Resorbable Blast Media Surface Research Articles

Comparison of mechanical stability of mini-screws with resorbable blasting media and micro-arc oxidation surface treatments under orthodontic forces: An in vitro biomechanical study

The aim of this study was to compare the primary stability of mini-screws with different surface treatments such as resorbable blasting media (RBM) and micro-arc oxidation (MAO) under in vitro orthodontic forces. Thirty-six self-drilling TiAl6V4-ELI grade 23 titanium alloy 1.6×8mm mini-screws were inserted into polyurethane foam blocks and divided into three groups according to surface properties: machine surface (MS), RBM-treated, and MAO-treated. An orthodontic force of 150g was applied to the mini-screws using NiTi coils. Maximum insertion torque (MIT) and maximum removal torque (MRT) were measured with a digital torque screwdriver during insertion and removal. For each mini-screw, stability measurements were made with the Periotest M device at day 0 and weeks 1, 2, 4, 8, and 12. Significant differences in MIT were observed between all groups in pairwise comparisons (P<0.001) with the highest value in the MAO-treated group and the lowest in the MS group. The mean MRT values differed in all three groups (P=0.001). In pairwise comparisons of MRT, only the difference between MS group and RBM-treated group was significant. The highest value was observed in the RBM-treated group, while the lowest value was observed in the MS group. Periotest values were significantly higher in the MAO-treated group than the RBM-treated group at weeks 8 and 12. A positive significant correlation was found between MIT and MRT in all groups. No significant correlation was found between MIT, MRT and Periotest values in all groups. RBM-treated group was significantly higher than the MS group in MIT and MRT values. According to Periotest values, RBM-treated group was found to be significantly more stable than the MAO-treated group at weeks 8 and 12. Therefore, RBM surface treatment was found to be more favourable than other surfaces to increase success rate in clinical applications.

A retrospective study of the long-term survival of RESTORE® dental implants with resorbable blast media surface.

The aim of this study was to retrospectively evaluate the survival and failure rates of RESTORE® implants over a follow-up period of 10-15 years at a university dental hospital and to investigate the factors affecting the survival rate of these dental implants. A total of 247 RESTORE® dental implants with a resorbable blast media (RBM) surface inserted in 86 patients between March 2006 and April 2011 at the Department of Periodontology of Seoul National University Dental Hospital were included. Patients with follow-up periods of less than 10 years were excluded, and data analysis was conducted based on dental records and radiographs. Over a 10- to 15-year period, the cumulative survival rate of the implants was 92.5%. Seventeen implants (6.88%) were explanted due to implant fracture (n=10, 4.05%), peri-implantitis (n=6, 2.43%), and screw fracture (n=1, 0.4%). The results of univariate regression analysis using a Cox proportional hazards model demonstrated that implants placed in male patients (hazard ratio [HR], 4.542; 95% confidence interval [CI], 1.305-15.807; P=0.017) and implants that supported removable prostheses (HR, 15.498; 95% CI, 3.105-77.357; P=0.001) showed statistically significant associations with implant failure. Within the limitations of this retrospective study, the RESTORE® dental implant with an RBM surface has a favorable survival rate with stable clinical outcomes.

