Functional Results Research Articles

Sanders IV Calcaneus Fracture Treated with Open Reduction and Internal Fixation with a Moldable Plate: A Case Report

Introduction: Calcaneus fractures are the most common tarsal bone fractures, affecting patients quality of life due to osteoarthrosis and a rigid gait. Management must be individualized based on fracture line characteristics, physical activity, and patient life expectancy. Clinical case: A 70-year-old Mexican woman with a history of osteopenia fell, imaging showed traces of a multi-fragmentary fracture, including involvement of the subtalar joint and widening and displacement of the posterior tuberosity of the calcaneus. Open surgery was scheduled 72 hours later, and the patient underwent early mobilization of the ankle, knee, and hip without support. Discussion: The calcaneus is an irregular bone that supports 50% of the forces in the foot during ambulation and standing, resulting in significant deficits after an injury. The surgical management of calcaneal fractures has been criticized for its sequelae, poor functional results, and associated risks. The best management for complex calcaneal fractures is open reduction with primary arthrodesis of the subtalar joint, resulting in a rigid, non-painful foot with adequate mobility. Conclusion: Calcaneal fractures are challenging to manage due to their high complexity and frequency. With advances in preoperative, transoperative, and post-surgical care, traditional methods can be satisfactory. However, infrequency and complexity make it difficult to define specific management definitively.

Inhibiting Interfacial Electron Leakage via An Artificial Rectified Layer for Longevous Zinc Metal Anodes.

Dendrites and water-induced side reactions impose greatly challenge on the implementation of aqueous zinc ion batteries. To tackle these problems, an artificial rectified layer (ARL) with hydrophobic, zincophilic and insulating features was in-situ synthesized on Zn surface rapidly to prevent the electron leakage from Zn anode to aqueous electrolyte, which is the underlying logic for uneven Zn deposition and parasitic side reactions. The ARL also displays a high Zn2+ transference number of 0.71 and can build fast Zn2+ transport channels to homogenize the interfacial ion flux and electric field according to the calculated work function and multi-physics phase simulation results. Therefore, the Zn anode with ARL shows preferred plating along with (002) crystal facet and an admirable Coulombic efficiency of 99.86% over 3200 cycles. Zn symmetric cells can withstand large current density up to 40 mA cm-2 and operate stably at 44.2% depth of discharge for 250 hours, surpassing most of published reports. The ARL also enables the Zn||MnO2 full batteries to circulate over 2600 cycles with a high-capacity retention of 80.1% and low self-discharge at 1 A g-1. This work provides a different perspective to comprehend and design satisfactory solid electrolyte interphase for Zn metal anodes.

Midterm to Long-term Follow-up After Limited Saucerization of a Discoid Lateral Meniscus: Radiological and Functional Outcomes With Age-Dependent Variations.

A discoid lateral meniscus (DLM) is the most common meniscus variant and is commonly treated with arthroscopic saucerization. There are mixed data regarding long-term results after surgery, especially in terms of radiological parameters. The aim was to evaluate the functional and radiological results of patients who underwent arthroscopic saucerization for a symptomatic DLM. It was hypothesized that successful outcomes can be achieved by avoiding excessive resection while reshaping only to an extent that prevents mechanical symptoms. Case series; Level of evidence, 4. This study retrospectively analyzed pediatric and adult patients who had a symptomatic discoid meniscus between 2000 and 2018, who underwent arthroscopic saucerization with at least 10 mm of peripheral length, and who had at least 5 years of follow-up. Radiological parameters were measured on both preoperative and follow-up radiographs. Patient-reported outcome measure scores were recorded at follow-up. The study included 57 knees of 53 patients (mean age, 27.6 years [range, 6-65 years]). The mean follow-up duration was 12.1 years (range, 5.0-23.1 years). There were 31 knees in the pediatric group and 26 knees in the adult group. No significant difference was found between the groups or between preoperative and follow-up values for the femorotibial angle (P > .05). When the preoperative and follow-up Kellgren-Lawrence grades were compared, no change was observed in the pediatric group (P = .125), while grades were shown to progress in the adult group (P < .001). The mean Lysholm score was 94.61 ± 7.61 and 84.23 ± 14.90 for the pediatric and adult groups, respectively (P = .001). Overall, 2 patients underwent arthroscopic surgery because of a symptomatic recurrence of symptoms, and 2 patients underwent arthroplasty because of osteoarthritis. The 10-year survival rate was 90.6%. Limited saucerization of a DLM helped to preserve coronal-plane knee joint alignment. Functional and radiological results were superior in the pediatric patients. Even when alignment was more varus in older patients, preoperative and follow-up femorotibial angles were not statistically significant. This outcome may be used to guide treatment in appropriately selected cases.

