Improved plant nutrition when applying organic and mineral fertilizers occurs due to nitrogen, phosphorus and potassium from fertilizers and soil. A significant part of them is fixed by soil. Depending on the amount of fertilizer applied and the mobility of soil nutrients, different conditions for the formation of the crop and its quality are created. Reproduction of soil fertility and increase in crop yields can only be achieved on the basis of the scientifically based use of fertilizers and other chemicals in crop rotations. Currently, the rational use of fertilizers, both organic and mineral, to increase productivity, quality of crops and improve soil fertility is of particular importance. Studying the effectiveness of various fertilizer systems in crop rotations and biologization of agriculture are currently becoming particularly important. Hence, this study highlights the comprehensive information on the influence of various fertilizer on the yield and quality of barley and potatoes.