Random Forest Classifier Research Articles

Specific microRNA Profile Associated with Inflammation and Lipid Metabolism for Stratifying Allergic Asthma Severity.

The mechanisms underlying severe allergic asthma are complex and unknown, meaning it is a challenge to provide the most appropriate treatment. This study aimed to identify novel biomarkers for stratifying allergic asthmatic patients according to severity, and to uncover the biological mechanisms that lead to the development of the severe uncontrolled phenotype. By using miRNA PCR panels, we analyzed the expression of 752 miRNAs in serum samples from control subjects (n = 15) and mild (n = 11) and severe uncontrolled (n = 10) allergic asthmatic patients. We identified 40 differentially expressed miRNAs between severe uncontrolled and mild allergic asthmatic patients. Functional enrichment analysis revealed signatures related to inflammation, angiogenesis, lipid metabolism and mRNA regulation. A random forest classifier trained with DE miRNAs achieved a high accuracy of 97% for severe uncontrolled patient stratification. Validation of the identified biomarkers was performed on a subset of allergic asthmatic patients from the CAMP cohort at Brigham and Women's Hospital, Harvard Medical School. Four of these miRNAs (hsa-miR-99b-5p, hsa-miR-451a, hsa-miR-326 and hsa-miR-505-3p) were validated, pointing towards their potential as biomarkers for stratifying allergic asthmatic patients by severity and providing insights into severe uncontrolled asthma molecular pathways.

Wearable Sensor-Based Assessments for Remotely Screening Early-Stage Parkinson's Disease.

Prevalence estimates of Parkinson's disease (PD)-the fastest-growing neurodegenerative disease-are generally underestimated due to issues surrounding diagnostic accuracy, symptomatic undiagnosed cases, suboptimal prodromal monitoring, and limited screening access. Remotely monitored wearable devices and sensors provide precise, objective, and frequent measures of motor and non-motor symptoms. Here, we used consumer-grade wearable device and sensor data from the WATCH-PD study to develop a PD screening tool aimed at eliminating the gap between patient symptoms and diagnosis. Early-stage PD patients (n = 82) and age-matched comparison participants (n = 50) completed a multidomain assessment battery during a one-year longitudinal multicenter study. Using disease- and behavior-relevant feature engineering and multivariate machine learning modeling of early-stage PD status, we developed a highly accurate (92.3%), sensitive (90.0%), and specific (100%) random forest classification model (AUC = 0.92) that performed well across environmental and platform contexts. These findings provide robust support for further exploration of consumer-grade wearable devices and sensors for global population-wide PD screening and surveillance.

Assessment of Machine Learning Algorithms for Land Cover Classification in a Complex Mountainous Landscape

Mapping land cover (LC) in mountainous regions, such as the Gilgit-Baltistan (GB) area of Pakistan, presents significant challenges due to complex terrain, limited data availability, and accessibility constraints. This study addresses these challenges by developing a robust, data-driven approach to classify LC using high-resolution Sentinel-2 (S-2) satellite imagery from 2019 within Google Earth Engine (GEE). The research evaluated the performance of various machine learning (ML) algorithms, including classification and regression tree (CART), maximum entropy (gmoMaxEnt), minimum distance (minDistance), support vector machine (SVM), and random forest (RF), without extensive hyperparameter tuning. Additionally, ten different scenarios based on various band combinations of S-2 data were used as input for running the ML models. The LC classification was performed using 2759 sample points, with 70% for training and 30% for validation. The results indicate that the RF algorithm outperformed all other classifiers under scenario S1 (using 10 bands), achieving an overall accuracy (OA) of 0.79 and a kappa coefficient of 0.76. The final RF-based LC mapping shows the following percentage distribution: barren land (46.7%), snow cover (22.9%), glacier (7.9%), grasses (7.2%), water (4.7%), wetland (2.9%), built-up (2.7%), agriculture (1.9%), and forest (1.2%). It is suggested that the best identified RF classifier within the GEE environment should be used for advanced multi-source data image classification with hyperparameter tuning to increase OA. Additionally, it is suggested to build the capacity of various stakeholders in GB for better monitoring of LC changes and resource management using geospatial big data.

