This paper presents the results of an experimental and numerical campaign aimed at investigating the flexural behaviour of both metallurgically bonded steel-aluminium foam-steel sandwich (MBSAFS) panels and steel-MBSAFS composite beams. Three-point bending tests were carried out and the obtained results were used to validate the accuracy of analytical models to predict the stiffness and resistance of both MBSAFS panels and the composite beams. The predictive capacity of the analytical equations was further verified against the results of parametric finite element simulations, which were also carried out to investigate the influence of the thickness of the steel sheet, the foam thickness, the strength of the materials, the span length, and the type of beam profile. The comparative analysis demonstrated that the predictive formulae accurately provide both stiffness and resistance. The stiffness was predicted with a mean ratio (analytical/FEM) equal to 1, accompanied by a coefficient of variation (CoV) equal to 0.02. The plastic resistance of the composite beam was predicted with a mean accuracy of 0.96 and a coefficient of variation of 0.01.