A series of freeze-thaw cycling tests, as well as cyclic loading and unloading tests, have been conducted on nodular sandstones to investigate the effect of fatigue loading and freeze-thaw cycling on the damage evolution of fractured sandstones based on damage mechanics theory, the microstructure and sandstone pore fractal theory. The results show that the number of freeze-thaw cycles, the cyclic loading level, the pore distribution and the complex program are important factors affecting the damage evolution of rocks. As the number of freeze-thaw cycles rises, the peak strength, modulus of elasticity, modulus of deformation and damping ratio of the sandstone all declined. Additionally, the modulus of elasticity and deformation increase nonlinearly as the cyclic load level rises. With the rate of increase decreasing, while the dissipation energy due to hysteresis increases gradually and at an increasing rate, and the damping ratio as a whole shows a gradual decrease, with a tendency to increase at a later stage. The NRM (Nuclear Magnetic Resonance) demonstrated that the total porosity and micro-pores of the sandstone increased linearly with the number of freeze-thaw cycles and that the micro-porosity was more sensitive to freeze-thaw, gradually shifting towards meso-pores and macro-pores; simultaneously, the SEM (Scanning Electron Microscope) indicated that the more freeze-thaw cycles there are, the more micro-fractures and holes grow and penetrate each other and the more loose the structure is, with an overall nest-like appearance. To explore the mechanical behavior and mechanism of cracked rock in high-altitude and alpine areas, a damage model under the coupling of freeze-thaw-fatigue loading was established based on the loading and unloading response ratio theory and strain equivalence principle.