Enhancing Car Segmentation for Thailand's Expressway Industry With an Automated Hybrid Machine Learning Framework

Car segmentation on Thailand's expressways poses challenges for traditional models due to unique characteristics, often resulting in predictive inaccuracies. Manual data analytics in this field is time-consuming and human centric. This research introduces an Automated Hybrid Machine Learning (AHML) framework leveraging advancements in AutoML, tailored for personalized customer segmentation in Thailand's expressway industry. The framework streamlines and automates the machine learning process, aiming to expedite model construction while enhancing performance. By employing clustering as an initial step followed by the Random Forest classifier as a hybrid classification approach, significant performance improvements are achieved compared to existing methods. Specifically, the model outperforms by 9.15% and 12.84% in both clusters, respectively. This research highlights the potential of the framework to address complex segmentation challenges and advance personalized customer targeting.

MCS-ML based line vulnerability for infrastructural resilience assessment with multi-wind speed cyclonic zones

The resilience of critical infrastructure is paramount for power systems prone to cyclonic activities characterized by varying wind speeds. This study conducts a thorough examination of the impact of cyclone lasting for a week on transmission lines for each passing day. Piecewise Cubic Hermite Interpolating Polynomial (PCHIP) is applied to extract hourly wind speed data for the cyclone. Sequential Monte Carlo Simulation (SMCS) is used to model the day-wise hourly transmission line fragility and determination of line vulnerabilities across high, medium, and low wind speed zones. Fragility curves are developed to depict the correlation between wind speeds and line failure probabilities in each zone. The line outage scenarios are generated based on the critical wind speeds and collapse wind speeds for each zone. Line Vulnerability Index (LVI) is proposed to determine the vulnerability and the resilience status of the transmission lines. Machine Learning (ML) based models, FFNN (Feed Forward Neural Network) and RFC (Random Forest Classifier), are proposed for assessment of infrastructure resilience by vulnerability ranking of the lines. Hourly wind speed and hourly line failure probability are the inputs to train the ML models and, LVI and ranking are predicted for the IEEE 30-bus system.

Unveiling the potential of machine learning approaches in predicting the emergence of stroke at its onset: a predicting framework

A stroke is a dangerous, life-threatening disease that mostly affects people over 65, but an unhealthy diet is also contributing to the development of strokes at younger ages. Strokes can be treated successfully if they are identified early enough, and suitable therapies are available. The purpose of this study is to develop a stroke prediction model that will improve stroke prediction effectiveness as well as accuracy. Predicting whether someone is suffering from a stroke or not can be accomplished with this proposed machine learning algorithm. In this research, various machine learning techniques are evaluated for predicting stroke on the healthcare stroke dataset. The feature selection algorithms used here are gradient boosting and random forest, and classifiers include the decision tree classifier, Support Vector Machine (SVM) classifier, logistic regression classifier, gradient boosting classifier, random forest classifier, K neighbors classifier, and Xtreme gradient boosting classifier. In this process, different machine-learning approaches are employed to test predictive methods on different data samples. As a result obtained from the different methods applied, and the comparison of different classification models, the random forest model offers an accuracy rate of 98%.

The prediction of semen quality based on lifestyle behaviours by the machine learning based models

