Rapid Leakage Research Articles

Fast search for toxic gas leakage on offshore platforms based on deep learning methods

In the context of addressing dangerous gas leakage on offshore platforms, the prompt identification of leakage sources is paramount for implementing targeted emergency measures. This paper introduces a rapid leakage source location method leveraging a preexisting database on gas leakage and dispersion consequences, coupled with a deep learning approach. Initially, latin hypercube sampling (LHS) and computational fluid dynamics (CFD) are employed to simulate the consequences of gas leakage and dispersion on offshore platforms. Subsequently, a neural network model, specifically a long short-term memory (LSTM) model, is trained using concentration data. This trained model facilitates the rapid localization of the leakage source based on real-time detector data. Furthermore, optimization of the model is conducted through an analysis of various hyperparameters. Finally, the efficacy of the proposed methodology is demonstrated through a comparison between predicted results and actual operating conditions. This approach enables swift and precise identification of leakage sources during incidents, thereby facilitating a more efficient emergency response.

Enhanced air filtration and ammonia sensing with cellulose nanofibers-based triboelectric nanogenerators under harsh environments

Fire accidents often occur in environments characterized by severe air pollution, toxic gas emissions, and microbial growth, creating significant challenges for developing multifunctional portable healthcare devices. These devices must achieve high filtration efficiency, minimal pressure drop, and the capability to provide early warnings of toxic gas leaks. Triboelectric nanogenerators present a sustainable solution as self-powered energy converters for advanced healthcare applications. In this study, we grafted Ti3C2Tx/MoS2 nanohybrid materials, which form Schottky heterojunctions, onto cellulose diacetate using tetraethyl orthosilicate, followed by electrospinning to produce nanofibrous films. When paired with a negatively charged material, the resulting device achieved an optimal balance with a low-pressure drop (52 Pa) and high filtration efficiency (98.72 % for PM0.3). It also demonstrated exceptional stability under high-temperature and high-humidity conditions. Notably, the device maintained rapid sterilization within 15 min and consistent filtration performance even after multiple washes. Furthermore, the device exhibited precise detection of trace amounts of NH3 (0.1 ppm) and demonstrated a rapid response, achieving an 86 % response rate within 2 s for 100 ppm NH3, providing an early warning 28 s faster than commercial NH₃ monitors. This study introduces a novel approach to the development of multifunctional, self-powered, wearable medical devices that offer high-efficiency air filtration and sterilization, breath monitoring, and rapid toxic gas leakage detection in harsh environments.

Exploring the Effects of Fissures on Hydraulic Parameters in Subsurface Flows from the Perspective of Energy Changes

Reynolds number (Re), pore water pressure (P), and water flow shear force (τ) are primary indicators reflecting the characteristics of subsurface flow. Exploring the calculation of these parameters will facilitate the understanding of the hydrodynamic characteristics in different subsurface flows and quantify their differences. Hence, we conducted a study to monitor soil water content, matrix potential, and pore water pressure in two typical soil profiles (with and without fissures). The distribution of Re, P, and τ in both matrix flow (MF) and preferential flow (PF) were calculated with an improved calculation method, focusing on their energy changes. Results showed that these hydrologic parameters are quite different between MF and PF. Re values in MF remained below 0.1, indicating lower water flow velocities, while the Re values ranged from 0.8 to 2 in PF, indicating higher flow velocities. The P values in PF was tens to hundreds of times higher than that in MF, which is mainly due to the rapid accumulation and leakage of water within soil fissures. Additionally, the larger hydraulic radius and gradient in PF also resulted in higher τ values in PF (2~6 N m−2) than in MF (0~1.5 N m−2). In PF, the pressure potential was the significant factor for τ, while τ in MF was dominated by the matrix potential and varies with the magnitude of the matrix potential gradient. This study suggests that Re, P, and τ could be considered as the major indexes to reflect dynamic characteristics of subsurface flow.

