Red Ginger Research Articles

PEMBERDAYAAN MASYARAKAT DALAM PEMANFAATAN JAHE MERAH (ZINGIBER OFFICINALE ROSCOE) DALAM MENURUNKAN TEKANAN DARAH PENDERITA HIPERTENSI DI DESA TARATARA SATU

High blood pressure, also known as hypertension, is a non-communicable disease (NCD), which is a condition where blood pressure increases above the normal threshold of 120/80 mmHg; this includes an increase in systolic blood pressure of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg in two measurements taken over five minutes in a resting or calm state. Red ginger also functions to lower blood pressure because the compounds contained in ginger have a mechanism that can inhibit the activity of angiotensin-converting enzyme (ACE) so that it can reduce high blood pressure. The aim of this activity is to empower the community in the use of red ginger (Zingiber officinale Roscoe) in reducing blood pressure in hypertension sufferers in Taratara Satu Village. The method used in this activity is the lecture method and providing education about the benefits of red ginger. Based on the results of PKM activities in Taratara Satu Village, Tomohon City, the results showed that there was an increase in public knowledge about the use of red ginger in lowering blood pressure in the community in Taratara Satu Village. It can be concluded that there has been an increase in public knowledge about the use of red ginger in lowering blood pressure in the community in Taratara Satu Village. As a suggestion for the public, to make more use of red ginger extract as part of complementary therapy to lower blood pressure.

Fish Pangek Processing Lake Singkarak In Solok Regency

This research is motivated by pangek in general made from sea fish and no additional ingredients, this is different from the pangek in Nagari Paninggahan which is made from lake fish, namely bilih fish and sasaudan fish mixed with additional ingredients such as young nagka, young papaya, chayote, and sijangkang. This research was conducted with the aim of identifying the composition of ingredients, spices, tools used in making pangek in Nagari Paninggahan and explaining the processing process used in making pangek in Nagari Paninggahan.The type of research used is qualitative, the location of this research was carried out in Nagari Paninggahan, Junjung Sirih District, Solok Regency in October 2023. The data sources are Bundo Kandung and people who are experts in making pangek. Data collection techniques by conducting observations, interviews, and documentation. Data analysis in the field which includes data reduction, data presentation, conclusion drawing and verification. The results showed that pangek in Nagari Paninggahan is made from bilih fish and Sasau fish, as well as additional ingredients such as young jackfruit, young papaya, chayote and sijangkang. The spices used are red chili, shallots, garlic, ginger, galangal, lemongrass, turmeric leaves, lime leaves, bay leaves, ruku-ruku leaves, lemongrass and belimbing wuluh. The tools used are knives, plastic kom, grindstone or blender, cauldron or talenang, stove and samba plate. The process of making

Physico-Chemical Properties and Antioxidant Stability of Liquid and Powdered Red Ginger Aquaresin: Modification of Plating Method with Silicon Dioxide and γ-Cyclodextrin

Red ginger extract (RGE) boasts high antioxidant activity due to its bioactive compounds but suffers from poor water solubility and dispersibility. This study aimed to improve these properties by converting RGE into liquid and powdered aquaresins. Diacetyl tartaric acid ester of mono- and diglycerides (DATEM) were used as emulsifiers due to their balanced hydrophile-lipophile balance (HLB). Aquaresins were prepared using plating methods due to their practicability and vacuum methods for the powdered form. The optimal RGE:DATEM ratio and characteristics of the aquaresins were investigated. A 45% RGE and 5% DATEM formulation yielded the highest levels of phenolic compounds, flavonoids, and 6-gingerol, while maintaining potent antioxidant activity over 60 days. The plating method significantly enhanced bioactive compound concentration compared to the vacuum method. Adding silicon dioxide and γ-cyclodextrin improved physical properties and antioxidant stability. The 45:5 RGE:DATEM ratio offered superior chemical properties and antioxidant activity in liquid aquaresin, while the plating method contributed to better chemical characteristics and antioxidant activity in powdered form. This study paves the way for incorporating RGE into various food and pharmaceutical applications.