PurposeTo find the machine learning (ML) method that has the highest accuracy in predicting the semen quality of men based on basic questionnaire data about lifestyle behavior.MethodsThe medical records of men whose semen was analyzed for any reason were collected. Those who had data about their lifestyle behaviors were included in the study. All semen analyses of the men included were evaluated according to the WHO 2021 guideline. All semen analyses were categorized as normozoospermia, oligozoospermia, teratozoospermia, and asthenozoospermia. The Extra Trees Classifier, Average (AVG) Blender, Light Gradient Boosting Machine (LGBM) Classifier, eXtreme Gradient Boosting (XGB) Classifier, Logistic Regression, and Random Forest Classifier techniques were used as ML algorithms.ResultsSeven hundred thirty-four men who met the inclusion criteria and had data about lifestyle behavior were included in the study. 356 men (48.5%) had abnormal semen results, 204 (27.7%) showed the presence of oligozoospermia, 193 (26.2%) asthenozoospermia, and 265 (36.1%) teratozoospermia according to the WHO 2021. The AVG Blender model had the highest accuracy and AUC for predicting normozoospermia and teratozoospermia. The Extra Trees Classifier and Random Forest Classifier models achieved the best performance for predicting oligozoospermia and asthenozoospermia, respectively.ConclusionThe ML models have the potential to predict semen quality based on lifestyles.

Tracking paddy rice acreage, flooding impacts, and mitigations during El Niño flooding events using Sentinel-1/2 imagery and cloud computing

The frequent occurrence of El Niño events, in the context of climate change, brings heavy precipitation and extreme heat, severely disrupting agricultural production. Previous efforts have focused on monitoring crop planting areas and evaluating affected crops during disasters. Nevertheless, a comprehensive analysis, including crop planting area mapping, crop damage assessment, and mitigation effectiveness throughout the entire course of a disaster, has been seldom addressed. In this study, we built a comprehensive framework to rapidly investigate the areas of early rice, the extent of flooding impacts, and the post-flood mitigations of early rice during the El Niño flooding event in a typical rice production region – Jiangxi Province in 2023. Early rice planting areas were first mapped by integrating 15-day time series gap-filled Sentinel-1/2 datasets using the Google Earth Engine (GEE) platform, based on a random forest classifier built with the 55 optimized training features. Then the flood-affected early rice map was produced by integrating the early rice planting areas and the Sentinel-1 images-based flood map. Finally, the post-flood newly planted rice fields were identified using the random forest algorithm and classification features from the Sentinel-1/2 images composited during four phenology phases of newly planted rice. The results showed the early rice planting area map, the flooding map, and the newly planted early rice map have overall accuracies of over 90 %. The early rice planting areas reached 120 × 104 ha, and an area of 3.60 × 104 ha (3 %) was flooded due to the heavy rain, and 3.43 × 104 ha flooded areas were newly planted, eventually mitigating the flooding impacts on the production of early rice. This study showcases the potential of all the available Sentinel-1/2 data, cloud computing, and well-established mapping algorithms for tracking rice areas, flooding impacts, and mitigations (i.e., after-flooding replanting) during extreme climate events. The established framework is expected to serve as an early warning system for agricultural adaptation to extreme climate events.

Beyond pixel: Superpixel-based MRI segmentation through traditional machine learning and graph convolutional network

Background and Objective:Tendon segmentation is crucial for studying tendon-related pathologies like tendinopathy, tendinosis, etc. This step further enables detailed analysis of specific tendon regions using automated or semi-automated methods. This study specifically aims at the segmentation of Achilles tendon, the largest tendon in the human body. Methods:This study proposes a comprehensive end-to-end tendon segmentation module composed of a preliminary superpixel-based coarse segmentation preceding the final segmentation task. The final segmentation results are obtained through two distinct approaches. In the first approach, the coarsely generated superpixels are subjected to classification using Random Forest (RF) and Support Vector Machine (SVM) classifiers to classify whether each superpixel belongs to a tendon class or not (resulting in tendon segmentation). In the second approach, the arrangements of superpixels are converted to graphs instead of being treated as conventional image grids. This classification process uses a graph-based convolutional network (GCN) to determine whether each superpixel corresponds to a tendon class or not. Results:All experiments are conducted on a custom-made ankle MRI dataset. The dataset comprises 76 subjects and is divided into two sets: one for training (Dataset 1, trained and evaluated using leave-one-group-out cross-validation) and the other as unseen test data (Dataset 2). Using our first approach, the final test AUC (Area Under the ROC Curve) scores using RF and SVM classifiers on the test data (Dataset 2) are 0.992 and 0.987, respectively, with sensitivities of 0.904 and 0.966. On the other hand, using our second approach (GCN-based node classification), the AUC score for the test set is 0.933 with a sensitivity of 0.899. Conclusions:Our proposed pipeline demonstrates the efficacy of employing superpixel generation as a coarse segmentation technique for the final tendon segmentation. Whether utilizing RF, SVM-based superpixel classification, or GCN-based classification for tendon segmentation, our system consistently achieves commendable AUC scores, especially the non-graph-based approach. Given the limited dataset, our graph-based method did not perform as well as non-graph-based superpixel classifications; however, the results obtained provide valuable insights into how well the models can distinguish between tendons and non-tendons. This opens up opportunities for further exploration and improvement.

