You have accessJournal of UrologyStone Disease: Basic Research II1 Apr 2014MP25-14 KIDNEY STONES ARE A RISK FACTOR FOR CKD AND ESRD Jonathan Shoag, Joshua Halpern, David Goldfarb, and Brian Eisner Jonathan ShoagJonathan Shoag More articles by this author , Joshua HalpernJoshua Halpern More articles by this author , David GoldfarbDavid Goldfarb More articles by this author , and Brian EisnerBrian Eisner More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.316AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Kidney stones and chronic kidney disease (CKD) are both common conditions that have been increasing in prevalence over the past two decades. Some evidence suggests that stone disease is a risk factor for CKD and end stage renal disease (ESRD). Our objective was to characterize the relationship between urolithiasis and CKD in the NHANES database. METHODS The National Health and Nutrition Examination Survey (NHANES 2008-2010) database was interrogated for patients with a history of kidney stones (n=12,110). Glomerular filtration rate (GFR) and urine albumin to creatinine ratio (ACR) data were available in 6,839 and 8,398 of patients, respectively. CKD was defined as a composite of albuminuria and GFR. Dialysis was assessed by the response to the question “Have you received dialysis in the past 12 months?” Demographics and comorbid conditions including age, sex, body mass index (BMI), diabetes, hemoglobin A1c, hypertension, gout and smoking were also assessed. Multivariate analysis adjusting for the aforementioned demographics and comorbidities was performed to assess differences in the prevalence of CKD and requirement of hemodialysis (HD) between the two groups. Statistical calculations were performed using Stata software (StataCorp LP, Texas) with determinations of p-values and 95% confidence intervals where appropriate. RESULTS The age adjusted prevalence of CKD was significantly higher in those with a history of kidney stones than those without (18.81 % vs 12.58%, p=0.0012). Simlarly, patients with a history of stones had a higher age adjusted need for dialysis (4.14% vs 1.52%, p=0.0009). These differences held true when controlled for demographics and comorbidities on multivariate analysis. Patients with a history of stones were more likely to have CKD odds ratio (OR) 1.42 (95% CI 1.044-1.935, p=0.028), and to require dialysis, OR 2.252 (1.097-4.624, p=0.029). A history of kidney stones also significantly increased the age adjusted probability of CKD among those with obesity, diabetes, and hypertension and combinations of these risk factors (figure 1, p for trend=0.006) CONCLUSIONS Kidney stone history is associated with an increased odds of chronic kidney disease and need for dialysis even after adjusting for co-morbid conditions. Large-scale prospective studies are needed to further characterize the relationship between urolithiasis and CKD. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e272 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Jonathan Shoag More articles by this author Joshua Halpern More articles by this author David Goldfarb More articles by this author Brian Eisner More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...