Optimization of Red Ginger (Zingiber officinale var. Rubrum) Extraction Using Microwave Assisted Hydrodistillation Method

Red ginger is a spice plant that has high economic and social value. One of the uses of red ginger is to process it into a product, namely essential oil. This study aims to determine the optimization of the extraction process conditions on solvent volume, time, and extraction power that can produce optimum yield and residual content of red ginger essential oil solvent. The extraction was carried out with the help of microwaves. The research method is experimental design and optimization process with Response Surface Methodology (RSM) type Box-Behnken Design (BBD). The results showed that the optimum yield was at 700 mL solvent volume, 1 min extraction time, and 10% power (69.9 watts) with the equation Y = 0.2076 + 0.0262A – 0.0300B – 0.0013C and the concentration conditions the optimum remaining solvent with the equation Y = 4.98 – 1.0000A + 4.56B + 5.44C. The optimal yield of red ginger essential oil was 0.205%, with a residual solvent content of 3.8%, specific gravity 0.885, acid number 1.399, refractive index 1.485. The results of the optimum residual solvent content of -6.023%. Based on the results obtained, the yield value with the help of microwaves is higher than that without the help of microwaves. Keywords: Essential oil, Microwave, Residual solvent content, Response surface methodology (RSM), Yield.

Biochemical and Histoarchitectural evaluation of 4-Vinylcyclohexane induced ovarian cancer against Alpinia purpurata (Vieill). K. Schum

ObjectiveAlpinia purpurata is being studied for its potential to treat various conditions, including diabetes, arthritis, and tuberculosis. This research explores the impact of Alpinia purpurata (Vieill). K. Schum on ovarian cancer induced by 4-vinyl cyclohexane in Wistar albino rats. Materials and methodsFive sets of 100–120 g Wistar albino rats were assembled. Group 1 was the control group. Group 2 received intraperitoneal injection of 4-vinyl cyclohexane (80 mg/kg) for one month. Group 3 Treated similarly to Group 2 subsequently for the next two months treated with oral administration of A. purpurata ethyl acetate leaf extract (200 mg/kg body weight) Group 4 Treated similarly to Group subsequently for the next two months treated with Standard Drug Cisplatin (5 mg/kg body weight) weekly twice intraperitoneally. Group 5 acquired daily oral A. purpurata leaf extract (200 mg/kg) for two months. The rats were euthanized after the experiment under light chloroform anesthesia. Ovary and liver samples were obtained for lipid peroxidation, anti-oxidants, membrane-bound enzymes, tumor indicators, and histological investigation. ResultsOver a 60-day period, rats were given an ethyl acetate extract of A. purpurata at a dose of 200 mg/kg, which lead to in a substantial (p < 0.05) increase in body protein content, as well as enzyme levels. Furthermore, the use of the ethyl acetate extract significantly (p < 0.05) recovered the altered lipid peroxidation activities in the ovarian tissues of both control and experimental rats to near-normal levels. These data imply that the extract has the capacity to quench free radicals, indicating possible anticancer effects. ConclusionThe results suggested that, the ethyl acetate extract of A. purpurata exhibited significant antitumor activity against 4-vinyl cyclohexane induced ovarian cancer bearing rats.

Phytochemicals and antimicrobial properties of Thai edible plant extracts and their prebiotic-like effects

