Two percentages of TiB + TiC reinforced Ti-6Al-4V composites from Ti-B4C-C and Ti-TiB2-TiC systems were fabricated by reactive hot-pressed sintering. Their microstructures and mechanical properties involving elastic modulus, Vickers hardness, bending strength and wear property were investigated comparatively. The experimental results show that needle-like TiB whiskers and near-equiaxed TiC particles are evenly distributed in the Ti-6Al-4V matrix. The mechanical properties of the (TiB + TiC)/Ti-6Al-4V composites are closely related with the nominal composition and synthesis system of TiB + TiC reinforcement and the microstructures of composites. With increasing the nominal volume fraction of reinforcement, both elastic modulus and Vickers hardness increase more or less and the bending strength decreases in varying degrees. A certain increase of pores in the composites with the sintering temperature increasing to 1300 °C can markedly affect the bending strength. Moreover, no matter what the sintering temperature and nominal volume fraction of reinforcement, the elastic modulus and Vickers hardness of composites from the Ti-TiB2-TiC system are higher than those from the Ti-B4C-C system. Similarly, the composites from the Ti-B4C-C system present better abrasion resistance than those from the Ti-TiB2-TiC system due to the difference of interfacial bonding between the TiC particles and Ti-6Al-4V matrix in the two kinds of composites.