Diabetes Mellitus is a chronic disease with far-reaching consequences, necessitating innovative diagnostic approaches. Current methods have limitations, highlighting the need for advanced techniques. This research leveraged machine learning algorithms to predict diabetes using the Pima Indian Diabetes Dataset. Six algorithms were developed and compared: Logistic Regression, Support Vector Machine, K-Nearest Neighbor, Naive Bayes, Random Forest, and Decision Tree. Standard evaluation metrics assessed their performance. The Random Forest Classifier emerged as the top-performing algorithm, achieving an impressive 91% accuracy and demonstrating exceptional reliability. This study showcases machine learning's potential to transform diabetes diagnosis and management. The developed web application provides a user-friendly interface for predicting diabetes, facilitating timely intervention and improved health outcomes. The findings contribute significantly to the development of intelligent disease prediction systems, promoting early detection and enhanced patient care. By harnessing machine learning, this research pioneers a new frontier in diabetes diagnosis, paving the way for improved patient outcomes and enhanced healthcare services.