Osteoconductivity of Porous Titanium Structure on Implants in Osteoporosis

In compromised bone conditions such as osteoporosis, developments of the implant surface are necessary to secure the stability of implants. This study investigated the effect of the surface porous titanium structure (PS) on the osseointegration of implants in osteoporotic bone. Bilateral ovariectomy (OVX) was performed in 4 female beagle dogs to induce osteoporosis for 32 wk. Success of induction was based on the evaluation of bone mineral density by Hounsfield units (HU) in computed tomography images. Posterior teeth in both mandibles were extracted 1 wk after OVX, and a total of 30 implants (15 implants in each group) were placed after 32 wk of osteoporosis induction. The control group implant underwent resorbable blast media (RBM) surface treatment, whereas the test group underwent RBM surface treatment in the coronal two-thirds and a PS added to the apical 3-mm portion. HU values in the mandibular trabecular bone, lumbar, and femoral head significantly decreased 32 wk after OVX, confirming osteoporotic condition after induction. Resonance frequency analysis and removal torque test showed comparable values between the 2 groups at 4 wk after implant placement. The surface topography of the implant after removal showed hard tissue integration at the PS in the test group. Bone-to-implant contact length was greater in the apical portion of the test group, although statistical significance was not found between the groups. Interthread bone area in the apical portion of the test group showed a significant increase compared to the control group (control: 0.059 ± 0.041 mm2, test: 0.121 ± 0.060 mm2, P = 0.028) with the histological feature of bone ingrowth at the PS. The findings of the study demonstrated that the surface PS could improve osteoconductivity in the osteoporotic trabecular bone by bone ingrowth at the pore space, thereby enhancing the osseointegration and stability of the implants.

İmplant Uzunluklarının ve Tasarımının İmplant Primer Stabilite Üzerine Etkilerinin Rezonans Frekans Analizi Kullanılarak Değerlendirilmesi: İn Vitro Bir Çalışma

Background:Primary stability (PS) is dependent on the length and diameter of the implant, micro-morphology of the implant surface, implant design, surgical procedure, bone quantity and quality.The aim of this study was to compare short and standart dental implants according to primary stability in bone type IV using Resonance frequency analysis (RFA) test equipment.Methods: Seventy two dental implants; sandblasting with large grit particles and acid etching (SLA) surface (Dentium®,SimpleLine II, Seoul, Korea), SLActive surface- (Straumann Roxolid®, Basel, Switzerland), Resorbable blast media (RBM) surface- (Implance®,Trabzon, TURKEY) with short (4-and 6-mm length) and standart dental implants (10-mm length) were placed in bovine cow ribs with bone quality similar to a type IV human bone.RFA was performed to evaluate the primary stability. The parameters of three groups were compared with the Mann–Whitney U test. Results:Implant stability quotient (ISQ)measurements of 4-mm and 6-mm length implants were similar however, 10-mm-length implants showed statistically difference inter-groups. SLActive surface in 10-mm-length implant group showed highest ISQ value (p &amp;lt; 0.005). When primary stability was compared in intra groups, SLA surface and RBM surface implants showed no significant difference, but 10-mm-length of SLActive surface implant showed higher ISQ value than 4-and 6-mm length (p&amp;lt; 0.005).Conclusion: The length and diameter of the implants might be more effective in primary stability compared to surface design and surface properties in short implants and SLActive surface implants may show better primary stabiliy in standard implants.

Influence on Bone-to-Implant Contact of Non-Thermal Low-Pressure Argon Plasma: An Experimental Study in Rats

Roughness characteristics play an essential role in osseointegration. However, there is a concern about the susceptibility of those surfaces to bacterial colonization. New techniques for cleaning and surface treatment have appeared that could favor osseointegration without the need to create surfaces as rough. Such is the case of non-thermal low-pressure argon plasma (NTLP-ArP). One hundred and forty-four implants were placed in the tibiae of 36 Sprague Dawley rats, distributed in four experimental groups: I: mechanized surface; II: mechanized surface treated with NTLP-ArP, III: resorbable blast media (RBM) surface; and IV: RBM surface treated with (NTLP-ArP). Bone-to-implant contact (BIC) percentages were calculated by microtomographic evaluation and histological analysis at one, two, and four weeks after implant placement. ANOVA and Mann–Whitney tests were used for statistical analysis, establishing p &lt; 0.05. No significant differences were found at one-week comparisons. The groups treated with NTLP-ArP obtained higher BIC% than those not treated at two and four weeks. Mechanized surfaces treated with NTLP-ArP obtained BIC values similar to RBM surfaces.

