The article attempts to analyze the level of social security in the Southern region of the country before and after the start of the full-scale invasion of Russia into the territory of Ukraine. It is defined that social security is determined by the nature of interaction between social groups on the basis of partnership, it is manifested at different levels (personal, group, regional, societal) in the capacity of state authorities to reproduce a stable, safe life. It has a subjective-objective nature and is determined both by the level of security of society and the region, as well as by individual or group well-being and awareness of one's security. The problems of assessing the level of social security have been identified, which are associated with the lack of a complete system of criteria assessment indicators and the inconsistency of the existing methodology and methods of data collection. It is proposed to monitor changes in the level of social security of the region under the influence of certain types of threats using an indicative sociological analysis based on the generalization of the values of objective sociogenic criteria and subjective evaluation judgments of the residents of the Southern region as objects of protection. It is proven that the unsatisfactory level of social security of the regional society is determined by a high level of insecurity, pessimistic perspectives regarding various types of social activity, and the impossibility of a quick return to normal life. There are outlined new threats to individual components of the social security of the population of Southern Ukraine associated with a full-scale war, in particular, demographic, economic, housing, educational, criminogenic, environmental security, etc. An attempt was made to identify possible ways of minimizing new threats to the social security of the South through the introduction of a number of economic, social and sociological mechanisms to minimize/overcome the consequences of these threats.