Comparison of some Paleozoic and Mesozoic gas shales has revealed a generally common sequence stratigraphy, consisting of, from the base upward: combined sequence boundary/transgressive surface of erosion (SB/TSE) upon which sits a transgressive systems tract (TST) enriched in organic matter, then a somewhat ‘cleaner gamma-ray’ highstand or regressive systems tract (HST/RST). When resolvable, this stratigraphy occurs at 2nd, 3rd, and 4th order relative sea level cyclicity, forming couplets of relatively organic-rich (TST and condensed section-CS) and organic-poor (HST/RST) strata at these time scales. A higher order sequence stratigraphy can be developed for Mesozoic shales than for Paleozoic shales owing to greater biostratigraphic age resolution of the former. The higher frequency cycles are superimposed upon lower frequency cycles, giving rise to a complex stratigraphy of several couplets of differing thickness and distribution. These documented common characteristics provide the basis for a unifying, general sequence stratigraphic model for shales which can be utilized to identify, predict and map the most productive facies within a shale stratigraphic interval.There also are several commonalities in geochemistry of gas shales. Prolific gas shales are usually >200 ft (65 m) thick, contain >3% TOC, have Hydrogen Index values >350 mg HC/g, contain Type II kerogen and have organic maturity values >1.1% Ro. Organic-rich shales typically contain minerals such as pyrite and phosphates (apatite) and show biomarker ratios (pristane/phytane, steranes distribution, C13–C20 regular isoprenoids and C18 aryl isoprenoids) indicative of anoxic conditions during source rock deposition. In high maturity areas, there is a reversal in ethane isotope abundance owing to secondary cracking of hydrocarbons; such a reversal is normally associated with best gas production. Relative hydrocarbon potential (S1 + S2/TOC) is a geochemical parameter which reflects oxygenation conditions in the depositional environment. It can be related to relative sea level fluctuations within a sequence stratigraphic context.Understanding the sequence stratigraphy of shale provides a powerful tool not only for regional-to-local stratigraphic correlations from well logs and seismic reflection records, but also for high-grading stratigraphic intervals most favorable for preservation of organic matter and gas generation and storage.