Finite cut-off JT and Liouville quantum gravities on the disk at one loop

Within the path integral formalism, we compute the disk partition functions of two dimensional Liouville and JT quantum gravity theories coupled to a matter CFT of central charge c, with cosmological constant Λ, in the limit c → −∞, |Λ| → ∞, for fixed Λ/c and fixed and finite disk boundary length ℓ, to leading and first subleading order in the 1/|c| expansion. In the case of Liouville theory, we find perfect agreement with the asymptotic expansion of the known exact FZZT partition function. In the case of JT gravity, we obtain the first explicit results for the partition functions at finite cut-off, in the three versions (negative, zero and positive curvature) of the model. Our findings are in agreement with predictions from the recent proposal for a microscopic definition of JT gravity, including the c → −∞ expansion of the Hausdorff dimension of the boundary. In the negative curvature case, we also provide evidence for the emergence of an effective Schwarzian description at length scales much greater than the curvature length scale.

Geometrically constrained quantum dynamics: numerical solution of the Schrödinger equation on a comb

Abstract The comb model constitutes a simplified model for investigation of the dynamics in heterogeneous and anisotropic media and its implementation in the Schrödinger equation enables understanding of the wave packet spreading in such media. In this article, the time-dependent Schrödinger equation (TDSE) in the presence of comb-like geometric constraints is numerically solved. The comb-like constraints in the Hamiltonian are tailored by a modified Laplacian operator, which incorporates the Dirac delta function. To devise an appropriate numerical scheme, we regularize the Dirac delta function by its approximation of Gaussian form. Further, the finite difference method for spatial discretization and the fourth order Runge-Kutta method for the time evolution are employed. The obtained results for the wave function are compared with the analytical solutions, previously obtained in an infinite domain and a thorough analysis is carried out. The best comparison is found for short and intermediate time intervals. After validating the numerical scheme, we investigate the influence of the initial conditions on the probability density function (PDF). The TDSE was first solved with the initial conditions of Gaussian form, and then a comb-like shape of the initial wave function was proposed. The latter leads to pronounced localization in the narrow regions along the backbone, which disappears after a long time and resembles the similar behaviour of the PDF, as in the case of Gaussian initial condition. The numerical scheme developed in this work widens the applicability of the comb model for finite domains and nontrivial initial conditions, where analytical solution is not possible. Therefore, this improves the perspectives for modeling of the realistic experimental situations, where the domains are finite.

Comparing Clinical Outcomes of Five-Strand Hamstring Tendon Autograft and Quadrupled Hamstring Tendon Autograft for Single Bundle Anterior Cruciate Ligament Reconstruction in Filipinos