In this study, the phytochemicals and antimicrobial activities of ethanolic extracts of Thai edible plants, green tea, red cotton tree flower, fingerroot and ginger were evaluated. The plant extracts were taken for evaluation of antimicrobial activities against Cutibacterium acnes DMST 14916, Staphylococcus epidermidis TISTR 518, and Staphylococcus aureus TISTR 746. The minimum inhibitory concentrations (MICs) of green tea, fingerroot, and ginger extracts against C. acnes DMST 14916 were 3.92, 0.49, and 7.85 mg cm-3, respectively and the minimum bacteriostatic concentrations (MBCs) were 3.92, 0.49, and 7.85 mg cm-3, respectively. The MICs and MBCs of fingerroot extract against S. epidermidis TISTR 518 were 0.12 and 0.49 mg cm-3, respectively, while those against S. aureus TISTR 746 were 0.12 and 0.98 mg cm-3, respectively. Red cotton tree flower extract showed no antimicrobial activity against the acne-causing bacteria. By scanning electron microscopy (SEM) evaluation, the bacterial cells treated with the plant extracts revealed visible shrinkages compared to the smooth cell surfaces of the controls. The phytochemicals in the plant extracts were analysed by liquid chromatography with tandem mass spectrometry (LC-MS/MS). Well-known antimicrobial compounds like azelaic acid, embelin and kaempferol 3-rutinoside-4′-glucoside were identified in all extracts. The cytotoxic effects of the plant extracts on human cell lines were further investigated. The green tea extract was slightly toxic to HaCaT cells found at the initial concentration of 62.5 mg cm-3, but not toxic to MRC-5 cells. The fingerroot and ginger extracts had no cytotoxicity on HaCaT cells, but promoted the MRC-5 cell proliferation. The combination effects of the plant extracts were prebiotic-like and indifferent effects. Regarding all results, the ethanolic extracts of green tea, fingerroot, and ginger could be used individually as natural anti-acne ingredients capable of further product development to improve human skin health.

Proximate, total phenolic, carotenoid, antioxidant activity, color, and FTIR analysis of red ginger powders (Zingiber officinale var. Rubrum) through the evaporation-crystallization process

Red ginger is a plant that is rich in antioxidants and is easily available in Indonesia. So far, red ginger has been used with various extraction methods by previous researchers, but the application of this process has not been able to be used by independent economic MSMEs. This research took place using evaporation-crystallization equipment as the main tool, accompanied by temperature variations (80 and 90°C) and granulated sugar as a crystallization agent (60 and 100%). The quality of the powdered red ginger product analyzed in this study showed good stability values for the fresh red ginger raw material before processing. The average value of the proximate content of red ginger products is 7.668; 12.116; 5.225; 0.422-1.708; 73.960% for moisture, ash, fat, protein, and carbohydrate content, respectively; and total glucose of 63.768 ppm. Meanwhile, the results of the phenolic and carotenoid content provide a significant reduction of up to 50%. The average content is 42.459 mg gallic acid/g; and 5.480 g respectively (including color - also a decrease in L, a, and b values) compared to the red ginger pulp raw material. The opposite value occurred in the DPPH antioxidant activity of red ginger pulp, the content of which was 2-3 times higher than fresh red ginger. These findings not only have an impact on the development of more health-beneficial food and beverage products but also encourage further understanding of the potential of bioactive compounds in ginger to support human well-being.

Utilization of Ginger and Its Waste

Ginger has become the focus of research because of its oleoresin and essential oil content. First, the drying process can maintain the quality of post-harvest products and increase the shelf life of dry products. Applying heat by air, microwave, vacuum, and freeze-drying can remove up to 5% (w.b.) of the moisture content of the material. High temperatures provide a greater driving force and result in the best possible product damage. The involvement of an adsorption dryer can be an opportunity to carry out drying at low temperatures by involving a dehumidified air agent. Apart from drying, the extraction process is an essential component of the ginger isolation technique. In addition to temperature, the physical properties involved in this process are density and pressure (having relatively great difficulty in achieving the desired properties). Significant components with GC-MS and GLC tests gave different peak area results from the drying and extraction processes. However, β-phellandrene and camphene represent the presence of ginger essential oil in both methods. Then, the pulp and skin can also be reprocessed through extraction to produce ginger oil and ginger pulp. The sustainability of ginger residue through pyrolysis can produce ginger charcoal products. Meanwhile, the ginger pulp contains sugar, acid, and micro-fibrillation of cellulose (MFC) through hydrolysis. The results of research related to ginger provide opportunities for SMEs to produce post-harvest products in red ginger powder. The extraction process with polar solvents and the role of appropriate technology have encouraged independent economic activities. In addition, dregs from raw materials and by-products can be exploited for opportunities to reduce the waste generated.

