Repeated Measures Test Research Articles

Understanding the Influence of Early-Life Stressors on Social Interaction, Telomere Length, and Hair Cortisol Concentration in Homeless Kittens

The early postnatal period is a critical neurodevelopmental stage characterized by rapid neural maturation and is adversely affected by early-life stressors. This study explored the behavioural, physiological, and epigenetic consequences of early-life stress in a population of homeless rescue kittens. This longitudinal study included 50 kittens rescued and placed into foster care by the Prince Edward Island Humane Society. They underwent behavioural testing at 8, 10, and 12 weeks of age. Hair cortisol concentration was measured at 8 weeks and served as a physiological marker of the previous 3 months’ cumulative stress response, which, for these kittens, included the late gestation period. A blood sample for relative telomere length measurement was taken at 10–12 weeks to estimate epigenetic changes as young kittens. Data were analyzed with respect to age and performance in all repeated measures tests, status as a stray or a surrender, and the presence of the dam in their foster homes. As expected, the performance of kittens in all tests changed over the 5 weeks of testing. Kittens separated from their mothers exhibited significantly higher hair cortisol concentrations (p = 0.02) and elongated relative telomere lengths (p = 0.04). No correlation was found between hair cortisol concentration and relative telomere lengths (p = 0.99). These results support the need for further study on the effects of epigenetics and early-life stress, both in kittens and across species.

Polyethylene glycol versus lactulose in the treatment of chronic functional constipation in children: A randomized clinical trial

Background and aims: Constipation in children is a serious problem that affects both children and their families. We aimed to compare the clinical efficacy of lactulose and polyethylene glycol in the treatment of constipation in children. Methods: This randomized clinical trial was performed on 92 patients referred to a private gastroenterology clinic in Shahrekord, Iran. The patients were randomly assigned into two groups receiving polyethylene glycol or lactulose. Defecation patterns and complications were assessed 0, 3, 7, and 21 days after the intervention. Data were analyzed using the chi-square test, repeated measures test, Mann–Whitney U test in SPSS version 16.0. P<0.05 was considered statistically significant. Results: No difference was found between the two interventional groups in terms of the frequency of painful defecation (P=0.31), fecal incontinence (P=0.50), hard stools (P=0.69), fear of defecation (P=0.09), poor appetite (P=0.29), straining at stool (P=0.50), and abdominal pain (P=0.07) within a follow-up period of 21 days. There were significant differences in the frequency of defecation on days 7 and 21 (P=0.02). The mean frequencies of abdominal cramps were significantly higher in those who received lactulose (P=0.001). The rate of nausea and vomiting was 10.6% in the lactulose group and 4.3% in the polyethylene glycol group, indicating no difference between the two groups (P=0.221). Conclusion: The administration of polyethylene glycol and lactulose had no significant difference in reducing the symptoms of chronic functional constipation in children. However, it seems that polyphenol glycol played a role in increasing the frequency of defecation.

Comparison Analysis of Peer-to-Peer Lending Performance During COVID-19 Activity Restrictions in Indonesia

In recent years the peer-to-peer lending industry has been popular and growing in Indonesia, however activity restrictions due to Covid 19 had an impact on the global economy, especially on financial institutions including peer-to-peer lending. The Indonesian government has determined activity restrictions due to Covid-19 in March 2020 and activity restrictions will be lifted in December 2023. Researchers conducted an analysis to see the stability of peer-to-peer lending by comparing performance data of peer-to-peer lending companies through loan default and the number of loan distributions in the period before, during and after there were no restrictions on Covid 19 activities. The sample in this study used a purposive sampling technique of 72 samples of monthly peer-to-peer lending statistical data that had been registered and supervised by Otoritas Jasa Keuangan in 2018-2023, research was conducted using the General Linear Model Repeated Measure Test and the Friedman Test to determine whether there were significant differences between the three groups, namely the period before, during and after there were no restrictions on Covid 19 activities. The results of the analysis showed that there were significant differences in the loan default statistical values between the group before and during restrictions, the group after and during the Covid 19 pandemic restrictions with p values respectively 0.012 and 0.005. The average amount of loan disbursement has increased every year, but it was found that there was no significant difference between conditions before and during the Covid-19 pandemic restrictions.