Background: Anterior cruciate ligament (ACL) tears are common, especially in athletes, and are often treated with hamstring tendon autografts using a single-bundle technique. Graft diameter is crucial, with evidence showing that larger grafts reduce failure risk. Asian populations typically have smaller graft diameters. This study compares the clinical outcomes of the five-strand versus the quadrupled technique in a Filipino Asian population to assess potential benefits in graft thickness and knee stability. Objective: To compare the functional outcomes, graft sizes, failure rates, and time to return to sports between five-strand and quadrupled hamstring tendon autografts in ACL reconstruction. Methodology: This ambi-directional cohort study involved Asian Filipino patients aged 18–50 with unilateral ACL tears who underwent single-bundle ACL reconstruction with either quadrupled or five-strand hamstring autografts between January 2022 and August 2023. Data on graft dimensions, IKDC scores, and time to return to sports were collected pre- and postoperatively. The analysis included descriptive statistics, Fisher’s exact test, t-tests, and ANOVA, with significance at p &lt; 0.05. Result: The study included 18 patients, showing no significant differences in demographic characteristics such as age (24.78 vs. 27.67 years, p = 0.202), height (1.71 vs. 1.64 meters, p = 0.146), weight (84.43 vs. 74.98 kg, p = 0.252) or body mass index (28.95 vs. 27.98 kg/m², p = 0.714); average return to sports (10.63 vs. 11.83 months, p = 0.642). There was no significant difference in thicknesses (p = 0.089) and lengths (p = 0.885) of the graft. IKDC scores showed no significant differences between the two groups in pre- or postoperative outcomes at six months and one year. Complications were minimal, with no significant difference found. Conclusion: Both the five-strand and quadrupled techniques demonstrated similar demographics, graft dimensions, and clinical outcomes, indicating comparable functional results and safety profiles.

Comparison of radiological, clinical, and functional results of Jakob type-2 lateral condyle fractures treated with closed reduction and percutaneous pinning versus open reduction and K-wire fixation.

Comparison of radiological, clinical, and functional results of Jakob type-2 lateral condyle fractures treated with closed reduction and percutaneous pinning versus open reduction and K-wire fixation.

Evaluation of Effectiveness of Nanocrystalline Hydroxyapatite and Demineralized Bone Matrix Combined with Titanium-platelet Rich Fibrin for Ridge Preservation: A Randomized Controlled Clinical Trial.

Preservation of ridge dimensions is the important aspect after tooth extraction for prosthetic and implant rehabilitation. Titanium-platelet rich fibrin (T-PRF) is an autologous biomaterial, and when used with bone graft it could enhance the bone regeneration. Hence, the aim of this study was to evaluate the combined effect of T-PRF with nanocrystalline hydroxyapatite (Nano-HA) and T-PRF with demineralized bone matrix (DMBM). Twenty systemically healthy patients were included in the study and were randomly assigned into two groups. Ten patients were treated with atraumatic extraction followed by ridge preservation using Nano-HA bone graft and T-PRF. In another group of ten patients, ridge preservation was done using a xenograft-DMBM. Preoperative cone beam computed tomography (CBCT) and postoperative CBCT after 3 months were evaluated for bone fill. The clinical parameters of ridge width (RW) and ridge height were measured clinically, with the help of UNC 15 probe, after 3 months. The treatment modality resulted in significant bone fill in CBCT and adequate RW clinically in both the groups. The mean bone density in the Nano-HA + T-PRF group was recorded as 776.72 ± 223.94, and 854.72 ± 183.57 was observed in the DMBM + T-PRF group, after 14-16 weeks. The study's findings indicate that ridge preservation performed at the time of extraction is a reliable and predictable approach for minimizing alveolar bone resorption. Additionally, the combination of T-PRF with bone grafts yields effective results in a relatively short timeframe. This technique involves combining osteoconductive material from Nano-HA and DMBM and the growth factor-rich matrix of T PRF for quicker healing and better esthetic and functional results. It reduces morbidity in patients, does not require an autogenous graft, is biocompatible, and is economical; therefore, both clinical practice and regenerative research in the field of dentistry are advanced. Hence, it is one of the important evidences through this original study. How to cite this article: Patil RT, Dhadse PV, Salian SS, et al. Evaluation of Effectiveness of Nanocrystalline Hydroxyapatite and Demineralized Bone Matrix Combined with Titanium-platelet Rich Fibrin for Ridge Preservation: A Randomized Controlled Clinical Trial. J Contemp Dent Pract 2024;25(11):1069-1076.