Optimizing machine learning algorithms for diabetes data: A metaheuristic approach to balancing and tuning classifiers parameters

Diabetes mellitus poses a global health concern, prompting the development of machine learning algorithms designed to construct a model for the accurate classification of patients, enabling precise diagnoses and early-stage treatment. However, the efficacy of classifying diabetes patients through machine learning relies on datasets, often plagued by imbalance, leading to biased classification and inaccurate diagnoses. Previous research attempts, employing techniques like random sampling (under-sampling and oversampling) and the Synthetic Minority Oversampling Technique (SMOTE), have struggled to achieve optimally balanced datasets. Additionally, setting the best parameters for machine learning classifiers remains a challenging task. To address these issues, this research focuses on devising a methodological metaheuristic optimization, a machine learning algorithm tailored for diabetes data balancing, and classifier hyperparameter tuning. Leveraging Particle Swarm Optimization (PSO) algorithm for diabetes data balancing and a genetic algorithm to select the optimal architecture for various machine learning classifiers. The study compares the performance of the proposed metaheuristic data balancer and classifier architecture parameter tuner using classification metrics (F1 score, Average Precision–Recall (APR), AUC, and accuracy). The PSO balanced dataset emerges as the most effective in classifying diabetes, with an Average Percentage Improvement (API) in classification performance metrics: 20.78% accuracy, 16.79% area under the curve for receiver operating characteristics, and a significant 32.78% enhancement in APR. Moreover, the XGBOOST classifier trained with a genetic algorithm demonstrates minimal computational training time for the Centre for Disease Control and Prevention (CDC) diabetes dataset compared to the artificial neural network and random forest classifier. Notably, the imbalanced CDC diabetes dataset exhibits the least APR compared to random under-sampling and the PSO data balancing technique.

An automated sample generation method by integrating phenology domain optical-SAR features in rice cropping pattern mapping

Accurate spatio-temporal information on rice cropping patterns is vital for predicting grain production, managing water resource and assessing greenhouse gas emissions. However, current automated mapping of rice cropping patterns at regional scale is heavily constrained by insufficient training samples and frequent cloudy weathers in major rice-producing areas. To tackle this challenge, we proposed a Phenology domain Optical-SAR feature inTegration method to Automatically generate single (SC-Rice) and double cropping Rice (DC-Rice) sample (POSTAR) for efficient and refined rice mapping. POSTAR includes three major steps: (1) generating a potential rice map using a phenology- and object-based classification method with optical data (Sentinel-2 MSI) to select candidate rice samples; (2) employing K-means to identify SC- and DC-Rice candidate samples according to unique SAR-based (Sentinel-1 SAR) phenological features; (3) implementing a two-step refinement strategy to filter high-confidence SC- and DC-Rice samples, maintaining a balance between intraclass phenological variance and sample purity. Test areas selected for validation include the Dongting Lake plain and Poyang Lake plain in South China, as well as Fujin county located in the Sanjiang plain of North China. POSTAR proved effective in producing reliable SC- and DC-Rice samples, achieving a high spectral correlation similarity (>0.85) and low dynamic time wrapping distance (<8.5) with field samples. Applying POSTAR-derived samples to random forest classifier yielded an overall accuracy of 89.6%, with F1 score of 0.899 for SC-Rice and 0.938 for DC-Rice in the Dongting Lake plain. Owing to the incorporation of knowledge-based optical and SAR phenological features, POSTAR exhibited strong spatial transferability, achieving an overall accuracy of 96.0% in the Poyang Lake plain and 97.8% in the Fujin county. These results demonstrated the effectiveness of the POSTAR method in accurately mapping rice cropping patterns without extensive field visits, providing valuable insights for crop monitoring in large, diverse, and cloudy regions through the integration of optical and SAR data.

