This study aims to assess feedwater, brine, and drinking water quality related to eight full-scale Egyptian seawater desalination plants. Collected water quality records from plants on the Mediterranean and Red Seas were monthly analyzed to identify different physical, chemical, and biological parameters during 2022. Statistical analysis and water quality indices (WQIs) approaches were applied to evaluate the various water quality states based on the available international and Egyptian guidelines. Analyzed seawater quality properties showed compliance with the most operating permissible limits except for high concentrations of turbidity, fats, oils, and greases, total bacteria in one plant, and iron, manganese, and silica in another plant. The monthly measured Weighted Arithmetic WQI classified 71 % and 100 % of desalination plants as having “Excellent” water rank according to the standard limits of the World Health Organization and the Egyptian Water Quality Standard, respectively. However, 65 % and 52 % of desalination plants were projected into the “good” water quality rank based on the Canadian Council of Ministers of the Environment WQI for the same guidelines. The results indicate that the feed intake type and the location of a desalination plant can optimize its performance efficiency, minimize contamination sources, and mitigate the potential environmental impacts of brine.