The Complications after General Anesthesia between Female and Male Genders in the First 24 Hours after Surgery

Background During surgery, the body responds to injury. These physiological responses lead to an imbalance in the physiologic activity of the body. Objective This study aimed to compare the incidence of complications after general anesthesia between males and females in the first 24 hours postoperatively. Methods This is a cross-sectional study. The study population included 150 patients who were candidates for surgery in the age range of 18-55. The sampling method was simple and sequential, and the selection of samples continued to reach 75 in both male and female groups. The collected data were analyzed by SPSS v.18 software and descriptive statistics, chi-square and Repeated Measure tests. Finally, P <0.05 was considered statistically significant. Results The incidence of some complications after general anesthesia was significantly higher in women than in men, including hypertension, tachycardia, tachypnea, restlessness, reduction of SaO2, hypotension, pain, vomiting, nausea, and drowsiness. Also, some complications were observed in women more than men, but they were not statistically significant, including voice violence, urinary retention, bradypnea, and shivering. Bradycardia was the only complication that was seen in men more than women but was not statistically significant. It was also observed that all complications after 24 hours significantly decreased in all patients. Conclusion It is suggested that in future studies, this type of study should be conducted with a larger sample size in different populations and compared with other types of anesthetics.

The Effect of Preconception Counseling According to the Theory of Planned Behavior with the Presence of the Spouse on Preconception Health Behaviors – A Training Trial Study

Background and Objective: Preconception care consists of biomedical, behavioral, and social services, along with health interventions, for women and couples before conception to improve their health status and reduce individual and environmental high-risk behaviors. This study aimed to assess to preconception counseling according to the theory of planned behavior with the presence of the spouse on preconception care behaviors. Materials and Methods: This study was an educational trial. The researcher randomly divided women into two intervention and control groups. The control group only received routine preconception care in the presence of the spouse. The intervention group, according to the theory of planned behavior, received 60-minute face-to-face counseling weekly sessions. The main outcomes of behavior were divided into two categories: screening tests and vaccinations and individual lifestyle (exercise, nutrition, and smoking). The questions also focused on men’s check-up tests. The data normality was analyzed by group, variable type, and measurement stage using the Shapiro-Wilk test and the skewness and kurtosis results. Levene's and Mochli's tests were used to check the homogeneity of variances and assumption of sphericity, respectively. Data were analyzed using independent t-tests, chi-square, repeated measures test, and SPSS 26 software. Result: The previous lifestyle behaviors were respectively 15.22 + 2.836, 15.49 + 2.769, and 16.84 + 1.894 before, immediately, and 4 weeks after the intervention in control, and 12.70 + 3.69, 15.53 + 3.02, and 16.60 + 2.73 in the intervention group, indicating no significant differences (p=0.08). However, the two groups significantly increased healthy lifestyles over time(p=0.001). The results also showed that the mean of test and vaccination was respectively 4.44 ± 2.99, 2.75 ± 6.42, and 2.49 ± 8.31 before, immediately, and 4 weeks after the intervention in control, and 4.09 + 3, 6.74 + 2.87, and 8.35 + 2.37 in the intervention group, indicating no significant differences(p=0.99). Conclusion: Since the presence of the husband during the training of women's pre-pregnancy care can affect their health behaviors regardless of the type of intervention, men are suggested to attend prepregnancy training and consultations for at least one session.

Pistacia vera and its Combination with Cisplatin: A Potential Anticancer Candidate by Modulating Apoptotic Genes.