Aspectos bioecológicos de Cynea (Cynea) diluta (Herrich-Schäffer, 1869) (Lepidoptera: Hesperiidae: Hesperiinae)

In Hesperiidae (Lepidoptera), many species build shelters during their ontogeny which may be serve as a scape strategy to reduce attacks from natural enemies and dislodgment from the host plant. This paper provides bioecological information regarding host plant, natural parasitism, and distribution of Cynea (Cynea) diluta (Herrich-Schäffer) (Hesperiidae: Hesperiinae) collected near remnants of the Atlantic Forest “Centro de Endemismo Pernambuco” (CEPE), Northeast Region of Brazil. Larvae and pupae, the later showing signs of parasitism, were collected from a garden at the Universidade Federal de Alagoas, Maceió, State of Alagoas, Brazil. They were brought to the laboratory to record emergences and possible parasitoids. Data from distribution were obtained from labels of hesperiid deposited from the Coleção Entomológica Padre Jesus Santiago Moure,Curitiba, State of Paraná. The host plant was identified as Alpinia purpurata (Vieill.) K. Schum. (Zingiberaceae). From the 13 larvae and two pupae collected in the environment, 20 specimens of Brachymeria sp. (Hymenoptera: Chalcididae) emerged from the pupae. This is the first report of parasitism on pupae of Cynea (C.) diluta.

The effect of adding dragon fruit peel (Hylocereus polyrhizus) and red ginger extract on characteristics of jelly candy from aloe vera

This research aimed to determine the effect of adding dragon fruit peel and red ginger extract on the characteristics of jelly candy made from Aloe vera. The study used a randomized block design (RBD) with two factors: the ratio of Aloe vera and dragon fruit peel (100:0, 90:10, 80:20, and 70:30) and red ginger extract (0%, 5%, and10 %). The parameters analyzed were moisture content, ash content, color value (⁰Hue), reducing sugar content, pH, crude fiber, anthocyanin value, antioxidant IC50, total phenol, as well as the hedonic values of color, aroma, taste, texture, and general acceptance. The results showed that the ratio of Aloe vera and dragon fruit peel significantly affected the ash content, color value (oHue), reducing sugar content, crude fiber, anthocyanin value, antioxidant IC50, total phenol, hedonic of color, and general acceptance. The red ginger extracts significantly affected ash content, color value (oHue), reducing sugar content, antioxidant IC50, total phenol, hedonic aroma, and taste. The interaction between the two factors significantly affected the color value (oHue) and total phenol. The formulation with a ratio of aloe vera:dragon fruit peel (70:30) and 10% red ginger extract yielded the best jelly candy.

In-vitro Anti-inflammatory Activity for Combination of Ethanol Extract from Sappan Wood (Caesalpinia sappan L.) and Red Ginger Rhizome (Zingiber officinale Roxb.)

Sappan wood and red ginger rhizome have been utilized as herbal medicine due to their anti-inflammatory, anti-oxidant, anti-microbial, analgesic, and immunomodulatory activities. Previous study revealed that sappan wood and red ginger rhizome showed good anti-inflammatory activity. However, the studies are focused on single extract. There are no research about combining the sappan wood extract and red ginger rhizome extract for antiinflammatory agent. Therefore, this study was conducted to determine the anti-inflammatory activity of the combination of sappan wood and red ginger rhizome ethanol extracts for antiinflammatory properties using red blood cell (RBC) membrane stabilization test. The tested samples consisted of sappan wood ethanol extract, red ginger rhizome ethanol extract, combination formulas (F1, F2, and F3), and positive control (diclofenac sodium). F1 comprises a 1:1 mixture of ethanol extract of sappan wood and red ginger rhizome, while F2 and F3 are composed of 2:1 and 1:2, respectively. The IC50 values for sappan wood ethanol extract, red ginger rhizome ethanol extract, and formulas F1, F2, and F3 were 47.63, 181.26, 101.93, 94.98, and 104.98 ppm, respectively. Statistical analysis using the one-way Anova followed by the Games-Howell post-hoc test revealed a statistically significant difference (p &lt; 0.05) in the IC50 of each sample. For single extracts, sappan wood is better as an anti-inflammatory. Meanwhile, in the formulations, Formula F2 is superior as an anti-inflammatory agent

