Background: Hospital Information Management System (HIMS) plays a pivotal role in modern healthcare facilities, encompassing administrative, medical, and financial components. Ensuring high-quality healthcare services hinges on the accuracy, continuity, and security of data, aligning with HIMS's mission. This quantitative research investigates the determinants influencing the implementation of HIMS at Puri Medika Hospital. Method: The research employs a dual-model approach, combining a modified HOT-Fit model with the DeLone and McLean Information Systems Success Model (D&M model), facilitating a comprehensive evaluation of factors affecting HIMS implementation. Result: The study scrutinizes pathways involving human, organizational, technological, and net benefit factors, shedding light on their intricate interactions. The findings reveal that determinants such as information quality, system development, user satisfaction, system benefits, service quality, system quality, organizational structure, environment, and user adoption significantly impact HIMS implementation at Puri Medika Hospital. Conclusion: This research contributes valuable insights into enhancing HIMS effectiveness and healthcare service quality.