Performance of Camellia oleifera Seedlings Under Alkali Stress Improved by Spraying with Types of Exogenous Biostimulants

Exogenous biostimulants (EB) are crucial for reducing abiotic stress in plants. It is currently unclear how EB such as melatonin (MT), betaine (BA), and salicylic acid (SA) regulate the stress in Camellia oleifera seedlings under alkali stress (XP). This study demonstrates the moderating effect of SA (0.5, 1, and 2 mmol/L), BA (0.2, 0.4, and 0.8 g/L), and MT (200, 400, and 800 μmol/L) on the relative chlorophyll content, photosynthetic parameters, chlorophyll fluorescence parameters, osmoregulatory substances, and antioxidant enzymes in C. oleifera seedlings under XP. The results showed that spraying different types and different concentrations of EB under alkali stress had a certain alleviating effect on the phenotype of C. oleifera seedlings. Whether 7 or 15 days after the application of EB, the relative chlorophyll content (SPAD) and the degree of yellowish-green in the control group were different from those in the other 10 treatment groups, but the difference in brightness was not significant. As far as the malondialdehyde (MDA) content is concerned, the SA2, BA3, MT2, and MT3 treatment groups can significantly reduce the MDA content on the 7th day of EB application. The electrolytic leakage (EL) is also significantly reduced by MT2 and MT3. It was found that treatment groups SA3 and MT2 could improve the photosynthetic parameters of C. oleifera seedlings to different degrees on the 7th day of EB application. On the 15th day of EB application, treatment groups SA1, SA3, BA1, and BA2 all increased the photosynthetic rate of C. oleifera compared to the XP treatment group, but other treatments did not increase. At the same time, the results showed that the fluorescence parameters of the seedlings showed different degrees of improvement under different EB spraying conditions. Under alkali stress, soluble proteins (SP) and soluble sugars (SS) increased in the XP group, but it was found that the SA3, BA3, and MT2 treatment groups could reduce the content of osmoregulatory substances both on the 7th and 15th days of EB application. In terms of proline (Pro) content, BA1, BA2, and MT2 treatment groups could reduce Pro content on the 7th and 15th days of EB spraying, respectively. As for the antioxidant enzymes, the SA2, BA3, MT2, and MT3 treatment groups could basically increase the activity of antioxidant enzymes and further reduce oxidative damage on the 7th day of application of EB. According to the comprehensive results of the membership function, whether on the 7th or 15th day of EB spraying, the MT2 treatment group has the best overall mitigation effect of the three EB applications, ranking in the top three. This study will help to improve the scientific understanding of C. oleifera’s alkali resistance and interaction with EB while filling the knowledge gap on the physiological response to oleofylline stress.

Some Results of R-Matrix Functions and Their Fractional Calculus

In this study, we explore various fractional integral properties of R-matrix functions using the Hilfer fractional derivative operator within the framework of fractional calculus. We introduce the θ integral operator and extend its definition to include the R matrix functions. The composition of Riemann–Liouville fractional integral and differential operators is determined using the θ-integral operator. Additionally, we investigate the compositional properties of θ-integral operators, and we establish their inversion, offering new insights into their structural and functional characteristics.

Bosworth fracture: Pathoanatomy, Complications, and Medium-term Results of Treatment.