Many bioactive phytochemicals have essential significance for handling various diseases and developing new drugs. The aim was to investigate the anti-tumor activity and the underlying mechanisms of pistachio pericarp extract (PPE) and pistachio kernel extract (PKE) alone and combined with cisplatin (CP) in the treatment of prostate cancer. The effects of the PPE, PKE, and CP alone and PPE and PKE in combination with CP (PPE+CP and PKE+CP) on the proliferation of PC-3 cells were determined using the MTT assay. The fold changes of BAX, BCL-2, P53, KLK2, TNF, TGF, and NANOG expression against β-actin were determined by real-time technique. Data were analyzed by two-way ANOVA and repeated measure tests. These research results indicated that a greater anti-proliferative effect of the PPE and PKE was shown in combination with CP compared with treatments using the PPE and PKE or CP alone. The extracts and Cisplatin in vitro had good synergistic effects on the inhibition of the proliferation of PC-3 cells. The IC50 values of PKE+CP were 4.141, 2.140, and 0.884 ug/mL, and PPE+CP were 2.754, 2.061, and 0.753 ug/mL after 24 h, 48 h, and 72 h treatment, respectively. Also, this result presented that the mRNA expression of BAX and P53 increased, and BCL-2, KLK2, TNF, TGF, and NANOG decreased in PC-3 cells. The finding of this research showed for the first time the anti-carcinogenesis effects of separately and in the combination of PPE, PKE, and CP on the PC-3 prostate cancer cells via modulating some genes and that it may be nominated for the herbal anti-cancer medications.

Comparative analysis of methods for measuring root canal curvature based on periapical radiography: A laboratory study.

To evaluate the agreement between six currently available periapical radiography-based methods for measuring the root canal curvatures in mesial roots of mandibular first molars, assessed by two examiners with different proficiency levels. Non-endodontically treated mesial roots of 41 human mandibular first molars were radiographed using the parallelling technique. Two independent observers (a specialist in endodontics and radiology and a final-year dental student) assessed their root canal curvature using the methodologies described by Schneider (1971, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 32, 271), Weine (1982, Endodontic therapy), Berbert and Nishiyama (1994, Revista Gaúcha de Odontología, 356), Luiten etal. (1995, Journal of Endodontics, 21, 26), Hankins and ElDeeb (1996, Journal of Endodontics, 22, 123) and Pettiette etal. (1999, Journal of Endodontics, 25, 230). Intra- and inter-examiner reliability was assessed using the intraclass correlation coefficient. The differences in curvature angle measured by the different methods were compared using the one-way anova for repeated measures test, followed by Tukey's post hoc analysis. The effect was calculated using the Cohen's d method. To determine the agreement between methods, the Bland-Altman analysis was used. The significance level was set at 5%. Agreement for the observers was excellent (>0.81) for the six methods considered. For the angle comparisons between methods, the maximum differences were for Schneider versus Weine (35.77°) and Luiten versus Hankins (35.14°), whilst the highest percentage of angles with a difference >10° were Weine versus Luiten and Berbert versus Pettiette (90%) and the comparison Weine versus Hankins presented with the lowest frequency (15%). Excellent agreement was found for five comparisons: Weine versus Luiten (0.940), Berbert versus Pettiette (0.917), Weine versus Pettiette (0.907), Luiten versus Pettiette (0.904) and Berbert versus Luiten (0.812). Compared to Schneider's method, the other methods showed a tendency of increasing difference as the angles became more acute. The other methods exhibited linear differences, remaining constant for smaller and larger angles. Reliability was excellent for all methods assessed separately. Maximum differences in curvature angles were found when comparing Schneider versus Weine and Luiten versus Hankins. Excellent agreement was found for Weine versus Luiten, Berbert versus Pettiette, Weine versus Pettiette, Luiten versus Pettiette and Berbert versus Luiten. In the presence of dilacerations, the method by Schneider was less sensitive.

