In the title complex, [Cu(NO3)2(C17H18FN3O3)2], the CuII ion is located on an inversion center. It exhibits a distorted octahedral geometry, being coordinated by six O atoms, four from two ciprofloxacin ligand molecules (L), which act as bidentate ligands, and two from two nitrate anions. In the ligand, the piperazine ring has a chair conformation and the quinoline system is essentially planar [maximum deviation = 0.097 (2) Å]. One of the nitrate O atoms is disordered over two positions [occupancy ratio = 0.51 (6):0.49 (6)]. There is a C—H⋯F interaction in the complex. In the crystal, molecules are linked via N—H⋯O hydrogen bonds generating a two-dimensional network lying parallel to (111). The presence of C—H⋯O interactions leads to the formation of a three-dimensional structure. The title complex was prepared by hydrothermal synthesis, and the hexahydrate form of this complex, synthesized by conventional methods, has been reported previously [Hernandez-Gil et al. (2009 ▶). Polyhedron, 28, 138–144].