Long-term evaluation of the prognosis of straight and tapered implant with resorbable blast media surface: Retrospective clinical study

Long-term evaluation of the prognosis of straight and tapered implant with resorbable blast media surface: Retrospective clinical study

Surface alterations following instrumentation with a nylon or metal brush evaluated with confocal microscopy

PurposeSurface alterations of titanium discs following instrumentation with either a nylon brush or a metal brush were evaluated.MethodsA total of 27 titanium discs with 3 surface types (9 discs for each type), including machined (M) surfaces, sandblasted and acid-etched (SA) surfaces, and surfaces treated by resorbable blast media (RBM), were used. Three discs were instrumented with a nylon brush, another 3 discs were instrumented with a metal brush, and the remaining 3 discs were used as controls for each surface type. Surface properties including the arithmetic mean value of a linear profile (Ra), maximum height of a linear profile (Rz), skewness of the assessed linear profile (Rsk), arithmetic mean height of a surface (Sa), maximum height of a surface (Sz), developed interfacial area ratio (Sdr), skewness of a surface profile (Ssk), and kurtosis of a surface profile (Sku) were measured using confocal microscopy.ResultsInstrumentation with the nylon brush increased the Ra, Sa, and Sdr of the M surfaces. On the SA surfaces, Ra, Sa and Sdr decreased after nylon brush use. Meanwhile, the roughness of the RBM surface was not affected by the nylon brush. The use of the metal brush also increased the Ra, Sa, and Sdr of the M surface; however, the increase in Sdr was not statistically significant (P=0.119). The decreases in the Rz, Sz, Ra, Sa, and Sdr of the SA surfaces were remarkable. On the RBM surfaces, the use of the metal brush did not cause changes in Ra and Sa, whereas Rz, Sz, and Sdr were reduced.ConclusionsTitanium surfaces were altered when instrumented either with a nylon brush or a metal brush. Hence, it is recommended that nylon or metal brushes be used with caution in order to avoid damaging the implant fixture/abutment surface.

Evaluation of Effect of Low-Dose Methotrexate on Osseointegration of Implants: A Biomechanical Study on Dogs.

Background:Methotrexate (MTX) is an immunosuppressive drug, widely used in inflammatory disturbances including rheumatoid arthritis. However, there is no consensus regarding the effect of MTX on implant osseointegration.Objective:The purpose of this experimental study was to investigate the effect of low dose MTX on Bone-Implant Contact (BIC) of dogs.Methods:Six mandibular premolar teeth (bilateral) of 8 mature dogs were extracted. After 3 months of healing, 6 implants (bone level, resorbable blast media surface) were inserted into the mandible of each dog (3 in each side). Dogs were randomly divided into a study group (receiving 2.5 mg/week MTX orally, 3 times per week for 4 weeks) and a control group each containing 4 dogs. In the 1st week, postoperative BIC was evaluated in 4 dogs, two from each group. In the 4th week, reverse torque and BIC were evaluated in the remaining 4 dogs. Data were analyzed with two-way ANOVA test for 95% confidence interval.Results:The reverse torque test of the 4th week, showed a satisfying osseointegration. Histopathologic evaluation revealed that the BIC was significantly higher in the control group in comparison to the MTX group in the 1st and 4th week. In addition, the BIC of both groups were significantly increased in the 4th week in comparison to the 1st week in both groups.Conclusion:MTX has the potential to interfere with osseointegration process.

The Effects of a Er:YAG Laser on Machined, Sand-Blasted and Acid-Etched, and Resorbable Blast Media Titanium Surfaces Using Confocal Microscopy and Scanning Electron Microscopy

