The poultry industry is a major source of odor pollution and has received significant attention because of its impact on air quality and human health. Acid scrubbing has been widely used in livestock houses to remove ammonia (NH3), but this method has not been optimized for other odorous compounds, such as volatile organic compounds (VOCs). In this study, on-farm acid scrubbing equipment was operated in an experimental closed broiler house to determine the removal efficiency of gaseous pollution. The equipment was applied to the broiler exhaust system. The pH value and the gas residence time (gRT) were evaluated using central composite design and response surface methodology to establish a quadratic regression NH3 removal model and to reduce emissions of VOCs and greenhouse gases under field conditions. The results showed that at gRT of 1.7 s and pH of 4.0 were the optimal process parameters. Under optimal treatment conditions, the NH3 removal efficiency reached a maximum of 83.4%. Oxygenated VOC (OVOC) removal efficiency affected the removal of other components, such as hydrocarbons, aromatic hydrocarbons, and sulfides by dissolving into the organic aqueous solution. The results indicate that OVOCs might be the key factors influencing the removal of total VOCs. The removal efficiencies of acetaldehyde, dimethyl disulfide, methyl mercaptan, methyl sulfide, acetone, ethane, propane, and CO2 under the optimal process were 90.6%, 69.5%, 81.7%, 100%, 97.5%, 84.3%, 70.6%, and 54.7%, respectively. The methane removal efficiency was undetermined because of the undetectable inlet concentration. This method can provide a basis for the application of acid scrubber equipment and technical support for collaborative treatment of gaseous pollutants in livestock houses.