Aiming at the problems of low data acquisition efficiency, unintuitive data form, low relative accuracy, and inability to continuously monitor the whole cross-section in traditional roadway rock deformation monitoring methods, a roadway rock deformation monitoring method based on mobile 3D laser scanning technology is proposed. Firstly, the mobile 3D laser scanning technology is used to obtain the real 3D point cloud data of the roadway surrounding rock; secondly, the multi-scale dimensional features are used to classify the 3D point cloud data, filter the invalid point cloud data, and form the accurate point cloud data of the roadway surrounding rock surface; then the 3D laser scanning is carried out on a regular basis for the deformation-prone areas of the roadway, and the Iterative Closest Point Algorithm (ICP algorithm) is used to align the overlapping part of the point cloud to achieve the point cloud splicing and point cloud stitching of the two scans. The point cloud splicing and point cloud overlapping of the two scans are achieved; finally, the multi-scale model-to-model point cloud comparison algorithm (M3C2 algorithm) is used to compare the point cloud data of the two periods of the roadway, and the appropriate parameters are selected to indicate the displacement change of the surface of the roadway rock with the size of the color value, so as to realize the monitoring of the deformation of the roadway rock in the three-dimensional full cross-section of the roadway. The method is applied to the deformation monitoring of the surrounding rock in the return roadway of 21407 working face in a coal mine, and the results show that: the mobile laser scanning technology can be used to obtain the complete point cloud data of the roadway, and the deformation area of the surrounding rock is successfully identified after the classification of the scanned point clouds in different time periods, the alignment of the point clouds, and the comparison of the point clouds, and the deformation condition of the surrounding rock of the roadway is visually reflected in the three-dimensional full-section deformation condition of the surrounding rock of the roadway. This method is suitable for monitoring the overall de-formation of the surrounding rock of the roadway under complex environmental conditions, and the de-formation of the surrounding rock is identified by different color areas.