Study on the impacts of refrigerant leakage on the performance and environmental benefits of heat pumps using R513A as replacement of R134a

The escalating threat of global warming has highlighted the imperative to address the greenhouse effect. R513A is recognized as a viable substitute for R134a, providing a lower global warming potential (GWP) while preserving similar thermodynamic properties. However, refrigerant leakage is one of the common faults in heat pump equipment. For industrial heat pumps, refrigerant leakage can make the system less stable and affect normal industrial production, while long-term leakage can also affect the carbon emissions of the industry. When substituting refrigerants, it is crucial to consider not only their distinct properties under typical operating conditions but also the stability and environmental impact of the alternative refrigerant in cases of leakage. This paper focuses on experimentally evaluating the impact of using R513A to replace R134a on the performance of refrigeration systems under the condition of rapid refrigerant leakage. Then the life cycle climate performance evaluation (LCCP) theory is used to assist experimental results in evaluating the carbon footprints of R513A and R134a systems at different annual leakage rates. The results show that R513A has better stability than R134a when responding to rapid refrigerant leakage. This paper determines the changes in annual electricity consumption and indirect emissions under several annual leakage rates and finds that the impact of leakage on indirect emissions is also not negligible. During the utilization phase of the equipment, when leakage was taken into account, the carbon emissions of the R134a system were higher.

Enhancement of battery thermal management effect by a novel MOF based composite phase change material

The introduction of phase change materials (PCMs) into battery thermal management systems (BTMS) can effectively enhance the cooling performance, safety and practical thermal management applications of lithium-ion batteries (LIBs). However, further study is needed to address the low heat conductivity and rapid phase change leakage of PCMs. This study proposed a metal–organic framework based shape-stabilized composite PCM (MOF/expanded graphite (EG) /multi-walled carbon nanotube (MWCNT) /paraffin wax (PW)) to construe battery cooling system, and its effect of battery thermal management is experimentally tested under various conditions. The results show the CPCM reveals a superior thermal management effect under varying ambient temperatures and discharge multipliers and outperforms natural convection. Even in the harsh environment of 40 °C and 3 C, the maximum temperature (Tmax) and Tmax difference (ΔTmax) of the CPCM-cooled module are 61.38 and 2.67 °C, which are 22 and 9 °C below the natural air-cooled module. Remarkably, the ΔTmax of the CPCM-cooled battery module in discharge decreases with the temperature rise at the discharge rate of 3 C, which is the exact opposite to the case of the air-cooled module. Moreover, the ΔTmax of CPCM-cooled module is 1.69, 1.84, 2.67 °C, all below the safe 5 °C at high temperatures (40 °C) as the discharge rate increases. The designed MOF-CPCM cooling system can effectively improve the temperature uniformity and thermal safety of the battery in harsh environments. Therefore, this novel MOF-based CPCM shows great promise in BTM.

Consequence analysis of a small-scale hydrogen leakage from the overhead hydrogen piping based on machine learning and physical modeling

Leakage from the overhead hydrogen piping (OHP) must be contained because of the wide flammability range and low minimum ignition energy of hydrogen; rapid leakage detection and appropriate emergency responses are necessary to ensure safe OHP operation. Consequence analysis after leakage detection is useful for hazardous-area estimation and assists operators in emergency-response planning. However, consequence analysis and leakage-detection methods have not been combined so far, and an integrated method has not yet been developed. This study aimed to develop a method based on machine learning (ML), physical modeling, and consequence analyses for rapid and appropriate decision-making after hydrogen leakage. Initially, an OHP model was constructed using physical modeling; this is a method that models target systems based on fundamental physical equations. Subsequently, an ML model for leakage detection was constructed based on various pressure or flow-rate profiles obtained from the OHP model. Regression models were constructed to estimate the leakage diameter. In addition, consequence analyses were conducted to estimate the effects of hydrogen explosions and fires using the leakage diameters predicted by the regression model. We confirmed that the ML model could distinguish between leakage and non-leakage conditions, and the estimated consequences could be used to visualize the risk level of hazardous areas near the leakage points in the case studies. The results of the case studies demonstrated the effectiveness of the proposed method for rapid decision making when hydrogen leaks from OHP. This method enables improved emergency responses in post-leakage situations.

Inorganic catalase-powered nanomotors with hyaluronic acid coating for pneumonia therapy

Clinical therapy for widespread infections caused by Streptococcus pneumoniae (S. pneumoniae), such as community-acquired pneumonia, is highly challenging. As an important bacterial toxin, hydrogen peroxide (H2O2) secreted by S. pneumoniae can suppress the host's immune system and cause more severe disease. To address this problem, a hyaluronic acid (HA)-coated inorganic catalase-driven Janus nanomotor was developed, which can cleverly utilize and decompose H2O2 to reduce the burden of bacterial infection, and have excellent drug loading capacity. HA coating prevents rapid leakage of loaded antibiotics and improves the biocompatibility of the nanomaterials. The Janus nanomotor converted H2O2 into oxygen (O2), gave itself the capacity to move actively, and encouraged widespread dispersion in the lesion site. Encouragingly, animal experiments demonstrated that the capability of the nanomotors to degrade H2O2 contributes to diminishing the proliferation of S. pneumoniae and lung tissue damage. This self-propelled drug delivery platform provides a new therapeutic strategy for infections with toxin-secreting bacteria.