Purpose: Laser treatment has become a popular method in implant dentistry, and lasers have been used for the decontamination of implant surfaces when treating peri-implantitis. This study was performed to evaluate the effects of an Erbium-doped:Yttrium-Aluminum-Garnet (Er:YAG) laser with different settings on machined (MA), sand-blasted and acid-etched (SA), and resorbable blast media (RBM) titanium surfaces using scanning electron microscopy and confocal microscopy. Materials and Methods: Four MA, four SA, and four RBM discs were either irradiated at 40 mJ/20 Hz, 90 mJ/20 Hz, or 40 mJ/25 Hz for 2 minutes. The specimens were evaluated with scanning electron microscopy and confocal microscopy. Result: The untreated MA surface demonstrated uniform roughness with circumferential machining marks, and depressions were observed after laser treatment. The untreated SA surface demonstrated a rough surface with sharp spikes and deep pits, and the laser produced noticeable changes on the SA titanium surfaces with melting and fusion. The untreated RBM surface demonstrated a rough surface with irregular indentation, and treatment with the laser produced changes on the RBM titanium surfaces. The Er:YAG laser produced significant changes on the roughness parameters, including arithmetic mean height of the surface (Sa) and maximum height of the surface (Sz), of the MA and SA surfaces. However, the Er:YAG laser did not produce notable changes on the roughness parameters, such as Sa and Sz, of the RBM surfaces. Conclusion: This study evaluated the effects of an Er:YAG laser on MA, SA, and RBM titanium discs using confocal microscopy and scanning electron microscopy. Treatment with the laser produced significant changes in the roughness of MA and SA surfaces, but the roughness parameters of the RBM discs were not significantly changed. Further research is needed to evaluate the efficiency of the Er:YAG laser in removing the contaminants, adhering bacteria, and the effects of treatment on cellular attachment, proliferation, and differentiation.

EVALUATION OF RESORBABLE BLAST MEDIA SURFACE IN IMMEDIATE DENTAL IMPLANT

INTRODUCTION: Ten adult patients with age ranged from 20-40 years having maxillary anterior tooth indicated for extraction. After extraction was done installation of immediate dental implant into fresh extraction socket using RBM surface treated dental implant. The patients were evaluated clinically and radiographically by using periapical radiograph and cone beam CT (CBCT). OBJECTIVE: This study aimed to evaluate the outcome of Resorbable Blast Media (RBM) surface treated dental implant placed into fresh extraction socket. MATERIALS AND METHODS: Ten adult patients with age ranged from 20-40 years having maxillary anterior tooth indicated for extraction. After extraction was done installation of immediate dental implant into fresh extraction socket using RBM surface treated dental implant. The patients were evaluated clinically and radiographically by using periapical radiograph and cone beam CT (CBCT). RESULTS: In this study no severe pain was recorded postoperatively. No signs of infection or swelling were observed in our patients along the follow up period. The Mean value of the primary stability was 64.10 ± 4.79 ISQ and the mean value of secondary stability (after 6 months) was 66.10 ± 4.77 ISQ which was statistically not significant. The mean value of marginal bone loss was 0.22 ± 0.07mm after 6 months. CONCLUSION: Immediate placement of dental implant in fresh extraction socket should be considered as a valuable option to replace missing tooth in anterior maxilla. The RBM surface treated dental implant can support osseointegration. KEY WORDS: Immediate implant, RBM surface, Osstell. CONFLICT OF INTEREST: The authors declare that they have no conflicts of interest.

Histological Evaluation of Nano-Micro Titanium Implant Surface Treatment in Beagle Humerus.

The objective of this study was to investigate the effects of nano-micro titanium implant surface using histology in beagle dogs. A total of 48 screw-shaped implants (Megagen, Daegu, Korea) which dimensions were 4 mm in diameter and 8.5 mm in length, were used. The implants were classified into 4 groups (n = 12): machined surface (M group), RBM (Resorbable Blasting Media) surface (R group), nano surface which is nanotube formation on the machined surface (MA group) and nano-micro surface which is nanotube formation on the RBM surface (RA group). Anodic oxidation was performed at a constant voltage of 20 V for 10 min using a DC power supply (Fine Power F-3005; SG EMD, Anyang, Korea). The bone blocks were investigated using histology. There was no inflammation around implants, and new bone formation was shown along with the nano-micro titanium implant surfaces. The amount of bone formation was increased depending on time comparing 4 weeks and 12 weeks. At 12 weeks, lamellar bone was more formed along with the nano-micro titanium implant surfaces than 4 weeks. It indicated that nano-micro surface showed good result in terms of osseointegration.