Evaluation of the impact of an integrated simulation model in basic life support training on knowledge and practice: A randomized control trial in Jordanian hospitals

This study aims to evaluate the effectiveness of simulation training (ST) in improving nurses' knowledge and practice, which is essential in the nursing field, particularly among nurses in Jordanian hospitals. ST has the potential to significantly enhance patient care outcomes. A Randomized Control Trial was conducted in five hospitals in Jordan, using three repeated measurement tests: a pre-test, an immediate post-test after the intervention, and a post-test three months later. The nonparametric Mann-Whitney statistical test showed that the control and experimental groups were similar, with no significant differences in the participants' demographic characteristics. The Independent T-test confirmed the similarity of the pre-test results in the control group's knowledge and practice and the intervention group's mean scores. The simulation intervention proved to be highly effective in enhancing Basic Life Support (BLS) knowledge and practice among nurses. It nearly doubled the knowledge pre-test percentage from 40% to 75.35% in the immediate post-test, improving the scores from poor in the pre-test to excellent in the post-test. This significant improvement highlights the importance of simulation training in enhancing nurses' knowledge and practice. Similarly, ST significantly increased the average practice score percentage from 47.5% to 70% after the intervention, demonstrating its substantial impact. In conclusion, BLS simulation is a highly efficient educational method that helps participants acquire knowledge and skills. Simulation training prepares learners to activate cardiopulmonary resuscitation (CPR) quickly and correctly in case of cardiopulmonary arrest. Therefore, simulation in training should be expanded in the nursing curriculum.

MIGRATION INHIBITION ACTIVITY BY METHANOL EXTRACT Hibiscus tiliaceus Linn. ON 4T1 BREAST CANCER

The prevalence of breast cancer cases in Indonesia is increasing along with the ability of cancer cells to migrate or move from the primary tumor mass and form new colonies elsewhere. The migration of cancer cells has encouraged the develop anticancer drugs from natural ingredients. Waru leaves have been shown to have cytotoxic activity. This study aims to determine the inhibition activity of migration of breast cancer cells 4T1 from methanol extract of waru leaves. Waru leaves methanol extract was obtained using the maceration method. Cytotoxic test of methanol extract of waru leaves (MEWL) was the migration test used in the scratch wound healing method at concentrations 162.5, 325, and 650 μg/mL at 0, 18, 24, and 42 hours after treatment. Analysis of IC50 using linear regression, while large areas were analyzed using Image-J software. The percentage of data closure was analyzed statistically with the Anova Repeated Measure test. All concentrations of Methanol Extract of Waru Leaves had significant inhibition of cell migration (p<0,05) compared to control at each observation time at 0, 18, 24, and 42 hours after treatment. So, MEWL is able to inhibit migration in 4T1 cells

Surface roughness of supra-nano spherical filled and nanohybrid composite resin after Coffea arabica immersion: an experimental study

ABSTRACTIntroduction: Supra-nano spherical filled composite resin (Omnichroma, Tokuyama, Japan) with sol-gel method has 0.26 μm filler size, while nanohybrid composite resin (ENA HRi, Micerium, Italy) has 0.2-1 μm filler size. Nanofillers enhance resistance from chlorogenic acid contained in Coffea arabica. This study analyzed the surface roughness difference between supra-nano spherical-filled and nanohybrid composite resins after Coffea arabica immersion for 7 and 14 days, with 15 minutes of immersion each day. Methods: This study was an in vitro laboratory experiment with a pretest-posttest control group design. Twenty composite resin samples were immersed in artificial saliva and divided into four groups; supra-nano coffee, nanohybrid coffee, supra-nano saliva (control), and nanohybrid saliva (control). After 24 hours, immersion in Coffea arabica was started for supra-nano coffee group and nanohybrid coffee group for 15 minutes daily until days 7 and 14. Control groups were immersed in saliva. Results: One-way ANOVA showed significant differences in the surface roughness between composite resin groups. Post-hoc Tukey showed a significant difference between supra-nano coffee (0.91± 0.29 μm) and nanohybrid saliva (1.43±0.42 μm). The GLM Repeated Measure test showed significant surface roughness changes in supra-nano after 14 days of immersion in Coffea arabica (1.47±0.13 μm), while nanohybrid experienced surface roughness changes in 7 days of immersion in Coffea arabica (1.94±0.55 μm) and increased in 14 days (2.25±0.47 μm). In saliva immersion (control group), nanohybrid experienced an increase in surface roughness after 14 days, while supra-nano did not experience a significant increase in surface roughness. Conclusion: Supra-nano spherical filled composite resin exhibits greater resistance to changes in surface roughness following immersion in Coffea arabica.KEYWORDSCoffea arabica, nanohybrid, composite resin, supra-nano spherical filled, surface roughness