AIR REBUSAN JAHE MERAH DAN AIR KELAPA TERHADAP INTENSITAS NYERI DISMENORE PADA REMAJA PUTRI

It is very important to treat dysmenorrhea, especially in teenagers, because if it is not treated it will affect the teenagers' own activities. The impact that arises from dysmenorrhea is the feeling of discomfort that women feel every time they menstruate, problems with the reproductive system can arise. To find out the comparison of the effectiveness of consuming red ginger boiled water and coconut water on the intensity of dysmenorrhea pain in young women at MTS Almarfuiyah in 2023. This research uses qualitative methods with a case study approach. This activity is carried out on young women who experience dysmenorrhea. In this study, the sample consisted of 2 people, where 1 sample used the intervention of consuming red ginger boiled water and 1 sample used green coconut water. The research instrument used to collect data is the data collection tool in this research using the Numeric Rating Scale (NRS) observation sheet. The study used univariate analysis to describe the comparison of the effectiveness of consuming red ginger boiled water and a mixture of coconut water on the intensity of dysmenorrhea pain in young women at MTS Almarfuiyah in 2023. Based on the results of these two observations, it is known that consumption of red ginger boiled water is more effective in reducing pain levels. Dysmenorrhea is seen from 3 days of intervention from scale 7 down to scale 4 and up to scale 1, while for consumption of green coconut water seen from 3 days of intervention from scale 7 down to scale 5 and up to scale 2. Midwives can collaborate with the school to register data on female students who experience dysmenorrhea to obtain information on how to reduce pain.&#x0D;

Effect of Ginger Extract in Lowering Blood Pressure in The Elderly with Hypertension

Background: Hypertension is a cardiovascular disease that is common to find in elderly. Its prevalence reached to 22% throughout the world in 2020. Pharmacological treatment to hypertension involves lifetime commitment to drug adherence. Ginger extract as complementary therapy has been widely common in Indonesia to reduce common flu symptoms and indigestion. It acts as a therapeutic effect that boosts immune system, improving the cardiovascular system by reducing the level of low-density lipoproteins and cholesterol. Prior studies showed its effect in lowering blood pressure in hypertension patients, while several other said the effect was stronger in less than 50 years old people. The aim of the study was to analyze red ginger extract as main therapy in hypertension in elderly. Methods: This study was a quasi-experimental with one group pretest-posttest without control group. Participants were 45-65 years old hypertension patients in Semper Barat II Primary Health Care. Intervention was 4 grams of minced ginger then added by 2 spoons of honey in 100 ml of water. The drink was consumed in 5 days. Results: Average age of participants were 62,9 (60-65) years old. Before intervention, mean blood pressure was 156,8 (140-180) / 98,03 (85-115) mmHg and lowered to 148,6 (125-170) / 92,57 (80-110) mmHg after 5 days of intervention (p=0,0001). Conclusion: We recommend ginger extract as an alternative to reduce blood pressure in elderly with hypertension. We hoped the results will become a new approach to treat hypertension.