Mechanical and Histological Effects of Resorbable Blasting Media Surface Treatment on the Initial Stability of Orthodontic Mini-Implants.

Introduction. This study aimed to evaluate the effects of resorbable blasting media (RBM) treatment on early stability of orthodontic mini-implants by mechanical, histomorphometric, and histological analyses. Methods. Ninety-six (64 for mechanical study and 32 for histological study and histomorphometric analysis) titanium orthodontic mini-implants (OMIs) with machined (machined group) or RBM-treated (CaP) surface (RBM group) were implanted in the tibiae of 24 rabbits. Maximum initial torque (MIT) was measured during insertion, and maximum removal torque (MRT) and removal angular momentum (RAM) were measured at 2 and 4 weeks after implantation. Bone-to-implant contact (BIC) and bone area (BA) were analyzed at 4 weeks after implantation. Results. RBM group exhibited significantly lower MIT and significantly higher MRT and RAM at 2 weeks than machined group. No significant difference in MRT, RAM, and BIC between the two groups was noted at 4 weeks, although BA was significantly higher in RBM group than in machined group. RBM group showed little bone resorption, whereas machined group showed new bone formation after bone resorption. Conclusions. RBM surface treatment can provide early stability of OMIs around 2 weeks after insertion, whereas stability of machined surface OMIs may decrease in early stages because of bone resorption, although it can subsequently recover by new bone apposition.

Bone cutting capacity and osseointegration of surface-treated orthodontic mini-implants.

ObjectiveThe objective of the study was to evaluate the practicality and the validity of different surface treatments of self-drilling orthodontic mini-implants (OMIs) by comparing bone cutting capacity and osseointegration.MethodsSelf-drilling OMIs were surface-treated in three ways: Acid etched (Etched), resorbable blasting media (RBM), partially resorbabla balsting media (Hybrid). We compared the bone cutting capacity by measuring insertion depths into artificial bone (polyurethane foam). To compare osseointegration, OMIs were placed in the tibia of 25 rabbits and the removal torque value was measured at 1, 2, 4, and 8 weeks after placement. The specimens were analyzed by optical microscopy, scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDS).ResultsThe bone cutting capacity of the etched and hybrid group was lower than the machined (control) group, and was most inhibited in the RBM group (p < 0.05). At 4 weeks, the removal torque in the machined group was significantly decreased (p < 0.05), but was increased in the etched group (p < 0.05). In the hybrid group, the removal torque significantly increased at 2 weeks, and was the highest among all measured values at 8 weeks (p < 0.05). The infiltration of bone-like tissue surface was evaluated by SEM, and calcium and phosphorus were detected via EDS only in the hybrid group.ConclusionsPartial RBM surface treatment (hybrid type in this study) produced the most stable self-drilling OMIs, without a corresponding reduction in bone cutting capacity.

Analysis of Removal Torque of Injection Molded Zirconia Implants; An Experimental Study on Beagles.

This study compared the removal torque between injection molded zirconia implants and titanium implants with resorbable blast media (RBM) surfaces in beagle humeri. Fifteen screw-shaped implants were classified into 3 groups; titanium implant with RBM surface (Group RT), injection molded zirconia implant (Group Zr) and injection molded zirconia implant with sand-blasted surface (Group ZrS). Implants were inserted into beagle humeri. After 12 weeks, removal torque values were measured. The Zr group has a slightly higher removal torque value than the RT and ZrS groups but there were no significant differences among groups. Zirconia implants shows a similar removal torque to RBM titanium implants. This in vivo study showed injection molded zirconia implants could be an alternative to RBM titanium implants in terms of removal torque.

Comparative Study of the Early Loading of Resorbable Blasting Media and Sandblasting with Large-grit and Acid-etching Surface Implants: A Retrospective Cohort Study.