Preliminary Investigation of Sudden Ground Subsidence and Building Tilt in Balitai Town, Tianjin City, on 31 May 2023

A short-term rapid subsidence event occurred in the Bi Guiyuan community in Balitai Town, Tianjin City, leading to the tilting of high-rise buildings and the emergency evacuation of over 3000 residents. In response to this incident, InSAR (Interferometric Synthetic Aperture Radar) technology was swiftly employed to monitor the subsidence in the area before and after the event. Our observations indicate that the region had maintained stability for 8 months prior to the incident. However, over the course of the 15-day event, the ground experienced more than 10mm of subsidence. By integrating the findings from an InSAR analysis with geological studies, we speculate that the rapid subsidence in the region is related to the extraction of geothermal resources. It is suspected that during drilling operations, the wellbore mistakenly penetrated a massive underground karst cavity. Consequently, this resulted in a sudden rapid leakage of drilling fluid, creating a pressure differential that caused the overlying soil layers to collapse and rapidly sink into the cavity. As a result, short-term rapid subsidence on the ground surface and tilting of high-rise buildings occurred.

Numerical and experimental analyses of methane leakage in shield tunnel

Tunnels constructed in gas-bearing strata are affected by the potential leakage of harmful gases, such as methane gas. Based on the basic principles of computational fluid dynamics, a numerical analysis was performed to simulate the ventilation and diffusion of harmful gases in a shield tunnel, and the effect of ventilation airflow speed on the diffusion of harmful gases was evaluated. As the airflow speed increased from 1.8 to 5.4 m/s, the methane emission was diluted, and the methane accumulation was only observed in the area near the methane leakage channels. The influence of increased ventilation airflow velocity was dominant for the ventilation modes with two and four fans. In addition, laboratory tests on methane leakage through segment joints were performed. The results show that the leakage process can be divided into “rapid leakage” and “slight leakage”, depending on the leakage pressure and the state of joint deformation. Based on the numerical and experimental analysis results, a relationship between the safety level and the joint deformation is established, which can be used as guidelines for maintaining utility tunnels.

Ready vascular permeability of a near-infrared fluorescent agent ASP5354 for intraoperative ureteral identification enables imaging of carcinoma tissues

This study investigates the ability of a near-infrared fluorescence (NIRF) imaging agent, ASP5354, for in vivo fluorescence imaging of esophageal squamous cell carcinoma (ESCC) tissues. The ability of ASP5354 was evaluated using a single dose of ASP5354 or indocyanine green (ICG), which was intravenously administered to a KYSE850 human ESCC xenograft mouse model. Subsequently, in vivo NIRF images of the mouse were obtained using a clinically available camera system. ASP5354-specific NIRF signals were strongly detectable in KYSE850 carcinoma tissues immediately (30 s) following ASP5354 administration compared with normal tissues. Meanwhile, ICG could not distinguish between normal and carcinomatous tissues. To elucidate the associated imaging mechanisms, the vascular permeability of ASP5354 and ICG was investigated in rat back dermis treated with saline or histamine, which enhances vascular permeability, using in vivo NIRF imaging. ASP5354 exhibited higher vascular permeability in histamine-treated skin than in normal skin. KYSE850 carcinoma tissues can be distinguished from normal tissues based on the measurement of ASP5354-specific NIRF signals, and the mechanism that enables imaging relies on the specific and rapid leakage of ASP5354 from the capillaries into the stroma of carcinoma tissues.