Counseling on making dragon fruit skin ginger powder drink 'JAKUNA'

Dragon fruit skin ginger powder drink is a nutritious beverage that combines the health benefits of ginger and dragon fruit. This blend results in a drink packed with antioxidants, vitamins, and other essential nutrients. Ginger is renowned for its anti-inflammatory properties and immune-boosting effects, while dragon fruit is rich in vitamin C, fiber, and antioxidant compounds. The objective of this initiative is to promote the utilization of red ginger and dragon fruit peel in creating processed healthy beverages. It aims to enhance community knowledge and skills in transforming ginger and dragon fruit peel into nutritious drinks, as well as to create entrepreneurial opportunities within the community. The approach involves providing counseling sessions. As a result of this activity, there has been an emergence of ideas and motivation in producing JAKUNA instant powder drinks, following increased training subsequent to counseling on the production of such beverages.

Optimizing slurry preparation for improved mechanical and physical characteristics of nata de coco-based edible packaging

Conventional plastic food packaging, primarily composed of non-biodegradable synthetic polymers, has been a significant environmental concern. To address this issue, this study proposes the use of nata de coco (NDC) as an eco-friendly, edible alternative for food packaging, aiming to optimize NDC-based packaging to enhance both food safety and packaging quality. The study also seeks to improve the solubility of NDC edible packaging when mixed with food. To achieve this, NDC was processed into a slurry using different preparation techniques: kitchen blender (B), blender-hand mixer (BM), blender-sieve (BS), and blender-food chopper (BFC). Furthermore, the BFC treatment achieved the highest water solubility at 96.85% and demonstrated a tensile strength 19.35% greater than the B treatment. In assessing the practical application, the shelf-life of red ginger powder packaged in NDC sachets was estimated. Impressively, the highest shelf-life was recorded at 8 °C, lasting 331.74 days. The development of this bacterial-resistant, edible, sustainable packaging offers a viable substitute for the environmental effects of traditional plastic packaging.

The effect of fractionated ethanol red ginger (Zingiber officinale var. rubrum) extract on the pH level of Streptococcus gordonii metabolism (In-vitro Laboratory Experimental Research)

Introduction: Oral health is important for the quality of human life, so maintaining oral health is necessary. However, many people have dental caries as one of the main diseases in the oral cavity. Dental caries can occur due to pH falling in the oral cavity by acid-producing bacteria, such as Streptococcus gordonii, which metabolizes sucrose as an energy source and produces lactic acid. Then, the environmental pH decreases. Chemicals are widely used as antibacterial agents, but long-term use can cause negative effects, hence antibacterial agents with minimal side effects are needed. Red ginger is one of the options that appears as a promising antibacterial agent. Even though a lot of research has been investigated regarding red ginger, there is limited information on the effect of fractionated red ginger extract on pH in bacterial metabolism, especially Streptococcus gordonii. This study aims to analyze the effect of the other components in red ginger besides its essential oil on the pH level of Streptococcus gordonii metabolism. Methods: The groups in this study are control group 1 (bacteria, BHIB), control 2 (bacteria, BHIB, 5% sucrose), and treatment groups (bacteria, BHIB, 5% sucrose, extract red ginger 1.56% and 0.78%). Data were analyzed with Duncan's One-Way ANOVA and Post-Hoc Multiple Comparison. Results: The pH level of control group 2 was lower than group control 1 and treatment groups (p&lt;0.05). Conclusion: Fractionated ethanol extract of red ginger inhibits the decreasing pH level in the Streptococcus gordonii.

Pemanfaatan Media Sosial Instagram Sebagai Media Komunikasi, Informasi, Dan Promosi Di UMKM Minuman Herbal Berkah Setia

The community service activity entitled "Use of social media as a means of communication, information, documentation and promotion in the Blessings of Faith herbal drink business" aims to implement the university's tridharma, namely Community Service. The purpose of this activity is to provide information regarding the use of social media Instagram for small businesses and provide training on the use of Instagram so that its use can later be implemented in marketing activities for the red blessing red ginger business. The method used in this activity is direct observation of the Red Blessings Faithful ginger business by conducting direct interviews and documenting product photos and product manufacture which are then uploaded to Instagram media. The final result of this service is the use of social media Instagram as a medium for communication, information, documentation and means of promoting each product produced and activities discussed by the Ginger Berkah Setia business unit including images and supporting information