The effects of a telenursing scheduled intervention of brief behavioral activation therapy on depression and anxiety symptoms of patients with mixed depression and anxiety disorder: A randomized controlled trial

BackgroundAlthough many studies have been conducted on the efficacy of behavioral activation in depression, few studies have evaluated the efficacy of this treatment in patients with mixed depression and anxiety through telecare. AimTo determine the effects of a telenursing scheduled intervention of brief behavioral activation therapy on depression and anxiety symptoms of patients with mixed anxiety and depression disorder (MADD). DesignA randomized controlled trial. MethodsThirty subjects with MADD were randomly assigned to an intervention group and a control group. The eight-session person-centered behavioral activation intervention was delivered twice weekly via tele-nursing. Depression and anxiety symptom severity were assessed using the Hamilton Anxiety Rating Scale and the Hamilton Depression Rating Scale at baseline, at the end, and one month after the intervention. Data were analyzed by independent t-tests, chi-square tests, and repeated-measures tests using SPSS version 24. ResultsThe results showed that after the implementation of the intervention, the depression score in the intervention group decreased from 19.86 (±8.56) to 17.21 (±6.71). In contrast, depression scores increased from 18.67 (±9.72) to 19.47 (±7.33) in the control group. For anxiety symptoms, there was a clinically significant decrease after the intervention only in the intervention group. ConclusionThe results showed the effects of brief behavioral activation tele-nursing on a non-significant reduction in depression symptoms and a significant clinical reduction in anxiety symptoms after the intervention in MADD.

The Effect of Yoga and Pelvic Floor Muscle Exercise on Sexual Function and Sexual Self-esteem of Reproductive-age Women: A Randomized Clinical Trial.

Sexual function is a part of sexual health which is an important aspect of the quality of life. Physical activity is one of the healthiest activities that can effectively reduce the risk of sexual disorders. Therefore, this study was conducted with the aim of evaluating the effect of yoga and pelvic floor muscle exercises on the sexual function and sexual self-esteem of reproductive-age women. This randomized clinical trial study was conducted from September to December 2023 on 46 women of reproductive age working in the Shahrekord University of Medical Sciences and its affiliated health centers. Multi-stage cluster sampling was used to select the subjects; later, they were randomly divided into two intervention groups A (N=21) and B (N=25). Participants in intervention groups A and B performed pelvic floor muscle exercises at home using an educational pamphlet 3 times a week for 6 weeks, with 3 times a day repetition. In addition, women in the intervention group A participated in a yoga training program for 2 sessions per week for 6 weeks. Data collection tools included a demographic information form, the Female Sexual Function Index, and Sexual Self-Esteem Inventory for women. Questionnaires were completed by both groups before, immediately, and one month after the intervention. The data were analyzed using the chi-square test, fisher's exact test, independent two-sample t-test, repeated measures test, and analysis of covariance in SPSS software version 16. A significance level of less than 0.05 was considered. The results showed no statistically significant difference between the two groups in sexual function (P=0.21) and sexual self-esteem (P=0.22) scores before the intervention. Also, the results showed no statistically significant difference between the two groups in terms of sexual function (P=0.35) and sexual self-esteem (P=0.59) scores one month after the intervention. However, the mean score of the sexual function index immediately after intervention showed a statistically significant difference between the intervention groups A (31.43±3.76) and B (29.41±2.38) (P<0.001). The mean score of the sexual self-esteem immediately after the intervention showed a statistically significant difference between the intervention groups A (181.19±19.90) and B (171.32±15.02) (P<0.001). Adding yoga exercises to pelvic floor muscle exercises can improve the sexual function and sexual self-esteem of women at their reproductive age. Trial Registration Number: IRCT20100524004015N1.