Bosworth fractures (BFs) with entrapment of a fibular fragment behind the posterior malleolus (PM) are rare but potentially serious injuries to the ankle. Despite an increased awareness through a more regular use of computed tomography (CT) scanning, there is still a scarcity of clinical outcome studies. Over a course of 25 years, data on 23 patients treated for BF at our institutions (mean age 44 years) were collected prospectively. Of those, 16 patients had a Weber type B fracture with displacement of the proximal fibular fragment and 7 patients Weber type C fractures with displacement of the distal fibular fragment behind PM. All but 1 patient, who refused operative treatment, were treated with open reduction and internal fixation. A total of 21 patients were followed up for an average of 66 (range, 18-204) months. The PM was fractured in 96% and the Tillaux-Chaput tubercle in 13% of cases. In 80% of patients with preoperative CT scans, the fibular fragment was entrapped between the posterior aspect of the distal tibia and the displaced PM fragment. An initial attempt at closed reduction was successful in 4 of 7 Weber type C fractures and in none of 16 Weber type B fractures. The overall complication rate was 22%. Eighty-one percent of patients rated their results as good or excellent. The American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot score at the final follow-up averaged 84.1 (range, 45-100). Risk factors for postoperative osteoarthritis and poor functional results included unsuccessful closed reduction, inadequate open reduction, and avascular necrosis of the talus. Clinical and radiographic results were correlated. Unsuccessful initial reduction and failure to achieve anatomic open reduction were associated with posttraumatic arthritis whereas open anatomic reduction and internal fixation resulted in favorable functional and radiographic results in the medium to long term.

Cartilage graft and temporal muscle fascia graft in revision myringoplasty: a comparison of anatomical and functional results with an innovative surgical technique

BackgroundThe temporal muscle fascia is the most widely used type of tissue graft in revision myringoplasty procedures. The aim of this study was to verify if the use of a cartilage graft may be a valid alternative to temporalis fascia. Tympanic reperforations are frequent after myringoplasty, especially in complicated, large, or anterior perforations, so we decided to compare the neodrum stability of two different surgical techniques.Materials and methodsThe study was conducted on 42 patients who underwent revision myringoplasty, carried out with the overlay technique, between 2004 and 2020. In all patients, the retroauricular approach was used. The subjects included in the study were divided into 2 groups: the former was treated with a cartilage graft, while in the latter a temporalis fascia graft was used. In the comparison of the two groups, the following outcomes were taken into consideration: engraftment rate, incidence of complications, pre- and postoperative air conduction pure tone average and air-bone gap.ResultsThe success rate was 100% for the first group and 83.3% for the second, with a statistically not significant difference. Among the subjects treated with cartilage graft, complications were observed in 8.3% of the cases, while in patients treated with fascia graft the observed complication rate was 43.3% (p = 0.03), maybe due to the shorter follow-up period of the first group. The improvement of the air conduction pure tone average was greater with cartilage graft (p = 0.02), whereas the difference between air-bone gap closures in the two groups was not statistically significant.ConclusionThe cartilage graft can represent a valid alternative to temporal muscle fascia, guaranteeing excellent engraftment, fewer complication rate and satisfactory hearing outcomes.

Can robotic arm-assisted total knee arthroplasty be applied to valgus deformity.

Total knee arthroplasty (TKA) in valgus knees is challenging. Optimal ligament balance, implant neutral or moderate valgus alignment are crucial but conventional instrumentations usually lead to outliers. Robotic arm assisted TKA (RATKA) advantages could answer this challenge. Objectives were to assess RATKA frontal alignment accuracy for valgus knees, rotational femoral component reliability, revision surgery rate and functional outcomes for this population. This study is based on a continuous series of 454 RATKA. Implants were positioned according to a patient-specific alignment and postero-stabilised inserts were used. Valgus values, range of motion, KOOS and revision surgery rates were assessed at one-year postoperative. Femoral component rotation was analysed intraoperatively. MAKO navigation system confirmed valgus preoperative deformity for 34 patients. Mean postoperative valgus value was - 1.5°±1.53 (range, -5 to 1), 85% patients had a residual valgus between 0 and - 3°, 97% of patients had a difference < 3° between valgus planned and valgus measured at one year postoperatively. Mean femoral rotation was + 2.65°±1.87 (range, 0 to 6.8°) of external rotation related to posterior condylar angle. No revision surgery has been performed. Mean KOOS value at one year was 80.79. 76% of patients (n = 26) had a good (70-80) or excellent (> 80) KOOS score. Mean flexion value was 133°±12 (range, 100 to 140). RATKA can be applicable in valgus knee, offering high precision in component positioning with very few outliers. It also facilitates component rotation positioning, providing excellent functional results and ROM.

