Context. The decrease in the probability of successful frame transmission in the infrastructure domain of IEEE 802.11 DCF wireless network is caused both by the influence of the collision intensity and by the impact of external interference in the radio path. Using the Markov chain approach as a baseline, we explicitly expressed the dependence of the network throughput on the number of operating stations, bit error rate (BER), and the frame fragmentation factor.
 Objective. The purpose of this article is to study the influence of interference intensity on the throughput of a wireless network domain in a wide range of the number of operating stations when transmitting frames of various lengths in the absence and with the use of the fragmentation mechanism.
 Method. The performed mathematical modelling showed, that in the range of increased and high noise intensity (BER = 10–5 – 10–4), a decrease in the length of the frame data field from the standard length of 12000 bits to 3000 bits is accompanied by a decrease in the throughput for all values of the number of competing stations. At the same time, it must be noted that as the amount of the frame data decreases, the throughput becomes less susceptible to an increase in the noise intensity. Qualitatively different results are obtained in the region of very high interference intensity (BER = 2·10–4). A significant increase in the probability of frame transmission in this region observed with a decrease in the standard length of the frame data field by 2–3 times, made it possible to increase the throughput compared to the original one. This effect is especially pronounced when the length is halved.
 Results. The study of the standard frame transmitting process, but with a fragmented data field, showed that if for BER = 5·10–5 and less with an increase in fragmentation factor, the throughput values decrease, in the entire range of the number of stations due to the predominant increase in overhead costs, then in the region of high (BER = 10–4) and very high noise intensity (BER = 2·10–4) we have the opposite effect. To the greatest extent, the throughput increases when the frame data is transmitted in two equal fragments. We have made a comparison of the network throughput determined by simply reducing the length of the frame data field and using fragmentation of a standard frame. The comparison showed that the use of the fragmentation mechanism is more beneficial both when throughput is stabilized under conditions of increased noise intensity and when the throughput is increased under conditions of high and very high noise intensity.
 Conclusions. In this article, a mathematical model has been modified for direct calculation of the wireless network throughput. Using this model, we studied the changes in throughput over a wide range of BER and a number of operation stations for various values of the transmitted frame fragmentation factor. The conditions for increasing the throughput are determined.