Purpose:This study compares the prognosis (the survival rate and marginal bone loss) of resorbable blasting media (RBM) surface implants and sandblasting with large-grit and acid-etching (SLA) surface implants in the early loading.Methods:This study targeted 123 patients treated by implants installation from January 2008 to March 2010. The loading was initiated in the maxilla within three to four months and in the mandible within one to two months. The types of restoration were single crown and fixed partial prosthesis. Those functioned over one year. The implants were classified by the surface of implants as Group 1: RBM surface (GS III; OSSTEM, Busan, Korea) and, Group 2: SLA surface (Superline; Dentium, Seoul, Korea). The groups were categorized by maxilla and mandible and compared by survival rate, marginal bone loss through clinical records evaluation, and radiographic measurements.Results:The marginal bone loss in the maxilla was 0.14±0.34 mm (Group 1) and 0.30±0.37 mm (Group 2), a statistically significant difference (P <0.05). In the mandible those were 0.28±0.54 mm (Group 1) and 0.20±0.33 mm (Group 2), not significant (P >0.05). There was no significant difference of marginal bone loss between maxilla and mandible by groups. During observation there was no implant failure, a survival rate of 100%.Conclusion:Both surfaces showed an excellent survival rate, and the marginal bone loss was not substantial.

Antibacterial releasing titanium surface using albumin nanoparticle carriers.

We developed a simple and highly efficient method for delivery from titanium (Ti) surfaces using albumin nanoparticle carriers. A Ti disc with a resorbable blasting media surface was used as a metal implant with a localized drug delivery structure. Human serum albumin (HSA) nanoparticles loaded with chlorhexidine (CHX) diacetate salt hydrate as the model drug were fabricated using a desolvation technique. The CHX-loaded HSA nanoparticles produced were cross linked with glutaraldehyde (GA). The nanoparticles were pre-coated with positively-charged polyethylenimine (PEI) molecules and then immobilized via electrical interactions on the negatively charged Ti disc surface. Our results suggested that the PEI-coated HSA nanoparticles loaded with CHX (PEI-CHX-HSA) were incorporated successfully and well-dispersed on the Ti disc surfaces. The agar diffusion test on the Ti surface treated with PEI-CHX-HSA nanoparticles showed a larger growth inhibition zone of Streptococcus mutans versus the control Ti surface, suggesting that this innovative delivery platform imparts potent antibacterial activity to the Ti surface. Thus, CHX, which inhibits the growth of oral bacteria, can be efficiently incorporated onto Ti surfaces by using HSA nanoparticles.

Evaluation of Stability Changes in Magnesium-Incorporated Titanium Implants in the Early Healing Period

The aim of the present study was to determine the bone response to magnesium (Mg) ion-incorporated titanium (Ti) implants during the early healing period. A total of 114 patients (69 men and 45 women aged between 29 and 71 years) participated in the study. Overall, one hundred thirty-three 10-mm-long fixtures were installed, composed of 65 Mg ion-incorporated fixtures in the test group (55 participants; 30 males and 25 females) and 68 resorbable blast media (RBM) surface fixtures in the control group (59 participants; 39 males and 20 females). The bone responses were evaluated by resonance frequency analysis (RFA) at the following time points after implant insertion (ie, the healing period): 0, 2, 4, 8, and 12 weeks. Each time an RFA measurement was taken, the stability changes relating to both bone quality and implant arch location (maxilla or mandible) were recorded for further analysis. The mean stabilities were lowest at week 4 of healing for both the test and control groups. Significant differences in RFA values between the 2 groups were found at week 12 of healing. The mean percentage change in implant stability quotient (ISQ) from the baseline revealed that the implant stability of the Mg ion-incorporated test group had increased (4.55%) more than the RBM surface group (2.23%) by week 12 of healing. With respect to bone quality, the mean ISQ of Mg-incorporated Ti implants only changed significantly during the 12-week period for type 4 bone. Furthermore, at weeks 4 and 12 of healing, significant differences were found between the 2 groups for type 2 and type 4 bone. A comparison of the stability patterns of mandibular and maxillary implants revealed that the overall stability was higher in the mandible; however, no significant difference was found for Mg-incorporated Ti implants. The Mg-incorporated Ti implants exhibited a slightly better bone response with respect to ISQ than did the RBM surface implants, and the percentage change in mean ISQ from the baseline was greater for the Mg-incorporated group than for the RBM surface group at the end point of this study.