Changes in Countermovement Vertical Jump Force-Time Metrics During a Game in Professional Male Basketball Players.

Cabarkapa, D, Johnson, QR, Cabarkapa, DV, Philipp, NM, Eserhaut, DA, and Fry, AC. Changes in countermovement vertical jump force-time metrics during a game in professional male basketball players. J Strength Cond Res 38(7): 1326-1329, 2024-As technology within elite basketball advances and is more available to sporting organizations, novel approaches for assessing and addressing athletic performance during practice or competition are being continuously explored. The aim of this investigation was to examine changes in neuromuscular performance during live basketball play. Eight professional male basketball players volunteered to participate in this study. The testing procedures were conducted during a pre-tournament camp over a span of 2 days. During the first day, the athletes were familiarized with the testing procedures, and baseline measurements were obtained. Using a uni-axial force plate system sampling at 1,000 Hz, each athlete performed 3 countermovement vertical jumps (CVJ) without an arm swing before proceeding with their regular training activities. During the second day of the pre-tournament camp, the athletes repeated identical CVJ testing procedures before the start of the first quarter and post-first, second, third, and fourth quarter of a simulated 5-on-5 basketball game. Repeated-measures testing design was used to examine statistically significant differences in various force-time metrics of interest in comparison to the baseline levels (p < 0.05). Besides a trivial decrease in eccentric mean force, the findings of this study revealed no statistically significant changes in any force-time metrics of interest within both eccentric and concentric phases of the CVJ (i.e., mean and peak force and power, jump height, impulse, velocity, and contraction time). Thus, we can conclude that these variables were not sensitive to acute fatigue, suggesting that the neuromuscular performances of professional male basketball players tend to remain unchanged throughout a 5-on-5 simulated game.

THE EFFECTIVENESS OF MINDFULNESS DEEP BREATHING TO INCREASE STUDENTS' ACADEMIC WELL-BEING

The study of positive psychology is currently an interesting part of efforts to form students who are active and happy in the learning process with meaningful activities. Mindfulness deep breathing in the learning process is not widely studied, because research is still limited to individual and group contexts. Thus, this research focuses on the application of classical mindfulness deep breathing format which is effective in improving students' academic well-being. The design used was multiple pretest post test with the research subjects being class X high school students. Data collection uses the Student Subjective Wellbeing Questionnaire (SSWQ). The results of the repeated measure test prove that the classical format mindfulness deep breathing is effective in improving students' academic well-being (f (1,72) = 272,80; p &lt;0,001). The findings in this study show the effectiveness of the mindfulness deep breathing technique implemented in a classical format in improving students' academic well-being.

Evaluation of contrast sensitivity in patients with congenital red-green color vision deficiency.

To evaluate mesopic and photopic contrast sensitivity in patients with congenital red-green color vision deficiency regarding with and without glare conditions and to compare these findings with age- and gender-matched healthy controls with normal color vision. Patients with congenital red-green color vision deficiency and age- and gender-matched healthy controls were included in this cross-sectional comparative study. Contrast sensitivity measurements were taken from all subjects in 4 different conditions; binocular mesopic-without glare, mesopic-with glare, photopic-without glare, photopic-with glare, and the results were compared. Twenty one patients with color vision deficiency (13 deuteranopic, 8 protanopic) and 22 age- and gender-matched healthy controls were included in the study. The mean age was 35.2 ± 13.5years in the protan group, 30.6 ± 7.7years in the deutan group, 32.0 ± 8.8years in the control group, and there was no significant difference in age between the groups (P > 0.05). The mean mesopic and photopic contrast sensitivity values of the groups at all spatial frequencies (1.5, 3, 6, 12, 18cpd) were not statistically significant when evaluated by the multifactor repeated measures test of ANOVA to evaluate the effect of light conditions (with and without glare) (P > .05). Mesopic and photopic contrast sensitivity values of patients with congenital red-green color vision deficiency were similar to healthy controls regarding with and without glare conditions.