An analysis of heavy silicone oil treatment for inferior proliferative vitreoretinopathy

PurposeProliferative vitreoretinopathy (PVR) is a complication of retinal detachment which requires multiple vitreoretinal surgical interventions and frequent use of oil endotamponade. In this study, we conducted an in-depth analysis of complications associated with the use of heavy silicone oil in the management of inferior PVR.MethodsA retrospective cohort study of 20 eyes that underwent vitrectomy for inferior PVR with use of heavy silicone oil (Densiron 68) between March 2021 and October 2022 at Oxford Eye Hospital. Complications were classified into major categories relating to intraocular pressure, inflammation, lens, and oil emulsification/migration. Visual outcomes and surgical success rate were also evaluated.ResultsFill-induced pressure spikes (> 30 mmHg) within 14 days post-surgery were common after Densiron tamponade, especially in patients previously on glaucoma drops. The number of glaucoma drugs were increased in 45% of patients during Densiron tamponade. In 20% of cases, an increased medication was continued long-term after Densiron removal. Significant cataract progression occurred in all phakic patients. In 25% of pseudophakic cases, posterior capsule opacification was noted. Inflammatory complications, such as anterior uveitis, were rare and any cystoid macular oedema was transient. No unexplained acute loss of vision following Densiron removal was encountered. The anatomical success rate at 30 days after Densiron removal was 70%. The mean (± SD) best-corrected visual acuities were 1.04 (± 0.79), 0.85 (± 0.62) and 0.50 (± 0.51) logMAR prior, during and after Densiron tamponade, respectively.ConclusionThe outcomes in this cohort treated with Densiron 68 were comparable to previously reported anatomical and functional results in cases with inferior PVR. IOP and lens-related complications require additional treatment during or after Densiron tamponade. Inflammatory complications rarely occurred over tamponade durations of around three months.Trial registrationAnalyses were conducted as an internal quality improvement audit and as such did not require external IRB review.

P0433 Pouchitis described by the SES-CD score is more associated with the need for biologics initiation after IPAA than endoscopic subscore of PDAI