Histologic Evaluation of a Retrieved Endosseous Implant: A Case Report

An implant that had penetrated the nasal cavity of a 53-year-old woman was removed after 10 months. The implant had a resorbable blast media surface and an external connection. Histomorphometric evaluation showed that the mean bone-implant contact ratio was 88.08%, and excellent osseointegration was observed. The mean bone fill between threads was 78.46%.

Prospective study of tapered resorbable blasting media surface implant stability in the maxillary posterior area

The purpose of this study was to evaluate the stability of tapered resorbable blasting media surface implants in the posterior maxilla. From September 2008 through January 2010, 20 patients (9 men, 11 women) who were treated with tapered GS III implants at Seoul National University Bundang Hospital were identified. Thirty-eight implants (14 premolar and 24 mol/L) were placed in maxillary posterior areas. The patients' mean age was 52.1 years, and the mean follow-up period was 12.6 months after final prosthesis delivery. The implant length was 11.8 ± 1.4 mm with a diameter of 4.6 ± 0.5 mm. The 1-year survival rate was 97.4%, and the success rate was 94.7%. The implant stability quotient value at implant placement was 63.6 and 74.4 at the second surgery, which indicated a significant difference. There was no significant difference in crestal bone loss according to implant diameter or length or sinus bone graft. This study showed the favorable clinical outcome of tapered implants that were placed in the maxillary posterior area.

The cytocompatibility and osseointegration of the Ti implants with XPEED® surfaces

This study evaluated cytocompatibility and osseointegration of the titanium (Ti) implants with resorbable blast media (RBM) surfaces produced by grit-blasting or XPEED(®) surfaces by coating of the nanostructured calcium. Ti implants with XPEED(®) surfaces were hydrothermally prepared from Ti implants with RBM surfaces in a solution containing alkaline calcium. The surface characteristics were evaluated by using a scanning electron microscope (SEM) and surface roughness measuring system. Apatite formation was measured with SEM after immersion in modified-simulated body fluid and the amount of calcium released was measured by inductively coupled plasma optical emission. The cell proliferation was investigated by MTT assay and the cell attachment was evaluated by SEM in MC3T3-E1 pre-osteoblast cells. Thirty implants with RBM surfaces and 30 implants with XPEED(®) surfaces were placed in the proximal tibiae and in the femoral condyles of 10 New Zealand White rabbits. The osseointegration was evaluated by a removal torque test in the proximal tibiae and by histomorphometric analysis in the femoral condyles 4 weeks after implantation. The Ti implants with XPEED(®) surfaces showed a similar surface morphology and surface roughness to those of the Ti implants with RBM surfaces. The amount of calcium ions released from the surface of the Ti implants with XPEED(®) surfaces was much more than the Ti implants with RBM surfaces (P < 0.05). The cell proliferation and cell attachment of the Ti implants showed a similar pattern to those of the Ti implants with RBM surfaces (P > 0.1). Apatite deposition significantly increased in all surfaces of the Ti implants with XPEED(®) surfaces. The removable torque value (P = 0.038) and percentage of bone-to-implant contact (BIC%) (P = 0.03) was enhanced in the Ti implants with XPEED(®) surfaces. The Ti implants with XPEED(®) surfaces significantly enhanced apatite formation, removal torque value, and the BIC%. The Ti implants with XPEED(®) surfaces may induce strong bone integration by improving osseointegration of grit-blasted Ti implants in areas of poor quality bone.