Retraction Note: Gramian matrix data collection-based random forest classification for predictive analytics with big data

Retraction Note: Gramian matrix data collection-based random forest classification for predictive analytics with big data

Land use land cover change in the African Great Lakes Region: a spatial–temporal analysis and future predictions

The African Great Lakes Region has experienced substantial land use land cover change (LULCC) over the last decades, driven by a complex interplay of various factors. However, a comprehensive analysis exploring the relationships between LULCC, and its explanatory variables remains unexplored. This study focused on the Lake Kivu catchment in Rwanda, analysing LULCC from 1990 to 2020, identifying major variables, and predicting future LULC scenarios under different development trajectories. Image classification was conducted in Google Earth Engine using random forest classifier, by incorporating seasonal composites Landsat images, spectral indices, and topographic features, to enhance discrimination and capture seasonal variations. The results demonstrated an overall accuracy exceeding 83%. Historical analysis revealed significant changes, including forest loss (26.6 to 18.7%) and agricultural land expansion (27.7 to 43%) in the 1990–2000 decade, attributed to political conflicts and population movements. Forest recovery (24.8% by 2020) was observed in subsequent decades, driven by Rwanda’s sustainable development initiatives. A Multi-Layer Perceptron neural network from Land Change Modeler predicted distinct 2030 and 2050 LULC scenarios based on natural, socio-economic variables, and historical transitions. Analysis of explanatory variables highlighted the significant role of proximity to urban centers, population density, and terrain in LULCC. Predictions indicate distinct trajectories influenced by demographic and socio-economic trends. The study recommends adopting the Green Growth Economy scenario aligned with ongoing conservation measures. The findings contribute to identifying opportunities for land restoration and conservation efforts, promoting the preservation of Lake Kivu catchment’s ecological integrity, in alignment with national and global goals.Graphical

Comparative analysis of features and classification techniques in breast cancer detection for Biglycan biomarker images.

Breast cancer (BC) is considered the world's most prevalent cancer. Early diagnosis of BC enables patients to receive better care and treatment, hence lowering patient mortality rates. Breast lesion identification and classification are challenging even for experienced radiologists due to the complexity of breast tissue and variations in lesion presentations. This work aims to investigate appropriate features and classification techniques for accurate breast cancer detection in 336 Biglycan biomarker images. The Biglycan biomarker images were retrieved from the Mendeley Data website (Repository name: Biglycan breast cancer dataset). Five features were extracted and compared based on shape characteristics (i.e., Harris Points and Minimum Eigenvalue (MinEigen) Points), frequency domain characteristics (i.e., The Two-dimensional Fourier Transform and the Wavelet Transform), and statistical characteristics (i.e., histogram). Six different commonly used classification algorithms were used; i.e., K-nearest neighbours (k-NN), Naïve Bayes (NB), Pseudo-Linear Discriminate Analysis (pl-DA), Support Vector Machine (SVM), Decision Tree (DT), and Random Forest (RF). The histogram of greyscale images showed the best performance for the k-NN (97.6%), SVM (95.8%), and RF (95.3%) classifiers. Additionally, among the five features, the greyscale histogram feature achieved the best accuracy in all classifiers with a maximum accuracy of 97.6%, while the wavelet feature provided a promising accuracy in most classifiers (up to 94.6%). Machine learning demonstrates high accuracy in estimating cancer and such technology can assist doctors in the analysis of routine medical images and biopsy samples to improve early diagnosis and risk stratification.