Detection of Landfill Leachate Leakage Based on ERT and OCTEM

Leakage in the impervious layer of a domestic waste landfill seriously pollutes the soil and groundwater. Therefore, it is necessary to carry out rapid nondestructive leakage location detection. In this research, the electrical resistivity tomography (ERT) method and the opposing-coils transient electromagnetic method (OCTEM) were used to detect the leakage location. The inversion sections of both methods showed a clear low–middle–high resistivity spectrum in the longitudinal direction that could be used to speculate the distribution pattern of the upper waste body layer, the bottom impermeable layer, and the lower limestone layer. The leakage area was identified in Zone B of the landfill on the basis of inversion results and drilling verification results. The results indicate that OCTEM and ERT were both sensitive to leakage detection. However, OCTEM had higher longitudinal resolution and more refined inversion results, resulting in more effective delineation for the location of the damage and leakage of the impervious landfill layer, thereby providing a new technical basis for landfill leakage detection.

On the Mechanism of Membrane Permeabilization by Tamoxifen and 4-Hydroxytamoxifen.

Tamoxifen (TMX), commonly used in complementary therapy for breast cancer, also displays known effects on the structure and function of biological membranes. This work presents an experimental and simulation study on the permeabilization of model phospholipid membranes by TMX and its derivative 4-hydroxytamoxifen (HTMX). TMX induces rapid and extensive vesicle contents leakage in phosphatidylcholine (PC) liposomes, with the effect of HTMX being much weaker. Fitting of the leakage curves for TMX, yields two rate constants, corresponding to a fast and a slow process, whereas in the case of HTMX, only the slow process takes place. Interestingly, incorporation of phosphatidylglycerol (PG) or phosphatidylethanolamine (PE) protects PC membranes from TMXinduced permeabilization. Fourier-transform infrared spectroscopy (FTIR) shows that, in the presence of TMX there is a shift in the νCH2 band frequency, corresponding to an increase in gauche conformers, and a shift in the νC=O band frequency, indicating a dehydration of the polar region. A preferential association of TMX with PC, in mixed PC/PE systems, is observed by differential scanning calorimetry. Molecular dynamics (MD) simulations support the experimental results, and provide feasible explanations to the protecting effect of PG and PE. These findings add new information to explain the various mechanisms of the anticancer actions of TMX, not related to the estrogen receptor, and potential side effects of this drug.

Bacteria-targeted delivery of black phosphorus quantum dots facilitates photothermal therapy against hypoxic tumors and complementary low-dose radiotherapy.

Many approaches have been employed to relieve hypoxia in solid tumors to enhance sensitivity to radiotherapy (RT), including O2 delivery or hydrogen peroxide (H2O2) decomposition strategies. To date, however, these modalities have been restricted by poor O2 loading, rapid O2 leakage, and limited endogenous H2O2 levels. To overcome these limitations, we therefore sought to develop an effective approach for the oxygen-independent treatment of hypoxic tumors. In this study, we designed a novel black phosphorus quantum dot (BPQD)/Escherichia coli (E. coli) hybrid system (BE) capable of facilitating the photothermal therapy (PTT) of hypoxic tumors. A simple electrostatic adsorption approach was used to conjugate BPQDs to E. coli. BE is capable of reliably targeting hypoxic tumors and mediating PTT. BPQDs in BE can directly facilitate X-ray-mediated radiosensitization of tumors, thereby achieving significant RT efficacy in response to lower doses of radiation, effectively and specifically damaging hypoxic tumor tissues to suppress the growth of tumors. Our results highlight this BE system as a novel approach to tumor radiosensitization with great potential for clinical application.

Antimicrobial peptide magainin 2-induced rupture of single giant unilamellar vesicles comprising E. coli polar lipids

Most antimicrobial peptides (AMPs) damage the cell membrane of bacterial cells and induce rapid leakage of the internal cell contents, which is a main cause of their bactericidal activity. One of the AMPs, magainin 2 (Mag), forms nanopores in giant unilamellar vesicles (GUVs) comprising phosphatidylcholine (PC) and phosphatidylglycerol (PG), inducing leakage of fluorescent probes. In this study, to elucidate the Mag-induced pore formation in lipid bilayer region in E. coli cell membrane, we examined the interaction of Mag with single GUVs comprising E. coli polar lipids (E. coli-lipid-GUVs). First, we investigated the Mag-induced leakage of a fluorescent probe AF488 from single E. coli-lipid-GUVs, and found that Mag caused rupture of GUVs, inducing rapid AF488 leakage. The rate constant of Mag-induced GUV rupture increased with the Mag concentration. Using fluorescence microscopy with a time resolution of 5 ms, we revealed the GUV rupture process: first, a small micropore was observed in the GUV membrane, then the pore radius increased within 50 ms without changing the GUV diameter, the thickness of the membrane at the pore rim concomitantly increased, and eventually membrane aggregates were formed. Mag bound to only the outer monolayer of the GUV before GUV rupture, which increased the area of the GUV bilayer. We also examined the physical properties of E. coli-lipid-GUVs themselves. We found that the rate constant of the constant tension-induced rupture of E. coli-lipid-GUVs was higher than that of PG/PC-GUVs. Based on these results, we discussed the Mag-induced rupture of E. coli-lipid-GUVs and its mechanism.