Surface hardness and wear resistance of prefabricated and CAD-CAM milled artificial teeth: A cross-over clinical study.

To clinically evaluate the surface roughness and wear resistance of prefabricated and CAD-CAM milled acrylic resin teeth for complete dentures. In a cross-over study design, 10 completely edentulous patients were randomly included in this study and given two complete dentures. The first complete denture was made using prefabricated teeth, while the second was constructed using CAD-CAM milled teeth. Following insertion (T0), 3months (T3), and 6months (T6), the complete dentures were scanned. Utilizing 3D surface super-imposition techniques, the vertical (2D wear), and volumetric (3D wear) material loss were measured. The hardness of the teeth was evaluated at the time of denture insertion (T0) and then after 6months (T6) of denture insertion by digital Vickers hardness tester. Statistical analysis was done using SPSS software. Paired groups were compared by paired t-test. Also, a repeated measure test was used. The significant difference was considered if p≤0.05. The time of denture function was linearly correlated with the wear of the prefabricated and CAD-CAM milled denture tooth. Prefabricated acrylic teeth had significantly more vertical and volumetric wear after 3 and 6months, compared to CAD-CAM milled denture teeth where p-values were 0.01, 0.009, 0.003, and 0.024, respectively. Additionally, CAD-CAM milled teeth displayed significantly higher hardness values than prefabricated teeth both before and after 6months of use where p-values were 0.001. After 6months, all studied teeth showed a decrease in their hardness. In terms of wear resistance and surface hardness, CAD-CAM milled acrylic resin teeth were superior to prefabricated acrylic resin artificial teeth once the complete denture functions.

Exercise systolic blood pressures are unaffected by time of day in healthy young adults.

Blood pressure (BP) assessment during exercise testing has the capacity to identify exaggerated exercise BP (EEBP). BP has a circadian rhythm; therefore, exercise BPs may change throughout the day complicating EEBP identification. The purpose of this study was to determine the effect of time of day on exercise BP in healthy young adults. Thirty-one participants [48% female; 23(4) years] completed a modified Bruce treadmill protocol in the morning (M), afternoon (A), and evening (E). Submaximal (stage 4) and peak (highest value) systolic BP (SBP) were determined and ΔSBP was calculated (peak SBP-pre-exercise SBP). Repeated-measures tests were used to compare SBP data. EEBP was defined as a submaximal SBP ≥ 170 mmHg. Chronotype was assessed using the Morning-Eveningness Questionnaire (MEQ) and Pearson correlations were used to determine the relationship between MEQ score and ΔSBP during all tests. Significance was set at P < 0.05. Submaximal SBP (M:159(25); A:156(16); E:162(24) mmHg; P = 0.295), peak SBP (M:177(32); A:184(25); E:185(26) mmHg; P = 0.087) and ΔSBP (M:62(29); A:67(23); 65(20) mmHg; P = 0.546) were similar across time points. Eight participants had an EEBP on at least two tests. MEQ scores were correlated with ΔSBP during the A test (r = 0.357, P = 0.049) and E test (r = 0.363, P = 0.045). In conclusion, time of day had no effect on SBP responses to exercise, but our correlational analysis suggests changes in SBP may differ between chronotypes depending on the time of day of exercise. Given the clinical value of EEBP, it is notable that 26% of our healthy young sample had EEBP.

