Thermochronological data from the Songpan-Ganze˛Fold Belt and Longmen Mountains Thrust-Nappe Belt, on the eastern margin of the Tibetan Plateau in central China, reveal several phases of differential cooling across major listric thrust faults since Early Cretaceous times. Differential cooling, indicated by distinct breaks in age data across discrete compressional structures, was superimposed upon a regional cooling pattern following the Late Triassic Indosinian Orogeny. 40Ar/ 39Ar data from muscovite from the central and southern Longmen Mountains Thrust-Nappe Belt suggest a phase of differential cooling across the Wenchuan-Maouwen Shear Zone during the Early Cretaceous. The zircon fission track data also indicate differential cooling across a zone of brittle re-activation on the eastern margin of the Wenchuan-Maouwen Shear Zone during the mid-Tertiary, between ∼38 and 10 Ma. Apatite fission track data from the central and southern Longmen Mountains Thrust-Nappe Belt reveal differential cooling across the Yingxiu-Beichuan and Erwangmiao faults during the Miocene. Forward modelling of apatite fission track data from the northern Longmen Mountains Thrust-Nappe Belt suggests relatively slow regional cooling through the Mesozoic and early Tertiary, followed by accelerated cooling during the Miocene, beginning at ca. 20 Ma, to present day. Regional cooling is attributed to erosion during exhumation of the evolving Longmen Mountains Thrust-Nappe Belt (LMTNB) following the Indosinian Orogeny. Differential cooling across the Wenchuan-Maouwen Shear Zone and the Yingxiu-Beichuan and Erwangmiao faults is attributed to exhumation of the hanging walls of active listric thrust faults. Thermochronological data from the Longmen Mountains Thrust-Nappe Belt reveal a greater amount of differential exhumation across thrust faults from north to south. This observation is in accord with the prevalence of Proterozoic and Sinian basement in the hanging walls of thrust faults in the central and southern Longmen Mountains. The two most recent phases of reactivation occurred following the initial collision of India with Eurasia, suggesting that lateral extrusion of crustal material in response to this collision was focused along discrete structures in the LMTNB.