Gas sealing behavior of gasketed segmental joints in shield tunnels: An experimental and computational study

When shield tunnels pass through gas-bearing strata, gas leakage through could damage tunnel structure and interior equipment during both construction and operation process. Previous studies on sealing behavior of the gasketed joints have focused on the waterproof performance. However, differences in physical characteristics between liquid and gas lead to different permeation properties. This paper presents a combined experimental and computational study to investigate the gas sealing behavior of the gasketed joints in a shield power tunnel project, named as Sutong GIL Utility Tunnel, which passes through soft soil strata rich in high-pressure biogas under Yangtze River. The tests are aimed to measure the air leakage rates through the gasketed joints with various combinations of joint openings and offsets under different pressures. Slight leakage and rapid leakage are defined in the tests, where the leakage rates differ drastically in magnitude. This paper takes critical pressure, which corresponds to the leakage rate of 100 ml∙min−1 per meter joint length, as the index of the capability to resist sealing failure under extreme conditions, takes leakage rate as the index of gas sealing performance during long-term ‘slight leakage’, and evaluates the effects of the joint deformation on the gas sealing behavior from the two aspects. Finite element models of the inner gasket-groove structure were created and set with different joint openings and offsets, loaded with different pressures. Gasket deformation and contact stress under different conditions were studied. Comparison between the numerical results and test results was made to investigate the gas sealing behavior. Based on the existing gas sealing model of rough surfaces, a computational method of leakage rate was developed and validated, which can be used at the stage of long-term ‘slight leakage’. Based on the study, gas sealing behavior of the gasketed joints was analyzed and suggestions of improvement were given.

Strategic trading with information acquisition and long-memory stochastic liquidity

This paper investigates the strategic interaction of information acquisition, information-based dynamic trading, and noise trading patterns, as well as its significant implications on market equilibrium outcomes. We consider a market where the strategic trader can dynamically acquire costly information about an asset’s payoff via private signals instead of endowing him with its full information. The noise trading, which provides necessary liquidity for the market, has the feature of long-range dependence. The risk-neutral market maker then sets the equilibrium price for the asset based on information gleaned from the market total order flow. We characterize the equilibria for both opaque and transparent markets depending on whether or not the trader’s order flow is disclosed. In particular, closed-form solutions are obtained for two special cases and associated financial interpretations are provided. We find that: (1) the endogenous information acquisition and information-based trading help improve the price informativeness over time, while the information efficiency could be decreasing; (2) long-memory stochastic liquidity leads to an excessive price volatility; and (3) in a transparent market, the trader should adopt a mixed strategy by adding an additional noise term to the trading strategy to prevent rapid information leakage.

Ecotoxicity and Sustainability of Emerging Pb‐Based Photovoltaics

Emerging Pb‐based photovoltaic (PV) technologies, including in particular solution processed halide perovskite solar cells (PSCs) and Pb chalcogenide quantum dot solar cells (QDSCs), are among the most promising next‐generation PV technologies for a range of disruptive energy and electronic applications. However, the potential toxicity and leakage of hazardous Pb species have become one of the main barriers to their large‐scale application. When solar cells are subject to physical damage or failure of encapsulation, rapid leakage of Pb may occur, which can be accelerated by exposure to external environmental weathering conditions such as rainfall and elevated temperature. Herein, an in‐depth investigation on the essential role of Pb in PSCs and QDSCs, as well as common causes of Pb leakage, is undertaken. The hazardous effects of Pb toxicity on soil plants, bacteria, animals, and human cells are also evaluated. Recent progress in developing effective strategies for Pb leakage reduction, such as Pb‐free or Pb‐less perovskite materials, device architecture design, encapsulation absorbers for PSCs, and core–shell structure and ligand exchange method for QDSCs, in addition to Pb recycling strategies of end‐of‐life solar cells are summarized. This review provides quantitative insights into the future development of eco‐friendly emerging Pb‐based PV technologies.

