Abstract
Background:Methotrexate (MTX) is an immunosuppressive drug, widely used in inflammatory disturbances including rheumatoid arthritis. However, there is no consensus regarding the effect of MTX on implant osseointegration.Objective:The purpose of this experimental study was to investigate the effect of low dose MTX on Bone-Implant Contact (BIC) of dogs.Methods:Six mandibular premolar teeth (bilateral) of 8 mature dogs were extracted. After 3 months of healing, 6 implants (bone level, resorbable blast media surface) were inserted into the mandible of each dog (3 in each side). Dogs were randomly divided into a study group (receiving 2.5 mg/week MTX orally, 3 times per week for 4 weeks) and a control group each containing 4 dogs. In the 1st week, postoperative BIC was evaluated in 4 dogs, two from each group. In the 4th week, reverse torque and BIC were evaluated in the remaining 4 dogs. Data were analyzed with two-way ANOVA test for 95% confidence interval.Results:The reverse torque test of the 4th week, showed a satisfying osseointegration. Histopathologic evaluation revealed that the BIC was significantly higher in the control group in comparison to the MTX group in the 1st and 4th week. In addition, the BIC of both groups were significantly increased in the 4th week in comparison to the 1st week in both groups.Conclusion:MTX has the potential to interfere with osseointegration process.
Highlights
Dental implants are the current replacement for missing teeth
As there is no consensus regarding the effect of MTX on implant osseointegration, the purpose of the current study was to investigate the effect of low dose MTX therapy on the osseointegration process of a canine model
This study was conducted in accordance with the Animal Welfare Act and the Guide for the Care and Use of Laboratory Animals
Summary
Dental implants are the current replacement for missing teeth. Direct bone formation on the surface of implants, later termed as Osseointegration, was first introduced by the experiments conducted by Branemark et al in the late 1960s. Osseointegration is a direct structural and functional connection between bone and the surface. Methotrexate (MTX) is an immunosuppressive drug, widely used in inflammatory disturbances including rheumatoid arthritis. There is no consensus regarding the effect of MTX on implant osseointegration
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