Abstract Background The ileal pouch-anal anastomosis (IPAA) is a well-established approach following proctocolectomy for ulcerative colitis (UC) or colorectal dysplasia. Although the functional results are good, many patients develop pouchitis. The pouchitis disease activity index (PDAI) is the most used tool to assess the inflammation of the pouch. However, the PDAI with endoscopic subscore of PDAI (ePDAI) is often not reliable or responsive (1, 2). The simplified endoscopic score for Crohn’s disease (SES-CD) has recently been proposed for this setting (3). In this retrospective study, we aim to describe the correlation between SES-CD score and several important clinical outcomes. Methods We performed a retrospective cohort study of patients who underwent IPAA surgery between March 2015 and February 2024 at out tertiary referral centre. According to internal hospital protocol, endoscopic and clinical examinations were performed at 1, 3, 6, and 12 months after IPAA for each patient. The ePDAI scores, demographics, comorbidities, laboratory tests and medication use were collected from the electronic medical records. Data was collected for the first year following IPAA surgery, and last known follow up. All pouchoscopies (n=497, 86.4% of total) with video- (83.5%) or photodocumentation (16.5 %) were reviewed by the same reviewer (JS) and additionally scored with SES-CD endoscopic score in the pouch body and afferent ileum. Descriptive and univariate analyses was performed. Kaplan-Meier curves were used to assess the impact of the ePDAI and SES CD scores for initiation of biologics. Pouchoscopies were classified as low-grade (ePDAI ≤ 1; SES CD ≤ 3) or high-grade inflammation (ePDAI &amp;gt; 1; SES CD &amp;gt; 3). Results The total cohort included 206 patients (46.1% female), of which 90.3% underwent IPAA surgery due to ulcerative colitis with a median follow up of 25 months after IPAA construction. Of those, 12.6% were receiving biologic therapy at the last follow up. There was linear corelation between ePDAI and SES-CD score (rho 0.69, p&amp;lt;0.001). For both scores, the patients with high-grade inflammation pouchoscopy at months 1 (p 0.0132 for ePDAI, p 0.0008 for SES-CD) and 6 (p 0.0001 for ePDAI, p 0.0007 for SES-CD) had a higher need for biologic therapy than patients with low-grade pouchoscopy. At month 3 and 12, only SES-CD was associated with higher need for biologic therapy (month 3: p 0.467 for ePDAI, p 0.042 for SES-CD; month 12: p 0.0571 for ePDAI and p 0.0387 for SES CD). Conclusion The SES-CD score may be an alternative to ePDAI for scoring of pouch inflammation. The pouch inflammation described by the SES-CD score is more associated with the need for biologics initiation in patients after IPAA than ePDAI. References (1)Jairath V, Feagan BG, Silverberg MS, et al. Mucosal healing with vedolizumab in patients with chronic pouchitis: EARNEST, a randomized, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. Published online 2024. doi: 10.1016/j.cgh.2024.06.037 (2)Sedano R, Nguyen TM, Almradi A, et al. Disease activity indices for pouchitis: A systematic review. Inflamm Bowel Dis. 2022;28(4):622-638. doi:10.1093/ibd/izab124 (3)Barnes EL, Long MD, Raffals L, et al. Development of the endoscopic pouch score for assessment of inflammatory conditions of the pouch. Clin Gastroenterol Hepatol. 2023;21(6):1663-1666.e3. doi: 10.1016/j.cgh.2022.04.026

P0498 Relationship Of Disease Activation And Treatment With Pulmonary Function Tests And Obstructive Sleep Apnea Syndrome In Ulcerative Colitis Patients

Abstract Background Ulcerative colitis (UC) is a chronic disease with relapses and remissions that may also be associated with extra-intestinal pathologies (1). Patients may develop anemia due to chronic disease or bloody diarrhea, which may cause shortness of breath and limitation in exercise capacity (2). The aim of this study was to compare UC patients with healthy subjects and to determine the relationship between the presence of the disease, activation status and treatment with pulmonary function and obstructive sleep apnea syndrome (OSAS). Methods The study included 55 UC patients admitted to the Inflammatory Bowel Diseases (IBD) outpatient clinic of Gaziantep University School of Medicine within the last year and 55 healthy controls. Disease activation and endoscopic evaluation were based on Mayo score. Pulmonary function test, lung diffusion test (DLCO), MMRC score and six-minute walk test were performed in all participants. In the Berlin Questionnaire, the patient is questioned about the frequency and severity of snoring, the frequency of diagnosed apnea and the presence of hypertension or obesity. Each category is evaluated within itself and if two or more categories are positive, the risk of OSAS is considered high according to the Berlin questionnaire. Results In the control group, the rate of patients who exceeded 80% of the expectation in the six-minute walk test was higher than UC patients (p:0.001). MMRC score was significantly higher in UC patients compared to the control group (p:0.001). According to the Berlin questionnaire, 56.4% of UC patients were at high risk for OSAS, while this rate was 30.9% in the control group (p:0.007). FEV1 value was higher in UC patients who received biological agents compared to those who did not (p:0.041). As the endoscopic mayo score increased, patients were found to be at higher risk for OSAS in the Berlin questionnaire (p:0.002). UC patients with severe disease were more likely to be at high risk for OSAS than patients with mild and moderate disease (p:0.001). Although the MMRC score was numerically higher in patients with severe disease than in patients with mild and moderate disease, it was not statistically significant (p:0.065). Conclusion Extra-intestinal manifestations such as arthritis, uveitis are more recognised in UC, but respiratory pathologies are often overlooked (3). As shown in our study, UC patients have poorer results in respiratory function and a higher risk of OSAS compared to healthy individuals, and conditions such as severe disease and high mayo score in subgroups of UC patients also adversely affect these parameters. For all these reasons, assessment of pulmonary function and OSAS risk in UC patients should be a routine part of patient management. References 1-Wangchuk P, Yeshi K, Loukas A. Ulcerative colitis: clinical biomarkers, therapeutic targets, and emerging treatments. Trends Pharmacol Sci. 2024;45(10):892-903. doi: 10.1016/j.tips.2024.08.003. 2-Kucharzik T, Koletzko S, Kannengiesser K, Dignass A. Ulcerative Colitis-Diagnostic and Therapeutic Algorithms. Dtsch Arztebl Int. 2020;117(33-34):564-574. doi: 10.3238/arztebl.2020.0564. 3-Hao G, Zhu B, Li Y, Wang P, Li L, Hou L.Sleep quality and disease activity in patients with inflammatory bowel disease: a systematic review and meta-analysis.Sleep Med. 2020;75:301-308. doi: 10.1016/j.sleep.2020.08.032.