Development and validation of a machine learning-based model to assess probability of systemic inflammatory response syndrome in patients with severe multiple traumas

BackgroundSystemic inflammatory response syndrome (SIRS) is a predictor of serious infectious complications, organ failure, and death in patients with severe polytrauma and is one of the reasons for delaying early total surgical treatment. To determine the risk of SIRS within 24 h after hospitalization, we developed six machine learning models.Materials and methodsUsing retrospective data about the patient, the nature of the injury, the results of general and standard biochemical blood tests, and coagulation tests, six models were developed: decision tree, random forest, logistic regression, support vector and gradient boosting classifiers, logistic regressor, and neural network. The effectiveness of the models was assessed through internal and external validation.ResultsAmong the 439 selected patients with severe polytrauma in 230 (52.4%), SIRS was diagnosed within the first 24 h of hospitalization. The SIRS group was more strongly associated with class II bleeding (39.5% vs. 60.5%; OR 1.81 [95% CI: 1.23–2.65]; P = 0.0023), long-term vasopressor use (68.4% vs. 31.6%; OR 5.51 [95% CI: 2.37–5.23]; P < 0.0001), risk of acute coagulopathy (67.8% vs. 32.2%; OR 2.4 [95% CI: 1.55–3.77]; P < 0.0001), and greater risk of pneumonia (59.5% vs. 40.5%; OR 1.74 [95% CI: 1.19–2.54]; P = 0.0042), longer ICU length of stay (5 ± 6.3 vs. 2.7 ± 4.3 days; P < 0.0001) and mortality rate (64.5% vs. 35.5%; OR 10.87 [95% CI: 6.3–19.89]; P = 0.0391). Of all the models, the random forest classifier showed the best predictive ability in the internal (AUROC 0.89; 95% CI: 0.83–0.96) and external validation (AUROC 0.83; 95% CI: 0.75–0.91) datasets.ConclusionsThe developed model made it possible to accurately predict the risk of developing SIRS in the early period after injury, allowing clinical specialists to predict patient management tactics and calculate medication and staffing needs for the patient.Level of evidenceLevel 3.Trial registrationThe study was retrospectively registered in the ClinicalTrials.gov database of the National Library of Medicine (NCT06323096).

Fine-Resolution Wetland Mapping in the Yellow River Basin Using Sentinel-1/2 Data via Zoning-Based Random Forest with Remote Sensing Feature Preferences

Accurate wetland classification in the Yellow River Basin (YRB) is crucial for China’s ecological security, sustainable development, and wetland resource management. This calls for more sustained research on regional variations and studies on remote sensing features, especially with temporal considerations. To address this and the optimization of feature extraction as well as ranking, Sentinel-1 and Sentinel-2 images were used. Additionally, to achieve more precise wetland classification, the YRB was subdivided into four regions for random forest classification. The results show that different remote sensing indices effectively distinguish various wetland types and that key percentiles play a significant role in distinguishing wetland types. The 10 m refined wetland classification map for 2020, with an overall accuracy of 85%, demonstrates that this framework can meet the needs of conventional large-scale wetland analysis and management. The total area of wetlands in the YRB in 2020 was 33,554.67 km2, mainly distributed in the upper reaches of the YRB (71%), with seasonal marshes being predominant. The total water area reached 8538.64 km2, primarily distributed in the upper reaches of the YRB (57.40%). This high-resolution wetland map offers crucial insights and tools for monitoring, protecting wetland resources, and shaping policies, advancing regional sustainable development goals.

