes.

Complementary and Alternative Medicine and Cancer Survivorship

Complementary and Alternative Medicine and Cancer Survivorship

Influence of rat strains and/or severity of hyperglycemia on systolic blood pressure and antioxidant enzymes in kidney of rats with hypertension and/or diabetes: Role of honey

Influence of rat strains and/or severity of hyperglycemia on systolic blood pressure and antioxidant enzymes in kidney of rats with hypertension and/or diabetes: Role of honey

Role of honey (Madhu) in the management of wounds (Dushta Vrana)

Application of Madhu (honey) is one among the Shashthi Upakrama (sixty treatment modalities) described by Sushruta. Clinical observation has shown its effectiveness in treatment of Dushta Vrana (chronic wounds). We report a case of Dushta Vrana on the anterior aspect of the right leg that was treated successfully with local application of Madhu and Neem (Azadirachata indica) bark decoction.

Effect of honey on intestinal morphology, intraabdominal adhesions and anastomotic healing

In the present study, attempts have been made to determine the effects of honey on intestinal morphology, postoperative adhesions, and the healing of colonic anastomoses in the rats after colonic resection and anastomosis. Thirty-six rats were randomly divided into three groups each including 12 animals. Colonic resection and anastomosis were performed on all animals. Rats were fed with standard rat chow in group I, standard rat chow plus 10 g/kg/day honey in group II and artificial honey including the same caloric amount with honey in group III. Adhesion scores, bursting pressures and histopathological examinations were evaluated. Colonic bursting pressures of honey group were significantly better than control and artificial honey groups. Histological analysis of anastomotic site showed that submucosa and muscularis propria were nearly filled with granulation tissue and regular fibrin matrix in honey group. There was statistically significant difference between the adhesion scores of honey vs artificial honey and control groups. The scores of histological changes of ileum in honey group were significantly different from other groups. These results indicate a protective role of honey against intraabdominal adhesions and anastomotic dehiscence.

Utilisation of topical honey in burns wounds contaminated with pseudomonas aeroginosa compared with silversulfadiazine and acetatmafenid

Background: Heat injury with consequent coagulation necrosis of skin layers provides an environment that is suitable for bacterial infection as a result of low tissue perfusion and high protein content. Gram negative bacteria and especially Pseudomonas aeroginosa have been recognized as the main causative organisms of burns wound infection. For long time, mankind has been interested in remedial role honey. The role of honey in deep burns wound remains especially after massive secondary bacteria infection has not been sufficiently if documented. Materials and method: In this study, 60 Indian piggies were categorised into three equal groups. A part of the skin of each piggy approximately 8.5cm2, was burned with steam (third degree burns). The wounds were each subsequently inoculated with 10 8 Pseudomonas aeroginosa. For each group a specific dressing agent was used to cover the wounds (honey, 1% silver sulfadiazine or 8.5%Acetatmafenid).On specific days, according to a formulated schedule, the weight of the animals, the condition and extent of wounds were recorded. Culture specimens were also taken for qualitative and quantitative analysis periodically. Results: Out of the three groups the Honey group had the least contamination in prepared specimens on the tenth day (20% compared with 95% and 100% in the other groups), the smallest remaining wound (percentage dwindle in size) 62%, compared to 29% and 22% in the other groups) and the most formation of granulation tissue (90% compared with 35% and 44% in the other groups) at 10 days. Mortality was also least in the honey group (30% with 40% and 45% in the other two groups). Conclusion:The topical use of honey in deep burn wounds contaminated with pseudomonas aeroginosa is superior to silver sulfadiazine and Acetatmefamid in terms of granulation tissue formation, wound healing and antimicrobial effect. Keywords: Indian piggy, honey acetatmafenid, silver sulfadiazine Nigerian Journal of Surgical Research Vol. 7(3&4) 2005: 293-295

An alternative treatment for pityriasis versicolor, tinea cruris, tinea corporis and tinea faciei with topical application of honey, olive oil and beeswax mixture: an open pilot study

Objective: To evaluate the possible role of honey, olive oil and beeswax in the treatment of skin fungal infections. Patients and methods: Thirty-seven patients with pityriasis versicolor, tinea cruris, tinea corporis and tinea faciei were studied. After clinical evaluation of redness, scaling, pruritis and burning/pain sensation and mycological assessment, honey mixture containing honey, olive oil and beeswax (1:1:1) was applied to the lesions three times daily for a maximum of 4 weeks. Results: Clinical response was obtained in 86% of patients with pityriasis versicolor, 78% of patients with tinea cruris and in 75% of patients with tinea corporis. Mycological cure was obtained in 75, 71 and 62% of patients with PV, tinea cruris and tinea corporis, respectively. The patient with tinea faciei showed clinical and mycological cure 3 weeks after commencement of therapy. Conclusion: Honey mixture may have place in the management of these skin conditions and rigorous, controlled trials are justified.

The sensitivity to honey of Gram-positive cocci of clinical significance isolated from wounds.

To determine the sensitivity to honey of Gram-positive cocci of clinical significance in wounds and demonstrate that inhibition is not exclusively due to osmotic effects. Eighteen strains of methicillin-resistant Staphylococcus aureus and seven strains of vancomycin-sensitive enterococci were isolated from infected wounds and 20 strains of vancomycin-resistant enterococci were isolated from hospital environmental surfaces. Using an agar incorporation technique to determine the minimum inhibitory concentration (MIC), their sensitivity to two natural honeys of median levels of antibacterial activity was established and compared with an artificial honey solution. For all of the strains tested, the MIC values against manuka and pasture honey were below 10% (v/v), but concentrations of artificial honey at least three times higher were required to achieve equivalent inhibition in vitro. Comparison of the MIC values of antibiotic-sensitive strains with their respective antibiotic-resistant strains demonstrated no marked differences in their susceptibilities to honey. The inhibition of bacteria by honey is not exclusively due to osmolarity. For the Gram-positive cocci tested, antibiotic-sensitive and -resistant strains showed similar sensitivity to honey. A possible role for honey in the treatment of wounds colonized by antibiotic-resistant bacteria is indicated.

The role of honey in the management of wounds.

A review of the evidence on the advantages of using honey as a topical wound treatment together with practical recommendations for its clinical use.

Nutrients in Social Wasp (Hymenoptera: Vespidae, Polistinae) Honey

Previous investigators have questioned the temporal occurrence, biochemistry, and nutritional use of honey sometimes present in nests of some social polistine wasps. Honey of species in the genera Polistes and Polybia contains diverse amino acids. Inositols (alicyclic polyalcohols) also are present in the honey of both genera; quercitol was the most abundant inositol in honey of Polistes metricus (Say) from Missouri, but it was not present in honey of Polybia diguetana R. du Buysson from Costa Rica. Honey of P. metricus from Missouri is similar to that of Brachygastra mellifica (Say) because it contained more fructose than glucose. Honey has been seen in P. metricus nests in Missouri at all phases of the colony cycle except late preemergence (1st pupae); scattered but suggestive observations indicate that swarm-founding tropical polistine wasps store honey primarily during low activity phases of the colony cycle in locales with alternating wet and dry or subtropical seasons. Although the nutritional value of wasp honey seems clear, the nutritional role of honey in wasp colonies remains unknown.