The Effect of Red Ginger Essential Oil on Adherence of Streptococcus mutans

Streptococcus mutans is a bacterium involved in the formation of caries. Red ginger essential oil is extracted from rhizomes, has a content of natural compounds, and is used in medicine for antibacterial, anti-inflammatory, and anticancer. To prove the effect of red ginger essential oil on Streptococcus mutans bacteria. The agar diffusion method is performed to test antimicrobial activity and determine the Minimum Inhibitory Concentration (MIC) against Streptococcus mutans. Furthermore, the adherence test of Streptococcus mutans bacteria was carried out using a spectrophotometer l = 570nm. MIC red ginger essential oil against Streptococcus mutans bacteria at concentrations of 0.78% and 1.56%. In the 0.78% concentrate, an adherence value of 2.12 was obtained and in the 1.56% concentrate, an adherence value of 1.93 was obtained and 3.125% concentrate obtained an adherence value of 1.78. Red ginger essential oil has potential as an antimicrobial agent by inhibiting the adherence of Streptococcus mutans bacteria.

Physicochemical and sensory characteristics of instant red ginger from various volumes of added water

The aim of this research is to obtain the right volume of water in ginger juice extract that has the best effect on the physicochemical and sensory properties of instant ginger. The research was carried out from March to May. The location of this research was carried out at the Agroindustry Laboratory, Faculty of Agriculture and Chemistry Laboratory, Faculty of Mathematics and Natural Sciences, Tadulako University, Palu. Research parameters include yield, water content, pH test, antioxidant activity and sensory tests with ginger juice extract and water treatment formulations, namely, (100g:100mL), (100g:150mL), (100g:200mL), (100g:250mL), (100g:300mL). The research results showed that the ratio of ginger juice extract and water at an added volume of 300 mL of water provide the best physicochemical and sensory characteristics of instant ginger drink. Yield, antioxidant activity, aroma, taste, preferences have a tendency increases with increasing water volume, while water content, pH and IC50 decrease.

Active Compounds of Red Ginger as Antioxidant Activity in the Supplementation and Treatment of Depression

This study examined compound active of red ginger related for supplementation and treatment of depression. Depression prevalence in Indonesia from the national population survey 6.9% had severe depression symptoms, 21.8% moderate to severe. Red ginger provided gold potential and demonstrated prominent natural phenomena and coexistence, abundant benefits. Standard herbal medicine and phytopharmaceuticals as one effort in dealing with depression disorder. Problem Statement. The use of medicines for depression disorder in the long term becomes a serious problem affecting various sectors and needs to be thought of side effects and complications. Objective. Antioxidants in red ginger (Zingiber Officinale Rosc. Var Rubrum has a secondary metabolite considered for treatment or supplementation in depression disorders. This study was experimental analytical study for analyzing secondary metabolism using phytochemical screening tests and examining active compounds with the combination of liquid chromatography with tandem mass spectrometry (LCMS/MS).Red ginger extracts contain secondary metabolic flavonoids of 48.79 mgQE/g, phenol 92.73 mgGAE/G and antioxidants of 39.96 ppm. Establishment of the active compound that has an effect as an antioxidant α-Eleostearic acid (C18 H30 O2) chemspider result 10, mzcloud 96, L Histidine (C6 H9 N3 O2) chemspiders result 6, mzcloud 94,8. Tetrahydrocurcumin (C21 H24 O6) chemspider result 41, mzcloud 92,5. Active compounds of red ginger antioxidants are diarylheptanoid, phenylbutenoid, flavonoid, diterpenoide, sesquiterpenoid, gingerol and shogaol. Red ginger extract content of active flavonoid compounds and has an effect as an antioxidant is potentially used as a supplement in the treatment of depression disorders.