The effectiveness of scaling therapy on periodontal indexes in adolescents with fixed orthodontic appliances: a prospective cohort study

ABSTRACT Background Although fixed orthodontic therapy offers numerous advantages, inadequate adherence to specific guidelines can lead to negative consequences, primarily affecting the gums. To enhance periodontal health, several surgical and non-surgical approaches, including scaling, have been employed.The purpose of this clinical study was to evaluate the adjunctive role of scaling therapy on (the improvement of gum health parameters among patients undergoing fixed orthodontic treatment(FOT) during the period of 6 months. Methods In this interventional study,78 patients were randomly assigned to either case or control groups. Oral hygiene techniques were taught to both groups. Periodic scaling was done were performed at three times (1,3 and 6 months) after the starting of orthodontic treatment in the intervention group. Periodontal indices were measured and compared at baseline and all follow-up times between groups. The data were analysed with the repeated measure test at the significant level of 0.05 in the SPSS software (ver.22). Findings This study was conducted on 78 patients with a mean age of 21 ± 9 years old, including 37 women and 41 men that assigned to two equal groups of 39. The results of repeated measured analysis showed that the mean of GI and BOP indices increased significantly during the follow-up period of the study in the control group, but a non-significant decrease was obtained in the intervention group. But, the average of Pl.I index decreased significantly during the follow-up period in the intervention group, compared to the control group. Conclusions Scaling as an adjunct therapy helps to improve clinical periodontal parameters in patients undergoing FOT.

The Effect of the Team Members Teaching Design vs. Regular Lectures method on the Self-efficacy of the Multiple sclerosis Patients in Iran. Randomised Controlled Trial.

This study was conducted with the aim of the effect of team members teaching design (TMTD) vs. regular Lectures method on the self-efficacy of the multiple sclerosis patients. This research is a randomized controlled trial study. In this study, 48 multiple sclerosis persons of members of Jahrom MS Society participated. The persons were selected by simple random sampling and then divided into three groups of: TMTD (n=16), regular lecture method (n=16), and control (n=16), by random allocation method. In the intervention groups, six training sessions were held twice a week; control group did not receive education. Data was collected by the MS self-efficacy questionnaire of Rigby et al. in the before, immediately and one month after the intervention. Patients in three intervention and control groups were similar in terms of demographic variables. The results of the repeated measurement test before, immediately and one month after the intervention showed that the mean of the all dimensions of self-efficacy in two intervention groups had increased significantly (p<0.05). While these changes were not significant in the control group (p ≥ 0.05). Also, there was a significant difference in the mean of the all dimensions of self-efficacy between the intervention groups of TMTD and regular lectures. Based on the findings, TMTD compared to regular lectures method had a more significant effect on improving the self-efficacy of multiple sclerosis patients. Therefore, it is recommended that nursing use this educational approach to increase patients' self-efficacy.

Comparing the Effectiveness of Schema-Based Parenting Training with Compassion-Based Parenting Training on Mothers' Parenting Self-efficacy, Self-concept, and Parental Acceptance of Children with Internalizing Problems

Background: Children and adolescents constitute a major segment of the world's population, and their health is particularly important in any society. In recent years, attention has been paid to the issues and challenges faced by children under the title of morbid psychology of children, as one of the major topics in psychiatry and psychology. Objectives: The present study was conducted with the aim of comparing the effectiveness of schema-based parenting training with compassion-based parenting training on mothers' parenting self-efficacy, self-concept, and parental acceptance of children with internalizing problems. Methods: The current research was conducted as a semi-experimental pre-test-post-test and follow-up study. The statistical population included all primary school-aged children in Tehran and their mothers in 2020. Forty-five children with internalizing problems and their mothers, who referred to counseling centers in Tehran and met the entry criteria, were selected through available sampling. They were then randomly assigned to two experimental groups (15 people in each group) and one control group (15 people). The study utilized Achenbach's Child Behavior Inventory (1991), the Children's Self-Concept Scale (1969), Rohner's Parental Rejection-Acceptance Questionnaire (Mother's Form) (1996), and Dumka's Parental Self-Efficacy Questionnaire (2007) to collect data. Data were analyzed using repeated measures tests and SPSS-24 software. Results: The results showed that both parenting education approaches had an effect on improving parental self-efficacy, self-concept, and parental acceptance. However, there was no significant difference between the two treatment methods. Conclusions: Therefore, according to the findings of this research, it can be concluded that both the schema-based parenting method and the compassion-based parenting training method can be used to reduce the internalized problems of children.