Against the characteristics of the temperature in reactor such as time-delay, time-varying and difficulty to build a precise mathematical model in the chemical industry. Through the analysis of dynamic characteristics of the controlled object, the method of fuzzy-PID control was designed based on a predictive model. According to the detected temperature signal, the output deviation of the controller and the on-line identification of prediction model, this algorithm gains the predictive value which uses a generalized predictive model and the fuzzy-PID control. Then compare the predictive value with the reference trajectory to get the deviation. Finally use this deviation and the change of the deviation to optimize the PID control parameters and attain the appropriate amount of system control. The simulation results show that the fuzzy-PID control based on prediction model has strong adaptability, good robustness, control accuracy and higher practical value.