Evaluation of Effectiveness of Nanocrystalline Hydroxyapatite and Demineralized Bone Matrix Combined with Titanium-platelet Rich Fibrin for Ridge Preservation: A Randomized Controlled Clinical Trial.

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Preservation of ridge dimensions is the important aspect after tooth extraction for prosthetic and implant rehabilitation. Titanium-platelet rich fibrin (T-PRF) is an autologous biomaterial, and when used with bone graft it could enhance the bone regeneration. Hence, the aim of this study was to evaluate the combined effect of T-PRF with nanocrystalline hydroxyapatite (Nano-HA) and T-PRF with demineralized bone matrix (DMBM). Twenty systemically healthy patients were included in the study and were randomly assigned into two groups. Ten patients were treated with atraumatic extraction followed by ridge preservation using Nano-HA bone graft and T-PRF. In another group of ten patients, ridge preservation was done using a xenograft-DMBM. Preoperative cone beam computed tomography (CBCT) and postoperative CBCT after 3 months were evaluated for bone fill. The clinical parameters of ridge width (RW) and ridge height were measured clinically, with the help of UNC 15 probe, after 3 months. The treatment modality resulted in significant bone fill in CBCT and adequate RW clinically in both the groups. The mean bone density in the Nano-HA + T-PRF group was recorded as 776.72 ± 223.94, and 854.72 ± 183.57 was observed in the DMBM + T-PRF group, after 14-16 weeks. The study's findings indicate that ridge preservation performed at the time of extraction is a reliable and predictable approach for minimizing alveolar bone resorption. Additionally, the combination of T-PRF with bone grafts yields effective results in a relatively short timeframe. This technique involves combining osteoconductive material from Nano-HA and DMBM and the growth factor-rich matrix of T PRF for quicker healing and better esthetic and functional results. It reduces morbidity in patients, does not require an autogenous graft, is biocompatible, and is economical; therefore, both clinical practice and regenerative research in the field of dentistry are advanced. Hence, it is one of the important evidences through this original study. How to cite this article: Patil RT, Dhadse PV, Salian SS, et al. Evaluation of Effectiveness of Nanocrystalline Hydroxyapatite and Demineralized Bone Matrix Combined with Titanium-platelet Rich Fibrin for Ridge Preservation: A Randomized Controlled Clinical Trial. J Contemp Dent Pract 2024;25(11):1069-1076.