Capsaicin-Modified Fluorosilicone Based Acrylate Coating for Marine Anti-Biofouling

Capsaicin has been extensively studied for its excellent antifouling activity and very low environmental toxicity. However, mixing natural capsaicin with coatings can cause rapid capsaicin leakage, severely shortening its antifouling cycle. In this study, we describe the preparation and performance of a new capsaicin-modified marine antifouling organofluorosilicone, which is based on silicone and fluorine acrylate monomers covalently bound to an organic antimicrobial monomer, HMBA (N-(4-hydroxy-3-methoxybenzyl)-acrylamide) on a polymer network. The chemical grafting of HMBA into the polymer has improved the problem of short antifouling life of the coating due to antifouling agent leakage and the environmental pollution caused by the leakage. The study focused on the synthesis of pristine acrylate monomers with organic bioactive groups prepared from vanillin amine salts and their co-polymerization in the presence of distal acrylate oligomers. The resulting cross-linked films were characterized using infrared spectroscopy, contact angle, and adhesion analyses. The results indicate that the materials had good adhesion, low surface energy, and were resistant to prolonged immersion in water. The polyacrylate coating synthesized from acrylate exhibited antibacterial and anti-algae activity. Biological tests on the marine microorganisms, Pseudomonas species, Shewanella species, and Navicula incerta, revealed a 97%, 98%, and 99% reduction compared to the blank control group, respectively, indicating that the coating has strong anti-adhesive ability. This work is expected to develop a promising material for marine antifouling.

Spray deposition of colorimetric H2 detector with Pd/MoO3 nanocomposites for rapid hydrogen leakage monitoring at room temperature

Here, we demonstrate a rapidly responsive colorimetric hydrogen detector based on Pd/MoO3 nanocomposites for hydrogen leakage monitoring at room temperature. The Mo5+-rich MoO3 nanobelts are synthesized via a simple one-step hydrothermal method by adding NaCl as the mineralizer. The structure of the detector is fabricated by a general spray deposition technique, not only forming uniform porous microstructures to promote the adsorption and diffusion of H2 but also solving the issue of performance degradation in ambient conditions by the strategy of on-site fabrication for immediate detection. The detector exhibits a rapid color change which could be recognized with naked eyes within 10 s even in as low as 1% of H2 at room temperature (25 °C) owing to the high content of active absorption sites (Mo5+) and the large surface area. The detector is also tested on a hydrogen storage tank with a prefabricated defect in the inner liner and exhibits a prompt and intense color change at the exact hydrogen leakage site, demonstrating its high efficiency in the visual hydrogen leakage detection in complicated systems. The facile fabrication approach as well as the rapid visual detection strategy enable the detector extensively applicable in the hydrogen industry.

Hydroxybutyl chitosan/ oxidized glucomannan self-healing hydrogels as BMSCs-derived exosomes carriers for advanced stretchable wounds

Skin wounds, especially full-thickness skin wounds on stretchable sites, including areas elbows, knees, and nape, usually undergo delayed or poor healing due to the frequent movements. Self-healing hydrogels are ideal candidates for wound dressings by automatically repairing the gel structural defects and restoring its function to solve the rapid degradation and leakage of loading materials caused by limb compression or movement. In this study, self-healing hydrogels loaded with biological exosome nanoparticles derived from bone mesenchymal stem cells was successfully constructed using hydroxybutyl chitosan and oxidized konjac glucomannan via reversible Schiff base reaction. Due to its three-dimensional porous structure and self-healing properties, hydrogels performed well in G′ recover under 350% strain, promoting cell migration and reducing the exosomes leakage by 30.4% and 42.4% at 14 h and 16 h when hydrogel network destroyed compared with hydroxybutyl chitosan hydrogels, respectively. In addition, hydrogels also exhibited antibacterial properties against E. coli and S. aureus contributed by the ε-poly-l-lysine coating. In vivo, exosome-loaded self-healing hydrogels significantly enhanced the stretchable wounds healing in full-thickness skin defects model by facilitating angiogenesis, promoting collagen deposition and helping skin remodeling. The results suggest that the novel multifunctional exosomes-loaded hydrogels as an advanced wound dressings exhibited great potential for tissue remodeling and regeneration on stretchable wounds.