Introduction: The concepts of Ayurveda are unique when considered it in terms of treatment of diseases as well as preventive care in healthy persons. ‘Anupana’ is one among them, which is practiced with medicine and food. It helps in fast spreading, quick absorbing of medicine and food in the body. By changing the Anupana of one drug, it can be used in different diseases, which makes it unique. In order to drag attention of researchers to this unexplored topic, critical review has been prepared to highlight it in different features.
 Methods: References were sought in Pub Med, AYUSH research portal, DHARA online and Google Scholar by utilizing all key words and MeSh terminologies along with Ayurveda textbooks. Based on PRISMA guideline, 06 full text articles were included in this study. Clinical studies were also found where Anupana was used as modality for management.
 Discussion: Present systematic review put the light on the different aspects of Anupana as a theoretically and clinically proven novel concept to enhance the efficacy of formulation or drug quickly. Anupana facilitates the action of pharmacokinetics as well as pharmacodynamics. 
 Conclusion: Anupana has multi-dimensional benefits, including nutritional, stimulating, preventative, and curative properties. An appropriate Anupana should be chosen that is suitable for us in order to receive all of the benefits from its intake. Hence it can be concluded that Anupana concept is an integral aspect of Ayurveda and a blessing to human beings in terms of health.