Abstract
Heat shock protein Hsp70 is one of the main cytoprotection components under the action of various external stimuli. The analysis of the literature data shows that nowadays, the researches’ overwhelming evidence has proven the role of Hsp70 as a biological target for the drug development; however, the ideas about its use as a drug are often multidirectional.The aim of the article is to analyze and generalize the literature data on the features of the physiological functions of heat shock protein Hsp 70, and indicate the possibilities of its use for the pharmacological correction of various pathological conditions.Materials and methods. In the process of selecting material for writing this review article, such databases as Google Patents, Science Research Portal, Google Scholar, ScienceDirect, CiteSeer, Publications, ResearchIndex, Ingenta, PubMed, KEGG, etc. were used The following words and word combinations were selected as markers for identifying the literature: Hsp70, Hsp70 stroke, Hsp70 neuroprotection, Hsp70 cytoprotection, recombinant drugs.Results. In this review, the pharmacology of one of the key members of this family, Hsp70, was focused on. The literary analysis confirms that this molecule is an endogenous regulator of many physiological processes and demonstrates tissue protective effects in modeling ischemic, neurodegenerative and inflammatory processes. The use of recombinant exogenous Hsp70 mimics the endogenous function of the protein, indicating the absence of a number of typical limitations characteristic of pharmacotherapy with high molecular weight compounds, such as immunogenicity, a rapid degradation by proteases, or a low penetration of histohematogenous barriers.Conclusion. Thus, Hsp70 may become a promising agent for clinical trials as a drug for the treatment of patients with neurological, immunological, and cardiovascular profiles.
Highlights
Белок теплового шока Hsp70 является одним из основных компонентов цитопротекции при действии различных внешних раздражителей
In the process of selecting material for writing this review article, such databases as Google Patents, Science Research Portal, Google Scholar, ScienceDirect, CiteSeer, Publications, ResearchIndex, Ingenta, PubMed, KEGG, etc. were used The following words and word combinations were selected as markers for identifying the literature: Hsp70, Hsp70 stroke, Hsp70 neuroprotection, Hsp70 cytoprotection, recombinant drugs
The use of recombinant exogenous Hsp70 mimics the endogenous function of the protein, indicating the absence of a number of typical limitations characteristic of pharmacotherapy with high molecular weight compounds, such as immunogenicity, a rapid degradation by proteases, or a low penetration of histohematogenous barriers
Summary
Белок теплового шока Hsp70 является одним из основных компонентов цитопротекции при действии различных внешних раздражителей. Применение рекомбинантного экзогенного Hsp70 имитирует эндогенную функцию белка, свидетельствуя об отсутствии ряда типичных ограничений, характерных для фармакотерапии высокомолекулярными соединениями, таких как иммуногенность, быстрое разрушение протеазами или низкая степень прохождения через гистогематические барьеры. Обобщить и проанализировать данные литературы об особенностях физиологических функций белка теплового шока Hsp70 и обозначить возможности его применения с целью фармакологической коррекции различных патологических состояний. Что взаимодействие между TNF и его рецепторами передает сигнал о смерти посредством рекрутирования двух адаптивных белков: домена смерти, связанного с рецепторами TNF (TRADD), и белка домена смерти, связанного с Fas (FADD).
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