Using Fin Ray Elemental Signatures and Growth Zone Width to Estimate Onset of Sexually Maturity in Lake Sturgeon (Acipenser fulvescens)

Characterizing inter- and intra-population levels of variability in age at sexual maturation for long-lived fishes provides insight into year-class strength and recruitment dynamics, allowing for more effective management practices. Here we analyzed the ontogenetic chronology of pectoral fin ray annuli trace elemental concentration profiles as well as changes in annuli growth in Lake Sturgeon (Acipenser fulvescens) to determine onset of sexual maturity (OSM). Elemental concentrations and growth-zone width were used to build a random forest classification model to discriminate year-specific signatures to before or after OSM from 98 individual fin rays from both sexes across multiple populations and watersheds. The model demonstrated an overall accuracy of 98.8%. Ba was the most important variable related to OSM discrimination success followed by zone width, Pb, Mn, Mg, Zn, Cu, and Sr. Fin ray elemental concentrations began to increase at approximately age 24 (± 4.7) in females and 15 (± 3.1) in males while zone width decreased. This study implies that new applications for fin ray microchemistry are possible and could benefit future fisheries management strategies specifically by adding nonlethal or less invasive sampling techniques for evaluating OSM in sturgeon.

Feature Identification Using Interpretability Machine Learning Predicting Risk Factors for Disease Severity of In-Patients with COVID-19 in South Florida.

Objective: The objective of the study was to establish an AI-driven decision support system by identifying the most important features in the severity of disease for Intensive Care Unit (ICU) with Mechanical Ventilation (MV) requirement, ICU, and InterMediate Care Unit (IMCU) admission for hospitalized patients with COVID-19 in South Florida. The features implicated in the risk factors identified by the model interpretability can be used to forecast treatment plans faster before critical conditions exacerbate. Methods: We analyzed eHR data from 5371 patients diagnosed with COVID-19 from South Florida Memorial Healthcare Systems admitted between March 2020 and January 2021 to predict the need for ICU with MV, ICU, and IMCU admission. A Random Forest classifier was trained on patients' data augmented by SMOTE, collected at hospital admission. We then compared the importance of features utilizing different model interpretability analyses, such as SHAP, MDI, and Permutation Importance. Results: The models for ICU with MV, ICU, and IMCU admission identified the following factors overlapping as the most important predictors among the three outcomes: age, race, sex, BMI, diarrhea, diabetes, hypertension, early stages of kidney disease, and pneumonia. It was observed that individuals over 65 years ('older adults'), males, current smokers, and BMI classified as 'overweight' and 'obese' were at greater risk of severity of illness. The severity was intensified by the co-occurrence of two interacting features (e.g., diarrhea and diabetes). Conclusions: The top features identified by the models' interpretability were from the 'sociodemographic characteristics', 'pre-hospital comorbidities', and 'medications' categories. However, 'pre-hospital comorbidities' played a vital role in different critical conditions. In addition to individual feature importance, the feature interactions also provide crucial information for predicting the most likely outcome of patients' conditions when urgent treatment plans are needed during the surge of patients during the pandemic.

A robust framework for Alzheimer’s disease detection and staging: incorporating multi-feature integration, MRMR feature selection, and Random Forest classification

A robust framework for Alzheimer’s disease detection and staging: incorporating multi-feature integration, MRMR feature selection, and Random Forest classification

Long COVID diagnostic with differentiation from chronic lyme disease using machine learning and cytokine hubs

The absence of a long COVID (LC) or post-acute sequelae of COVID-19 (PASC) diagnostic has profound implications for research and potential therapeutics given the lack of specificity with symptom-based identification of LC and the overlap of symptoms with other chronic inflammatory conditions. Here, we report a machine-learning approach to LC/PASC diagnosis on 347 individuals using cytokine hubs that are also capable of differentiating LC from chronic lyme disease (CLD). We derived decision tree, random forest, and gradient-boosting machine (GBM) classifiers and compared their diagnostic capabilities on a dataset partitioned into training (178 individuals) and evaluation (45 individuals) sets. The GBM model generated 89% sensitivity and 96% specificity for LC with no evidence of overfitting. We tested the GBM on an additional random dataset (106 LC/PASC and 18 Lyme), resulting in high sensitivity (97%) and specificity (90%) for LC. We constructed a Lyme Index confirmatory algorithm to discriminate LC and CLD.