Ultrasound-guided release of carpal tunnel syndrome - anterograde technique.

Compression of the median nerve in the carpal tunnel is a frequent pathology with severe functional impact. An ultrasound-guided technique was developed to preserve structures, diminish scar fibrosis and enable fast return to full activity. Its advantages are safety and low additional cost. Ultrasound-guided carpal tunnel release is indicated in moderate and severe carpal tunnel syndrome persisting after conservative treatment. A preoperative ultrasound scan is recommended to evaluate anatomy. Recurrent carpal tunnel syndrome, secondary carpal tunnel syndrome and anatomic variants compromising the safety of transverse carpal ligament division are contraindications. The procedure is performed under local anesthesia without tourniquet. The entry point is a short transverse incision proximal to the wrist crease. The transverse carpal ligament is divided anterogradely, using a dedicated blade under ultrasound control, making sure no nerves, tendons or blood vessels are injured. The final step is to check that the division is complete. Early return to use of the hand is permitted. Reports of similar techniques demonstrated early symptomatic relieve, favorable patient-reported outcome measures from within 1 week after surgery to 2 years' follow-up, with early return to normal daily activity and work. The complications rate is low: many series showed no complications. Comparative studies between ultrasound-guided carpal tunnel release and the mini-open technique reported similar or greater and quicker symptom relief, less scar pain and better strength. Final functional results tend to be similar.

Retrospective cross-sectional study on bronchiectasis in adult Aboriginal Australians: disease characteristics and comparison with ethnically diverse global bronchiectasis registry cohorts

BackgroundGlobally, adult Indigenous people, including Aboriginal Australians, have a high burden of chronic respiratory disorders, and bronchiectasis is no exception. However, literature detailing bronchiectasis disease characteristics among adult Indigenous people...

Pure Open Internal Subtalar Dislocation: About A Case

Subtalar dislocation is a rare traumatic injury to the foot in which the calcaneus and the navicular bone are displaced relative to the talus which maintains its normal relationship within the tibiotalar mortise. It must be considered a therapeutic emergency, and no treatment is specific to this lesion. We report a case of pure open internal subtalar dislocation stage 2 of Gustillo and Anderson following a domestic accident falling from the height of a Baobab tree of approximately 3 m: The patient benefited from an urgent reduction followed by a stabilization with arthrosis by two calcaneo-talo-tibial pins, and cast immobilization for six weeks. After a 12-month follow-up, the functional results were satisfactory.

ON THE CONVERGENCE OF ZETA FUNCTIONS OF PREHOMOGENEOUS VECTOR SPACES

Abstract We prove a general convergence result for zeta functions of prehomogeneous vector spaces extending results of H. Saito, F. Sato and Yukie. Our analysis points to certain subspaces which yield boundary terms. We study it further in the setup arising from nilpotent orbits. In certain cases we determine the residue at the rightmost pole of the zeta function.